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Kollam, India

Amrita Vishwa Vidyapeetham or Amrita University is a multi-campus, multi-disciplinary research university in India. The University is accredited 'A' by NAAC and is ranked as one of the best research universities in India. The university is spread across nine hundred acres campuses in the three states of South India in Kerala, Tamil Nadu and Karnataka. The University Headquarters is at Ettimadai in an 800 acres well-planned campus with scenic beauty near the foothills of the Western Ghats, about 22 km from Coimbatore City. Extensive interaction between all campuses is made possible through the Amrita-ISRO satellite network for e-learning.Presently, It is the only university in India having Nobel laureate as faculty. In 2011, Nobel laureate Dr Leland H. Hartwell joined Amrita University as an Adjunct faculty. Furthermore, Amrita Varsity was the first to install PARAM 10000 supercomputer in India; ahead of IISc & IITs. The university continuously collaborates with the top US universities including Ivy league universities and top European universities for regular student exchange programs. The university offers bachelors, masters, and doctoral degree programs in computer science, engineering, business, biotechnology, nanotechnology, ayurveda, medicine, nursing, pharmacy, dentistry, social work, communication, education, and basic science. Areas of specialization which include Medical Informatics, Computational Engineering, Cyber Security, Clinical Research, and Oncology have been designed keeping in mind India's National Development Plans. 13,000 students are enrolled in nearly a 100 different degree programs. Wikipedia.

We report the effect of carboxyl functionalization of graphene in pacifying its strong hydrophobic interaction with cells and associated toxic effects. Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized hydrophilic graphene was internalized by the cells without causing any toxicity.

Sahoo B.D.,Amrita University | Razavi B.,University of California at Los Angeles
IEEE Journal of Solid-State Circuits | Year: 2013

This paper describes a pipelined analog-to-digital converter that resolves 4 b in its first stage and amplifies the residue by a factor of 2, thereby relaxing the opamp linearity, voltage swing, and gain requirements. Calibration in the digital domain removes the effect of capacitor mismatches and corrects for the gain error. Using a one-stage opamp with a gain of 10 and realized in 65-nm CMOS technology, the ADC digitizes a 490-MHz input with a signal-to-(noise+distortion) ratio of 52.4 dB, achieving a figure of merit of 97 fJ/conversion-step. © 1966-2012 IEEE.

Chandran S.,Amrita University
Current drug delivery | Year: 2013

Ovarian cancer is the ninth most common cancer amongst women and ranked as fifth in terms of the cause of cancer related mortality accounting for more deaths than any other cancer of the female reproductive system. Gemcitabine is the most common chemotherapeutic agent used in the treatment of ovarian cancer despite of its disadvantage of having a very lesser half life. In this study, we have envisaged the use of a highly porous, biomimetic and implantable pectin scaffold embedded with gemcitabine loaded fibrin nanoconstructs to improve the half life of the drug, thereby providing localized therapy for ovarian cancer. The controlled and sustained release of the chemokine from the scaffold system was extensively analyzed in vitro different pH environments. The composite scaffolds were found to be highly biocompatible when tested with mammalian cell lines. The excellent cytotoxicity and apoptosis responses induced in ovarian cancer, PA- 1 cell lines proved that the nanocomposite Pectin scaffolds loaded with specific chemokine can be used as implantable "therapeutic wafers" for distracting metastatic cancer cells and thus improve the survival rate of ovarian cancer afflicted individuals.

Kanakasabapathy P.,Amrita University
International Journal of Electrical Power and Energy Systems | Year: 2013

Pumped storage hydroelectric plants are attractive in competitive electricity markets because of their operational flexibility and ability to provide rapid response to change in spot price of electricity. Operating pumped storage plant affects the consumer and producer surplus of the individual market and hence leads to significant changes in energy prices. This paper investigates the impact of pumped storage energy trading on the social welfare of electricity market. A theoretical analysis and intuitive explanation are presented and numerical case study is also illustrated to validate the analytical results developed. Energy trading by pumped storage increases the overall social welfare of the market, when both storing and releasing energy. Further, the implications of pumped storage energy trade are producers benefit more during storage and consumers benefit more during release of stored energy. © 2012 Elsevier Ltd. All rights reserved.

The present invention is related to flexible, fibrous, biocompatible and biodegradable polymeric wafer; consists of more than one polymeric fibers, each one loaded with different therapeutic agents having mutually exclusive synergistic activity. The wafer is capable of delivering the drugs locally in to the diseased site like tumor, inflammation, wound, etc., in a controlled and sustained fashion for enhanced therapeutic effect. The combination of drugs loaded in the wafer is chosen in such a way that the second or consecutive drugs will enhance or improve the therapeutic effect of the first drug.

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