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Blagoveshchensk, Russia

Edunov A.V.,Moscow State Pedagogical University | Kurochkina G.I.,Moscow State Pedagogical University | Grachev M.K.,Moscow State Pedagogical University | Levina I.I.,Moscow State Pedagogical University | And 2 more authors.
Russian Journal of Organic Chemistry | Year: 2011

Selectively substituted derivatives of α-cyclodextrin and hexa-O-tert-butyldimethylsilyl-α-cyclodextrin containing a definite number of acylated primary or secondary hydroxy groups were synthesized using benzoic, acetylsalicylic, and 2-(4-isobutylphenyl)propionic acid chlorides in various solvents in the presence of different bases. The acyl residues were assigned to the C2, C3, or C6 atoms in the carbohydrate fragments on the basis of 13C NMR data. Desilylation of the silyl derivatives with ammonium fluoride in methanol gave the corresponding O-acyl derivatives having free primary hydroxy groups in the α-cyclodextrin skeleton. © 2011 Pleiades Publishing, Ltd.

Li M.-C.,Chongqing Medical University | Yang G.,Chongqing Medical University | Zhou X.-D.,Chongqing Medical University | Tselluyko S.,Amur State Medical Academy
International Journal of Molecular Medicine | Year: 2014

In a recent study, we demonstrated that transient receptor potential melastatin 8 (TRPM8), a calcium-permeable cation channel that is activated by cold temperatures, is localized in the bronchial epithelium and is upregulated in subjects with chronic obstructive pulmonary disease, which causes them to be more sensitive to cold air. In the present study, we found that exposure to cold temperatures induced ciliary ultrastructural anomalies and mucus accumulation on the epithelial surface. Male Sprague-Dawley rats were exposed to cold temperatures to determine the effects of cold air on ultrastructural changes in cilia and the airway epithelial surface. The rats were also exposed to cigarette smoke and/or cold temperatures to determine the effects of smoke and cold air on TRPM8 expression and the role of cold air in cigarette smoke-induced mucus hypersecretion. Following real-time RT-PCR and western blot analysis, we observed a high expression of TRPM8 mRNA and protein in the bronchial tissue following cigarette smoke inhalation. As shown by ELISA, concurrent cold air enhanced the levels of mucin 5AC (MUC5AC) protein, as well as those of inflammatory factors [tumor necrosis factor (TNF)-α and interleukin (IL)-8] that were induced by cigarette smoke inhalation to a greater extent than stimulation with separate stimuli (cold air and cigarette smoke separately). The results suggest that cold air stimuli are responsible for the ultrastructural abnormalities of bronchial cilia, which contribute to abnormal mucus clearance. In addition, cold air synergistically amplifies cigarette smoke-induced mucus hypersecretion and the production of inflammatory factors through the elevated expression of the TRPM8 channel that is initiated by cigarette smoke inhalation.

Leonenko N.A.,Russian Academy of Sciences | Vanina E.A.,Amur State Medical Academy | Veselov E.M.,Amur State University | Kuzmenko A.P.,Kursk State University
Journal of Nano- and Electronic Physics | Year: 2015

The effect of continuous laser radiation on complex ore minerals objects containing gold, not extracted by monerd methods was investigated. It was established the formation of different structural surfaces of gold, revealed general patterns of sintering and concentration of sub-micron gold. © 2015 Sumy State University.

Grigor'ev N.R.,Amur State Medical Academy | Li-Tingli,Heilongjiang University of Chinese Medicine | Xiao-Yan L.,Heilongjiang University of Chinese Medicine
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova | Year: 2014

The components of cognitive operant behavior of rats was investigated after preliminary development of a unilateral conditioned reinforcement reflex ofan active avoidance aversive stimulus in the problem chamber. It is established, that cognitive abilities associated with phenotypes factors, as age and a sex. In applied aspect of research comparable actions by efficiency with Pyracetamum are reveal nootrop and activating properties at the Chinese vegetative preparation. Use of neurotropic preparations has allowed reveal their positive and negative influence on primary mental components operant behavior of an active avoidance. © 2014, Maik Nauka-Interperiodica Publishing. All rights reserved.

Kurochkina G.I.,Moscow State Pedagogical University | Grachev M.K.,Moscow State Pedagogical University | Batalova T.A.,Amur State Medical Academy
Russian Journal of General Chemistry | Year: 2014

Stable nanoscaled mono- and dimeric inclusion complexes of β-cyclodextrin with hosts based on symmetric diols of various length containing fragments of benzoic, nicotinic, or isonicotinic acid were synthesized. © 2014 Pleiades Publishing, Ltd.

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