Baker S.J.,Anacor Pharmaceuticals Inc. |
Tomsho J.W.,Pennsylvania State University |
Benkovic S.J.,Pennsylvania State University
Chemical Society Reviews | Year: 2011
The use of boron in small-molecule pharmaceuticals is increasing. Boron's ubiquitous occurrence in nature and the recent success of a boronic acid drug (Velcade®) in the clinic have alleviated many concerns over its use in pharmaceuticals. In addition, the unique physicochemical properties of boronic acids make them an attractive addition to the medicinal chemists toolbox. This tutorial review will discuss these properties and potential benefits for anyone interested in finding novel enzyme inhibitors. An exceptional class of boronic acids, the oxaboroles, will be highlighted and their properties and uses will be discussed in detail. Finally, the current paradigm for the reaction of boronic acids with enzyme nucleophiles will be summarized. © The Royal Society of Chemistry 2011. Source
Anacor Pharmaceuticals Inc. | Date: 2014-01-31
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
Anacor Pharmaceuticals Inc. | Date: 2015-03-23
Anacor Pharmaceuticals Inc. | Date: 2015-09-11
This invention provides novel compounds, methods of using the compounds, and pharmaceutical formulations comprising the compounds.
Anacor Pharmaceuticals Inc. | Date: 2014-11-10
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.