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Kānpur, India

Gupta N.,Andnnm College | Singh M.,P.A. College
Asian Journal of Chemistry | Year: 2012

Green technologies are required essentially to protect our environment from pollution. Microwave-induced organic reaction enhancement techniques are potentially valuable as they reduce the need for organic solvents and also increase 'atom economy' by improving product selectivity and chemical yield. This method displays both economic and environmental advantages. High yields are achieved even on a gram scale, while reaction times are considerably shortened. Ceric ammonium nitrate has been found to be an efficient catalyst for the solid phase green synthesis of amide derivatives of substituted carboxylic acid with urea in excellent yields under microwave irradiation conditions. Present paper reveals the method of synthesis of some amide derivatives using ceric ammonium nitrate as catalyst and their pharmaceutical application.

Arti S.,Andnnm College | Anurag S.,Da V College | Sarika Y.,Andnnm College
International Journal of Pharma and Bio Sciences | Year: 2011

A physico-chemical study was made on cellulase enzymes from a highly cellulolytic fungus Aspergillus niger. Various kinetic parameters were estimated by making use of potent fungicides, viz. m-dinitrobenzene and pentachlorophenol. The enzyme showed maximum activity at pH 5.0 and temp. 55°C. The half-life was found to be 42 minutes at optimum pH. The Michaelis Constant, Km, was observed as 13.3mM and Vmax. as 6.65μM/sec. The inhibition constant, Ki, for MDB was observed to be 19.2mM and for PCP as 22.6mM, thereby indicating that MDB is a more potent inhibitor than PCP.

Gupta N.,Andnnm College | Naaz R.,Andnnm College | Nigam G.D.,CSJM University
International Journal of Pharma and Bio Sciences | Year: 2010

The condensation reactions of aliphatic and aromatic aldehydes and amines carried out efficiently in a water suspension medium. The formation of imines and imidazoles are carried out without catalyst using water as solvent. In this method yields are high, reactions are fast and products are isolated easily by filtration.

Saxena G.,Andnnm College | Kalra S.S.,CSJM University | Gupta N.,Andnnm College | Gupta N.,CSJM University
International Journal of Pharma and Bio Sciences | Year: 2011

Some Pathogens are resistant to various antimicrobial agents. The essential oils/terpenoids were found to exhibit antimicrobial activity against P.aeruginosa, E.coli, S.aureus and C.albicans. In the present study GRAS (generally recognized as safe) terpenoids are grouped according to the structure and their MIC (minimum inhibitory concentration), studied to specify the activity of terpenes against P.aeruginosa, E.coli, S.aureus and C.albicans pathogens. It is concluded that the terpenoid from natural resources could combat the resistant pathogens and make environmentally benign antimicrobial agents.

Gupta N.,Andnnm College | Saxena G.,Andnnm College
International Journal of Pharma and Bio Sciences | Year: 2010

GS/MS of essential oils from Cinnamomum camphorum and Mentha piperita revealed the main chemical components, bornyl acetate, terpinen-4-ol, 1,8 cineole, camphor, eugenol, limonene, ά-pinene, β pinene, geraniol, cinnamaldehyde, linalool, borneol and menthol.GC-MS studies of the essential oils of Mentha piperita and Cinnamomum camphorum have revealed the major constituents as menthol and camphor respectively as per the retention time (area 30.07%,mol.wt. 156.26 for menthol and 67.66% area, mol.wt.142 for camphor). Two terpenoids were subjected for the study of their antimicrobial activity against E.coli and S.aureus. Menthol showed greater zone of inhibition in 24 hrs. at maximum 2% concentration, while less zone of inhibition in 24 hrs. was observed at 2% concentration with camphor.Structure - activity relationship has been observed in the following trend. Methoxy terpene > Alcoholic Terpene > Ketonic terpene On the basis of the above observation these terpenes can be used as natural medicines in the treatment of several diseases like cold & Flu, infectious diseases, bronchitis and also as flavouring liquors, cosmetics, fragrances etc.

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