Blagoveshchensk, Russia
Blagoveshchensk, Russia

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Dorovskikh V.A.,Amur State Medical Academy | Li O.N.,Amur State Medical Academy | Simonova N.V.,Amur State Medical Academy | Shtarberg M.A.,Amur State Medical Academy
Eksperimental'naya i Klinicheskaya Farmakologiya | Year: 2016

The possibility of correcting free radical oxidation of lipid membranes by the administration of cytoflavin was experimentally studied in rats. It is established that daily cold exposure for 3 h leads to increase in the level of lipid hydroperoxides, diene conjugates, and malonic dialdehyde on the background of decrease in activity of the antioxidant system in the blood of experimental animals. The introduction of cytoflavin (100 mg/kg, i.p.) for 21 day immediately prior to cold exposure leads to reliable (p < 0.05) decrease in the blood level of lipid hydroperoxides (by 13-21%), diene conjugates (by 24-25%), and malonic dialdehyde (by 20-33%) in comparison to rats of the control group. Analysis of the effect of cytoflavin on activity of the antioxidant system components showed that the level of ceruloplasmin and Vitamin E in the blood of animals was reliably (p < 0.05) higher by 10-33% than analogous indicator in rats of the control group. Thus, the application of cytoflavin under conditions of long-term influence of cold on the organism of animals leads to stabilization of the processes of lipid peroxidation on the background of increased activity of the blood antioxidant system.


PubMed | Amur State Medical Academy
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Positive reaction of the bronchi to distilled water inhalation in asthmatics is associated with significant stimulation of the respiratory epithelium desquamation against the background of increased content of eosinophilic and neutrophilic leukocytes in induced sputum, predomination of eosinophil and neutrophil cytolysis, and lower activity of myeloperoxidase in leukocyte granules (in comparison with the parameter in patients with a negative response to bronchostimulation). Enhanced cytolysis and destruction of leukocytes and high myeloperoxidase concentration in the extracellular space are essential for the development of bronchial hyperresponsiveness to hypoosmotic stimulus in asthma.


Reshetnik E.I.,Far East State Agrarian University | Utochkina E.A.,Amur State Medical Academy
Foods and Raw Materials | Year: 2013

In this paper the results of the study of the structure and properties of arabinogalactan extracted from Dahurian larch as well as its influence on the formation of fermented milk products are presented. The optimum application rate of arabinogalactan in a composite mixture is determined. The choice of the starter culture for the production of a functional fermented milk product is justified.


Golokhvast K.,Far Eastern Federal University | Sergievich A.,Amur Region Education Development Institute | Grigoriev N.,Amur State Medical Academy
Asian Pacific Journal of Tropical Biomedicine | Year: 2014

Objective: To discusse the impact of geophagy on behavior and conditioned-reflex activity of Wistar rats subjected to instrumental stress under experimental conditions. Methods: Experimental geophagy was simulated by adding zeolite-containing tuff (clinoptilolite) to animal feed, the amount relating to 2% of body mass. Tuff was obtained from areas where animals usually eat subsurface rock. Search activity of animals and peculiarities of information and emotional stress were studied through the use of a universal problem chamber. Results: The results of this experimental study showed the negative impact of instrumental stress on laboratory animals, manifested in behavioral dysfunction, in the form of changes in qualitative and quantitative characteristics of search activity. Experimental geophagy contributed to significant improvement in behavioral parameters, confirming the anti-stress effects of the use of natural ingredients. Conclusions: These results suggest that, in natural environmental conditions, "edible" rocks serve as an adaptive tool for recovery from various types of environmental stresses, and are examples of self-medication. © 2014 by the Asian Pacific Journal of Tropical Biomedicine.


Kurochkina G.I.,Moscow State Pedagogical University | Grachev M.K.,Moscow State Pedagogical University | Batalova T.A.,Amur State Medical Academy
Russian Journal of General Chemistry | Year: 2014

Stable nanoscaled mono- and dimeric inclusion complexes of β-cyclodextrin with hosts based on symmetric diols of various length containing fragments of benzoic, nicotinic, or isonicotinic acid were synthesized. © 2014 Pleiades Publishing, Ltd.


Grebenyuk V.V.,Amur State Medical Academy | Yusan N.V.,Amur State Medical Academy
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2010

The program of actions for the assessment of severity of biliar sepsis and the choice of algorithms for relevant medical-diagnostic measures is presented. The account is taken of the traumatic factor of operation, the method of narcosis (endotracheal, local anaesthesia) and severity of the initial condition in individual patients. It is suggested to use this program in the form of computer software for the diagnosis of severity of the disease in septic patients, creation of the database and electron archives of the results of the treatment for the purpose of continuous monitoring the patients' conditions.


Borozda I.V.,Amur State Medical Academy | Danilov M.A.,Amur State Medical Academy | Golokhvast K.S.,Far Eastern Federal University
Asian Pacific Journal of Tropical Biomedicine | Year: 2015

Objective: To propose an original method of surgical treatment for the acromial extremity of the clavicle rupture (Rockwood II-VI) with modeled Kirschner wire and cortical screw. Methods: Anatomical study and a test method were applied to 43 cadavers of both sexes. During the period between 2000 and 2013, 34 patients of both sexes were operated upon using the new method. In the comparison group (n = 120), the fixation of the acromial extremity of the clavicle rupture was performed with hamate plate, Lee hook and Kirschner wires. Results: Its application allows, according to the evaluation scale of Constant and Murley (1987), 10% more preservation of the function of the shoulder compared with traditional methods of surgical treatment, and shortens the required hospital treatment and temporary disability periods. Conclusions: It is shown that the proposed author's method combines low invasiveness, minimum dimensions of the construction and low-cost treatment. © 2015 Hainan Medical University.


PubMed | Far East Scientific Center for the Physiology and Pathology of Respiration, Amur State Medical Academy, Far Eastern Federal University and RAS Boreskov Institute of Catalysis
Type: | Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections | Year: 2015

The results of the first study on the effects of multi-walled carbon nanotubes (MWNTs) on the exploratory activity and the emotional state in laboratory rats assessed by the open field test are reported. During three or ten days, rats received 8-10 nm MWNTs added to their food at a dose of 500 mg/kg. It was demonstrated that, in the group of rats which were fed with MWNTs, the integrated anxiety level index began to increase as early as the third day of the experiment; on the tenth day, it appeared to be twice increased. It was also demonstrated that MWNTs decreased the integrated exploratory activity index nearly twofold on the third day and nearly fourfold on the tenth day.


PubMed | Amur State Medical Academy
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2016

Autoimmune ophthalmopathy (AIO) is currently regarded as an independent genetically determined autoimmune disease characterized by lesions of the organs of vision and can be combined with other endocrine and non-endocrine autoimmune disorders. There are few publications about the combination and the differential diagnosis of myasthenia gravis and AIO. The authors present a clinical case of the combination of myasthenia gravis and autoimmune eye disease with the symptoms of the malignant exophthalmos. Our case report is of interest because the symptoms of AIO not only remain but became worse in pharmacological hypothyroidism that confirms the independence of this disease.


Olifirova O.S.,Amur State Medical Academy | Knalyan S.V.,Amur State Medical Academy
Novosti Khirurgii | Year: 2015

Objectives. To assess the diagnostic significance of tumor markers of galectin-3, thyroglobulin (TG), carcinoembryonic antigen (CEA) and human chorionic gonadotropin (HCG) in the blood serum and aspirate washout in patients with nodular thyroid disease. Methods. The study involved 80 patients with nodular thyroid diseases. Highly differentiated cancer was registered in 37 patients and benign nodular disease - in 43 ones. In the preoperative period tumor markers (galectin-3, thyroglobulin, CEA and HCG) were determined by enzyme immunoassay in blood serum and aspirate washout obtained by fine-needle aspiration biopsy of thyroid nodules. Results. In highly differentiated cancer of thyroid gland a significant increase of galectin-3 and CEA in the blood serum galectin-3 and thyroglobulin in aspirate washout were found in comparison with benign nodular thyroid disease. The sensitivity and specificity of galectin-3 in blood serum were 51,4% and 95,3%; galectin-3 in aspirate washout - 59,7% and 90,7%; TG in aspirate washout - 64,9% and 93%; serum CEA - 66,7% and 91,3%, respectively. Conclusion. Study of tumor markers in the blood serum (galectin-3, CEA) and aspirate washout (galectin-3, thyroglobulin) as the additional parameters with standard methods allows increasing the efficiency of diagnosis of nodular thyroid diseases. Due to the determination of galectin-3 in the blood serum the sensitivity in differentiated diagnosis of thyroid cancer has increased from 83,8% up to 92%, galectin-3 in thyroid aspirate washout - up to 97, 3%, TG thyroid aspirate washout - up to 89,2%, CEA in blood serum - up to 94,4%.

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