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Zabeti A.R.,Iran Khodro Khorasan Co | Haghighi B.,Islamic Azad University at Neyshabur | Papari M.M.,Shiraz University of Technology | Ghiamati E.,Analytical Chemistry Research Laboratory
Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry | Year: 2012

An analytical equation of state (EoS) proposed by Ihm-Song- Mason (ISM) is employed to calculate the density of normal alkanes from methane to decane. The best available values of the Lennard-Jones (12,6) parameters have been used to evaluate the second virial coefficient of the EoS for each compound. The second virial coefficient is not very sensitive to the feature of the intermolecular potential. The remaining parameters in the EoS depend only on the repulsive part of the potential. Consequently, they are insensitive to the details of the interaction potential. The calculated second virial coefficients in conjunction with other temperature-dependent parameters of the EoS are employed to predict the density of all alkanes (C1-C10). There is a good agreement comparison between the experimental values of density and the calculated values from ISM EoS for all of the compounds.


Pingale S.G.,Analytical Chemistry Research Laboratory | Badgujar M.,Analytical Chemistry Research Laboratory | Mangaonkar K.V.,Analytical Chemistry Research Laboratory | Mastorakis N.E.,Hellenic Naval Academy
WSEAS Transactions on Biology and Biomedicine | Year: 2012

An analytical method based on solid phase extraction has been developed and validated for analysis of amoxicillin in human plasma using gemifloxacin as an internal standard. A COSMOSIL 5C18-PAQ column provided chromatographic separation of analytes followed by detection with mass spectrometry. The method involves simple isocratic chromatographic conditions and mass spectrometric detection in the positive ionization mode using an API-3000 system. The proposed method has been validated with linear range of 10015000 ng/mL for amoxicillin. The intra-run and inter-run precision values are within 3.53% and 5.63% respectively for amoxicillin at the LOQ level. Total elution time was as low as 2 min. This validated method was used successfully for analysis of plasma samples from a bioequivalence study.


Badgujar M.A.,Analytical Chemistry Research Laboratory | Mangaonkar K.V.,Analytical Chemistry Research Laboratory
Asian Journal of Chemistry | Year: 2011

A simple, fast, precise, specific, accurate and stability-indicating reversed phase high performance liquid chromatographic (HPLC) method was developed and validated for the simultaneous determination of diacerein and aceclofenac in tablets. The column used was Inertsil ODS 3V C18, 250 × 4.6 mm, i.d. 5 μm and a mobile phase composed of methanol: acetonitrile:buffer (0.02 M KH2PO4) (50:20:30), pH 5.9 adjusted with 0.1 % triethylamine. The retention times of diacerein and aceclofenac were found to be 3.2 and 6.2 min, respectively. Linearity was established for diacerein and aceclofenac in the range of 20-100 μg/mL and 40-200 μg/mL, respectively. The percentage recoveries of diacerein and aceclofenac were found to be in the range of 99.99 to 101.34 % and 97.90 to 100.35 % respectively. Both these drugs were subjected to acid, alkali, oxidation and thermal degradation. The degradation study shows 22.58 and 13.49 % degradation for diacerein and aceclofenac respectively, under alkali degradation condition. The degradation products of diacerein and aceclofenac were well resolved from the pure drug with significant differences in their retention time values. This method can be successfully employed for simultaneous quantitative analysis of diacerein and aceclofenac in bulk drugs and formulations.


Veer V.S.,Analytical Chemistry Research Laboratory | Badgujar M.A.,Sheth Jn Paliwala College Pali | Mangaonkar K.V.,Analytical Chemistry Research Laboratory
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

A simple, fast, precise and rapid isocratic reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of atovaquone and proguanil hydrochloride from tablet dosage form. The chromatographic separation was performed on Supelcosil C8, DB 250 x 4.6 mm, 5 μm particle size. Mobile phase consisted of a mixture of ammonium formate buffer (10 mM HCOONH4, pH adjusted to 3.5 using formic acid) and acetonitrile-methanol (90:10 v/v) in the ratio of 30:70 v/v at a flow rate of 1.0 mL/min. The wavelength was set at 254 nm. The proposed method was validated for linearity, accuracy, precision, LOD and LOQ. The calibration was linear over the range of 125-375 μg/mL for atovaquone and 50-150 μg/mL for proguanil hydrochloride. The retention times were found as 4.2 min for proguanil hydrochloride and 8.3 min for atovaquone. This method can be successfully employed for simultaneous quantitative analysis of atovaquone and proguanil hydrochloride in bulk drugs and formulations.


Badgujar M.A.,Analytical Chemistry Research Laboratory | Pingale S.G.,Analytical Chemistry Research Laboratory | Mangaonkar K.V.,Analytical Chemistry Research Laboratory
E-Journal of Chemistry | Year: 2011

A precise and rapid isocratic reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of paracetamol, chlorzoxazone and diclofenac sodium from tablet dosage form. The chromatographic separation was performed on an inertsil C18 column (250 mm × 4.6 mm i.d 5 μm particle size). Mobile phase consisted of a mixture of phosphate buffer (0.02 M KH2PO4, pH adjusted to 3.7 using orthophosphoric acid), acetonitrile and methanol in the ratio of (25: 25: 50) at a flow rate of 1.0 mL/min. The wavelength was set at 220 nm. The proposed method was validated for linearity, accuracy, precision, LOD and LOQ. The calibration was linear over the range of 50-150 μg/mL for paracetamol, 50-150 μg/mL for chlorzoxazone and 5-15 μg/mL for diclofenac sodium. The retention times were found as 2.8 min for paracetamol, 4.2 min for chlorzoxazone and 6.4 min for diclofenac sodium. The method can be easily adopted for quality control analysis.

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