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Vishākhapatnam, India

Hancock P.,Andrology Laboratory | Lindsay K.,Imperial College London | Tomlinson M.T.,Nottingham Hospital
British Journal of Biomedical Science | Year: 2014

Vasectomy is the surgical procedure used for male contraception. Traditionally, operative success has been established by the issue of a laboratory report stating the achievement of azoospermia. The purpose of this study is to establish if this is an achievable or realistic status and if a change to the current best practice would provide an acceptable and cost-effective alternative. In principle, human fecundity is complex and measured in probabilities, which is inconsistent with the implied absolute requirement to establish the complete absence of spermatozoa.

Sripada S.,Aberdeen Maternity Hospital | Townend J.,Medical Research Council | Campbell D.,University of Aberdeen | Murdoch L.,Dugald Baird Center | And 2 more authors.
Fertility and Sterility | Year: 2010

Objective: To explore the association between semen parameters and spontaneous pregnancy. Design: Case-control study. Setting: Aberdeen Fertility Centre, Aberdeen, Scotland. Patient(s): A total of 1,426 untreated couples attending a subfertility clinic with no evidence of azoospermia, anovulation, or tubal disease were observed for 180 weeks. "Cases" were couples who achieved conception spontaneously within the follow-up period; controls were those who did not. Intervention(s): None. Main Outcome Measure(s): Sperm density, sperm motility, and sperm morphology. Result(s): In women who achieved spontaneous conception (n = 488) the mean (SD) age was 30.6 (4.8) years and median (interquartile range) parity was 1 (0-1), compared with 32.0 (5.4) years and 1 (0-1) in those who did not (n = 938). The median (interquartile range) duration of infertility was 24 (17-36) and 18 (14-24) months in nonpregnant and pregnant couples, respectively. After adjusting for male and female age, parity, year of first visit, and duration of infertility, sperm motility and normal morphology were significantly associated with spontaneous pregnancy, whereas sperm density was not. For motility, the area under the receiver operating characteristic curve was 0.545 (95% confidence interval 0.514-0.577). For morphology, the area under the receiver operating characteristic curve was 0.565 (95% confidence interval 0.534-0.597). Conclusion(s): In subfertile couples, sperm motility and morphology have limited predictive value for spontaneous conception. © 2010 American Society for Reproductive Medicine.

Kovac J.R.,McMaster Institute of Urology | Flood D.,McMaster Institute of Urology | Brendan Mullen J.,Andrology Laboratory | Fischer M.A.,McMaster Institute of Urology
Journal of Andrology | Year: 2012

Genitourinary sarcoidosis is uncommon, with only rare documented cases of testicular involvement reported. We detail the case of a 37-year-old male who initially presented for azoospermia and secondary infertility. A testicular biopsy revealed nonnecrotizing granulomas and a chest x-ray identified perihilar lymphadenopathy and granulomatous lung nodules. A corticosteroid regimen was administered, and routine semen analyses were conducted. Significant improvements were noted after prednisone treatments. A successful in vivo fertilization was obtained. This is the first known case of testicular sarcoidosis diagnosed during investigations into azoospermia and secondary infertility which, after treatment with corticosteroids, resulted in natural fertilization. © American Society of Andrology.

Benkhalifa M.,University of Picardie Jules Verne | Benkhalifa M.,IVF and Reproductive Genetics Laboratory | Montjean D.,IVF Unit | Belloc S.,Reproductive Biology Unit | And 5 more authors.
Expert Review of Molecular Diagnostics | Year: 2014

Male factors account for approximately 50% of reproductive pathology. Different disorders, including urogenital and endocrine system development abnormalities, lead to testicular and gametogenesis defects. Parallely, studies have reported that somatic and germ cell genome decay are a major cause of male infertility. It has been shown that in somatic karyotype, there is a higher incidence of chromosomal aberrations in infertile men than neonatal population and significant chromosome Y microdeletion or specific gene alterations in affected spermatogenesis. Karyotyping and FISH application at somatic and germ cell levels are no longer sufficient to investigate the potential contribution of genome disorders on male infertility. A wide range of molecular methods are required for better understanding of male infertility causes. Molecular omes and omics techniques have become a great tool to investigate male infertility from chromosome to protein. This review reports different molecular tests and methods that can be offered for male infertility investigation. © 2014 Informa UK, Ltd.

Landau R.,Hebrew University of Jerusalem | Weissenberg R.,Andrology Laboratory
Human Reproduction | Year: 2010

Background Despite the prevalence of donor conception and the worldwide trend towards openness, there has been little research on whether parents do disclose the nature of the conception to their donor-conceived children. This analysis focuses on whether and how older Israeli single mothers disclose to their children that were conceived using a donor and whether the donor conception causes concern for them.Method SSixty-two single mothers of donor-conceived children in Israel were asked whether they would like to know the identity of the sperm donor; whether they would like their children to know the identity of the sperm donor when reaching the age of 18, whether they disclosed the circumstances of conception to their children or intend to do so in the future; and whether the sperm donation causes concern to them.Result SThe mothers were divided on whether they wanted to know the identity of the sperm donor. However, less than one-fifth of them did not want their children to have identifying information about the genetic father at the age of 18. About two-thirds of the mothers had not yet disclosed the donor conception to their children but intended to do so in the future. A total of 77.4 of the mothers reported being concerned about the donor conception: for the psychosocial development of the child, fear of genetic disorders, fear of incest and lack of certainty of access to genetic information when needed.Conclusion SThe tendency to postpone the disclosure reveals the difficulty of these mothers in finding the appropriate way of sharing the information about the conception with their children. Given the importance attached to the age of disclosure and the mothers' concern for the psychosocial development of their children, more professional counselling in this area is warranted.

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