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Nistico S.P.,University of Catanzaro | Cazzola P.,Anatomia e Istologia Patologica
Journal of Plastic Dermatology | Year: 2014

Ozone therapy can be defined as a bio-oxidative therapy in which the ozone is administered through different routes (gaseous, dissolved in water or oil) to obtain a beneficial effect in a living system sick. Ozone has many actions that have encouraged the use of this molecule in the field of dentistry, orthopedics and dermatology. In fact, ozone has the following properties: antimicrobial, immunostimulant, antihypoxic, biosynthetic, analgesic and hemostatic. The substrates containing unsaturated lipids react with the O2/O3 gas mixture causing the formation of derivatives ozonized therapeutically active. The therapeutic use of ozone gas for the treatment of skin diseases is unwieldy and for this reason the ozonated oils may represent a valid alternative. The oil extracted from the seeds of sunflower is characterized by a high percentage of unsaturated fatty acids and a low content of saturated fatty acids. Ozonation of sunflower seeds oil leads to the formation of ozonides of linoleic acid which possess high stability (up to 15 years). The daily application of ozonized oils in pressure ulcers has resulted in the rapid disappearance of bacterial superinfection and the formation of granulation tissue, which favored the reduction of the affected area.

For the treatment of dry skin topical preparations are designed to repair the lipid barrier, to facilitate the intake and retention of water and accelerate the reparative processes of the stratum corneum. The constituents of a new dermatological line (Bioclin A-Topic - Ganassini Institute, Milan) meet this objective. The aim of the fo l lowing study was to verify, on a large sample of subjects the degree of correspondence of the results obtained from the use of these preparations to the expectations generated by their specific clinical indications. Dermatologists collected the opinions expressed by 1629 individuals. The results indicate that the products of this line were judged in a very positive way (Good/Excellent) by a high percentage of users, with numerous peaks greater than 90%.

Background: Acne vulgaris is a very common disease in adolescents and young adults. It is a disorder of the pilosebaceous unit, in which seborrhoea, poral occlusion and Pro pio - ni bacterium acnes leads to the formation of comedones, papules, pustules and cysts. Aim and design: Aim of this pilot trial was to test the effectiveness of a cosmetic cream (Alusac®) in mild acne. We enrolled seventy-eight male or female subjects with a basal score of 2 (mild) on the Investigator's Global Assessment (IGA) score. All subjects had to use the product twice daily for eight weeks. Results: At the end of the study, 61.9% of included subjects were classified as complete responders, with a IGA score reduction from 2 to 0 (clear skin) (p < 0.05). The remaining 38.1% was classified as partial responder, with a IGA score reduction from 2 to 1 (skin almost clear). In the partial responder group, the regression of non inflammatory lesions was higher than the inflammatory lesions (72.7 vs 50.9; p < 0.05). The test product was well tolerated and no adverse effects were registered. Conclusions: The application of this new cosmeceutical product is effective and safe in mild acne vulgaris.

Storti P.,University of Parma | Bolzoni M.,University of Parma | Donofrio G.,University of Parma | Airoldi I.,Airc Laboratory Of Immunology And Tumors | And 16 more authors.
Leukemia | Year: 2013

Hypoxia-inducible transcription factor-1 (HIF-1α) is overexpressed in multiple myeloma (MM) cells within the hypoxic microenvironment. Herein, we explored the effect of persistent HIF-1α inhibition by a lentivirus short hairpin RNA pool on MM cell growth either in vitro or in vivo and on the transcriptional and pro-angiogenic profiles of MM cells. HIF-1α suppression did not have a significant impact on MM cell proliferation and survival in vitro although, increased the antiproliferative effect of lenalidomide. On the other hand, we found that HIF-1α inhibition in MM cells downregulates the pro-angiogenic genes VEGF, IL8, IL10, CCL2, CCL5 and MMP9. Pro-osteoclastogenic cytokines were also inhibited, such as IL-7 and CCL3/MIP-1α. The effect of HIF-1α inhibition was assessed in vivo in nonobese diabetic/severe combined immunodeficiency mice both in a subcutaneous and an intratibial MM model. HIF-1α inhibition caused a dramatic reduction in the weight and volume of the tumor burden in both mouse models. Moreover, a significant reduction of the number of vessels and vascular endothelial growth factors (VEGFs) immunostaining was observed. Finally, in the intratibial experiments, HIF-1α inhibition significantly blocked bone destruction. Overall, our data indicate that HIF-1α suppression in MM cells significantly blocks MM-induced angiogenesis and reduces MM tumor burden and bone destruction in vivo, supporting HIF-1α as a potential therapeutic target in MM. © 2013 Macmillan Publishers Limited. All rights reserved.

Chillemi A.,University of Turin | Zaccarello G.,University of Turin | Quarona V.,University of Turin | Lazzaretti M.,University of Parma | And 6 more authors.
Frontiers in Bioscience - Landmark | Year: 2014

This review summarizes the events ruled by CD38 in shaping the bone marrow environment, recapitulating old and new aspects derived from the body of knowledge on the molecule. The disease models considered were myeloma and chronic lymphocytic leukemia (CLL). CD38 has been analyzed considering its twin function as receptor and enzyme, roles usually not considered in clinics, where it is used as a routine marker. Another aspect pertaining basic science concerns the role of the molecule as a member of an ectoenzyme network, potentially metabolizing soluble factors not yet analyzed (e.g., NAD+, ATP, NAM) or influencing hormone secretion (e.g., oxytocin). The last point is focused on the use of CD38 as a target of an antibody-mediated therapeutic approach in myeloma and CLL. A recent observation is that CD38 may run an escape circuit leading to the production of adenosine. The generation of local anergy may be blocked by using anti-CD38 antibodies. Consequently, not only might CD38 be a prime target for mAb-mediated therapy, but its functional block may contribute to general improvement in cancer immunotherapy and outcomes.

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