Andrzej Frycz Modrzewski University

Kraków, Poland

Andrzej Frycz Modrzewski University

Kraków, Poland

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Trystula M.,John Paul II Hospital | Zychowska M.,University of Gdansk | Wilk-Franczuk M.,Cracow Rehabilitation and Orthopedics Center | Kropotov J.D.,Russian Academy of Sciences | And 2 more authors.
Genetics and Molecular Research | Year: 2017

The aim of this study was to evaluate dysregulation of gene expression associated with the cellular stress response in a patient with a post-“warning stroke” depressive disorder confirmed by the presence of a neurophysiological neuromarker through the use of quantitative EEG and event-related potentials. The patient was tested for seven genes associated with the stress reaction: HSPA1A, HSPB1, IL6, IL10, CRP, and HSF-1 along with NF-κB, compared to gene expression in health controls. A 54-year-old patient with a past history of schizophrenia (at the age of 20), and of transient ischemic attack (at the age of 53) and depressive disorder confirmed by functional, cognitive, emotional, and affectional diagnostics underwent additional testing for expression of the genes associated with stress response. The expression of genes coding for heat shock protein (HSPA1A, HSPB1), interleukins (IL6, IL10), and C-reactive protein was tested along with factors that regulate their expression. The results of the tests conducted on this patient were compared with 42 healthy control subjects. Diagnostic testing revealed upregulation in expression of these genes, presenting as increased expression of the target genes and of the regulatory genes. A post-“warning stroke” depressive disorder appears to be associated with overexpression of the genes coding for HSP and interleukins. Further research on larger groups of people may provide grounds for treatment modification. © 2017 The Authors.


Manko G.,Jagiellonian University | Ziolkowski A.,Academy of Physical Education and Sport in Gdansk | Pachalska M.,Andrzej Frycz Modrzewski University
Annals of Agricultural and Environmental Medicine | Year: 2013

Objective: To evaluate the health-related quality of life (HRQOL) in patients aroused from prolonged coma after a severe traumatic brain injury (TBI) treated by physiotherapists trained in the 'Academy of Life' programme. It was assumed that physiotherapists who acquired this knowledge and experience would create a better therapeutic milieu, and would be more effective than physiotherapists who had not received this training. Material and methods: 40 patients who had suffered a severe TBI in a motor vehicle accident and had been aroused from prolonged coma were examined. All the patients underwent long-term rehabilitation according to a standard, phased programme. They were divided into two numerically even groups: an experimental group, treated by therapists trained in the 'Academy of Life' programme, and a control group, treated by physiotherapists who were not trained in this programme. The research instruments included an analysis of documentation, a structured clinical interview, and the Quality of Life Scale. Results: As hypothesized, the experimental group showed significant improvement in HRQOL, whereas in the control group improvement was statistically non-significant. Conclusions: The patients from the experimental group, treated by physiotherapists trained in the 'Academy of Life', obtained a significantly greater improvement in physical and social functioning, and thus in HRQOL, than patients from the control group.


Zielinska J.,Pedagogical University of Cracow | Goral-Polrola J.,Old Polish University | Polrola P.,Jan Kochanowski University | Luckos M.,Andrzej Frycz Modrzewski University | And 3 more authors.
Annals of Agricultural and Environmental Medicine | Year: 2016

Objective. The study aimed to evaluate the hyperactivity of the frontal lobes in a patient with obsessive-compulsive disorders. Case description. A 21-year-old female met the diagnostic criteria of DSM-5 since her behaviour was characterized by a preoccupations with negative thoughts and by repetitive attempts to decrease or stop those behaviours. Two working hypotheses were tested to find neuromarkers of OCD and anxiety in the patient described. In agreement with the 'OCD hypothesis' an increase of the frontal beta activity and an increase of the parietalalpha activity pattern was found. The 'anxiety' hypothesis found confirmation in an increased left temporal P1 wave in response to the visual stimuli observed in ERPs. In all three conditions (EO, EC, GO/NOGO task), two characteristics were deviant from the normative average data in EEG spectra. First, an increase of frontal beta activity and the increase of parietal alpha activity was noted. The independent component analysis applied for 700 ms EEG fragments in GO and NOGO conditions revealed a strong activation over the central areas. Conclusions. Specific patterns of QEEG and ERPs, the increase of beta activity frontally, and the increase of parietal alpha activity pattern which produce hyper-frontality, might be useful in the diagnosis of an OCD patient. ERPs in a GO/NOGO task can be used in the assessment of functional brain changes in OCD patients. © 2016, Institute of Agricultural Medicine. All rights reserved.


Ziolkowski A.,Academy of Physical Education in Katowice | Blachnio A.,Kazimierz Wielki University in Bydgoszcz | Pachalska M.,Andrzej Frycz Modrzewski University
Annals of Agricultural and Environmental Medicine | Year: 2015

Introduction and objective. Modern medicine is still searching for the antecedents which will lead to successful aging. The article discusses the self-perception of life satisfaction and health of senior citizens. The aim of the study was to determine the relationship between self-evaluation of life satisfaction and health by senior citizens in comparison to different age groups. Materials and method. The study included 463 persons – 230 men and 233 women. The age of the participants was in the range 16 – 83 years. All participants were asked to fill the Life Satisfaction Questionnaire (Fragebogen zur Lebenszufriedenheit – FLZ). The FLZ questionnaire assesses the global life satisfaction of a person and health domain separately. Results. The results show age-related differences in the evaluation of life satisfaction. Accordingly, there is a significant change in health evaluations in different age groups, but there are no significant gender differences in health self-report data. The senior citizens’ assessment of general health, although the lowest among all the age-subgroups, showed significant difference only in relation to the people below 45 years of age. The significant differences in satisfaction from mental health occurred only for the elderly and participants aged 25–34 and 35–44. Conclusions. Life satisfaction is associated with subjective health evaluations. There are two domains (mental health and performance) that are positively evaluated by more than two-thirds of senior citizens. The observed differences challenge stereotypes and prejudices relating to negative aging process. Senior citizens can improve their control beliefs and develop self-regulation and coping skills. © 2015, Institute of Agricultural Medicine. All rights reserved.


Kluska-Nawarecka S.,Poland Foundry Research Institute | Kluska-Nawarecka S.,University of Lodz | Wilk-Kolodziejczyk D.,Andrzej Frycz Modrzewski University | Regulski K.,AGH University of Science and Technology
Studies in Computational Intelligence | Year: 2011

Until now, the use of attribute tables, which enable approximate reasoning in tasks such as knowledge integration, has been posing some difficulties resulting from the difficult process of constructing such tables. Using for this purpose the data comprised in relational databases should significantly speed up the process of creating the attribute arrays and enable getting involved in this process the individual users who are not knowledge engineers. This article illustrates how attribute tables can be generated from the relational databases, to enable the use of approximate reasoning in decision-making process. This solution allows transferring the burden of the knowledge integration task to the level of databases, thus providing convenient instrumentation and the possibility of using the knowledge sources already existing in the industry. Practical aspects of this solution have been studied on the background of the technological knowledge of metalcasting. © 2011 Springer-Verlag Berlin Heidelberg.


Kluska-Nawarecka S.,Poland Foundry Research Institute | Wilk-Kolodziejczyk D.,Andrzej Frycz Modrzewski University | Regulski K.,AGH University of Science and Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

Until now, the use of attribute tables, which enable approximate reasoning in tasks such as knowledge integration, has been posing some difficulties resulting from the difficult process of constructing such tables. Using for this purpose the data comprised in relational databases should significantly speed up the process of creating the attribute arrays and enable getting involved in this process the individual users who are not knowledge engineers. This article illustrates how attribute tables can be generated from the relational databases, to enable the use of approximate reasoning in decision-making process. This solution allows transferring the burden of the knowledge integration task to the level of databases, thus providing convenient instrumentation and the possibility of using the knowledge sources already existing in the industry. Practical aspects of this solution have been studied on the background of the technological knowledge of metalcasting. © 2013 Springer-Verlag Berlin Heidelberg.


Guzy G.,University School of Physical Education in Cracow | Ridan T.,University School of Physical Education in Cracow | Szpitalak M.,Jagiellonian University | Franczuk B.,Andrzej Frycz Modrzewski University
Ortopedia Traumatologia Rehabilitacja | Year: 2013

Background. The study analyzed correlations between selected variables in cervical derangement syndromes. Material and methods. We analyzed data from 63 patients regarding pain (VAS, McGill Pain Question-naire), mobility (CROM goniometer), dizziness, nausea, the duration of the current episode, and the number of previous episodes (history). Student's t and chi2 tests and Pearson's r correlation were used. Results. Overall pain intensity correlated positively with the indexes of the McGill Pain Questionnaire, the duration of the current episode, intensity of the proximal and distal symptoms and negatively with protraction or extension. Headache correlated positively with neck pain and negatively with retraction. Neck pain cor-related negatively with multiple cervical movements and positively with intensity of the distal symptoms. A po-sitive relationship between shoulder and upper limb pain was observed. Patients with higher overall pain inten-sity or lower shoulder pain intensity experienced dizziness more often. The duration of the current episode cor-re-lated positively with the number of previous episodes, the frequency of nausea, limited extension and limited protraction. Nausea coexisted with dizziness and reduced protraction. The degree of flexion restriction corre-lated positively with the number of previous episodes. Conclusions. 1. Overall and proximal pain intensity, mobility of the cervical spine, the duration of the current epi-sode and dizziness are useful in diagnosis of cervical derangement syndromes. 2. Intensity of the distal symptoms, the number of pre-vious episodes and nausea should be particularly monitored. © MEDSPORTPRESS, 2013.

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