Analytical and Pharmaceutical Research Laboratory

Ajmer, India

Analytical and Pharmaceutical Research Laboratory

Ajmer, India
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Pareek D.,Analytical and Pharmaceutical Research Laboratory | Chaudhary M.,Analytical and Pharmaceutical Research Laboratory | Pareek P.K.,M D S University | Ojha K.G.,M D S University | Pareek A.,Analytical and Pharmaceutical Research Laboratory
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: Present research work is carried out for development of some biological active new heterocyclic moieties. Methods: The substituted-2-aryl-3-(benzothiazolyl)-1,3-thiazolidine-4-ones have been synthesized by the reaction of substituted-2- aminobenzothiazoles with aromatic aldehydes (benzaldehyde, p-chlorobenzaldehyde, anisaldehyde, salicylaldehyde) followed by condensation with mercapto acetic acid. All the synthesized compounds were characterized by elemental analysis, IR spectra, 1H NMR and Mass spectral studies. The newly synthesized compounds were screened for their anti-inflammatory, antiulcer, antitumor, entomological and antibacterial activities. Results: The results of various biological activities show synthesized compounds would be of better use in drug development to combat bacterial infections and as antifeedant and acaricidal agents in future. Conclusion: All the newly synthesized compounds were screened for antibacterial activity at a concentration of 200 μg/mL and 100 μg/mL using DMF as a control and Streptomycin and Ceftazidime used as standard against gram positive and gram negative bacteria.


Chaudhary M.,Analytical and Pharmaceutical Research Laboratory | Pareek D.,Analytical and Pharmaceutical Research Laboratory | Pareek P.K.,M D S University | Kant R.,Hygia Institutes of Pharmaceutical Education and Research | And 2 more authors.
Bulletin of the Korean Chemical Society | Year: 2011

Synthesis of N-(1H-benzimidazol-2-yl)-6-substituted-1,3-benzothiazol-2- amines and 6-substituted-N-(4,5-dihydro-1H-imidazol-2-yl)-1,3-benzothiazol-2- amines by the reaction of substituted 2-aminobenzothiazoles with carbon disulphide and methyl iodide followed by the reaction with o-phenylene diamine/ethylene diamine are reported. All the synthesized compounds were characterized by elemental analysis, IR spectra and 1H NMR spectral studies. The potent antibacterial and entomological (antifeedant, acaricidal, contact toxicity and stomach toxicity) activities of the synthesized compounds were investigated.

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