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Li Y.,Anhui University of Science and Technology | Li Y.,Anhui Key Laboratory for Optoelectronic Science and Technology | Li Y.,Hefei National Laboratory for Physical science at Microscale | Gong L.,Anhui University of Science and Technology | And 6 more authors.
Zhongguo Jiguang/Chinese Journal of Lasers | Year: 2015

Optical tweezers, a significant application technology of the laser, are capable of trapping microscopic particles by photon linear momentum transfer. Currently, it is a vital member of the family of micromanipulation tools as well as the precision measurement instrument of pico-Newton force spectroscopy. Its invention does not only aroused vast applications in optics but also plays an important role, as a bridge, in the interdisciplinary research. A short overview on the basic physical principles and concepts of optical trapping over the latest 30 years is provided. Further, some important applications of optical tweezers in cell biology, single molecular biology, the physics of colloidal systems and nano-science are presented as well as the main technical features implied in these applications. Finally, we discuss and expect the perspective of application of optical tweezers in the future. ©, 2014, Science Press. All right reserved. Source


Zhong M.,Hefei University of Technology | Zhong M.,Anhui Key Laboratory for Optoelectronic Science and Technology | Xue G.,Hefei University of Technology | Zhou J.,Hefei University of Technology | And 4 more authors.
Chinese Optics Letters | Year: 2012

Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) are found to promote cell adhesion, they are modified at numerous materials surface for medical applications such as drug delivery and regenerative medicine. Peptide-cell surface interactions play a key role in the above applications. In this letter, we study the adhesion force between the RGD-coated bead and Hela cell surface by optical tweezes. The adhesion is dominated by the binding of α5β1 and RGD-peptide with higher adhesion probability and stronger adhesion strength compared with the adhesion of bare bead and cell surface. The binding force for a single α5β1-GRGDSP pair is determined to be 16.8 pN at a loading rate of 1.5 nN/s. The unstressed off-rate is 1.65 × 10-2s-1 and the distance of transition state for the rigid binding model is 3.0 nm. © 2012 Chinese Optics Letters. Source


Zhong M.,Hefei University of Technology | Zhong M.,Anhui Key Laboratory for Optoelectronic Science and Technology | Zhou J.,Hefei University of Technology | Li Y.,Hefei University of Technology | And 2 more authors.
Chinese Optics Letters | Year: 2010

The transverse trapping forces on a dielectric sphere located at an oil-water interface are theoretically investigated with the ray-optics model. The transverse trapping forces rely on the internal property of the particle-interface system, and increase with either the decrease of three phase contact angles at the oil-water interface or the use of oil phase with low refractive index. The numerical results also show that the transverse trapping forces can be improved by either decreasing the numerical aperture of the microscope objective or shrinking the diameter of the trapping laser beam. © 2010 Chinese Optics Letters. Source

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