ITV Anglia, previously known as Anglia Television or Anglia, is the ITV franchise holder for the East of England. The station is based at Anglia House in Norwich, with regional news bureaux in Cambridge, Ipswich and Northampton. ITV Anglia is owned and operated by ITV plc under the licence name of ITV Broadcasting Limited.ITV Anglia broadcasts to Norfolk, Suffolk, Essex, Cambridgeshire, Northamptonshire, Bedfordshire, northern Hertfordshire, northern Buckinghamshire, southern Lincolnshire, southern Rutland and a small part of southern Leicestershire. Wikipedia.
News Article | May 25, 2017
How a pest control company in Cambridge is managing nuisance birds Looking at Cambridge from a bird’s eye view, it’s easy to see that the city, like many others is a haven for birds. Birds have become an increasing problem on buildings and structures throughout towns and cities across the UK. The most common birds in the UK are pigeons and gulls. As they scavenge for food in our towns and cities they frequently nest and roost on rooftops and ledges. As well as being responsible for attacking people, they cause serious damage to properties and pose a health hazard to human health through their faecal droppings. Many of Cambridge’s historic and much loved buildings are made limestone. They are literally being eaten away by the acidic pigeon excrement and the fungi that lives on the excrement, causing thousands of pounds’ worth of damage. Pest birds like pigeons, gulls, sparrows and starlings are gregarious creatures. As they roost in large numbers they can cause large scale contamination of buildings and the surrounding areas. Breeding during the spring and summer, their nesting material often contains insects which can lead to significant secondary infestations of properties. Leaving these birds uncontrolled can cost you money and adversely affect the smooth running of your business. It’s not just the historic buildings which are at risk, birds can cause serious damage to modern buildings as well. Abate Pest Management Services have been managing nuisance birds in Cambridge and across East Anglia for over 18 years. This month will see them implementing a huge bird spiking project in the city. The building has had pigeons nesting and perching on it creating a general mess on windows, ledges etc. Spike systems are made up of strips of upright metal or plastic pins which are an effective deterrent to birds landing. This system is very adaptable, cost-effective, simple to apply and can be used to proof a wide variety of both plain and ornate buildings. There are many other bird proofing methods which can be employed depending on the nature of the problem and the building itself. Netting and post-and-wire systems Bird netting systems screen off problem areas and can successfully and harmlessly help move birds away from a problem property. Post-and-wire systems are another tried and tested deterrent which can be used on ledges, ridges and other structures to prevent birds gaining a foothold. Gel systems Gel systems are applied to building ledges and ridges. They form a flexible barrier that feels unpleasant and unstable to the birds’ feet and discourages them from perching. Lasers Lasers are the latest line of defence in bird proofing technology. At Abate we use the Agrilaser Autonomic, a fully automated laser bird repelling system. This state of the art bird control solution uses the birds’ own natural instincts to harmlessly deter them from nesting or roosting. It works by projecting a moving laser beam across a roof top. The birds see the beam as a threat and stay away from the building. We’ve developed a unique solution to manage and monitor the Agrilaser system remotely, allowing you to remotely control the laser from the convenience and safety of your office – saving you time and money. This system has been proven to be very successful at removing nesting and roosting birds from buildings and reducing the associated problems their presence causes. Electric bird deterrents Electrical bird deterrent systems offer a valuable professional management option. At Abate we use Avishock, a RSPB approved system which teaches birds not to land or nest through a harmless electric shock; much in the same way that an electric fence manages cattle. These systems are particularly useful for Grade 1 and 2 listed buildings and other sites where more conventional bird control methods are not allowed. Abate Pest Control At Abate our team has over 55 years combined experience in bird proofing. After an in-depth site survey, we will recommend how best to deal with the bird control problems on your premises. We will solve your bird pest problems quickly and discreetly, with as minimal disruption to your day as possible. If you need effective bird control call us on 01223 631765 or contact us here.
News Article | May 24, 2017
Scientists at the University of Kent, working with colleagues from the genetics research industry, have developed a new genetic screening device and protocol that helps pig breeding Scientists at the University of Kent, working with colleagues from the genetics research industry, have developed a new genetic screening device and protocol that helps pig breeding. Through her work, Dr Rebecca O'Connor in the School of Biosciences, found previously undiscovered, fundamental flaws in the pig genome, the results of which have contributed to improved mapping of the pig genome. In pigs - which provide 43% of the meat consumed worldwide - a chromosome defect can affect fertility. With each pig producing as many as 14 piglets per litter, a faulty chromosome can reduce this by as much as half, with massive economic costs to the producer. Dr O'Connor's research, carried out in the Griffin Laboratory, has led to the development of chromosome screening devices for both pigs and cattle and a chromosome screening service to multiple agricultural food providers. Now with 13 clients in eight different countries, the team are screening hundreds of samples a year, as well as adapting the method to screen for chromosome abnormalities in other species. The research findings were presented to agricultural industry leaders at the Pig Breeders Round Table Conference, one of the foremost international conferences on livestock genetics, held at the University of Kent in May 2017. Dr O'Connor, research associate in the School of Biosciences, won the 2017 University Prize for Postgraduate Research in recognition of her 'exceptional publication record, and achievements far beyond those normally expected of a doctoral student'. The paper was entitled Isolation of subtelomeric sequences of porcine chromosomes for translocation screening reveals errors in the pig genome assembly (Dr Rebecca O'Connor and Professor Darren Griffin, University of Kent; Dr. G. Fonseka, Dr. M. Lawrie and R. Frodsham, Cytocell Ltd, Cambridge; Professor A. L. Archibald, The Roslin Institute, R(D)SVS, University of Edinburgh, Division of Genetics and Genomics, Midlothian; and G. A. Walling, JSR Genetics, Southburn, Driffield, North Humberside) was published in Animal Genetics. For further information or interview requests contact Sandy Fleming at the University of Kent Press Office. Tel: 01227 823581/01634 888879 Email: S.Fleming@kent.ac.uk News releases can also be found at http://www.  Genetics industry partners are Cytocell Ltd and JSR Genetics. Established in 1965, the University of Kent - the UK's European university - now has almost 20,000 students across campuses or study centres at Canterbury, Medway, Tonbridge, Brussels, Paris, Athens and Rome. It has been ranked: 22nd in the Guardian University Guide 2018; 23rd in the Times and Sunday Times University Guide 2017; and 25th in the Complete University Guide 2018. In the Times Higher Education (THE) World University Rankings 2015-16, Kent is in the top 10% of the world's leading universities for international outlook and 66th in its table of the most international universities in the world. The THE also ranked the University as 20th in its 'Table of Tables' 2016. Kent is ranked 17th in the UK for research intensity (REF 2014). It has world-leading research in all subjects and 97% of its research is deemed by the REF to be of international quality. In the National Student Survey 2016, Kent achieved the fourth highest score for overall student satisfaction, out of all publicly funded, multi-faculty universities. Along with the universities of East Anglia and Essex, Kent is a member of the Eastern Arc Research Consortium. The University is worth £0.7 billion to the economy of the south east and supports more than 7,800 jobs in the region. Student off-campus spend contributes £293.3m and 2,532 full-time-equivalent jobs to those totals. In 2014, Kent received its second Queen's Anniversary Prize for Higher and Further Education.
News Article | June 26, 2017
Nord Anglia Education (NYSE: NORD) is the world's leading premium schools organization. Our 44 international schools are located in China, Europe, the Middle East, Southeast Asia and North America. Together, they educate more than 38,400 students from kindergarten through to the end of secondary education. We are driven by one unifying philosophy – we are ambitious of our students, our people and our family of schools. Our schools deliver a high quality education through a personalized approach enhanced with unique global opportunities to enable every student to succeed. We primarily operate in geographic markets with high foreign direct investment, large expatriate populations and rising disposable income. We believe that these factors contribute to high demand for premium schools and strong growth in our business. Nord Anglia Education is headquartered in Hong Kong SAR, China. Our website is www.nordangliaeducation.com. For further information, please contact: To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/nord-anglia-education-inc-to-report-third-quarter-fiscal-2017-results-on-july-25-2017-300479420.html
Agency: GTR | Branch: NERC | Program: | Phase: Research Grant | Award Amount: 98.72K | Year: 2016
Blue Opportunities from the Future is a collaborative project co-designed between the University of East Anglia, the New Anglia Local Enterprise Partnership, Norfolk and Suffolk Coastal Councils, the Environment Agency, Orbis Energy and the RSPB. The project is driven by a desire to make better use of NERC funded research in coastal and marine environments to drive innovation and forward thinking in the delivery of future sustainable management and economic growth. East Anglia is already a centre for delivering advances in this area through its research organisations, forward-thinking local authorities, active wildlife conservation organisations and the Green Economy Pathfinder initiative of the New Anglia Local Enterprise Partnership. This project provides a timely opportunity to broaden regional good practice by taking a more marine-facing view. In the East Anglian region there is growing interest among the institutions involved in planning for the coast and marine sectors in taking a more integrated and opportunity-focused look at the long-term future of our environment. This is driven by a recognition of inevitable on-going coastal change and the potential for significant future changes, for example due to global warming and rising sea level. There is a need to think creatively, adaptively and in an inclusive manner, and to consider future change as an opportunity to do better. By connecting the coastal and offshore zones, and working from a bespoke set of 100 year futures scenarios, this project takes a novel and positive approach to thinking about the future of coastal and marine environments in an integrated way. We will undertake an innovative futures analysis to 2115 to explore the potential future opportunities, spanning land and sea, for East Anglias Blue economy. We will co-create a Blue Futures toolkit of methods and associated knowledge base with which project partners can go on to develop a Blue pathfinder for the region to help drive sustainable blue economic growth. This will provide an exemplar approach that will be disseminated to end-users in other regions in the UK, EU and worldwide. The project will draw upon many aspects of the extensive portfolio of NERC funded and related work at UEA, Cefas, partner organisations and beyond, from ecosystem service valuations (natural capital), to marine biogeochemistry. UEA is well placed to deliver novel creative thinking on future opportunities for sustainable growth, with extensive experience of research into the long-term sustainable futures of complex environments and the impacts of environmental change on economies and society. Integration of our partner groups within the project ensures our work is targeted appropriately and beneficially to maximise utility for the development of sustainable management by local and national bodies throughout the UK and beyond.
RNA biology | Year: 2011
microRNAs are non-coding RNAs that regulate gene expression. A significant proportion of microRNAs is perfectly conserved across the vertebrate clade, including miR-140, which is specifically expressed in cartilage. Although it has been computationally predicted that a large majority of microRNA targets are conserved, experimental evidence for this hypothesis remains scarce. In this work we use mRNA expression profiles obtained after manipulation of miR-140 activity levels in human and chicken primary chondrocytes to explore the extent of miR-140 target conservation. Our data suggest that miR-140 has a large number of targets conserved between human and chicken and we validate one of these, BMP2. However, we also found a significant number of non-conserved targets in the two species. In addition, we found that a commercially available scrambled siRNA, which is regularly used as a negative control, regulate the accumulation of many genes.
Pharmaceutical research | Year: 2013
To evaluate the role of polymer-surfactant interactions in drug solubilisation/stabilisation during the dissolution of spray-dried solid dispersions and their potential impact on in vivo drug solubilisation and absorption. Dissolution/precipitation tests were performed on spray-dried HPMC-Etravirine solid dispersions to demonstrate the impact of different surfactants on the in vitro performance of the solid dispersions. Interactions between HPMC and bio-relevant and model anionic surfactants (bile salts and SDS respectively) were further characterised using surface tension measurements, fluorescence spectroscopy, DLS and SANS. Fast and complete dissolution was observed in media containing anionic surfactants with no drug recrystallisation within 4 h. The CMCs of bile salts and SDS were dramatically reduced to lower CACs in the presence of HPMC and Etravirine. The maximum increases of the apparent solubility of Etravirine were with the presence of HPMC and SDS/bile salts. The SANS and DLS results indicated the formation of HPMC-SDS/bile salts complexes which encapsulated/solubilised the drug. This study has demonstrated the impact HPMC-anionic surfactant interactions have during the dissolution of non-ionic hydrophilic polymer based solid dispersions and has highlighted the potential relevance of this to a fuller understanding of drug solubilisation/stabilisation in vivo.
Cochrane database of systematic reviews (Online) | Year: 2012
Reduction and modification of dietary fats have differing effects on cardiovascular risk factors (such as serum cholesterol), but their effects on important health outcomes are less clear. To assess the effect of reduction and/or modification of dietary fats on mortality, cardiovascular mortality, cardiovascular morbidity and individual outcomes including myocardial infarction, stroke and cancer diagnoses in randomised clinical trials of at least 6 months duration. For this review update, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE, were searched through to June 2010. References of Included studies and reviews were also checked. Trials fulfilled the following criteria: 1) randomised with appropriate control group, 2) intention to reduce or modify fat or cholesterol intake (excluding exclusively omega-3 fat interventions), 3) not multi factorial, 4) adult humans with or without cardiovascular disease, 5) intervention at least six months, 6) mortality or cardiovascular morbidity data available. Participant numbers experiencing health outcomes in each arm were extracted independently in duplicate and random effects meta-analyses, meta-regression, sub-grouping, sensitivity analyses and funnel plots were performed. This updated review suggested that reducing saturated fat by reducing and/or modifying dietary fat reduced the risk of cardiovascular events by 14% (RR 0.86, 95% CI 0.77 to 0.96, 24 comparisons, 65,508 participants of whom 7% had a cardiovascular event, I(2) 50%). Subgrouping suggested that this reduction in cardiovascular events was seen in studies of fat modification (not reduction - which related directly to the degree of effect on serum total and LDL cholesterol and triglycerides), of at least two years duration and in studies of men (not of women). There were no clear effects of dietary fat changes on total mortality (RR 0.98, 95% CI 0.93 to 1.04, 71,790 participants) or cardiovascular mortality (RR 0.94, 95% CI 0.85 to 1.04, 65,978 participants). This did not alter with sub-grouping or sensitivity analysis.Few studies compared reduced with modified fat diets, so direct comparison was not possible. The findings are suggestive of a small but potentially important reduction in cardiovascular risk on modification of dietary fat, but not reduction of total fat, in longer trials. Lifestyle advice to all those at risk of cardiovascular disease and to lower risk population groups, should continue to include permanent reduction of dietary saturated fat and partial replacement by unsaturates. The ideal type of unsaturated fat is unclear.
Cochrane database of systematic reviews (Online) | Year: 2012
Viral warts are a common skin condition, which can range in severity from a minor nuisance that resolve spontaneously to a troublesome, chronic condition. Many different topical treatments are available. To evaluate the efficacy of local treatments for cutaneous non-genital warts in healthy, immunocompetent adults and children. We updated our searches of the following databases to May 2011: the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, MEDLINE (from 2005), EMBASE (from 2010), AMED (from 1985), LILACS (from 1982), and CINAHL (from 1981). We searched reference lists of articles and online trials registries for ongoing trials. Randomised controlled trials (RCTs) of topical treatments for cutaneous non-genital warts. Two authors independently selected trials and extracted data; a third author resolved any disagreements. We included 85 trials involving a total of 8815 randomised participants (26 new studies were included in this update). There was a wide range of different treatments and a variety of trial designs. Many of the studies were judged to be at high risk of bias in one or more areas of trial design.Trials of salicylic acid (SA) versus placebo showed that the former significantly increased the chance of clearance of warts at all sites (RR (risk ratio) 1.56, 95% CI (confidence interval) 1.20 to 2.03). Subgroup analysis for different sites, hands (RR 2.67, 95% CI 1.43 to 5.01) and feet (RR 1.29, 95% CI 1.07 to 1.55), suggested it might be more effective for hands than feet.A meta-analysis of cryotherapy versus placebo for warts at all sites favoured neither intervention nor control (RR 1.45, 95% CI 0.65 to 3.23). Subgroup analysis for different sites, hands (RR 2.63, 95% CI 0.43 to 15.94) and feet (RR 0.90, 95% CI 0.26 to 3.07), again suggested better outcomes for hands than feet. One trial showed cryotherapy to be better than both placebo and SA, but only for hand warts.There was no significant difference in cure rates between cryotherapy at 2-, 3-, and 4-weekly intervals.Aggressive cryotherapy appeared more effective than gentle cryotherapy (RR 1.90, 95% CI 1.15 to 3.15), but with increased adverse effects.Meta-analysis did not demonstrate a significant difference in effectiveness between cryotherapy and SA at all sites (RR 1.23, 95% CI 0.88 to 1.71) or in subgroup analyses for hands and feet.Two trials with 328 participants showed that SA and cryotherapy combined appeared more effective than SA alone (RR 1.24, 95% CI 1.07 to 1.43).The benefit of intralesional bleomycin remains uncertain as the evidence was inconsistent. The most informative trial with 31 participants showed no significant difference in cure rate between bleomycin and saline injections (RR 1.28, 95% CI 0.92 to 1.78).Dinitrochlorobenzene was more than twice as effective as placebo in 2 trials with 80 participants (RR 2.12, 95% CI 1.38 to 3.26).Two trials of clear duct tape with 193 participants demonstrated no advantage over placebo (RR 1.43, 95% CI 0.51 to 4.05).We could not combine data from trials of the following treatments: intralesional 5-fluorouracil, topical zinc, silver nitrate (which demonstrated possible beneficial effects), topical 5-fluorouracil, pulsed dye laser, photodynamic therapy, 80% phenol, 5% imiquimod cream, intralesional antigen, and topical alpha-lactalbumin-oleic acid (which showed no advantage over placebo).We did not identify any RCTs that evaluated surgery (curettage, excision), formaldehyde, podophyllotoxin, cantharidin, diphencyprone, or squaric acid dibutylester. Data from two new trials comparing SA and cryotherapy have allowed a better appraisal of their effectiveness. The evidence remains more consistent for SA, but only shows a modest therapeutic effect. Overall, trials comparing cryotherapy with placebo showed no significant difference in effectiveness, but the same was also true for trials comparing cryotherapy with SA. Only one trial showed cryotherapy to be better than both SA and placebo, and this was only for hand warts. Adverse effects, such as pain, blistering, and scarring, were not consistently reported but are probably more common with cryotherapy.None of the other reviewed treatments appeared safer or more effective than SA and cryotherapy. Two trials of clear duct tape demonstrated no advantage over placebo. Dinitrochlorobenzene (and possibly other similar contact sensitisers) may be useful for the treatment of refractory warts.
Neurorehabilitation and neural repair | Year: 2011
This third chapter discusses the evidence for the rehabilitation of the most common movement disorders of the upper extremity. The authors also present a framework, building on the computation, anatomy, and physiology (CAP) model, for incorporating some of the principles discussed in the 2 previous chapters by Frey et al and Sathian et al in the practice of rehabilitation and for discussing potentially helpful interventions based on emergent neuroscience principles.
Cochrane database of systematic reviews (Online) | Year: 2012
Urinary incontinence is common after both radical prostatectomy and transurethral resection of the prostate (TURP). Conservative management includes pelvic floor muscle training with or without biofeedback, electrical stimulation, extra-corporeal magnetic innervation (ExMI), compression devices (penile clamps), lifestyle changes, or a combination of methods. To assess the effects of conservative management for urinary incontinence after prostatectomy. We searched the Cochrane Incontinence Group Specialised Register (searched 24 August 2011), EMBASE (January 1980 to Week 48 2009), CINAHL (January 1982 to 20 November 2009), the reference lists of relevant articles, handsearched conference proceedings and contacted investigators to locate studies. Randomised or quasi-randomised controlled trials evaluating conservative interventions for urinary continence in men after prostatectomy. Two or more review authors assessed the methodological quality of trials and abstracted data. We tried to contact several authors of included studies to obtain extra information. Thirty-seven trials met the inclusion criteria, 33 amongst men after radical prostatectomy, three trials after transurethral resection of the prostate (TURP) and one trial after either operation. The trials included 3399 men, of whom 1937 had an active conservative intervention. There was considerable variation in the interventions, populations and outcome measures. Data were not available for many of the pre-stated outcomes. Men's symptoms improved over time irrespective of management. Adverse effects did not occur or were not reported.There was no evidence from eight trials that pelvic floor muscle training with or without biofeedback was better than control for men who had urinary incontinence after radical prostatectomy (e.g. 57% with urinary incontinence versus 62% in the control group, risk ratio (RR) for incontinence after 12 months 0.85, 95% confidence interval (CI) 0.60 to 1.22) as the confidence intervals were wide, reflecting uncertainty. However, one large multicentre trial of one-to-one therapy showed no difference in any urinary or quality of life outcome measures and had narrower confidence intervals. There was also no evidence of benefit for erectile dysfunction (56% with no erection in the pelvic floor muscle training group versus 55% in the control group after one year, RR 1.01, 95% CI 0.84 to 1.20). Individual small trials provided data to suggest that electrical stimulation, external magnetic innervation or combinations of treatments might be beneficial but the evidence was limited. One large trial demonstrated that there was no benefit for incontinence or erectile dysfunction from a one-to-one pelvic floor muscle training based intervention to men who were incontinent after transurethral resection of the prostate (TURP) (e.g. 65% with urinary incontinence versus 62% in the control group, RR after 12 months 1.05, 95% CI 0.91 to 1.23).In eight trials of conservative treatment of all men after radical prostatectomy aimed at both treatment and prevention, there was an overall benefit from pelvic floor muscle training versus control management in terms of reduction of UI (e.g. 10% with urinary incontinence after one year versus 32% in the control groups, RR for urinary incontinence 0.32, 95% CI 0.20 to 0.51). However, this finding was not supported by other data from pad tests. The findings should be treated with caution, as most trials were of poor to moderate quality and confidence intervals were wide. Men in one trial were more satisfied with one type of external compression device, which had the lowest urine loss, compared to two others or no treatment. The effect of other conservative interventions such as lifestyle changes remains undetermined as no trials involving these interventions were identified. The value of the various approaches to conservative management of postprostatectomy incontinence after radical prostatectomy remains uncertain. It seems unlikely that men benefit from one-to-one pelvic floor muscle training therapy after transurethral resection of the prostate (TURP). Long-term incontinence may be managed by external penile clamp, but there are safety problems.