New York, NY, United States
New York, NY, United States

Anavex Life Sciences Corp. is a pharmaceutical company that develops drug candidates.ANAVEX 2-73 has been shown to provide protection from oxidative stress, which damages and destroys neurons and is believed to be a primary cause of Alzheimer's disease. Research in recent years indicates that oxidative stress is a precursor to amyloid-beta plaques and tau , and could be a novel and appropriate therapeutic target. Wikipedia.


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The present invention involves new and original sigma receptors ligands: (Mono-or di-alkylaminoalkyl)--butyrolactones, their analogues aminotetrahydrofuranes, the (1-adamantyl) phenyl(s) alkylamines, the N,N Dialkyl -[(adamantyl-l)benzyloxy-2] alkylamines and the 3-cyclopentyl adamantyl-amines or alkylamines or alkyl phenylamines, their enantiomers or diastereoisomers and their pharmaceutically acceptable salts, with pro-apoptotic and/or anti-apoptotic properties over cellular biochemical mechanisms, with anti-cancer, anti-metastatic, anti-(chronic) inflammatory, neuro-protective, anticonvulsive, antidepressive and nooanaleptic or sedative action.


NEW YORK, May 22, 2017 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq:AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain, and various types of cancer, today announced new preclinical data for ANAVEX 2-73 in the neurodevelopmental disorders Angelman syndrome, Fragile X syndrome and Rett syndrome. The data was presented at the Antiepileptic Drug Trials XIV 2017 Conference in Aventura, Florida. Characterized as an autism spectrum disorder, Angelman syndrome is a rare neuro-genetic disorder that occurs in one in 15,000 live births.  Individuals with Angelman syndrome exhibit severe cognitive and physical impairments, including ataxia, intellectual disability, speech impairment, sleep disorders, and seizures (the latter being present in over 80 percent of affected individuals). ANAVEX 2-73 (10 mg/kg IP dosed daily for 14 days) was assessed in the Ubiquitin-protein ligase E3A (Ube3a) mouse model of Angelman syndrome for the development of audiogenic seizures in 3-4-month-old animals.  Sponsored by FAST (Foundation for Angelman Syndrome Therapeutics) and conducted in the laboratory of Associate Professor Anne Anderson, MD, at Baylor College of Medicine in Houston, Texas. The results indicated that ANAVEX 2-73 administration significantly reduced audiogenic-induced seizures (p<0.01). “We are impressed with the positive anti-seizure signal of ANAVEX 2-73,” said Paula M. Evans, Chairperson of FAST. “Most people with Angelman syndrome have recurrent seizures throughout their lives, which is a serious challenge for the individual and caretakers.” ANAVEX 2-73 has previously been shown to normalize an array of behavioral impairments in a mouse model of Fragile X (see announcement from June 6, 2016). In a recent study sponsored by Fraxa Research Foundation (FRAXA), the effects of ANAVEX 2-73 (1 mg/kg IP dosed twice daily for 14 days) on potential biomarkers were evaluated in Fragile X mental retardation 1 knockout (Fmr1 KO) mice. Vehicle-treated Fmr1 KO mice demonstrate significantly lower brain-derived neurotrophic factor (BDNF) expression in the hippocampus compared to wild-type mice. The experiments demonstrated that ANAVEX 2-73 restored hippocampal BDNF expression to normal levels (p<0.05). BDNF under-expression has been observed in many neurodevelopmental and neurodegenerative pathologies. BDNF signaling promotes maturation of both excitatory and inhibitory synapses. ANAVEX 2-73 normalization of BDNF expression could be a contributing factor for the positive data observed in both neurodevelopmental and neurodegenerative disorders. In addition, ANAVEX 2-73 has been further evaluated in the MECP2 Rett syndrome disease mouse model. In an experiment sponsored by Rettsyndrome.org, ANAXEX 2-73 was evaluated in automatic visual response and respiration tests in 7-month old mice, an age at which advanced pathology is evident. Vehicle-treated methyl-CpG binding protein 2 (MECP2) mice demonstrated fewer automatic visual responses than wild-type mice. Treatment with ANAVEX 2-73 (30 mg/kg/day PO) for four weeks significantly increased the automatic visual response in the MECP2 Rett syndrome disease mouse (p<0.05). In Rett syndrome there are disturbances in respiration characterized by an irregular breathing pattern and frequent apnea that are common and debilitating. A trend was observed in MECP2 mice treated with ANAVEX 2-73 – that is, a reduction in apnea counts to levels comparable to those observed in wild-type animals. “We are encouraged by these converging positive preclinical findings, confirming the potential therapeutic effect of ANAVEX 2-73 in neurodevelopmental diseases,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. “We plan to continue exploring the links between preclinical findings and clinical manifestations in our ongoing translational research efforts.” The presentation is available on the Anavex website. About Angelman Syndrome Angelman syndrome (AS) is a rare neuro-genetic disorder that affects approximately one in 15,000 people – about 500,000 individuals worldwide. Children and adults with Angelman syndrome typically have balance issues, motor impairment and debilitating seizures. Some individuals never walk. Most do not speak. Individuals with Angelman syndrome require continuous care and are unable to live independently. They have a normal life expectancy. Typical characteristics of Angelman syndrome are not usually evident at birth. People with the disorder have feeding difficulties as infants and noticeable delayed development around 6-12 months of age. They need intensive therapies to help develop functional skills. In most cases, Angelman syndrome isn't genetically inherited. Angelman syndrome affects every race and both genders. It is often misdiagnosed as autism or cerebral palsy. For more information about Angelman syndrome, please visit www.CureAngelman.org. About FAST (Foundation for Angelman Syndrome Therapeutics) FAST is a Section 501(c)(3) nonprofit research organization singularly focused on funding research that holds the greatest promise of treating Angelman syndrome. FAST is the largest, non-governmental funder of Angelman-specific research. Paula Evans, the mother of a young girl with Angelman syndrome, founded FAST in 2008. The foundation is based in Downers Grove, Ill. About Fragile X Syndrome and Autism Spectrum Disorders Fragile X syndrome is the most common form of inherited intellectual disability and the most frequent single gene cause of autism, affecting approximately one in 4,000 males and one in 6,000 females. The disorder is caused by the unstable expansion of a CGG repeat in the FMR1 gene and abnormal methylation, which results in suppression of FMR1 transcription and decreased protein levels in the brain. The average age for diagnosis of Fragile X syndrome in boys and girls is 35 to 37 months and 42 months, respectively. Behavioral abnormalities, including autism spectrum disorder, are common. Autism spectrum disorder is a behavioral diagnosis while Fragile X syndrome is a medical/genetic diagnosis. Many studies have evaluated the Fragile X syndrome-autism spectrum disorders link over the past decade. Since many children with Fragile X syndrome are interested in social interactions, they may not meet the diagnostic criteria for autism spectrum disorders, even though they exhibit some features of autism spectrum disorders such as poor eye contact, shyness, social anxiety, hand-flapping and sensory issues. Autism is much more common in boys with Fragile X syndrome than in girls with Fragile X syndrome. According to the Centers for Disease Control and Prevention (CDC), a national parent survey found that 46% of males and 16% of females with Fragile X syndrome have been diagnosed or treated for autism spectrum disorders. About FRAXA FRAXA’s mission is to find effective treatments and a cure for children and adults with Fragile X and related disorders such as autism. FRAXA has funded over $25,000,000 in biomedical research, yielding discoveries which can change the lives of all families struggling with Fragile X. FRAXA Research Foundation is a non-profit, 501(c)(3) organization which is dedicated to funding biomedical research for improved treatment and a cure for Fragile X, the leading inherited cause of intellectual disability and autism. About Rett Syndrome Rett syndrome is a rare, non-inherited genetic postnatal progressive neurodevelopmental disorder that occurs almost exclusively in girls and leads to severe impairments, affecting nearly every aspect of the child’s life: their ability to speak, walk, eat and even breathe easily. The hallmark of Rett syndrome is near constant repetitive hand movements while awake. It is characterized by normal early growth and development (6 to 18 months) followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures and intellectual disability. There is currently no cure for Rett syndrome and treatment of the disorder is symptomatic. Management of symptoms is done through a multidisciplinary approach utilizing medication for motor difficulties, breathing irregularities and control of seizures through anticonvulsant drugs. Rett syndrome is caused by mutations in the MECP2 gene and strikes all racial and ethnic groups and occurs worldwide in approximately one in every 10,000 to 15,000 live female births. About Rettsyndrome.org Rettsyndrome.org is the most comprehensive nonprofit organization dedicated to accelerating research of treatments and a cure for Rett syndrome and related disorders while providing information and family empowerment. As the world’s leading private funder of Rett syndrome research, Rettsyndrome.org has funded over $40M in high-quality, peer-reviewed research grants and programs to date. The organization hosts the largest global gathering of Rett researchers and clinicians to establish research direction for the future. Rettsyndrome.org, a 501(c)(3) organization, has earned Charity Navigator’s most prestigious 4 star rating year after year. To learn more about our work and Rett syndrome, visit www.rettsyndrome.org or call (800) 818-7388 (RETT). About Anavex Life Sciences Corp. Anavex Life Sciences Corp. (Nasdaq: AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer. Anavex’s lead drug candidate, ANAVEX 2-73, recently completed successfully a Phase 2a clinical trial for Alzheimer’s disease. ANAVEX 2-73 is an orally available drug candidate that restores cellular homeostasis by targeting sigma-1 and muscarinic receptors. Preclinical studies demonstrated its potential to halt and/or reverse the course of Alzheimer’s disease. It has also exhibited anticonvulsant, anti-amnesic, neuroprotective and anti-depressant properties in animal models, indicating its potential to treat additional CNS disorders, including epilepsy and others. The Michael J. Fox Foundation for Parkinson’s Research has awarded Anavex a research grant to develop ANAVEX 2-73 for the treatment of Parkinson’s disease to fully fund a preclinical study, which could justify moving ANAVEX 2-73 into a Parkinson’s disease clinical trial. ANAVEX 3-71, also targeting sigma-1 and M1 muscarinic receptors, is a promising preclinical drug candidate demonstrating disease modifications against the major Alzheimer’s hallmarks in transgenic (3xTg-AD) mice, including cognitive deficits, amyloid and tau pathologies, and also with beneficial effects on neuroinflammation and mitochondrial dysfunctions. Further information is available at www.anavex.com. You can also connect with the company on Twitter, Facebook and LinkedIn. Forward-Looking Statements Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements are only predictions based on current information and expectations and involve a number of risks and uncertainties. Actual events or results may differ materially from those projected in any of such statements due to various factors, including the risks set forth in the Company’s most recent Annual Report on Form 10-K filed with the SEC. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and Anavex Life Sciences Corp. undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof.


NEW YORK, May 22, 2017 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq:AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain, and various types of cancer, today announced new preclinical data for ANAVEX 2-73 in the neurodevelopmental disorders Angelman syndrome, Fragile X syndrome and Rett syndrome. The data was presented at the Antiepileptic Drug Trials XIV 2017 Conference in Aventura, Florida. Characterized as an autism spectrum disorder, Angelman syndrome is a rare neuro-genetic disorder that occurs in one in 15,000 live births.  Individuals with Angelman syndrome exhibit severe cognitive and physical impairments, including ataxia, intellectual disability, speech impairment, sleep disorders, and seizures (the latter being present in over 80 percent of affected individuals). ANAVEX 2-73 (10 mg/kg IP dosed daily for 14 days) was assessed in the Ubiquitin-protein ligase E3A (Ube3a) mouse model of Angelman syndrome for the development of audiogenic seizures in 3-4-month-old animals.  Sponsored by FAST (Foundation for Angelman Syndrome Therapeutics) and conducted in the laboratory of Associate Professor Anne Anderson, MD, at Baylor College of Medicine in Houston, Texas. The results indicated that ANAVEX 2-73 administration significantly reduced audiogenic-induced seizures (p<0.01). “We are impressed with the positive anti-seizure signal of ANAVEX 2-73,” said Paula M. Evans, Chairperson of FAST. “Most people with Angelman syndrome have recurrent seizures throughout their lives, which is a serious challenge for the individual and caretakers.” ANAVEX 2-73 has previously been shown to normalize an array of behavioral impairments in a mouse model of Fragile X (see announcement from June 6, 2016). In a recent study sponsored by Fraxa Research Foundation (FRAXA), the effects of ANAVEX 2-73 (1 mg/kg IP dosed twice daily for 14 days) on potential biomarkers were evaluated in Fragile X mental retardation 1 knockout (Fmr1 KO) mice. Vehicle-treated Fmr1 KO mice demonstrate significantly lower brain-derived neurotrophic factor (BDNF) expression in the hippocampus compared to wild-type mice. The experiments demonstrated that ANAVEX 2-73 restored hippocampal BDNF expression to normal levels (p<0.05). BDNF under-expression has been observed in many neurodevelopmental and neurodegenerative pathologies. BDNF signaling promotes maturation of both excitatory and inhibitory synapses. ANAVEX 2-73 normalization of BDNF expression could be a contributing factor for the positive data observed in both neurodevelopmental and neurodegenerative disorders. In addition, ANAVEX 2-73 has been further evaluated in the MECP2 Rett syndrome disease mouse model. In an experiment sponsored by Rettsyndrome.org, ANAXEX 2-73 was evaluated in automatic visual response and respiration tests in 7-month old mice, an age at which advanced pathology is evident. Vehicle-treated methyl-CpG binding protein 2 (MECP2) mice demonstrated fewer automatic visual responses than wild-type mice. Treatment with ANAVEX 2-73 (30 mg/kg/day PO) for four weeks significantly increased the automatic visual response in the MECP2 Rett syndrome disease mouse (p<0.05). In Rett syndrome there are disturbances in respiration characterized by an irregular breathing pattern and frequent apnea that are common and debilitating. A trend was observed in MECP2 mice treated with ANAVEX 2-73 – that is, a reduction in apnea counts to levels comparable to those observed in wild-type animals. “We are encouraged by these converging positive preclinical findings, confirming the potential therapeutic effect of ANAVEX 2-73 in neurodevelopmental diseases,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. “We plan to continue exploring the links between preclinical findings and clinical manifestations in our ongoing translational research efforts.” The presentation is available on the Anavex website. About Angelman Syndrome Angelman syndrome (AS) is a rare neuro-genetic disorder that affects approximately one in 15,000 people – about 500,000 individuals worldwide. Children and adults with Angelman syndrome typically have balance issues, motor impairment and debilitating seizures. Some individuals never walk. Most do not speak. Individuals with Angelman syndrome require continuous care and are unable to live independently. They have a normal life expectancy. Typical characteristics of Angelman syndrome are not usually evident at birth. People with the disorder have feeding difficulties as infants and noticeable delayed development around 6-12 months of age. They need intensive therapies to help develop functional skills. In most cases, Angelman syndrome isn't genetically inherited. Angelman syndrome affects every race and both genders. It is often misdiagnosed as autism or cerebral palsy. For more information about Angelman syndrome, please visit www.CureAngelman.org. About FAST (Foundation for Angelman Syndrome Therapeutics) FAST is a Section 501(c)(3) nonprofit research organization singularly focused on funding research that holds the greatest promise of treating Angelman syndrome. FAST is the largest, non-governmental funder of Angelman-specific research. Paula Evans, the mother of a young girl with Angelman syndrome, founded FAST in 2008. The foundation is based in Downers Grove, Ill. About Fragile X Syndrome and Autism Spectrum Disorders Fragile X syndrome is the most common form of inherited intellectual disability and the most frequent single gene cause of autism, affecting approximately one in 4,000 males and one in 6,000 females. The disorder is caused by the unstable expansion of a CGG repeat in the FMR1 gene and abnormal methylation, which results in suppression of FMR1 transcription and decreased protein levels in the brain. The average age for diagnosis of Fragile X syndrome in boys and girls is 35 to 37 months and 42 months, respectively. Behavioral abnormalities, including autism spectrum disorder, are common. Autism spectrum disorder is a behavioral diagnosis while Fragile X syndrome is a medical/genetic diagnosis. Many studies have evaluated the Fragile X syndrome-autism spectrum disorders link over the past decade. Since many children with Fragile X syndrome are interested in social interactions, they may not meet the diagnostic criteria for autism spectrum disorders, even though they exhibit some features of autism spectrum disorders such as poor eye contact, shyness, social anxiety, hand-flapping and sensory issues. Autism is much more common in boys with Fragile X syndrome than in girls with Fragile X syndrome. According to the Centers for Disease Control and Prevention (CDC), a national parent survey found that 46% of males and 16% of females with Fragile X syndrome have been diagnosed or treated for autism spectrum disorders. About FRAXA FRAXA’s mission is to find effective treatments and a cure for children and adults with Fragile X and related disorders such as autism. FRAXA has funded over $25,000,000 in biomedical research, yielding discoveries which can change the lives of all families struggling with Fragile X. FRAXA Research Foundation is a non-profit, 501(c)(3) organization which is dedicated to funding biomedical research for improved treatment and a cure for Fragile X, the leading inherited cause of intellectual disability and autism. About Rett Syndrome Rett syndrome is a rare, non-inherited genetic postnatal progressive neurodevelopmental disorder that occurs almost exclusively in girls and leads to severe impairments, affecting nearly every aspect of the child’s life: their ability to speak, walk, eat and even breathe easily. The hallmark of Rett syndrome is near constant repetitive hand movements while awake. It is characterized by normal early growth and development (6 to 18 months) followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures and intellectual disability. There is currently no cure for Rett syndrome and treatment of the disorder is symptomatic. Management of symptoms is done through a multidisciplinary approach utilizing medication for motor difficulties, breathing irregularities and control of seizures through anticonvulsant drugs. Rett syndrome is caused by mutations in the MECP2 gene and strikes all racial and ethnic groups and occurs worldwide in approximately one in every 10,000 to 15,000 live female births. About Rettsyndrome.org Rettsyndrome.org is the most comprehensive nonprofit organization dedicated to accelerating research of treatments and a cure for Rett syndrome and related disorders while providing information and family empowerment. As the world’s leading private funder of Rett syndrome research, Rettsyndrome.org has funded over $40M in high-quality, peer-reviewed research grants and programs to date. The organization hosts the largest global gathering of Rett researchers and clinicians to establish research direction for the future. Rettsyndrome.org, a 501(c)(3) organization, has earned Charity Navigator’s most prestigious 4 star rating year after year. To learn more about our work and Rett syndrome, visit www.rettsyndrome.org or call (800) 818-7388 (RETT). About Anavex Life Sciences Corp. Anavex Life Sciences Corp. (Nasdaq: AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer. Anavex’s lead drug candidate, ANAVEX 2-73, recently completed successfully a Phase 2a clinical trial for Alzheimer’s disease. ANAVEX 2-73 is an orally available drug candidate that restores cellular homeostasis by targeting sigma-1 and muscarinic receptors. Preclinical studies demonstrated its potential to halt and/or reverse the course of Alzheimer’s disease. It has also exhibited anticonvulsant, anti-amnesic, neuroprotective and anti-depressant properties in animal models, indicating its potential to treat additional CNS disorders, including epilepsy and others. The Michael J. Fox Foundation for Parkinson’s Research has awarded Anavex a research grant to develop ANAVEX 2-73 for the treatment of Parkinson’s disease to fully fund a preclinical study, which could justify moving ANAVEX 2-73 into a Parkinson’s disease clinical trial. ANAVEX 3-71, also targeting sigma-1 and M1 muscarinic receptors, is a promising preclinical drug candidate demonstrating disease modifications against the major Alzheimer’s hallmarks in transgenic (3xTg-AD) mice, including cognitive deficits, amyloid and tau pathologies, and also with beneficial effects on neuroinflammation and mitochondrial dysfunctions. Further information is available at www.anavex.com. You can also connect with the company on Twitter, Facebook and LinkedIn. Forward-Looking Statements Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements are only predictions based on current information and expectations and involve a number of risks and uncertainties. Actual events or results may differ materially from those projected in any of such statements due to various factors, including the risks set forth in the Company’s most recent Annual Report on Form 10-K filed with the SEC. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and Anavex Life Sciences Corp. undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof.


NEW YORK, May 22, 2017 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq:AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain, and various types of cancer, today announced new preclinical data for ANAVEX 2-73 in the neurodevelopmental disorders Angelman syndrome, Fragile X syndrome and Rett syndrome. The data was presented at the Antiepileptic Drug Trials XIV 2017 Conference in Aventura, Florida. Characterized as an autism spectrum disorder, Angelman syndrome is a rare neuro-genetic disorder that occurs in one in 15,000 live births.  Individuals with Angelman syndrome exhibit severe cognitive and physical impairments, including ataxia, intellectual disability, speech impairment, sleep disorders, and seizures (the latter being present in over 80 percent of affected individuals). ANAVEX 2-73 (10 mg/kg IP dosed daily for 14 days) was assessed in the Ubiquitin-protein ligase E3A (Ube3a) mouse model of Angelman syndrome for the development of audiogenic seizures in 3-4-month-old animals.  Sponsored by FAST (Foundation for Angelman Syndrome Therapeutics) and conducted in the laboratory of Associate Professor Anne Anderson, MD, at Baylor College of Medicine in Houston, Texas. The results indicated that ANAVEX 2-73 administration significantly reduced audiogenic-induced seizures (p<0.01). “We are impressed with the positive anti-seizure signal of ANAVEX 2-73,” said Paula M. Evans, Chairperson of FAST. “Most people with Angelman syndrome have recurrent seizures throughout their lives, which is a serious challenge for the individual and caretakers.” ANAVEX 2-73 has previously been shown to normalize an array of behavioral impairments in a mouse model of Fragile X (see announcement from June 6, 2016). In a recent study sponsored by Fraxa Research Foundation (FRAXA), the effects of ANAVEX 2-73 (1 mg/kg IP dosed twice daily for 14 days) on potential biomarkers were evaluated in Fragile X mental retardation 1 knockout (Fmr1 KO) mice. Vehicle-treated Fmr1 KO mice demonstrate significantly lower brain-derived neurotrophic factor (BDNF) expression in the hippocampus compared to wild-type mice. The experiments demonstrated that ANAVEX 2-73 restored hippocampal BDNF expression to normal levels (p<0.05). BDNF under-expression has been observed in many neurodevelopmental and neurodegenerative pathologies. BDNF signaling promotes maturation of both excitatory and inhibitory synapses. ANAVEX 2-73 normalization of BDNF expression could be a contributing factor for the positive data observed in both neurodevelopmental and neurodegenerative disorders. In addition, ANAVEX 2-73 has been further evaluated in the MECP2 Rett syndrome disease mouse model. In an experiment sponsored by Rettsyndrome.org, ANAXEX 2-73 was evaluated in automatic visual response and respiration tests in 7-month old mice, an age at which advanced pathology is evident. Vehicle-treated methyl-CpG binding protein 2 (MECP2) mice demonstrated fewer automatic visual responses than wild-type mice. Treatment with ANAVEX 2-73 (30 mg/kg/day PO) for four weeks significantly increased the automatic visual response in the MECP2 Rett syndrome disease mouse (p<0.05). In Rett syndrome there are disturbances in respiration characterized by an irregular breathing pattern and frequent apnea that are common and debilitating. A trend was observed in MECP2 mice treated with ANAVEX 2-73 – that is, a reduction in apnea counts to levels comparable to those observed in wild-type animals. “We are encouraged by these converging positive preclinical findings, confirming the potential therapeutic effect of ANAVEX 2-73 in neurodevelopmental diseases,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. “We plan to continue exploring the links between preclinical findings and clinical manifestations in our ongoing translational research efforts.” The presentation is available on the Anavex website. About Angelman Syndrome Angelman syndrome (AS) is a rare neuro-genetic disorder that affects approximately one in 15,000 people – about 500,000 individuals worldwide. Children and adults with Angelman syndrome typically have balance issues, motor impairment and debilitating seizures. Some individuals never walk. Most do not speak. Individuals with Angelman syndrome require continuous care and are unable to live independently. They have a normal life expectancy. Typical characteristics of Angelman syndrome are not usually evident at birth. People with the disorder have feeding difficulties as infants and noticeable delayed development around 6-12 months of age. They need intensive therapies to help develop functional skills. In most cases, Angelman syndrome isn't genetically inherited. Angelman syndrome affects every race and both genders. It is often misdiagnosed as autism or cerebral palsy. For more information about Angelman syndrome, please visit www.CureAngelman.org. About FAST (Foundation for Angelman Syndrome Therapeutics) FAST is a Section 501(c)(3) nonprofit research organization singularly focused on funding research that holds the greatest promise of treating Angelman syndrome. FAST is the largest, non-governmental funder of Angelman-specific research. Paula Evans, the mother of a young girl with Angelman syndrome, founded FAST in 2008. The foundation is based in Downers Grove, Ill. About Fragile X Syndrome and Autism Spectrum Disorders Fragile X syndrome is the most common form of inherited intellectual disability and the most frequent single gene cause of autism, affecting approximately one in 4,000 males and one in 6,000 females. The disorder is caused by the unstable expansion of a CGG repeat in the FMR1 gene and abnormal methylation, which results in suppression of FMR1 transcription and decreased protein levels in the brain. The average age for diagnosis of Fragile X syndrome in boys and girls is 35 to 37 months and 42 months, respectively. Behavioral abnormalities, including autism spectrum disorder, are common. Autism spectrum disorder is a behavioral diagnosis while Fragile X syndrome is a medical/genetic diagnosis. Many studies have evaluated the Fragile X syndrome-autism spectrum disorders link over the past decade. Since many children with Fragile X syndrome are interested in social interactions, they may not meet the diagnostic criteria for autism spectrum disorders, even though they exhibit some features of autism spectrum disorders such as poor eye contact, shyness, social anxiety, hand-flapping and sensory issues. Autism is much more common in boys with Fragile X syndrome than in girls with Fragile X syndrome. According to the Centers for Disease Control and Prevention (CDC), a national parent survey found that 46% of males and 16% of females with Fragile X syndrome have been diagnosed or treated for autism spectrum disorders. About FRAXA FRAXA’s mission is to find effective treatments and a cure for children and adults with Fragile X and related disorders such as autism. FRAXA has funded over $25,000,000 in biomedical research, yielding discoveries which can change the lives of all families struggling with Fragile X. FRAXA Research Foundation is a non-profit, 501(c)(3) organization which is dedicated to funding biomedical research for improved treatment and a cure for Fragile X, the leading inherited cause of intellectual disability and autism. About Rett Syndrome Rett syndrome is a rare, non-inherited genetic postnatal progressive neurodevelopmental disorder that occurs almost exclusively in girls and leads to severe impairments, affecting nearly every aspect of the child’s life: their ability to speak, walk, eat and even breathe easily. The hallmark of Rett syndrome is near constant repetitive hand movements while awake. It is characterized by normal early growth and development (6 to 18 months) followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures and intellectual disability. There is currently no cure for Rett syndrome and treatment of the disorder is symptomatic. Management of symptoms is done through a multidisciplinary approach utilizing medication for motor difficulties, breathing irregularities and control of seizures through anticonvulsant drugs. Rett syndrome is caused by mutations in the MECP2 gene and strikes all racial and ethnic groups and occurs worldwide in approximately one in every 10,000 to 15,000 live female births. About Rettsyndrome.org Rettsyndrome.org is the most comprehensive nonprofit organization dedicated to accelerating research of treatments and a cure for Rett syndrome and related disorders while providing information and family empowerment. As the world’s leading private funder of Rett syndrome research, Rettsyndrome.org has funded over $40M in high-quality, peer-reviewed research grants and programs to date. The organization hosts the largest global gathering of Rett researchers and clinicians to establish research direction for the future. Rettsyndrome.org, a 501(c)(3) organization, has earned Charity Navigator’s most prestigious 4 star rating year after year. To learn more about our work and Rett syndrome, visit www.rettsyndrome.org or call (800) 818-7388 (RETT). About Anavex Life Sciences Corp. Anavex Life Sciences Corp. (Nasdaq: AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer. Anavex’s lead drug candidate, ANAVEX 2-73, recently completed successfully a Phase 2a clinical trial for Alzheimer’s disease. ANAVEX 2-73 is an orally available drug candidate that restores cellular homeostasis by targeting sigma-1 and muscarinic receptors. Preclinical studies demonstrated its potential to halt and/or reverse the course of Alzheimer’s disease. It has also exhibited anticonvulsant, anti-amnesic, neuroprotective and anti-depressant properties in animal models, indicating its potential to treat additional CNS disorders, including epilepsy and others. The Michael J. Fox Foundation for Parkinson’s Research has awarded Anavex a research grant to develop ANAVEX 2-73 for the treatment of Parkinson’s disease to fully fund a preclinical study, which could justify moving ANAVEX 2-73 into a Parkinson’s disease clinical trial. ANAVEX 3-71, also targeting sigma-1 and M1 muscarinic receptors, is a promising preclinical drug candidate demonstrating disease modifications against the major Alzheimer’s hallmarks in transgenic (3xTg-AD) mice, including cognitive deficits, amyloid and tau pathologies, and also with beneficial effects on neuroinflammation and mitochondrial dysfunctions. Further information is available at www.anavex.com. You can also connect with the company on Twitter, Facebook and LinkedIn. Forward-Looking Statements Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements are only predictions based on current information and expectations and involve a number of risks and uncertainties. Actual events or results may differ materially from those projected in any of such statements due to various factors, including the risks set forth in the Company’s most recent Annual Report on Form 10-K filed with the SEC. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and Anavex Life Sciences Corp. undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof.


NEW YORK, May 22, 2017 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq:AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain, and various types of cancer, today announced new preclinical data for ANAVEX 2-73 in the neurodevelopmental disorders Angelman syndrome, Fragile X syndrome and Rett syndrome. The data was presented at the Antiepileptic Drug Trials XIV 2017 Conference in Aventura, Florida. Characterized as an autism spectrum disorder, Angelman syndrome is a rare neuro-genetic disorder that occurs in one in 15,000 live births.  Individuals with Angelman syndrome exhibit severe cognitive and physical impairments, including ataxia, intellectual disability, speech impairment, sleep disorders, and seizures (the latter being present in over 80 percent of affected individuals). ANAVEX 2-73 (10 mg/kg IP dosed daily for 14 days) was assessed in the Ubiquitin-protein ligase E3A (Ube3a) mouse model of Angelman syndrome for the development of audiogenic seizures in 3-4-month-old animals.  Sponsored by FAST (Foundation for Angelman Syndrome Therapeutics) and conducted in the laboratory of Associate Professor Anne Anderson, MD, at Baylor College of Medicine in Houston, Texas. The results indicated that ANAVEX 2-73 administration significantly reduced audiogenic-induced seizures (p<0.01). “We are impressed with the positive anti-seizure signal of ANAVEX 2-73,” said Paula M. Evans, Chairperson of FAST. “Most people with Angelman syndrome have recurrent seizures throughout their lives, which is a serious challenge for the individual and caretakers.” ANAVEX 2-73 has previously been shown to normalize an array of behavioral impairments in a mouse model of Fragile X (see announcement from June 6, 2016). In a recent study sponsored by Fraxa Research Foundation (FRAXA), the effects of ANAVEX 2-73 (1 mg/kg IP dosed twice daily for 14 days) on potential biomarkers were evaluated in Fragile X mental retardation 1 knockout (Fmr1 KO) mice. Vehicle-treated Fmr1 KO mice demonstrate significantly lower brain-derived neurotrophic factor (BDNF) expression in the hippocampus compared to wild-type mice. The experiments demonstrated that ANAVEX 2-73 restored hippocampal BDNF expression to normal levels (p<0.05). BDNF under-expression has been observed in many neurodevelopmental and neurodegenerative pathologies. BDNF signaling promotes maturation of both excitatory and inhibitory synapses. ANAVEX 2-73 normalization of BDNF expression could be a contributing factor for the positive data observed in both neurodevelopmental and neurodegenerative disorders. In addition, ANAVEX 2-73 has been further evaluated in the MECP2 Rett syndrome disease mouse model. In an experiment sponsored by Rettsyndrome.org, ANAXEX 2-73 was evaluated in automatic visual response and respiration tests in 7-month old mice, an age at which advanced pathology is evident. Vehicle-treated methyl-CpG binding protein 2 (MECP2) mice demonstrated fewer automatic visual responses than wild-type mice. Treatment with ANAVEX 2-73 (30 mg/kg/day PO) for four weeks significantly increased the automatic visual response in the MECP2 Rett syndrome disease mouse (p<0.05). In Rett syndrome there are disturbances in respiration characterized by an irregular breathing pattern and frequent apnea that are common and debilitating. A trend was observed in MECP2 mice treated with ANAVEX 2-73 – that is, a reduction in apnea counts to levels comparable to those observed in wild-type animals. “We are encouraged by these converging positive preclinical findings, confirming the potential therapeutic effect of ANAVEX 2-73 in neurodevelopmental diseases,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. “We plan to continue exploring the links between preclinical findings and clinical manifestations in our ongoing translational research efforts.” The presentation is available on the Anavex website. About Angelman Syndrome Angelman syndrome (AS) is a rare neuro-genetic disorder that affects approximately one in 15,000 people – about 500,000 individuals worldwide. Children and adults with Angelman syndrome typically have balance issues, motor impairment and debilitating seizures. Some individuals never walk. Most do not speak. Individuals with Angelman syndrome require continuous care and are unable to live independently. They have a normal life expectancy. Typical characteristics of Angelman syndrome are not usually evident at birth. People with the disorder have feeding difficulties as infants and noticeable delayed development around 6-12 months of age. They need intensive therapies to help develop functional skills. In most cases, Angelman syndrome isn't genetically inherited. Angelman syndrome affects every race and both genders. It is often misdiagnosed as autism or cerebral palsy. For more information about Angelman syndrome, please visit www.CureAngelman.org. About FAST (Foundation for Angelman Syndrome Therapeutics) FAST is a Section 501(c)(3) nonprofit research organization singularly focused on funding research that holds the greatest promise of treating Angelman syndrome. FAST is the largest, non-governmental funder of Angelman-specific research. Paula Evans, the mother of a young girl with Angelman syndrome, founded FAST in 2008. The foundation is based in Downers Grove, Ill. About Fragile X Syndrome and Autism Spectrum Disorders Fragile X syndrome is the most common form of inherited intellectual disability and the most frequent single gene cause of autism, affecting approximately one in 4,000 males and one in 6,000 females. The disorder is caused by the unstable expansion of a CGG repeat in the FMR1 gene and abnormal methylation, which results in suppression of FMR1 transcription and decreased protein levels in the brain. The average age for diagnosis of Fragile X syndrome in boys and girls is 35 to 37 months and 42 months, respectively. Behavioral abnormalities, including autism spectrum disorder, are common. Autism spectrum disorder is a behavioral diagnosis while Fragile X syndrome is a medical/genetic diagnosis. Many studies have evaluated the Fragile X syndrome-autism spectrum disorders link over the past decade. Since many children with Fragile X syndrome are interested in social interactions, they may not meet the diagnostic criteria for autism spectrum disorders, even though they exhibit some features of autism spectrum disorders such as poor eye contact, shyness, social anxiety, hand-flapping and sensory issues. Autism is much more common in boys with Fragile X syndrome than in girls with Fragile X syndrome. According to the Centers for Disease Control and Prevention (CDC), a national parent survey found that 46% of males and 16% of females with Fragile X syndrome have been diagnosed or treated for autism spectrum disorders. About FRAXA FRAXA’s mission is to find effective treatments and a cure for children and adults with Fragile X and related disorders such as autism. FRAXA has funded over $25,000,000 in biomedical research, yielding discoveries which can change the lives of all families struggling with Fragile X. FRAXA Research Foundation is a non-profit, 501(c)(3) organization which is dedicated to funding biomedical research for improved treatment and a cure for Fragile X, the leading inherited cause of intellectual disability and autism. About Rett Syndrome Rett syndrome is a rare, non-inherited genetic postnatal progressive neurodevelopmental disorder that occurs almost exclusively in girls and leads to severe impairments, affecting nearly every aspect of the child’s life: their ability to speak, walk, eat and even breathe easily. The hallmark of Rett syndrome is near constant repetitive hand movements while awake. It is characterized by normal early growth and development (6 to 18 months) followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures and intellectual disability. There is currently no cure for Rett syndrome and treatment of the disorder is symptomatic. Management of symptoms is done through a multidisciplinary approach utilizing medication for motor difficulties, breathing irregularities and control of seizures through anticonvulsant drugs. Rett syndrome is caused by mutations in the MECP2 gene and strikes all racial and ethnic groups and occurs worldwide in approximately one in every 10,000 to 15,000 live female births. About Rettsyndrome.org Rettsyndrome.org is the most comprehensive nonprofit organization dedicated to accelerating research of treatments and a cure for Rett syndrome and related disorders while providing information and family empowerment. As the world’s leading private funder of Rett syndrome research, Rettsyndrome.org has funded over $40M in high-quality, peer-reviewed research grants and programs to date. The organization hosts the largest global gathering of Rett researchers and clinicians to establish research direction for the future. Rettsyndrome.org, a 501(c)(3) organization, has earned Charity Navigator’s most prestigious 4 star rating year after year. To learn more about our work and Rett syndrome, visit www.rettsyndrome.org or call (800) 818-7388 (RETT). About Anavex Life Sciences Corp. Anavex Life Sciences Corp. (Nasdaq: AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer. Anavex’s lead drug candidate, ANAVEX 2-73, recently completed successfully a Phase 2a clinical trial for Alzheimer’s disease. ANAVEX 2-73 is an orally available drug candidate that restores cellular homeostasis by targeting sigma-1 and muscarinic receptors. Preclinical studies demonstrated its potential to halt and/or reverse the course of Alzheimer’s disease. It has also exhibited anticonvulsant, anti-amnesic, neuroprotective and anti-depressant properties in animal models, indicating its potential to treat additional CNS disorders, including epilepsy and others. The Michael J. Fox Foundation for Parkinson’s Research has awarded Anavex a research grant to develop ANAVEX 2-73 for the treatment of Parkinson’s disease to fully fund a preclinical study, which could justify moving ANAVEX 2-73 into a Parkinson’s disease clinical trial. ANAVEX 3-71, also targeting sigma-1 and M1 muscarinic receptors, is a promising preclinical drug candidate demonstrating disease modifications against the major Alzheimer’s hallmarks in transgenic (3xTg-AD) mice, including cognitive deficits, amyloid and tau pathologies, and also with beneficial effects on neuroinflammation and mitochondrial dysfunctions. Further information is available at www.anavex.com. You can also connect with the company on Twitter, Facebook and LinkedIn. Forward-Looking Statements Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements are only predictions based on current information and expectations and involve a number of risks and uncertainties. Actual events or results may differ materially from those projected in any of such statements due to various factors, including the risks set forth in the Company’s most recent Annual Report on Form 10-K filed with the SEC. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and Anavex Life Sciences Corp. undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof.


NEW YORK, May 01, 2017 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq:AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer, today announced the appointment of Emmanuel O. Fadiran, RPh, PhD, as Senior Vice President of Regulatory Affairs. Dr. Fadiran has 24 years of regulatory experience within the U.S. Food and Drug Administration (FDA), having held leadership positions at the FDA’s Center for Drug Evaluation and Research (CDER). “Dr. Fadiran has an accomplished track record of working within the FDA,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. “His depth of experience makes him an excellent choice to manage the considerable number of regulatory filings that Anavex has planned.” Prior to joining Anavex, Dr. Fadiran served as a Clinical Pharmacology Team Leader at the FDA’s CDER. During his 24-year (1993-2017) tenure at the FDA, Dr. Fadiran reviewed hundreds of New Drug Applications (NDAs), supplemental New Drug Applications (sNDAs), Biologics License Application (BLAs), Abbreviated New Drug Applications (ANDAs) and Investigational New Drug applications (INDs) for approval and made strategic recommendations for the development of several products across many therapeutic categories.  He was on review teams for several novel therapies including first-in-class approvals. Dr. Fadiran also led a cross-disciplinary NDA review team and authored the first Cross-Discipline Team Leader (CDTL) review for the Division of the Pulmonary and Allergy Products, Office of Drug Evaluation II, CDER. He was actively involved in the writing, internal/external training and implementation of the U.S. FDA Guidance for Industry for population pharmacokinetics. “I am very pleased to be joining Anavex at this important and exciting time for the company,” stated Dr. Fadiran. “There are tremendous opportunities ahead, and I look forward to working with the Anavex team to deliver on the corporate objectives for 2017 and beyond.” Dr. Fadiran has been involved in the formulation of significant strategic FDA regulatory initiatives including serving as a member of the Senior Management Teams for the Data Standard (Janus) and Sentinel Initiatives. He was an active member of the FDA Senior Science Council working group for the creation and launching of the FDA’s Strategic Plan for Regulatory Science in 2012. Recently, he has played an active role in the development of the Comprehensive in vitro Proarrhythmia Assay (CiPA) for future replacement of the thorough QT studies. As a long-term member of the FDA Institutional Review Board (IRB), he actively contributed to the development of standard operating procedures (SOP) for the committee. Dr. Fadiran holds a BS (Pharmacy) and MS from Obafemi Awolowo University, Ile-Ife, Nigeria and a PhD in Pharmaceutical Sciences from the University of Strathclyde, Glasgow, UK.  Dr. Fadiran is a recipient of the prestigious Fogarty International Fellowship of the National Institutes of Health (NIH) (1991-1993) as well as numerous awards from the FDA, among them the Commissioner’s Award of Excellence, in recognition of his outstanding contributions to regulatory review of applications and development of regulatory guidance and policies. About Anavex Life Sciences Corp. Anavex Life Sciences Corp. (Nasdaq:AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer. Anavex’s lead drug candidate, ANAVEX 2-73, recently successfully completed a Phase 2a clinical trial for Alzheimer’s disease. ANAVEX 2-73 is an orally available drug candidate that restores cellular homeostasis by targeting sigma-1 and muscarinic receptors and successfully completed Phase 1. Preclinical studies demonstrated its potential to halt and/or reverse the course of Alzheimer’s disease. ANAVEX 2-73 has also exhibited anticonvulsant, anti-amnesic, neuroprotective and anti-depressant properties in animal models, indicating its potential to treat additional CNS disorders, including epilepsy and others. The Michael J. Fox Foundation for Parkinson’s Research has awarded Anavex a research grant to develop ANAVEX 2-73 for the treatment of Parkinson’s disease to fully fund a preclinical study, which could justify moving ANAVEX 2-73 into a Parkinson’s disease clinical trial. ANAVEX 3-71, also targeting sigma-1 and M1 muscarinic receptors, is a promising preclinical drug candidate demonstrating disease modifications against the major Alzheimer’s hallmarks in transgenic (3xTg-AD) mice, including cognitive deficits, amyloid and tau pathologies, and also with beneficial effects on neuroinflammation and mitochondrial dysfunctions. Further information is available at www.anavex.com. You can also connect with the company on Twitter, Facebook and LinkedIn. Forward-Looking Statements Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements are only predictions based on current information and expectations and involve a number of risks and uncertainties. Actual events or results may differ materially from those projected in any of such statements due to various factors, including the risks set forth in the Company’s most recent Annual Report on Form 10-K filed with the SEC. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and Anavex Life Sciences Corp. undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof.


— Neurodegenerative Disorders Drug Development Pipeline Review, 2017 market report says Small molecule drugs dominate the pipeline, with approximately 64% of total pipeline molecules. In comparison, the number of biologics in the pipeline is much lower, representing approximately 26% of the pipeline. Overall the neurodegenerative disorders pipeline is large, with a substantial proportion of products being early-stage assets at the Preclinical development stage. Browse the 200 Tables and Figures, Spread across 797 Pages Report Available at http://www.reportsnreports.com/contacts/discount.aspx?name=964827. There are over 1,400 products in active development in the neurodegenerative disorders therapy area. The current market landscape consists of a number of biologics and small molecules, while the pipeline also consists of gene therapies and cell therapies, demonstrating broader pharmaceutical research and development. The report provides comprehensive information on the pipeline development landscape for is Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic lateral sclerosis and Multiple sclerosis, from Discovery through to the Pre-registration stage. This includes an analysis of products by stage of development, molecular target, mechanism of action (MoA), route of administration (RoA) and molecule type. Finally, the report provides an overview of key players involved in the development of products in this area, and outlines recent updates and press releases in the field. Scope of The Report • Which companies are the most active within the pipeline for neurodegenerative disorders? • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication? • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies? • What are the most important R&D milestones and data publications to have happened in this disease area? Alzheimer's Disease – Pipeline for AB Science SA, AbbVie Inc, AC Immune SA, Accera, Inc., Acelot, Inc., Actinogen Limited, Acumen Pharmaceuticals, Inc., Addex Therapeutics Ltd, Affibody AB, AFFiRiS AG, Alector LLC, Alkermes Plc, Allergan Plc, Allinky Biopharma, ALSP, Inc., Alzhyme Pty Ltd, Alzinova AB, AlzProtect SAS, Amarantus Bioscience Holdings, Inc., Amgen Inc., Anavex Life Sciences Corp., Aphios Corporation, Apodemus AB, Applied Research using OMIC Sciences, S.L., Araclon Biotech, S.L., Archer Pharmaceuticals, Inc., ArmaGen Inc., Artery Therapeutics, Inc., AskAt Inc., Astellas Pharma Inc., AstraZeneca Plc, Asubio Pharma Co., Ltd., Ausio Pharmaceuticals, LLC, Avineuro Pharmaceuticals, Inc., Axon Neuroscience SE, Axovant Sciences Ltd., Axsome Therapeutics, Inc., Axxam SpA, Beactica AB, Berg LLC, BioArctic Neuroscience AB, Bioasis Technologies Inc., Biogen Inc, Biomar Microbial Technologies, Bionature E.A. Ltd., Boehringer Ingelheim GmbH, Bristol-Myers Squibb Company, Bsim2, Cardax Pharmaceuticals, Inc., Carna Biosciences, Inc., Celon Pharma Sp. z o.o., CHA Bio & Diostech Co., Ltd., Chase Pharmaceuticals Corporation, Clera Inc., Cognition Therapeutics, Inc., Cognosci, Inc., CohBar, Inc., Connexios Life Sciences Pvt. Ltd., ContraVir Pharmaceuticals, Inc., Corium International, Inc., Coronis Partners Ltd., Cortice Biosciences, Inc., Critical Outcome Technologies Inc., Crossbeta Biosciences B.V., D-Pharm Ltd., Daewoong Pharmaceutical Co., Ltd., Daiichi Sankyo Company, Limited, Daval International Limited, DermaXon, LLC, Dongkook Pharmaceutical Co., Ltd., Eisai Co., Ltd., Eli Lilly and Company, Emergent BioSolutions Inc., EncephRx, Inc., Endece, LLC, ENKAM Pharmaceuticals A/S, Ensemble Therapeutics Corporation, Ensol Biosciences Inc., Epigen Biosciences, Inc., Euroscreen S.A., Evotec AG, F. Hoffmann-La Roche Ltd., FORUM Pharmaceuticals Inc., Genentech, Inc., Genervon Biopharmaceuticals, LLC, GlaxoSmithKline Plc, GliaCure Inc., Glialogix, Inc., Golden Biotechnology Corp., Grifols, S.A., H. Lundbeck A/S, Heptares Therapeutics Limited, HitGen LTD, Humanetics Corporation, Ichor Medical Systems, Inc., Icure Pharmaceutical Inc., Immungenetics AG, Impel NeuroPharma, Inc., ImStar Therapeutics Inc., Inovio Pharmaceuticals, Inc., IntelGenx Corp., Intellect Neurosciences, Inc., Intra-Cellular Therapies, Inc., INVENT Pharmaceuticals, Inc., Io Therapeutics, Inc., Iproteos S.L., Jeil Pharmaceutical Co. Ltd., Jiangsu Kanion Pharmaceutical Co.Ltd., Johnson & Johnson, K-Stemcell Co.Ltd., Kadmon Corporation, LLC, Kalgene Pharmaceuticals Inc., Kareus Therapeutics, SA, KineMed, Inc., Krenitsky Pharmaceuticals Inc., Kyowa Hakko Kirin Co.Ltd., Lead Discovery Center GmbH, Les Laboratoires Servier SAS, Lipopharma Therapeutics SL, Living Cell Technologies Limited, Lupin Limited, M3 Biotechnology, Inc., ManRos Therapeutics, MedDay SA, Medestea Research & Production S.p.A., MedImmune, LLC, Medisyn Technologies, Inc., MEDRx Co.Ltd., Merck & Co.Inc., Metabolic Solutions Development Company, LLC Place Order to This Report at http://www.reportsnreports.com/purchase.aspx?name=964827. List of Tables Number of Products under Development for Alzheimer's Disease 28 Number of Products under Development for Alzheimer's Disease – Comparative Analysis 29 Comparative Analysis by Late Stage Development, Alzheimer's Disease 85 Comparative Analysis by Clinical Stage Development, Alzheimer's Disease 86 Alzheimer's Disease – Pipeline by AB Science SA, 158 Alzheimer's Disease – Pipeline by AbbVie Inc, 159 List of Figures Number of Products under Development for Alzheimer's Disease 28 Number of Products under Development for Alzheimer's Disease – Comparative Analysis 29 Comparative Analysis by Late Stage Development, Alzheimer's Disease 85 Comparative Analysis by Clinical Stage Development, Alzheimer's Disease 86 Number of Products by Top 10 Mechanism of Actions, Alzheimer's Disease 556 Assessment by Monotherapy Products, Amyotrophic Lateral Sclerosis 585 In Depth Table of Content for Neurodegenerative Disorders Drug Development Pipeline Review, 2017 About Us: ReportsnReports.com is your single source for all market research needs. 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