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News Article | November 7, 2016
Site: en.prnasia.com

BEACHWOOD, Ohio, Nov. 8, 2016 /PRNewswire/ -- OMNOVA Solutions Inc. (NYSE: OMN) today announced that it is moving forward with its CEO succession process, and Kevin M. McMullen is stepping down as Chairman, Chief Executive Officer and President, and as a member of the Board of Directors, effective December 1, 2016, to pursue other interests. In over 16 years leading the Company, McMullen succeeded in repositioning OMNOVA as a leader in specialty chemicals and engineered surfaces including aggressive portfolio actions highlighted by the acquisition of Eliokem International. OMNOVA has experienced significant positive momentum with adjusted earnings per share up nearly 60% year-to-date through the third quarter, following 29% growth for the full year 2015. He is enthused about his future and proud of the Company's progress under his leadership. McMullen will be succeeded by Anne P. Noonan as OMNOVA's President and Chief Executive Officer, effective December 1, 2016. Ms. Noonan will also be appointed to the Company's Board of Directors. In connection with this leadership transition, the Board of Directors has determined to separate the Chairman and Chief Executive Officer roles, electing William R. Seelbach as the Company's independent, non-executive Chairman, also effective December 1, 2016. Michael J. Merriman, the Presiding Director of the OMNOVA Board of Directors, commented, "Kevin is a high-integrity leader with strong strategic and business acumen. We are thankful for Kevin's many years of leadership and his dedicated service to OMNOVA, both as Chief Executive Officer and as Chairman. He has consistently been aggressive in assessing the market and competitive environment, and taking the necessary actions to make the Company better. He leaves an organization with a well-designed growth strategy and strong leadership team in place. On behalf of the entire OMNOVA Board and the Company, I want to express our gratitude for a job well done and wish Kevin only the best. He will be missed." McMullen's initiatives over the years ensured OMNOVA's prominence and profitability despite many market-based challenges. A predominately U.S.-based company when he took charge, McMullen led OMNOVA's transformation into a global enterprise. Today, OMNOVA products are sold in over 90 countries around the world, supported by manufacturing and technology centers on three continents. He drove initiatives to dramatically expand the breadth of OMNOVA's technology to significantly enhance its position as a value-added solutions provider. McMullen, 56, joined the Company in 1996 as President of its Decorative and Building Products unit. He took over as Chief Executive Officer of the Company in 2000 and became Chairman of the Board in 2001. Prior to OMNOVA, McMullen worked for GE and McKinsey & Co. "I feel really good about where OMNOVA is today as a company," McMullen said. "Our specialty businesses are poised for above-market growth, our balance sheet has improved significantly, and we just completed a far-reaching strategic planning process that highlighted many exciting long-term opportunities. The Company is well-positioned to deliver significant long-term shareholder value." He added, "We have a strong and committed team – I will truly miss the people. But I'm relatively young and I want to pursue other interests. I think now is the time to pursue them." Noonan, 53, is currently the President of OMNOVA's Performance Chemicals business. Under her leadership, the segment has significantly improved financial results. These results were accomplished through aggressive implementation of a manufacturing footprint alignment and business model restructuring, delivering cost reductions in excess of $10 million per year while establishing a cost competitive "blueprint" for future specialty growth. Additionally, through a focus on innovation and commercial excellence, a foundation has been established to accelerate specialty growth with accomplished market-specialized talent and a reinvigorated innovation pipeline. "We are confident Anne will continue to drive enhanced value for shareholders. Anne is an accomplished executive with deep knowledge of the chemicals industry and OMNOVA," Merriman said. "She has a proven record of transformational change and improving performance through her leadership, customer focus, and emphasis on value creation. We are pleased she has agreed to lead OMNOVA, and we look forward to the contributions she will make to the Company and the Board." Noonan brings nearly 30 years of experience in the chemicals industry. Prior to joining OMNOVA in 2014, Noonan served as Senior Vice President and President of Chemtura Corporation's Industrial Engineered Products business segment with over $1 billion in revenues. During her 27 years with Chemtura and its predecessor, Great Lakes Chemical Corporation, Noonan served in roles of increasing responsibility in mergers & acquisitions, strategic business development, marketing, sales, and technology. She began her career as an Analytical Research Chemist with McNeil Specialty Chemicals Company and Squibb-Linson, Co. She earned her M.S. in organometallic chemistry and her B.S. Honors degree in chemistry from University College Dublin, Ireland. Since 2015, Noonan has been a member of the Board of Directors of CF Industries (NYSE: CF), as well as the Board of Directors of the American Chemistry Council. Noonan said, "I am excited to have the opportunity to lead OMNOVA and look forward to working with this dedicated, talented team to position the Company as a premier global, innovative specialty solutions provider. Kevin has provided a solid foundation to build upon, developing and leading an organization that is committed to its customers, employees, communities and shareholders." William R. Seelbach, 68, will succeed McMullen as OMNOVA's Chairman. Seelbach has been a non-executive member of OMNOVA's Board of Directors since 2002. Seelbach is a Senior Advisor with the Riverside Company, the world's largest private equity firm focused on investing in companies at the smaller end of the middle market, and a Senior Managing Director of Headwaters SC, a consulting firm for privately owned businesses. Previously, he was the President and Chief Executive Officer of the Ohio Aerospace Institute, a technology-focused research organization, from 2003 to 2006. Prior to that, he was the President of Brush Engineered Materials, Inc., now known as Materion Corporation, a manufacturer of high performance engineered materials, and held various executive roles with Brush Wellman, Inc. from 1998 to 2002. Seelbach was also the Chairman and Chief Executive Officer of Inverness Partners, a limited liability company engaged in acquiring and operating Midwestern manufacturing companies, and a Partner with McKinsey & Co. OMNOVA Solutions is a global innovator of performance-enhancing chemistries and surfaces used in products for a variety of commercial, industrial, and residential applications. As a strategic business-to-business supplier, OMNOVA provides The Science in Better Brands, with emulsion polymers, specialty chemicals, and functional and decorative surfaces that deliver critical performance attributes to top brand-name, end-use products sold around the world. OMNOVA's sales for the last twelve months ended August 31, 2016 were $773 million. The Company has a global workforce of approximately 1,950. Visit OMNOVA Solutions on the internet at . Statements included in this Press Release that are not historical facts are forward looking statements. These statements involve risks and uncertainties including, but not limited to the operations of the Company and other related items that are detailed in risk factors and elsewhere in the Company's Annual Report on Form 10-K for the fiscal year ended November 30, 2015, subsequent Quarterly Reports on Form 10-Q and other filings with the U.S. Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize (or the consequences of such a development worsen), or should underlying assumptions prove incorrect, actual outcomes may vary materially from those forecasted or expected. The Company disclaims any intention or obligation to update publicly or revise such statements, whether as a result of new information, future events or otherwise.


News Article | November 7, 2016
Site: www.prnewswire.co.uk

Kevin M. McMullen to step down as Chairman, Chief Executive Officer and President of OMNOVA Solutions William R. Seelbach named Chairman of the Board of Directors BEACHWOOD, Ohio, Nov. 7, 2016 /PRNewswire/ -- OMNOVA Solutions Inc. (NYSE: OMN) today announced that it is moving forward with its CEO succession process, and Kevin M. McMullen is stepping down as Chairman, Chief Executive Officer and President, and as a member of the Board of Directors, effective December 1, 2016, to pursue other interests. In over 16 years leading the Company, McMullen succeeded in repositioning OMNOVA as a leader in specialty chemicals and engineered surfaces including aggressive portfolio actions highlighted by the acquisition of Eliokem International. OMNOVA has experienced significant positive momentum with adjusted earnings per share up nearly 60% year-to-date through the third quarter, following 29% growth for the full year 2015. He is enthused about his future and proud of the Company's progress under his leadership. McMullen will be succeeded by Anne P. Noonan as OMNOVA's President and Chief Executive Officer, effective December 1, 2016. Ms. Noonan will also be appointed to the Company's Board of Directors. In connection with this leadership transition, the Board of Directors has determined to separate the Chairman and Chief Executive Officer roles, electing William R. Seelbach as the Company's independent, non-executive Chairman, also effective December 1, 2016. Michael J. Merriman, the Presiding Director of the OMNOVA Board of Directors, commented, "Kevin is a high-integrity leader with strong strategic and business acumen. We are thankful for Kevin's many years of leadership and his dedicated service to OMNOVA, both as Chief Executive Officer and as Chairman. He has consistently been aggressive in assessing the market and competitive environment, and taking the necessary actions to make the Company better. He leaves an organization with a well-designed growth strategy and strong leadership team in place. On behalf of the entire OMNOVA Board and the Company, I want to express our gratitude for a job well done and wish Kevin only the best. He will be missed." McMullen's initiatives over the years ensured OMNOVA's prominence and profitability despite many market-based challenges. A predominately U.S.-based company when he took charge, McMullen led OMNOVA's transformation into a global enterprise. Today, OMNOVA products are sold in over 90 countries around the world, supported by manufacturing and technology centers on three continents. He drove initiatives to dramatically expand the breadth of OMNOVA's technology to significantly enhance its position as a value-added solutions provider. McMullen, 56, joined the Company in 1996 as President of its Decorative and Building Products unit. He took over as Chief Executive Officer of the Company in 2000 and became Chairman of the Board in 2001. Prior to OMNOVA, McMullen worked for GE and McKinsey & Co. "I feel really good about where OMNOVA is today as a company," McMullen said. "Our specialty businesses are poised for above-market growth, our balance sheet has improved significantly, and we just completed a far-reaching strategic planning process that highlighted many exciting long-term opportunities. The Company is well-positioned to deliver significant long-term shareholder value." He added, "We have a strong and committed team – I will truly miss the people. But I'm relatively young and I want to pursue other interests. I think now is the time to pursue them." Noonan, 53, is currently the President of OMNOVA's Performance Chemicals business. Under her leadership, the segment has significantly improved financial results. These results were accomplished through aggressive implementation of a manufacturing footprint alignment and business model restructuring, delivering cost reductions in excess of $10 million per year while establishing a cost competitive "blueprint" for future specialty growth. Additionally, through a focus on innovation and commercial excellence, a foundation has been established to accelerate specialty growth with accomplished market-specialized talent and a reinvigorated innovation pipeline. "We are confident Anne will continue to drive enhanced value for shareholders. Anne is an accomplished executive with deep knowledge of the chemicals industry and OMNOVA," Merriman said. "She has a proven record of transformational change and improving performance through her leadership, customer focus, and emphasis on value creation. We are pleased she has agreed to lead OMNOVA, and we look forward to the contributions she will make to the Company and the Board." Noonan brings nearly 30 years of experience in the chemicals industry. Prior to joining OMNOVA in 2014, Noonan served as Senior Vice President and President of Chemtura Corporation's Industrial Engineered Products business segment with over $1 billion in revenues. During her 27 years with Chemtura and its predecessor, Great Lakes Chemical Corporation, Noonan served in roles of increasing responsibility in mergers & acquisitions, strategic business development, marketing, sales, and technology. She began her career as an Analytical Research Chemist with McNeil Specialty Chemicals Company and Squibb-Linson, Co. She earned her M.S. in organometallic chemistry and her B.S. Honors degree in chemistry from University College Dublin, Ireland. Since 2015, Noonan has been a member of the Board of Directors of CF Industries (NYSE: CF), as well as the Board of Directors of the American Chemistry Council. Noonan said, "I am excited to have the opportunity to lead OMNOVA and look forward to working with this dedicated, talented team to position the Company as a premier global, innovative specialty solutions provider. Kevin has provided a solid foundation to build upon, developing and leading an organization that is committed to its customers, employees, communities and shareholders." William R. Seelbach, 68, will succeed McMullen as OMNOVA's Chairman. Seelbach has been a non-executive member of OMNOVA's Board of Directors since 2002. Seelbach is a Senior Advisor with the Riverside Company, the world's largest private equity firm focused on investing in companies at the smaller end of the middle market, and a Senior Managing Director of Headwaters SC, a consulting firm for privately owned businesses. Previously, he was the President and Chief Executive Officer of the Ohio Aerospace Institute, a technology-focused research organization, from 2003 to 2006. Prior to that, he was the President of Brush Engineered Materials, Inc., now known as Materion Corporation, a manufacturer of high performance engineered materials, and held various executive roles with Brush Wellman, Inc. from 1998 to 2002. Seelbach was also the Chairman and Chief Executive Officer of Inverness Partners, a limited liability company engaged in acquiring and operating Midwestern manufacturing companies, and a Partner with McKinsey & Co. OMNOVA Solutions is a global innovator of performance-enhancing chemistries and surfaces used in products for a variety of commercial, industrial, and residential applications. As a strategic business-to-business supplier, OMNOVA provides The Science in Better Brands, with emulsion polymers, specialty chemicals, and functional and decorative surfaces that deliver critical performance attributes to top brand-name, end-use products sold around the world. OMNOVA's sales for the last twelve months ended August 31, 2016 were $773 million. The Company has a global workforce of approximately 1,950. Visit OMNOVA Solutions on the internet at . Statements included in this Press Release that are not historical facts are forward looking statements. These statements involve risks and uncertainties including, but not limited to the operations of the Company and other related items that are detailed in risk factors and elsewhere in the Company's Annual Report on Form 10-K for the fiscal year ended November 30, 2015, subsequent Quarterly Reports on Form 10-Q and other filings with the U.S. Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize (or the consequences of such a development worsen), or should underlying assumptions prove incorrect, actual outcomes may vary materially from those forecasted or expected. The Company disclaims any intention or obligation to update publicly or revise such statements, whether as a result of new information, future events or otherwise.


News Article | November 8, 2016
Site: www.prnewswire.co.uk

Kevin M. McMullen tritt als Vorsitzender, Chief Executive Officer und President von OMNOVA Solutions zurück Anne P. Noonan wird zum President und Chief Executive Officer ernannt William R. Seelbach wird zum Vorsitzenden des Verwaltungsrates ernannt BEACHWOOD, Ohio, 8. November 2016 /PRNewswire/ -- OMNOVA Solutions Inc. (NYSE: OMN) gab heute bekannt, dass man den Nachfolgeprozess für den CEO vorzieht und dass Kevin M. McMullen mit Wirkung vom 1. Dezember 2016 als Vorsitzender, Chief Executive Officer und President sowie als Mitglied des Verwaltungsrates zurücktritt, um andere Interessen zu verfolgen. In den 16 Jahren, in denen McMullen OMNOVA leitete, hat er es als führendes Unternehmen bei Spezialchemikalien und behandelten Oberflächen neu positioniert, einschließlich aggressiver Portfolioaktivitäten, unter denen die Akquisition von Eliokem International besonders zu erwähnen ist. OMNOVA entwickelte mit dem im dritten Quartal im Jahresvergleich um fast 60 % gestiegenen, bereinigten Ergebnis je Aktie nach einem Wachstum von 29 % im gesamten Jahr 2015 eine beachtliche, positive Dynamik. Er freut sich auf seine Zukunft und ist auf den Fortschritt des Unternehmens unter seiner Leitung stolz. Foto - http://photos.prnewswire.com/prnh/20161107/436649 Foto - http://photos.prnewswire.com/prnh/20161107/436648 Foto - http://photos.prnewswire.com/prnh/20161107/436647 McMullen wird mit Wirkung vom 1. Dezember 2016 von Anne P. Noonan als President und Chief Executive Officer von OMNOVA abgelöst. Fr. Noonan wird ebenfalls Mitglied des Verwaltungsrates des Unternehmens. In Zusammenhang mit den Veränderungen in der Firmenleitung hat der Verwaltungsrat entschieden, die Rollen des Vorsitzenden und Chief Executive Officers zu trennen und William R. Seelbach ebenfalls mit Wirkung vom 1. Dezember 2016 zum unabhängigen, nicht exekutiven Vorsitzenden zu ernennen. Michael J. Merriman, der Presiding Director des Verwaltungsrates von OMNOVA, kommentierte: „Kevin ist ein hoch integrer Manager mit starker strategischer und unternehmerischer Ausrichtung. Wir danken Kevin für die vielen Jahre als Manager und sein Engagement für OMNOVA, sowohl als Chief Executive Officer als auch als Vorsitzender. Er war bei seiner Beurteilung des Markt- und Konkurrenzumfeldes unermüdlich aggressiv und hat die zum Erfolg des Unternehmens erforderlichen Schritte eingeleitet. Er hinterlässt ein Unternehmen mit einer gut konzipierten Strategie und einem starken Führungsteam. Im Namen des gesamten Verwaltungsrates von OMNOVA möchte ich ihm unseren Dank für seine hervorragende Arbeit aussprechen und ihm viel Erfolg wünschen. Er wird uns fehlen." Die von McMullen in den Jahren eingeleiteten Initiativen stellten die Präsenz und Ertragskraft von OMNOVA trotz zahlreicher marktwirtschaftlicher Herausforderungen sicher. Als McMullen das Unternehmen übernahm, war es vorwiegend in den USA tätig und er verwandelte OMNOVA in einen Weltkonzern. Heute vertreibt OMNOVA, unterstützt von Produktions- und Technologiezentren auf drei Kontinenten, seine Produkte in mehr als 90 Ländern. Er startete Initiativen zur dramatischen Ausweitung der Technologie von OMNOVA, um die Position des Unternehmens als wertsteigender Lösungsanbieter nennenswert zu verbessern. McMullen, 56, kam im Jahr 1996 als President des Geschäftsfeldes Decorative and Building Products zum Unternehmen. Im Jahr 2000 wurde er Chief Executive Officer des Unternehmens und im Jahr 2001 Vorsitzender des Verwaltungsrates. Vor seiner Tätigkeit bei OMNOVA arbeitete McMullen für GE und McKinsey & Co. „Ich bin stolz darauf, wo OMNOVA heute als Unternehmen positioniert ist", sagte McMullen. „Unser Spezialgeschäft ist auf Marktwachstum vorbereitet, unsere Bilanz ist erheblich gestärkt und wir haben soeben einen weitreichenden strategischen Planungsprozess abgeschlossen, der zahlreiche interessante und langfristige Chancen aufzeigt. Das Unternehmen ist hervorragend für die langfristige Schaffung von nennenswertem Shareholder Value positioniert." Er fügte hinzu: „Wir haben ein starkes und engagiertes Team, das mir sicher fehlen wird. Aber ich bin noch relativ jung und möchte andere Interessen verfolgen. Die Zeit ist jetzt reif, genau das zu tun." Noonan, 53, ist derzeit President des Geschäftsfeldes Performance Chemicals von OMNOVA. Unter ihrer Leitung konnte das Geschäftsfeld sein Finanzergebnis erheblich steigern. Das Ergebnis wurde durch die aggressive Umsetzung der Anpassung der Produktionspräsenz und die Neugestaltung des Geschäftsmodells erzielt, die zu Kosteneinsparungen von $ 10 Millionen pro Jahr führten und gleichzeitig eine wettbewerbsfähige „Blaupause" für künftiges Wachstum bei Spezialprodukten schufen. Des Weiteren konnte Sie durch die Konzentration auf Innovation und Commercial Excellence mit erfolgreichen Marktspezialisten und einer wiederbelebten Innovationspipeline die Grundlage für beschleunigtes Wachstum bei Spezialprodukten schaffen. „Wir sind überzeugt, dass Anne weiterhin Mehrwert für unsere Aktionäre erzielen wird. Anne ist eine erfolgreiche Managerin mit umfassenden Kenntnissen über die Chemiebranche und OMNOVA", sagte Merriman. „Sie kann aufgrund ihres Managementstils, ihrer Kundenorientierung und ihrer Konzentration auf Wertschöpfung nennenswerte Erfolge bei umwälzenden Veränderungen und Leistungssteigerung vorweisen. Wir sind froh, dass sie zugstimmt hat, OMNOVA zu leiten und freuen uns auf ihre Beiträge zum Wohle des Unternehmens und des Verwaltungsrates." Noonan verfügt über fast 30 Jahre Erfahrung in der Chemiebranche. Bevor sie 2014 zu OMNOVA kam, war Noonan als Senior Vice President und President des Geschäftsfeldes Industrial Engineered Products von Chemtura Corporation und einen Umsatz von mehr als $ 1 Milliarde verantwortlich. Während ihrer 27-jährigen Tätigkeit bei Chemtura und dessen Vorgängerunternehmen Great Lakes Chemical Corporation übernahm Noonan Aufgaben mit ständig steigender Verantwortung in den Bereichen Übernahmen und Fusionen, strategische Geschäftsentwicklung, Marketing, Vertrieb und Technologie. Sie begann ihre Karriere als Analytical Research Chemist bei McNeil Specialty Chemicals Company und Squibb-Linson, Co. Sie erwarb ihren M.Sc. in metallorganischer Chemie und ihren B.Sc. Honors in Chemie am University College Dublin, Irland. Noonan ist seit 2015 Mitglied des Verwaltungsrates von CF Industries (NYSE: CF) sowie des Verwaltungsrates des American Chemistry Council. Noonan sagte: „Ich bin über die Möglichkeit stolz, OMNOVA zu leiten und freue mich auf die Zusammenarbeit mit dem engagierten, talentierten Team bei der Positionierung des Unternehmens als weltweit führenden, innovativen Anbieter von Speziallösungen. Kevin hat eine solide Basis für den weiteren Aufbau geschaffen und ein Unternehmen entwickelt und geleitet, das sich für seine Kunden, Mitarbeitenden, Gemeinschaften und Aktionäre engagiert." William R. Seelbach, 68, folgt McMullen als Vorsitzender von OMNOVA nach. Seelbach ist seit 2002 nicht exekutives Mitglied des Verwaltungsrates von OMNOVA. Seelbach ist Senior Advisor von Riverside Company, des größten Privat Equity-Unternehmens der Welt, das sich auf Investition in Unternehmen im unteren Bereich des mittleren Marktsegments spezialisiert, und Senior Managing Director von Headwaters SC, eines Beratungsunternehmens für Privatunternehmen. Von 2003 bis 2006 war er President und Chief Executive Officer des Ohio Aerospace Institute, einer Forschungsorganisation mit dem Schwerpunkt auf Technologie. Zuvor war er President von Brush Engineered Materials, Inc., jetzt Materion Corporation, eines Herstellers von technischen Hochleistungswerkstoffen, und von 1998 bis 2002 hatte er verschiedene Managementpositionen bei Brush Wellman, Inc. inne. Seelbach war ebenfalls Vorsitzender und Chief Executive Officer von Inverness Partners, einer Gesellschaft mit beschränkter Haftung, die auf die Übernahme und den Betrieb von Produktionsunternehmen im mittleren Westen spezialisiert ist sowie ein Partner bei McKinsey & Co. OMNOVA ist ein weltweiter Innovator von leistungssteigernden Chemieprodukten und Oberflächen, die in einer Vielfalt von kommerziellen, industriellen und Wohnbauanwendungen eingesetzt werden. Als strategischer Business-to-Business-Anbieter von Emulsionspolymeren bietet OMNOVA Spezialchemikalien sowie funktionale und dekorative Oberflächen an, die in der ganzen Welt verkauften Endprodukten führender Marken kritische Leistungseigenschaften unter dem Motto The Science in Better Brands liefern. OMNOVA erwirtschaftete in den zwölf Monaten vor dem 31. August 2016 einen Umsatz von $ 773 Millionen. Das Unternehmen beschäftigt weltweit ca. 1.950 Mitarbeitende. Besuchen Sie OMNOVA Solutions im Internet unter www.omnova.com. Aussagen in dieser Pressemitteilung, die sich nicht auf die Vergangenheit beziehen, sind zukunftsgerichtete Aussagen. Diese Aussagen beinhalten Risiken und Ungewissheiten, darunter, ohne sich darauf zu beschränken, jene hinsichtlich der betrieblichen Tätigkeit des Unternehmens sowie anderer Punkte, die unter Risikofaktoren und an anderen Stellen des Jahresberichtes des Unternehmens auf Formular 10-K für das am 30. November 2015 geendete Geschäftsjahr sowie in danach bei der U.S. Securities and Exchange Commission auf Formular 10-Q eingereichten Quartalsberichten genauer aufgeführt sind. Falls eines oder mehrere dieser Risiken und Ungewissheiten eintreten (oder sich die Auswirkungen solcher Entwicklungen als schlechter erweisen) oder sich die zugrunde liegenden Annahmen als falsch herausstellen sollten, könnten die tatsächlichen Ergebnisse erheblich von den vorhergesagten oder erwarteten abweichen. Das Unternehmen beabsichtigt und verpflichtet sich nicht, zukunftsweisende Aussagen aufgrund neuer Informationen, zukünftiger Ereignisse oder anderer Umstände zu aktualisieren oder anzupassen.


Ito N.,Gunma University | Shibuguchi N.,Analytical Research | Ishikawa R.,Gunma Prefectural College of Health Sciences | Tanaka S.,Takasaki University of Health and Welfare | And 3 more authors.
Bioscience, Biotechnology and Biochemistry | Year: 2013

Calcineurin (CN) is a Ca2+/calmodulin (CaM) dependent serine/threonine protein phosphatase and plays important role in several cellular functions in both higher and lower eukaryotes. Here we report inhibition of CN by linear alkylbenzene sulfonate. The clue to the finding was obtained while identifying the inhibitory material leaching from acrylonitrile butadiene rubber used for packing. Using standard dodecylbenzene sulfonate (C12-LAS), we obtained strong inhibition of CN with a half maximal inhibitory concentration of 9.3μM, whereas analogs such as p-octylbenzene sulfonate and SDS hardly or only slightly affected CN activity. Three alkaline phosphatases, derived from shrimp, bacteria, and calf-intestine, which exhibit similar enzymatic activities to CN, were not inhibited by C12-LAS at concentrations of up to 100μM. Furthermore, C12-LAS did not inhibit Ca2+/CaM-dependent myosin light chain kinase activity when tested at concentrations of up to 36μM. The results indicate that C12-LAS is a potent selective inhibitor of CN activity.


Ishida M.,Global Formulation Research | Ishida M.,Pharmaceutical Science and Technology Core Function Unit | Uchiyama J.,New Chemical Entity Demand Chain Unit | Isaji K.,Analytical Research | And 5 more authors.
Drug Development and Industrial Pharmacy | Year: 2014

The applicability of porous spherical silica (PSS) was evaluated as core particles for pharmaceutical products by comparing it with commercial core particles such as mannitol (NP-108), sucrose and microcrystalline cellulose spheres. We investigated the physical properties of core particles, such as particle size distribution, flow properties, crushing strength, plastic limit, drying rate, hygroscopic property and aggregation degree. It was found that PSS was a core particle of small particle size, low friability, high water adsorption capacity, rapid drying rate and lower occurrence of particle aggregation, although wettability is a factor to be carefully considered. The aggregation and taste-masking ability using PSS and NP-108 as core particles were evaluated at a fluidized-bed coating process. The functional coating under the excess spray rate shows different aggregation trends and dissolution profiles between PSS and NP-108; thereby, exhibiting the formation of uniform coating under the excess spray rate in the case of PSS. This expands the range of the acceptable spray feed rates to coat fine particles, and indicates the possibility of decreasing the coating time. The results obtained in this study suggested that the core particle, which has a property like that of PSS, was useful in overcoming such disadvantages as large particle size, which feels gritty in oral cavity; particle aggregation; and the long coating time of the particle coating process. These results will enable the practical fine particle coating method by increasing the range of optimum coating conditions and decreasing the coating time in fluidized bed technology. © 2014 Informa Healthcare USA, Inc.


Teleha C.A.,High Output Synthesis | Branum S.,High Output Synthesis | Zhang Y.,High Output Synthesis | Reuman M.E.,High Output Synthesis | And 12 more authors.
Organic Process Research and Development | Year: 2014

The preparation of a novel chemokine receptor type 2 (CCR-2) antagonist is described on a 135 g scale. The synthesis of an all-carbon bicyclic core was accomplished using a radical cyclization strategy using chiral precursors, wherein elaboration led to N-Boc carboxylic acid in good yield. After amidation using a traditional coupling reaction, a reductive amination using enantiomerically enriched 3-methoxy-4-pyranone led to the final compound. Although several steps of the syntheses involved reagents that would not be preferred in process and chromatography was used to provide the free-base diastereomer of the final succinate salt, the overall route went through stable intermediates that could be used for future scale-up. This lab-scale synthesis struck a balance between a quick scale-up and a more thorough process review of all possible methods and routes. © 2014 American Chemical Society.


Teleha C.A.,High Output Synthesis | Branum S.,High Output Synthesis | Zhang Y.,High Output Synthesis | Reuman M.E.,High Output Synthesis | And 12 more authors.
Organic Process Research and Development | Year: 2014

The preparation of a chemokine receptor type 2 (CCR-2) antagonist bearing a cyclopenta[b]furan core is described on a 600 g scale. Compared to our previously reported synthesis of the all-carbon core CCR-2 antagonist with a similar peripheral 3-methoxypyran appendage, our work required a redesign of the original Discovery Chemistry route and took advantage of a side product seen in the diastereoselective alkylation reaction. Elaboration by reduction and oxy-cyclization eventually led to the required N-Boc acid method. After amidation using a traditional coupling reaction, a reductive amination using enantiomerically enriched 3-methoxy-4-pyranone led to the final compound. Although several steps of the syntheses involved reagents such as selenium and chromium that would not be used in a large-scale process setting, the overall route went through intermediates that could certainly be used for future scale-up campaigns. The synthesis provided a method to make lab-scale quantities of the final succinate salt to support tox/toleration studies. Relative to the Discovery Chemistry route, this lab-scale route featured novel intermediates that could open new avenues for future research in this area. © 2014 American Chemical Society.


Tian F.,University of Shanghai for Science and Technology | Li Y.,East China University of Science and Technology | Xing J.,East China University of Science and Technology | Tian H.,CAS Zhengzhou Research Institute | And 3 more authors.
Materials Letters | Year: 2014

Anatase titanium dioxide nanosheets with exposed highly active {001} facets are very important for photo-catalysis because of their superior catalytic properties. However, pores are always found to be present on the nanosheets in transmission electron microscopy (TEM) observation, which would degrade their catalytic performance. The origin of the pores is as yet unclear. In this study we use TEM to investigate the origin and nature of the pores. It is found that, instead of chemicals used in the preparation process, it is irradiation damage from the electron beam results in the pores. © 2014 Published by Elsevier B.V.

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