Anhui Provincial Chest Hospital
Anhui Provincial Chest Hospital
Liu S.-S.,Anhui Medical University |
Liu S.-S.,Anhui Provincial Chest Hospital |
Zhang Y.-B.,Anhui Medical University
Chinese Journal of Antibiotics | Year: 2015
Objective: To investigate the value of serum procalcitonin (PCT) level in guiding the use of antibiotic in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: 108 patients with AECOPD were divided into the PCT group (n=52) and the conventional treatment group (n=56) according to the mantissa of their admission number. Serum PCT levels in patients from the PCT group were measured in day 1, 4, 7 and 10 after hospitalization, and decide whether use antibiotic according to the test result. In conventional treatment group, patients received antibiotics according to the clinical features and treatment guidelines of antibiotics. Results: There was no statistical significance in the clinical effective rate of moderate and severe patients between two groups, while the clinical effective rate of extremely severe patients in PCT group was lower significantly than that in conventional treatment group. The differences between two groups in the antibiotic utilization rate, duration of antibiotic therapy, hospitalization and medical expense were significant. The two groups' exacerbation times and time to next exacerbation were not significant within 6 months. Conclusion: Serum procalcitonin can guide the antibiotic treatment on the moderate and severe patients with AECOPD, and it can reduce the exposure of antibiotics.
Zhu F.,Anhui Medical University |
Zhu F.,Anhui Provincial Chest Hospital |
Ge J.-J.,Anhui Medical University
International Journal of Clinical and Experimental Medicine | Year: 2016
This study aimed to provide theoretical bases for choosing examination methods onpatients with mediastinal lymphadenectasis. The clinical characteristics of 140 patients with unexplained mediastinal lymphadenectasis who received video-assisted mediastinoscopy (VAM) were reviewed retrospectively. The relationship between various factors and pathological results of mediastinal lymphadenectasis was analyzed. There were no severe complications or death in these patients. The average operation time was 75.00±33.22 min and average blood loss was 55.07±14.13 ml. Pathological results showed that there were 74 malignant cases and 66 benign cases. The accuracy, sensitivity and specificity of VAM were 97.9%, 98.6% and 100% in identifying causes of mediastinal lymphadenectasis, respectively. These findings demonstrated that: 1) VAM is minimally invasive, safe and effective for the diagnosis and treatment of mediastinal lymphadenectasis. 2) During the diagnosis and staging of lung cancer or unexplained mediastinal lymphadenectasis with pulmonary abnormalities, endobronchial ultrasound-guided transbronchial needle aspiration may be applied first, and VAMis indicative for further diagnosis if negative results are found. 3) If patients with mediastinal lymphadenectasis have nopulmonary abnormalities or mediastinal neoplasm, VAMis preferred for examination. © 2016, E-Century Publishing Corporation. All rights reserved.