Anatomic Pathology

Verona, Italy

Anatomic Pathology

Verona, Italy
SEARCH FILTERS
Time filter
Source Type

PubMed | Reading Health System, Neurosurgery, King Edward Medical University, Anatomic Pathology and Rawalpindi Medical College
Type: Journal Article | Journal: Journal of community hospital internal medicine perspectives | Year: 2015

Follicular thyroid cancer (FTC) metastasizes most commonly to the lungs and non-cranial bones. Skull and skin are uncommon sites and usually manifest well after the diagnosis of primary malignancy. Metastasis to skull and skin as the presenting feature of FTC is infrequently reported in the literature.A 65-year-old Caucasian woman with a history of thyroid nodule presented with the complaint of rapidly growing skull nodules which had been present for 3 years but were stable previously. She denied any fevers, chills, history of trauma, or weight loss. She denied any history of smoking or head and neck irradiation. On physical examination, she had two non-tender gray cystic lesions - one on her left temporal region and the other on the right parietal region. Biopsy was consistent with metastatic FTC. Magnetic resonance imaging of the brain demonstrated 7.13.8 cm and 3.74.5 cm fairly homogeneous, enhancing, relatively well-defined masses centered in the posterior and left anterior lateral calvarium with intracranial and extracranial extensions but without any vasogenic edema or mass effect on the brain. Thyroid ultrasound showed numerous nodules in both lobes. The patient underwent a total thyroidectomy. Histopathological studies of the thyroid gland revealed a well-differentiated FTC in the left lobe. Then she underwent resection of the tumor in multiple stages. She did not have any recurrence of the FTC or metastases during the follow-up period and will be receiving radioactive iodine treatment.Bone and lung are the common sites of metastasis from FTC, but involvement of skull or skin is unusual, particularly as the presenting feature. Metastases from FTC should be in the differential of patients with new osteolytic hypervascular skull lesions or cutaneous lesions in head and neck area.


PubMed | Surgical Oncology and Anatomic Pathology
Type: Journal Article | Journal: Rare tumors | Year: 2015

Capillary hemangioblastoma (CHB) is a benign, highly vascularized tumor that generally occurs in central nervous system either in the setting of von Hippel-Lindau (VHL) disease or, more often, as a solitary sporadic lesion that is increasingly recognized in extraneural sites. We present the case of a 18 year-old man with abdominal pain, nausea and hematemesis, the endoscopy showed polypoid tumor bleeding of 5 cm in gastric antrum. The patients had not signs of VHL disease and was subjected to subtotal gastrectomy and referred to our institution. To our knowledge this is the first reported case of CHB occurring in stomach.


PubMed | Kangwon National University and Anatomic Pathology
Type: Journal Article | Journal: The Journal of biological chemistry | Year: 2016

Sirtuin 3 (SIRT3) is an NAD(+)-dependent protein deacetylase. Recent studies have shown that SIRT3 expression is decreased in nonalcoholic fatty liver disease (NAFLD). Moreover, SIRT3 is a key regulator of succinate dehydrogenase (SDH), which catalyzes the oxidation of succinate to fumarate. Increased succinate concentrations and the specific G protein-coupled receptor 91 (GPR91) are involved in the activation of hepatic stellate cells (HSCs). In this study, we aimed to establish whether SIRT3 regulated the SDH activity, succinate, and GPR91 expression in HSCs and an animal model of NAFLD. Our goal was also to determine whether succinate released from hepatocytes regulated HSC activation. Inhibiting SIRT3 using SIRT3 siRNA exacerbated HSC activation via the SDH-succinate-GPR91 pathway, and SIRT3 overexpression or honokiol treatment attenuated HSC activation in vitro In isolated liver and HSCs from methionine- and choline-deficient (MCD) diet-induced NAFLD, the expression of SIRT3 and SDH activity was decreased, and the succinate concentrations and GPR91 expression were increased. Moreover, we found that GPR91 knockdown or resveratrol treatment improved the steatosis in MCD diet-fed mice. This investigation revealed a novel mechanism of the SIRT3-SDH-GPR91 cascade in MCD diet-induced HSC activation in NAFLD. These findings highlight the biological significance of novel strategies aimed at targeting SIRT3 and GPR91 in HSCs with the goal of improving NAFLD treatment.


The North American Laboratory Information System Market is Projected to Grow at a CAGR of 9.2% from 2017 to 2022 – Axiom MRC Extensive primary research is conducted to bring insights into the market share, key industry trends, new technologies, and future outlook of laboratory information system market. All secondary findings are verified and validated by the industry experts and subject matter experts which typically include: CEOs/CMOs of the key healthcare IT companies, Key Opinion Leaders such as Research Experts, Consultants, Knowledge Professionals and others, managers and top executives. New York, NY, November 22, 2016 --( Download The Sample Report @ http://axiommrc.com/request-for-sample/?report=860 Major Drivers and Restraints of the market The laboratory information systems market is driven by factors such as increasing number of conferences and symposiums to create awareness about LIS, rising need for improving the workflow efficiency of laboratories, increasing requirement for data storage and record keeping and rising demand for quality diagnosis with minimum errors and maximum accuracy. Along with this, growing prevalence of chronic diseases and rising ageing population in North American states are demanding advanced healthcare systems wherein high importance is given to the patient history, past records, multiple test results and follow up with patients. Similarly, the market growth is attributed to increasing government participation in promoting LIS as well as growing IT (Information Technology) sector in healthcare. Lack of trained healthcare professionals, high development cost and decreased revenues of laboratories are restraining the market growth. Clinical Pathology LIS holds the largest market share According to its types, the laboratory information systems market is segmented into Clinical Pathology LIS and Integrated LIS. The market is dominated by Clinical Pathology LIS due to existence of large number of clinical laboratories in North American countries and effective use of clinical pathology in such laboratories. Browse Report Details @ http://axiommrc.com/product/860-north-american-laboratory-information-system-market-research-report/ Standalone LIS accounts for the largest market share The market by product is studied for Standalone LIS and Integrated LIS. The Standalone LIS products dominate the LIS market while Integrated LIS is projected to be the fastest growing market due to rising demand for the same mainly due to its reduced installation cost and maintenance. LIS Services dominate the market for LIS LIS is a software or services based system, designed for data management of medical laboratory test results and related information. According to the components, the market is segmented into Software and Services. The Services segment dominates the market, while softwares segment is projected to be the fastest growing segment in the coming years. On-Premise mode of delivery is the highest used delivery mode for LIS According to the mode of delivery, the market is segmented into On-Premise, Remotely Hosted, and Cloud Based. The most commonly used LIS delivery mode is on-premise due to its user-friendliness and privacy maintenance features accepted by laboratories. But gradually the cloud systems are taking over all wherein the data is stored and delivered through a common platform. Clinical Diagnostic laboratories use LIS to the largest extent. The laboratory information systems market by end users is segmented into Clinical Diagnostic Laboratories, Anatomic Pathology Laboratories, Molecular Diagnostic Laboratories, Hospitals, Blood Banks among others. The use of these systems is highest in clinical diagnostic laboratories due to high need for data management, affordability and specifically designed systems for clinical laboratories. Established healthcare industry, technological advancement and growing need for diagnostic laboratories for rising patient population led to the growth of laboratory information systems in the U.S. The U.S. dominated the market with the largest market share followed by Canada and Mexico. The leading players include Cerner Corporation, Compugroup Medical AG, Computer Programs and Systems, Inc. (CPSI), EPIC Systems Corporation, Mckesson Corporation, Meditech (Medical Information Technology, Inc.), Merge Healthcare, Inc., Orchard Software Corporation, SCC Soft Computer, Sunquest Information Systems, Inc. among others. These players are expanding their presence in the market by innovating new and unique types of products and services for a wide variety of applications. Other Reports from Axiom MRC. European Laboratory Information System Market Research Report, Product, Type, Component, Delivery Mode, End User and Country - Market trends, Market share, Industry analysis and Forecast 2015 – 2022 Email Us: sales@axiommrc.com In Vitro Diagnostics Market Research Report, By Type, Technique, Therapeutic Application, End Users And Geography – Global Market Share, Trend Analysis And Forecast Up To 2023 http://axiommrc.com/product/1131-in-vitro-diagnostics-market-research-report/ New York, NY, November 22, 2016 --( PR.com )-- Axiom MRC added a report on Laboratory Information System (LIS) Market in North America. The market is projected to grow at a CAGR of 9.2% from 2017 to 2022. The market was studied for its types namely Clinical Pathology LIS and Anatomic Pathology LIS. The major products considered were Standalone LIS and Integrated LIS; Components considered were Software and Services; by Delivery Modes the market was studied for On-Premise Delivery Mode, Remotely Hosted Delivery Mode, and Cloud Based Delivery Mode. The End Users considered for the study were Clinical Diagnostic Laboratories, Hospitals, Anatomic Pathology Laboratories, Blood Banks, Molecular Diagnostic Laboratories among others. North American laboratory information system was studied for the U.S., Canada and Mexico.Download The Sample Report @ http://axiommrc.com/request-for-sample/?report=860Major Drivers and Restraints of the marketThe laboratory information systems market is driven by factors such as increasing number of conferences and symposiums to create awareness about LIS, rising need for improving the workflow efficiency of laboratories, increasing requirement for data storage and record keeping and rising demand for quality diagnosis with minimum errors and maximum accuracy. Along with this, growing prevalence of chronic diseases and rising ageing population in North American states are demanding advanced healthcare systems wherein high importance is given to the patient history, past records, multiple test results and follow up with patients. Similarly, the market growth is attributed to increasing government participation in promoting LIS as well as growing IT (Information Technology) sector in healthcare. Lack of trained healthcare professionals, high development cost and decreased revenues of laboratories are restraining the market growth.Clinical Pathology LIS holds the largest market shareAccording to its types, the laboratory information systems market is segmented into Clinical Pathology LIS and Integrated LIS. The market is dominated by Clinical Pathology LIS due to existence of large number of clinical laboratories in North American countries and effective use of clinical pathology in such laboratories.Browse Report Details @ http://axiommrc.com/product/860-north-american-laboratory-information-system-market-research-report/Standalone LIS accounts for the largest market shareThe market by product is studied for Standalone LIS and Integrated LIS. The Standalone LIS products dominate the LIS market while Integrated LIS is projected to be the fastest growing market due to rising demand for the same mainly due to its reduced installation cost and maintenance.LIS Services dominate the market for LISLIS is a software or services based system, designed for data management of medical laboratory test results and related information. According to the components, the market is segmented into Software and Services. The Services segment dominates the market, while softwares segment is projected to be the fastest growing segment in the coming years.On-Premise mode of delivery is the highest used delivery mode for LISAccording to the mode of delivery, the market is segmented into On-Premise, Remotely Hosted, and Cloud Based. The most commonly used LIS delivery mode is on-premise due to its user-friendliness and privacy maintenance features accepted by laboratories. But gradually the cloud systems are taking over all wherein the data is stored and delivered through a common platform.Clinical Diagnostic laboratories use LIS to the largest extent.The laboratory information systems market by end users is segmented into Clinical Diagnostic Laboratories, Anatomic Pathology Laboratories, Molecular Diagnostic Laboratories, Hospitals, Blood Banks among others. The use of these systems is highest in clinical diagnostic laboratories due to high need for data management, affordability and specifically designed systems for clinical laboratories.Established healthcare industry, technological advancement and growing need for diagnostic laboratories for rising patient population led to the growth of laboratory information systems in the U.S.The U.S. dominated the market with the largest market share followed by Canada and Mexico. The leading players include Cerner Corporation, Compugroup Medical AG, Computer Programs and Systems, Inc. (CPSI), EPIC Systems Corporation, Mckesson Corporation, Meditech (Medical Information Technology, Inc.), Merge Healthcare, Inc., Orchard Software Corporation, SCC Soft Computer, Sunquest Information Systems, Inc. among others. These players are expanding their presence in the market by innovating new and unique types of products and services for a wide variety of applications.Other Reports from Axiom MRC.European Laboratory Information System Market Research Report, Product, Type, Component, Delivery Mode, End User and Country - Market trends, Market share, Industry analysis and Forecast 2015 – 2022Email Us: sales@axiommrc.comIn Vitro Diagnostics Market Research Report, By Type, Technique, Therapeutic Application, End Users And Geography – Global Market Share, Trend Analysis And Forecast Up To 2023http://axiommrc.com/product/1131-in-vitro-diagnostics-market-research-report/


The International Association of HealthCare Professionals is pleased to welcome Selly Strauch Rivers, MD, Pathologist, to their prestigious organization with her upcoming publication in The Leading Physicians of the World. She is a highly trained and qualified pathologist with an extensive expertise in all facets of her work. Dr. Rivers has been in practice for over two years and is currently serving as an Assistant Medical Examiner at Hillsborough County Medical Examiner’s Office in Tampa, Florida. Furthermore, she serves as Assistant Professor of Forensic and Hospital Autopsy at the University of Mississippi Medical Center in Jackson, Mississippi. Dr. Rivers graduated with her Medical Degree in 2008 from the American University of the Caribbean School of Medicine. She then served her residencies in Anatomic and Clinical Pathology at the University of Mississippi School of Medicine and West Virginia University, followed by her Forensic Pathology fellowship at Wake Forest Baptist Medical Center. Dr. Rivers is certified by the American Board of Pathology in Anatomic Pathology, Clinical Pathology, and Forensic Pathology. To keep up to date with the latest advances in her field, Dr. Rivers maintains professional memberships with the American Academy of Forensic Sciences, the National Association of Medical Examiners, the College of American Pathologists, the American Medical Association, and the American Society for Clinical Anatomic Pathology. In 2013, she was honored with the Resident Teacher Award for 2013 at the University of Mississippi Medical Center. Dr. Rivers attributes her success to her passion for her field, and when she is not working, dedicates her free time to Taekwondo. Learn more about Dr. Rivers by reading her upcoming publication in The Leading Physicians of the World. FindaTopDoc.com is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics.  Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review.  FindaTopDoc.com features each doctor’s full professional biography highlighting their achievements, experience, patient reviews, and areas of expertise.  A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life.  For more information about FindaTopDoc, visit:http://www.findatopdoc.com


Luna-Ortiz K.,Head and Neck Surgery | Salcedo-Hernandez R.A.,Head and Neck Surgery | Lino-Silva L.S.,Anatomic Pathology | Gomez-Pedraza A.,Head and Neck Surgery
International Journal of Surgery Case Reports | Year: 2013

INTRODUCTION: There are only few cases reported about the role of surgery in the presence of single or multiple bulky bone metastases. The literature about treatment for bulky sternal metastases is scarce. PRESENTATION OF CASE: We present two patients treated surgically for metastatic thyroid lesions. Case 1 is a female with tumor of the thyroid right lobe, mediastinal extension and multiple pulmonary metastases. Bony infiltration was observed in the sternum and ribs. Case 2 is a female with a lesion in the cervical region of the thyroid left lobe and increase in volume on the upper sternal manubrium. DISCUSSION: Patients with well-differentiated thyroid cancer may present with extracervical metastasis in 5-10% of cases at diagnosis. Bone metastases occur in 0.4% of cases of papillary carcinoma. Management remains controversial. There are only isolated cases reported in the literature of the role surgery plays in the presence of single or multiple bulky bone metastases. The basis for initial surgical approach is keeping in mind that the surgical procedure is palliative in order to achieve optimal hypothetical ablation as a result of reduced tumor volume. CONCLUSION: Surgery is the elective treatment and can be performed safely and with adequate results, allowing proper optimization of the dose of 131I for ablative therapy. © 2012 Surgical Associates Ltd.


Tamura K.,Kyushu University | Ohtsuka T.,Kyushu University | Ideno N.,Kyushu University | Aso T.,Kyushu University | And 9 more authors.
Annals of Surgery | Year: 2014

OBJECTIVES:: To clarify the recurrence pattern after resection of main duct intraductal papillary mucinous neoplasms (MD-IPMNs) using molecular analyses and determine the most adequate treatment strategy. BACKGROUND:: The most appropriate resection line for MD-IPMNs remains an unresolved issue. METHODS:: Medical records of 56 patients with pancreatectomy were retrospectively reviewed. Histological subtypes and Kras/GNAS mutations were assessed in patients with recurrence in the remnant pancreas. RESULTS:: Forty-nine patients underwent partial pancreatectomy and 7 underwent total pancreatectomy. Thirty-six patients (64%) had malignant MD-IPMNs. Recurrence was observed in 7 of 49 patients (14%), including 6 with malignant IPMNs and 1 with pancreatic ductal adenocarcinoma, all of whom underwent remnant pancreatectomy. The cumulative disease-specific survival rate of patients with pancreatic recurrence was greater than that of patients with extrapancreatic recurrence (P < 0.001). Although the pancreatic margin status at the initial operation did not affect the pancreatic recurrence rate, all 4 recurrent IPMNs examined had histological subtypes and Kras/GNAS mutations identical to those of the initial lesions. Four patients experienced recurrence in the remnant pancreas or systemic recurrence after resection of high-grade dysplasia of MD-IPMN. Three of the 56 patients had concomitant pancreatic ductal adenocarcinomas and MD-IPMNs. CONCLUSIONS:: One-step total pancreatectomy can be avoided, and remnant total pancreatectomy would lead to favorable outcomes even in patients with pancreatic recurrence, some cases of which seem to involve residual lesions. Postoperative surveillance of high-grade dysplasia should be performed as if malignant, and close attention should be paid to the occurrence of concomitant pancreatic ductal adenocarcinomas in patients with MD-IPMNs. © 2013 by Lippincott Williams and Wilkins.


Lucioni M.,University of Pavia | Novara F.,University of Pavia | Riboni R.,University of Pavia | Fiandrino G.,University of Pavia | And 7 more authors.
Human Pathology | Year: 2011

Increased expression of cyclin D1 is notoriously associated with mantle cell lymphoma because of translocation t(11;14)(q13;q32) or variants involving the cyclin D1 gene. We present an unusual case of CD5-negative diffuse large B-cell lymphoma expressing cyclin D1 in the absence of translocation by fluorescence in situ hybridization analysis. Using array-comparative genomic hybridization, we found a complex karyotype without the characteristic chromosomal aberrations accompanying cyclin D1 translocation in mantle cell lymphoma; instead, there was monoallelic deletion of AKT interacting protein and glycogen synthase kinase-3 β genes, both involved in the AKT/glycogen synthase kinase-3 β cascade-controlling nuclear levels of cyclin D1. These findings suggest that posttranslational events regulating cyclin D1 activity may take place also in a subset of diffuse large B-cell lymphomas and contribute to lymphomagenesis. As a consequence, the sole cyclin D1 positivity by immunohistochemistry may not be enough to distinguish pleomorphic/blastoid mantle cell lymphoma from diffuse large B-cell lymphoma. Search for t(11;14) with fluorescence in situ hybridization probes should always be performed in doubtful cases. © 2011 Elsevier Inc. All rights reserved.


Tallini G.,University of Bologna | Gallo C.,Anatomic Pathology
International Journal of Surgical Pathology | Year: 2011

Fine-needle aspiration (FNA) and frozen section evaluation are traditional components of the management of thyroid lesions. Their role and usefulness are dictated by some basic facts about thyroid pathology: (a) nodules are very common; (b ) they are benign in the majority of cases; and (c) the diagnosis of malignancy is primarily based on cytologic features in the case of papillary carcinoma, and on the presence of invasion of the tumor capsule or of blood vessels in the case of follicular carcinoma. The common occurrence of benign thyroid nodules mandates a cost-effective effective method for preoperative screening. Since, as already stated, the diagnosis of papillary thyroid carcinoma (by far the most common thyroid malignancy) is based on the identification of characteristic cytologic features, FNA has easily emerged in the past 30 years as the most accurate and cost-effective tool - indeed a true cornerstone - for the preoperative management of thyroid nodules. Standardized terminology to report cytologic diagnoses is highly recommended and is being implemented worldwide. Conversely, the importance of intraoperative frozen section diagnosis has been constantly decreasing over the past years, as a direct consequence of the widespread application of FNA. It may, however, be very useful in cases that are suspicious for papillary carcinoma on FNA and in selected cases with an indeterminate cytologic diagnosis. © The Author(s) 2011.


PubMed | Anatomic Pathology
Type: Case Reports | Journal: Journal of cutaneous pathology | Year: 2015

The early stages of follicular mycosis fungoides (FMF) have not been described previously in the literature.Our goal was to better categorize the clinicopathologic features of early stages of FMF.The clinical notes of patients with a diagnosis of FMF seen during the previous 5 years were reviewed to identify any cases that at presentation had only hyperkeratotic follicular lesions.Eight patients (five male, three female) with a mean age of 55.4 years were enrolled. Noteworthy, FMF was not a clinical consideration in any of these patients initially. Patients presented with disseminated, slightly erythematous, hyperkeratotic, spiky follicular papules which, histopathologically, showed hyperkeratotic columns protruding from follicular plugging in concert with selective infiltration of the infundibular epithelium by atypical, mostly CD4+, lymphocytes. T-cell clonality was demonstrated in four of eight cases. The mean duration of the lesions before diagnosis was 17.1 months. The course was indolent in most of the cases (median follow up: 18 months), whilst progression to overt FMF was noted in two patients.The number of cases is small and follow up relatively short.Spiky FMF is a deceptive clinicopathologic presentation of FMF that has been poorly described and that can mimic numerous follicular disorders.

Loading Anatomic Pathology collaborators
Loading Anatomic Pathology collaborators