Analytical Research Division

Nāgpur, India

Analytical Research Division

Nāgpur, India
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Islam M.K.,University of Dhaka | Sohrab M.H.,University of Dhaka | Jabbar A.,Analytical Research Division
International Journal of Pharmaceutical Sciences | Year: 2012

Fruits of the plant were air dried for several days and cut into small pieces, which were subjected to oven dried for 24 hours at 45-50°C to effect further chopping. Cold methanol extract of fruits were subjected to acid-base treatment to separate the alkaloids. The treated extract was subjected to column chromatography to isolate the pure compound. The xanthine alkaloid, 1, 3, 7-trimethyl-1H-purine-2, 6 (3H, 7H)-dione, caffeine (compound 1) and also p-anisaldehyde (compound 2) were isolated from the column fraction of this 'alkaloid containing residue' by elution with ethyl acetate/10% methanol and ethyl acetate/50-100% methanol, respectively. The isolated pure compounds were identified by extensive spectral ( 1H-NMR, 13C-NMR, DEPT, HMBC, HSQC, Mass) data analysis. Greshoff isolated an alkaloid, pithecolobin from the bark, which is saponin like in its action. Wehmer stated that the seeds also contain pithecolobin. In the Philippines, a decoction of the inner bark (fresh cambium) and the fresh leaves of this tree is used in diarrhea. All these above mentioned study lead us to work on it.

Alam F.,Jagannath University | Haque M.,ACME | Sohrab H.,Analytical Research Division | Monsur M.A.,Analytical Research Division | And 2 more authors.
Latin American Journal of Pharmacy | Year: 2011

Studies were carried out on the rhizome of Lasia spinosa (L.). The petroleum ether, ethyl acetate and the methanolic extract revealed moderate activities against Escherichia coli, Bacillus cereus, Staphylococcus aureus, Candida albicans, Aspergillus niger and Vibrio parahemolyticus test organisms. The crude extracts and purified compound, meridinol (1) were screened for antimicrobial activity against a wide range of gram-positive and gram-negative bacteria and fungi by the disc diffusion method. The cytotoxic potential of the extractives and meridinol was also determined by using brine shrimp lethality bioassay, where the extractives demonstrated significant cytotoxic activities. The petroleum ether, ethyl acetate, methanol extracts, one column fraction and compound 1 demonstrated LC90 of 11.22 μg/ml, 12.3 μg/ml, 13.49 μg/ml, 11.57 μg/ml and 15.85 μg/ml, respectively.

Rahman I.M.M.,Fukushima University | Barua S.,Kanazawa University | Barua S.,Chittagong University | Barua R.,Chittagong University | And 6 more authors.
Food Control | Year: 2017

The perception of choosing bottled water over tap water for drinking is based on the expectation that it will be of superior quality, more palatable and free from health hazards. The quality of bottled drinking water of 14 different brands as sold in Bangladesh market are evaluated in the current work in terms of the physical and aggregate properties, non-metal inorganic constituents, metal concentrations and microbial contents. The experimental values are compared with the information printed on the labels and regulatory recommendations from the national and international authorities. The experimental values for physical and aggregate properties and non-metal inorganic constituents are either lower or within the range of regulatory limits (p < 0.05). The heterotrophic plate count and total coliform count confirms that the bottled waters are microbiologically safe. A total of 24 elements are checked and the content of Al, which is an aesthetic hazard, is found higher than the permissible range, while the concentration of Pb, which is a potentially toxic element, is not significantly different (p < 0.05) from the guideline values. The data printed on the bottle labels are inconsistent and not informative enough and does not correspond to the real scenario of constituents in the packaged water. A comparison to the tap water quality confirms that the bottled waters possess better quality regarding aesthetic considerations, microbial hazards, and Pb contaminations. The experimental data of the bottled waters are further compared with the mineral water classification system. The characteristics are matched with the very low or low mineral content category with a hint of saline character and very soft water-hardness in most, followed by a suitability for low-sodium diets. © 2016 Elsevier Ltd

Ahmed Y.,Islamic University | Sohrab Md.H.,Analytical Research Division | Al-Reza S.M.,Islamic University | Tareq F.S.,Islamic University | And 2 more authors.
Food and Chemical Toxicology | Year: 2010

Six compounds, namely, Lupeol (1), Betulin (2), β-Taraxerol (3), Taraxerone (4), Stigmasterol (5) and β-Sitosterol (6) were isolated from the petroleum ether extract of the leaves of Sapium baccatum based on spectroscopic evidence. Lupeol (1), Betulin (2) and Stigmasterol (5) were isolated for the first time from this plant. The cytotoxic potential of the different solvent extracts (methanol, petroleum ether, carbon-tetrachloride and dichloromethane); six column fractions (F-4, F-7, F-10, F-12, F-18 and F-22) of petroleum ether extract and three pure compounds 1, 4 and 6 were determined by using brine shrimp lethality bioassay. The LC50 of all the tested samples were showed to be lethal to brine shrimp nauplii. However, petroleum ether, carbon-tetrachloride extract, column fractions F-4 and F-18 of petroleum ether extract and pure compound 6 showed quite potent activity in brine shrimp lethality bioassay with LC50 1.33, 1.35, 1.40, 1.58 and 1.58 μg/ml, respectively. These result suggested that they might be contain antitumor or pesticidal activity. Further, the methanol extract and four column fractions (F-7, F-12, F-18 and F-22) of petroleum ether showed significant activity against the tested microorganisms. © 2009 Elsevier Ltd. All rights reserved.

Hasan A.B.,University of Rajshahi | Kabir S.,University of Rajshahi | Selim Reza A.H.M.,University of Rajshahi | Zaman M.N.,IMMM | And 3 more authors.
Marine Pollution Bulletin | Year: 2013

This study reveals potential accumulation of trace metals in the sea and groundwater due to ship breaking activities which take place along the Bay of Bengal in Sitakund Upazilla, Chittagong, Bangladesh. When compared with WHO and Bangladesh domestic standards for water quality, it is revealed that seawater was strongly polluted by Fe and Hg, moderately by Mn and Al, and slightly by Pb and Cd. Groundwater was strongly polluted by Fe, Pb and Hg, moderately by Mn and Al, and slightly by As. Trace element concentrations of all seawater samples exceeded the average concentration of elements in the Earth's seawater. The application of Principal Components Analysis identified two sources of pollution-marine and ship breaking. The mechanism of groundwater pollution inferred that if seawater is polluted, nearby groundwater is also polluted with trace metals due to the influence of seawater intrusion. © 2013 Elsevier Ltd.

Hasan A.B.,University of Rajshahi | Kabir S.,University of Rajshahi | Selim Reza A.H.M.,University of Rajshahi | Nazim Zaman M.,IMMM | And 2 more authors.
Journal of Geochemical Exploration | Year: 2013

This study reveals that some trace metals were found in sediments of the Sitakund Upazilla of Chittagong, Bangladesh, largely due to ship breaking activities in the area. This was seen when comparing levels of trace metals in the sediments of the study area with the recommended values of unpolluted sediments. Thus, it was inferred that the trace metal concentrations around the ship breaking area were higher than that of the control site, Sandwip, and near the Karnafully River mouth. The trace elements in the sediment samples were significantly correlated with one another. Enrichment factor values of the sediment samples revealed that most of the sediments were minor to severely enriched by trace metals. Sediments of three stations out of 11 stations of the study area were minor to moderately enriched by Cd metal. The geo-accumulation index (Igeo) values of the sediment samples revealed that the sediments of the ship breaking area were affected from slight to strong contamination with trace metals and sediments in two stations of the study area were affected moderately contaminated by Cd metal. Potential contamination indices of the sediment samples indicated that Cr, Zn, As, and Pb were the greatest contaminants. © 2012 Elsevier B.V.

Sultana N.,Analytical Research Division | Afolayan A.J.,University Of Fort Hare
Journal of Asian Natural Products Research | Year: 2011

Usnea undulata Stirton (Usneaaceae) is a fruticose lichen used locally in ethnoveterinary medicine to treat mammary infections in cattle while human beings use it for the treatment of wounds in Eastern Cape, South Africa. Bioactivity-guided fractionation of its extracts led to the isolation and characterization of a new depsidone, 2′-O-methylhypostictic acid (8), together with seven known compounds, i.e. methyl β-orsellinate (1), norstictic acid (2), menegazziaic acid (3), (+) usnic acid (4), hypoconstictic acid (5), salazinic acid (6), and galbinic acid (7). The structures of the compounds were elucidated on the basis of their spectral analysis including homo- and hetero-nuclear correlation NMR experiments (COSY, NOESY, HMQC, and HMBC) and mass spectra as well as by comparison with available data in the literature. The minimum inhibitory concentrations (MICs) values of the compounds against six bacteria were determined. Compound 8 showed inhibitory activity against Bacillus cereus, Bacillus subtilis, and Staphylococcus epidermidis with MICs of 31, 62.5, 62.5μg/ml, respectively. (+) Usnic acid was most active against B. subtilis, B. cereus, Staphylococcus aureus, and Escherichia coli with MICs of 8, 8, 31, and 31 mg/ml, respectively, while other compounds exhibited moderate activity. © 2011 Taylor & Francis.

Sultana N.,Analytical Research Division | Akter K.,University of Dhaka | Nahar N.,University of Dhaka | Khan M.S.H.,University of Dhaka | And 3 more authors.
Natural Product Research | Year: 2010

Three novel flavonoid glycosides, 5,6-dimethyoxy-3′,4″- dioxymethylene-7-O-(6″-β-D-glucopyranosyl-β-D-glucopyranosyl) flavanone (1), 5,4′-dihydroxy-3-O-α-L-rhamnopyranosyl-6-C- glucopyranosyl-7-O-(6″-para-coumaroyl-β-D-glucopyranosyl) flavone (2) and 5,4′-dihydroxy-3-O-(2″‴-β-glucopyranosyl-α- L-rhamnopyranosyl)-6-C-glucopyranosyl-7-O-(6″-para-coumaroyl-β- D-glucopyranosyl) flavone (3) were isolated from the 1-butanol soluble fraction of the bulbs of the plant Urginea indica (Indian squill). The structures of the compounds were elucidated on the basis of spectral analysis, including homo- and heteronuclear correlation NMR experiments (COSY, NOESY, HSQC and HMBC) and mass spectra. © 2010 Taylor & Francis.

Singh U.,Analytical Research Division | Puttewar S.P.,Analytical Research Division
Journal of the Indian Chemical Society | Year: 2013

Quantification of vanadium (as V2O5) in Bayer liquor (Spent) and precipitated vanadium sludge have been done using ICP-AES and classical methods. Samples were prepared by acid digestion technique for the complete dissolution of free as well as bound vanadium in highly alkaline samples. Concentration of vanadium in spent liquor was obtained to be 1.2 gpl to 2.8 gpl and 11.2 to 17.8% as V2O5 in the sludge collected from different Indian alumina refineries. In this paper, optimization of operating condition of ICP-AES, sample preparation methodology, validation of data and their significance has been studied. Precision of measurement in the standards sample and industrial samples were indicated by % RSD which was achieved as low as 0.9. A comparative study of conventional (classical) and instrumental (ICP-AES) methods in the determination of vanadium for liquor and sludge have been discussed.

PubMed | University of Dhaka, RMIT University and Analytical Research Division
Type: Journal Article | Journal: SpringerPlus | Year: 2016

With regard to previously reported Lead (Pb) and Chromium (Cr) contamination in egg, a semi-quantitative assessment of the general environment of Bangladesh is carried out through nation-wide sampling of commonly grown and consumed vegetables. Five vegetables, namely, White Potato (

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