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Kukulj S.,University of Zagreb | Popovic F.,University of Zagreb | Budimir B.,University of Zagreb | Drpa G.,University of Zagreb | And 2 more authors.
Psychiatria Danubina | Year: 2014

Background: Lung cancer is the most common cancer in the world. According to the latest available data, in the year 2012 Croatia was among 20 countries with the highest incidence of lung cancer. Although tobacco smoking is a proven cause of lung cancer, recent data show that more than one quarter of adult inhabitants of Croatia are everyday smokers. The purpose of this study was to present epidemiology and treatment modalities of lung cancer in the Department for mediastinal tumors, Clinic for lung diseases Jordanovac, and to make a comparison between the available data from Croatia and the rest of the world. Subjects and methods: The study cohort included 212 newly diagnosed lung cancer patients who had referred to our Department from January 2012 until December 2012. Features such as age, gender, cytology and histology of the tumor, stage at diagnosis and applied therapy were evaluated respectively. Results: Approximately two-thirds of all newly diagnosed lung cancers occurred in men. Out of the study cohort, 12.3% were diagnosed with small cell lung cancer (SCLC) and 87.7% were diagnosed with non-small cell lung cancer (NSCLC). The majority of the patients diagnosed with NSCLC had adenocarcinoma (47.9%), followed by squamous cell carcinoma (33.9%) and large cell carcinoma (15%). Only a small number of patients diagnosed and treated for lung cancer in our Department had never smoked tobacco. The majority of those patients were women and the most common histological type found was adenocarcinoma. Conclusion: The number of patients who had potentially operable disease at presentation was around 10%. That is why, in most cases, therapeutic options were confined to palliative chemotherapy or radiotherapy. Attention should be directed to an early detection of lung cancer patients, which could provide better treatment options and improve overall survival. © Medicinska naklada - Zagreb, Croatia

Pili K.,University of Applied science Velika Gorica | Kastelan S.,Clinical Hospital Dubrava | Karabatic M.,University of Applied science Velika Gorica | Kasun B.,Special Hospital for Medical Rehabilitation Stubicke Toplice | Culig B.,Andrija Stampar Teaching Institute of Public Health
Psychiatria Danubina | Year: 2014

Background: The aim of this study is to analyze the relationship between the self-reported symptoms and objective signs of dry eye disease in long-term rigid gas-permeable (RGP) or soft contact lens (SCL) wearers. Subjects and methods: The study included 84 eyes of Caucasian RGP and SCL wearers between the age of 15 and 71 who wore contact lenses on a continuous daily basis for more than 1 year. Symptoms were assessed according to the Ocular Surface Disease Index (OSDI). Clinical assessments included corneal fluorescein staining according to the National Eye Institute (NEI) staining grid and tear film break-up time (TBUT). Results: There were more female (76.19%) than male (23.81%) persons with a higher proportion of RGP wearers among the females (88.89% vs. 11.11%). The mean duration of daily lens wear was 7.71±2.72 hours. No RGP wearer in this study had a NEI corneal staining grid score higher than 2. A weak negative correlation was found between daily lens wear duration and TBUT (Pearson's coefficient, r=-0.1467). A strong negative correlation was found between TBUT and OSDI values (r=-0.844). Conclusion: The results of the study emphasize the importance of early and accurate diagnosis of dry eye disease for successful long term RGP and SCL contact lens wear. This will hopefully motivate future larger scale investigations on dry eye related problems in contact lens wearers. © Medicinska naklada - Zagreb, Croatia

Bajs M.M.,Andrija Stampar Teaching Institute of Public Health | Stimac D.,Andrija Stampar Teaching Institute of Public Health | Stimac D.,University of Zagreb | Maric N.,Sv. Duh Clinical Hospital
Psychiatria Danubina | Year: 2014

Background: The program covered all persons who had not been in contact with a physician for two years or had failed to notice symptoms themselves or to timely respond to the symptoms observed. The aim of the present study was to analyze the results of the program and try to draw conclusions regarding the necessity further implementation. Subjects and methods: This paper analyzes data on a cohort of 1375 subjects aged 45+, collected on preventive examinations by family physicians during the 2009-2013 period. Results: Results show 24.4% smokers and 15.5% former smokers. Up to three alcoholic drinks per week consumed 18.5% respondents (27.8% male and 11.2% female). Overweight (body mass index 25-30) was recorded in 50.6% and 38.6%, obesity (body mass index >30) in 30.1% and 29.4%, hypertension in 14.6% and 11.8%, isolated systolic hypertension in 20.5% and 17.4%, and isolated diastolic hypertension in 3.3% and 3.0% of male and female subjects, respectively. Suspicion of one or more newly diagnosed disease was recorded in 52.9% (95% CI 50.2-55.5) of study subjects. Fifty-four subjects (7.4%; 95% CI 5.5-9.3) were suspected to have neoplasm and they were immediately referred for further diagnostic evaluation. Conclusions: Timely manner suspicion of malignant disease is of crucial influence on the course of treatment and outcome of the disease. The study results confirm the importance of continuing the implementation of prevention programs. © Medicinska naklada - Zagreb, Croatia

Krivohlavek A.,Andrija Stampar Teaching Institute of Public Health | Zuntar I.,University of Zagreb | Ivesic M.,Andrija Stampar Teaching Institute of Public Health | Andacic I.M.,Andrija Stampar Teaching Institute of Public Health | Sikic S.,Andrija Stampar Teaching Institute of Public Health
Psychiatria Danubina | Year: 2014

Background: Honey is used for nutritional, medicinal and industrial purposes and antibiotic residues may harm its quality and constitute a danger to human health. The broad spectrum antibiotic chloramphenicol (CAP) was used for curative purposes in veterinary medicine, but is now forbidden in European Union (EU) because of its many serious side effects (e.g. aplastic anaemia, grey syndrome, severe bone marrow depression and hypersensitivity). The aim of this study was to facilitate analyses of the quality and safety of Croatian honey distributed to whole European Union market; an assessment that has not previously been made. Subjects and methods: CAP in honey was qualifying and quantifying by validated liquid chromatography tandem mass spectrometry with negative electrospray ionisation method (LC-MS/MS). The target antibiotic was separated on chromatographic column Zorbax SB C18 (150 mm × 2.1 mm, 3.5 μm) with a gradient elution using acetonitrile - 0.1% formic acid mobile phase at a flow rate of 0.3 mL/min, with column temperature 35 oC for CAP and 5D-CAP as internal standard. Homogenised honey samples were diluted with acetate buffer solution and extracted on Oasis Hydrophilic-Lipophilic-Balanced (HLB) sorbents. The method was used to analyse 280 domestic honey samples collected throughout Croatia between 2005.-2013. Results: Recoveries of the method for real (acacia, chestnut, linden and flower) honey samples were 102% with RSD 8.4%. The value CCα and CCβ were 0.09 and 0.12 μg/kg, respectively. Results showed only three subsequent positive detections (1.1%) of CAP in honey. Conlusions: Analysed honey samples from Croatia showed good quality and safety what is the one of the main objective in consumer health policy in EU. © Medicinska naklada - Zagreb, Croatia

Imsiragic A.S.,Neuropsychiatric Hospital Dr. Ivan Barbot | Begic D.,University of Zagreb | Vukovic I.S.,Andrija Stampar Teaching Institute of Public Health | Simicevic L.,University of Zagreb | Javorina T.,Andrija Stampar Teaching Institute of Public Health
Psychiatria Danubina | Year: 2014

Background: Risk factors of postpartum depression, although relatively well investigated, remain largely unclear. The aim of this study was to identify the most relevant predictors of postpartum depressive symptomatology that are of clinical importance using the Edinburgh Postnatal Depression Scale (EPDS) 3-5 days and 6 to 9 weeks after childbirth. Subject and methods: In order to explore predictors of depression, 3-5 days after childbirth, 372 participants fulfilled several questionnaires: Edinburgh Postnatal Depression Scale (EPDS), Impact of Events Scale Revised (IES-R), Big Five Inventory, and questions regarding breastfeeding practice as well as social and demographic factors. Six to nine weeks after childbirth, the same participants fulfilled the following questionnaires: IES-R, EPDS and breastfeeding practice questions. Results: On a multivariate level of analysis, the predictors that increased the odds for postnatal depression symptomatology at the first study point were: unsuccessful breast feeding initiation (odds ratio (OR) 2.58; confidence interval (CI) 1.35-4.91) and personality traits neuroticism (OR 1.16; CI 1.07-1.25.). The predictors that increased the odds for depression symptomatology at the second study phase were: fear for labor outcome (OR 2.44; C1.03-5.80) and the baseline EPDS score (OR 3.32; CI 1.31-8.40). The predictor that decreased the odds at the second study phase was the personality trait Openness (OR 0.9; CI 0.86-0.99). Conclusions: Immediately after childbirth biological and psychological factors seem to be predictive for postpartum symptomatology while later only psychological factors are of greater importance. © Medicinska naklada - Zagreb, Croatia

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