Anadolu Health Center

İzmit, Turkey

Anadolu Health Center

İzmit, Turkey
SEARCH FILTERS
Time filter
Source Type

Uskudar Teke H.,Eskiehir Osmangazi University | Gunduz E.,Eskiehir Osmangazi University | Meltem Akay O.,Eskiehir Osmangazi University | Bal C.,Eskiehir Osmangazi University | Gulbas Z.,Anadolu Health Center
Turkish Journal of Hematology | Year: 2015

Objective: Pro-inflammatory and pro-angiogenic cytokines play an important role in the pathogenesis of lymphoma, and recent studies have shown that cytokines can be used as prognostic markers. Non-Hodgkin lymphoma (NHL) patients with high levels of serum interleukin-6 (s-IL6) and serum vascular endothelial growth factor (s-VEGF) have poor prognosis and shorter survival time. We aimed to determine pre-treatment levels of s-IL6 and s-VEGF and their relation with known prognostic markers, especially International Prognostic Index (IPI) scores, and to examine their effects on overall survival in newly diagnosed, untreated aggressive NHL patients. Materials and Methods: The study included 51 newly diagnosed NHL patients and 17 healthy controls. Blood samples were obtained to study s-IL6 and s-VEGF cytokine levels. Results: Patients with aggressive NHL diagnosis had higher s-VEGF and s-IL6 levels than the healthy population. If the s-IL6 levels of patients were above the cut-off levels, the overall survival time was shorter. There was no relation between s-VEGF and overall survival time. Conclusion: s-IL6 is an independent prognostic factor that may be included in IPI risk classification. In addition to the s-IL6 level, age, erythrocyte sedimentation rate, beta-2 microglobulin, WHO performance status, and IPI score are independent prognostic factors that are effective, especially for overall survival, in the clinical follow-up of NHL patients. © 2015, Turkish Society of Hematology. All rights reserved.


Teke H.U.,Eskiehir Osmangazi University | Gulbas Z.,Anadolu Health Center | Bal C.,Eskiehir Osmangazi University
Journal of B.U.ON. | Year: 2014

Purpose: Recent studies have shown that cytokines and autoantibodies that have an important role in pathogenesis of lymphoma can be used as prognostic markers. In this study, we aimed to determine the prognostic significance of a large panel of serum cytokines and compare them with a control group, and also to see for any relationship with known classical prognostic factors, the frequency of autoantibody positivity and autoimmune phenomena in patients with untreated non Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). Methods: For cytokine studies blood samples were obtained in the morning after fasting for at least 8-12 h. We used empty tubes for serum and EDTA-containing tubes for plasma samples. Blood samples were then transferred to laboratory in 5-10 min, plasma and sera were separated by centrifugation, and stored at -75 °C until assayed. Then, all sera were warmed to room temperature. All the cytokine levels were studied with Panomics Company Procarta™ Human Cytokine multiplex kits. Results: In lymphoma patients INF-γ was related with thyroglobulin antibody positivity and IL-6 with direct Coombs positivity. IL-6 was the most important cytokine connected with lymphopenia and B symptoms in lymphoma patients. IL-Iß, INF-γ, IL-2 and IL-4 were markers associated with poor prognosis in HL. At least one autoantibody was positive in 50% of NHL and HL patients. At least one antiphospholipid antibody (APA) was positive in 26% of NHL and 38% of HL patients. Conclusion: TNF-a and IL-6 are poor prognostic factors that may be included in the International Prognostic Index (IPI). To understand the effects of autoantibodies in the prognosis of HL and NHL, long-term patient follow-up studies are required.


Recent developments in cancer therapy have resulted in increases in treatment success rates and survival. One of the basic goals of such therapy is improving patient quality of life. Chemotherapy protocols for solid or hematological malignancies-most of which include multiple agents-negatively impact patient quality of life. Additionally, there have been developments in supportive care, which seeks to ameliorate or minimize the negative effects of chemotherapy. Herein we present a review and brief summarization of some of the agents used for supportive care in cancer patients in light of the latest guidelines.


Goker I.,Yeditepe University | Ertas M.,Anadolu Health Center | Ulgen Y.,Bogazici University
Journal of Clinical Neurophysiology | Year: 2010

Juvenile myoclonic epilepsy is a genetically inherited disorder characterized by myoclonic jerks and generalized seizures. It has been proposed that patients with juvenile myoclonic epilepsy have larger motor units (MUs) than normals by MU number estimation and macro electromyography techniques. In this study, an experimental setup for scanning electromyography was built to investigate electrophysiologic cross-sections of the MU territories in 9 patients with juvenile myoclonic epilepsy, 3 patients with spinal muscular atrophy, and 10 healthy volunteers. Scanning electromyography was performed on the biceps brachii muscle. For each MU, three-dimensional maps of the MU territories were plotted. The length of MU cross-section and the maximum amplitude of each MU were measured from these maps and compared among the three groups of subjects. Like spinal muscular atrophy patients, patients with juvenile myoclonic epilepsy had significantly larger MU territories than normal controls. Copyright © 2010 by the American Clinical Neurophysiology Society.


Ustuner Z.,Eskiehir Osmangazi University | Meltem Akay O.,Eskiehir Osmangazi University | Keskin M.,Eskiehir Osmangazi University | Kus E.,Eskiehir Osmangazi University | And 2 more authors.
Medical Oncology | Year: 2012

The aim of this study was to evaluate coagulation disorders in patients with metastatic colorectal cancer treated with bevacizumab by using rotation thrombelastogram (ROTEM®) and correlate ROTEM® parameters with routine coagulation tests. A total of 18 colorectal cancer patients who received bevacizumab combined with chemotherapy were included. There was no statistically significant difference between results of platelet count, prothrombin time (PT) and activated partial thromboplastin time (APTT), fibrinogen, and D-Dimer obtained at baseline and on day 1 of chemotherapy cycles 4, 8, and 12. CFT value was significantly increased on day 1 of cycle 12 compared with baseline value by both INTEM and EXTEM assays while CT and MCF showed no significant difference. Correlation analysis revealed significant correlation between laboratory parameters and ROTEM® parameters. Platelet count showed a positive correlation with MCF in INTEM (r = 0.627) and EXTEM (r = 0.699) assays while showed a negative correlation with CFT in EXTEM (r = -603). There was a significant negative correlation between fibrinogen levels and CFT in INTEM (r = -0.617) and EXTEM (r = -0.512). Our data demonstrated the value of TEG over conventional coagulation tests in evaluating antiangiogenesis agents-induced coagulation disorders. © 2012 Springer Science+Business Media, LLC.


Ertekin A.A.,Istanbul Science University | Nihan Ozdemir N.,Training and Research Hospital | Sahinoglu Z.,Anadolu Health Center | Gursoy T.,Koç University | And 2 more authors.
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2016

Abstract: Objective: We investigated the effects of delayed and early clamping of the cord on the hematologic status of the baby at birth and at the end of second month. Methods: Umbilical cord of 74 babies were clamped in the first 30 s (Group 1) and 76 were clamped at 90–120 s (Group 2). Levels of hemoglobin, hematocrit, iron and ferritin were analyzed from the umbilical cord blood at birth and from the venous samples at the end of second month. Results: Hemoglobin, hematocrit, iron and ferritin levels of cord blood were similar in both groups. However, their levels other than ferritin were higher in Group 2 at the end of second month. Two babies had respiratory distress and twelve neonates received phototherapy in Group 2 whereas only five neonates received phototherapy in Group 1. Conclusion: Term babies to whom delayed cord clamping was performed had improved hematological parameters at the end of second month. Therefore, delaying cord clamping in these babies may be a favorible approach in preventing anemia. © 2015 Taylor & Francis.


Demir A.,Kafkas University | Turker P.,Namik Kemal University | Bozkurt S.U.,Marmara University | Ilker Y.N.,Anadolu Health Center
Central European Journal of Urology | Year: 2015

Introduction In this animal study, we reviewed the histomorphological findings in rabbit kidneys after a high number of high-energy shock wave applications and observed if there were any cumulative effects after repeated sessions. Material and methods We formed 2 groups, each consisting of 8 rabbits. Group 1 received 1 session and group 2 received 3 sessions of ESWL with a 7 day interval between sessions, consisting of 3500 beats to the left kidney and 5500 beats to the right kidney per session. The specimens of kidneys were examined histomorphologically after bilateral nephrectomy was performed. For statistical analysis, 4 groups of specimens were formed. The first and second groups received 1 session, 3500 and 5500 beats, respectively. The third and fourth groups received 3 sessions, at 3500 and 5500 beats per each session, respectively. The sections were evaluated under a light microscope to determine subcapsular thickening; subcapsular, intratubular and parenchymal hemorrhage; subcapsular, intersitital, perivascular and proximal ureteral fibrosis; paranchymal necrosis; tubular epithelial vacuolization; tubular atrophy; glomerular destruction and calcification. Results In histopathological examinations capsular thickening, subcapsular hematoma, tubuloepithelial vacuolisation, glomerular destruction, parenchymal hemorrhage, interstitial fibrosis, and perivascular fibrosis were observed in all groups. In statistical analysis, on the basis of perivascular fibrosis and tubular atrophy, there was a beats per session dependent increase of both. Conclusions The detrimental effects from ESWL are dose dependent but not cumulative for up to 3 sessions. Histopathological experimental animal studies will aid in understanding local and maybe, by means of these local effects, systemic effects. © 2015, Central European Journal of Urology. All rights reserved.


PubMed | Bagcilar Training and Research Hospital, Anadolu Health Center, Training and Research Hospital, Koç University and Istanbul Science University
Type: Journal Article | Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | Year: 2016

We investigated the effects of delayed and early clamping of the cord on the hematologic status of the baby at birth and at the end of second month.Umbilical cord of 74 babies were clamped in the first 30s (Group 1) and 76 were clamped at 90-120s (Group 2). Levels of hemoglobin, hematocrit, iron and ferritin were analyzed from the umbilical cord blood at birth and from the venous samples at the end of second month.Hemoglobin, hematocrit, iron and ferritin levels of cord blood were similar in both groups. However, their levels other than ferritin were higher in Group 2 at the end of second month. Two babies had respiratory distress and twelve neonates received phototherapy in Group 2 whereas only five neonates received phototherapy in Group 1.Term babies to whom delayed cord clamping was performed had improved hematological parameters at the end of second month. Therefore, delaying cord clamping in these babies may be a favorible approach in preventing anemia.


PubMed | Anadolu Health Center, Kafkas University, Namik Kemal University and Marmara University
Type: Journal Article | Journal: Central European journal of urology | Year: 2015

In this animal study, we reviewed the histomorphological findings in rabbit kidneys after a high number of high-energy shock wave applications and observed if there were any cumulative effects after repeated sessions.We formed 2 groups, each consisting of 8 rabbits. Group 1 received 1 session and group 2 received 3 sessions of ESWL with a 7 day interval between sessions, consisting of 3500 beats to the left kidney and 5500 beats to the right kidney per session. The specimens of kidneys were examined histomorphologically after bilateral nephrectomy was performed. For statistical analysis, 4 groups of specimens were formed. The first and second groups received 1 session, 3500 and 5500 beats, respectively. The third and fourth groups received 3 sessions, at 3500 and 5500 beats per each session, respectively. The sections were evaluated under a light microscope to determine subcapsular thickening; subcapsular, intratubular and parenchymal hemorrhage; subcapsular, intersitital, perivascular and proximal ureteral fibrosis; paranchymal necrosis; tubular epithelial vacuolization; tubular atrophy; glomerular destruction and calcification.In histopathological examinations capsular thickening, subcapsular hematoma, tubuloepithelial vacuolisation, glomerular destruction, parenchymal hemorrhage, interstitial fibrosis, and perivascular fibrosis were observed in all groups. In statistical analysis, on the basis of perivascular fibrosis and tubular atrophy, there was a beats per session dependent increase of both.The detrimental effects from ESWL are dose dependent but not cumulative for up to 3 sessions. Histopathological experimental animal studies will aid in understanding local and maybe, by means of these local effects, systemic effects.


Goker I.,Okan University | Osman O.,Istanbul Arel University | Ozekes S.,Istanbul Arel University | Baslo M.B.,Istanbul University | And 2 more authors.
Journal of Medical Systems | Year: 2012

In this paper, classification of Juvenile Myoclonic Epilepsy (JME) patients and healthy volunteers included into Normal Control (NC) groups was established using Feed-Forward Neural Networks (NN), Support Vector Machines (SVM), Decision Trees (DT), and Naïve Bayes (NB) methods by utilizing the data obtained through the scanning EMG method used in a clinical study. An experimental setup was built for this purpose. 105 motor units were measured. 44 of them belonged to JME group consisting of 9 patients and 61 of them belonged to NC group comprising ten healthy volunteers. k-fold cross validation was applied to train and test the models. ROC curves were drawn for k values of 4, 6, 8 and 10. 100% of detection sensitivity was obtained for DT, NN, and NB classification methods. The lowest FP number, which was obtained by NN, was 5. © 2011 Springer Science+Business Media, LLC.

Loading Anadolu Health Center collaborators
Loading Anadolu Health Center collaborators