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Venkatraman V.,Jawaharlal Institute of Postgraduate Medical Education & Research | Balasubramanian D.,Jawaharlal Institute of Postgraduate Medical Education & Research | Balasubramanian D.,Amrita Institute of Medical science AIMS | Gopalakrishnan S.,Jawaharlal Institute of Postgraduate Medical Education & Research | And 2 more authors.
European Archives of Oto-Rhino-Laryngology | Year: 2012

In recent literature, there has been an interest in the use of Mitomycin C to reduce post-operative complications following endoscopic sinus surgery. We report our results on a prospective, randomized controlled trial involving 50 patients with chronic bilateral rhino sinusitis. We eliminated various confounding factors by studying a single group of patients, with symmetrical disease, without preexisting gross anatomical abnormalities. Patients requiring revision sinus surgery were excluded. On completion of the surgery, a cotton pledget soaked in Mitomycin C was placed in one nostril (test) and saline-soaked pledget (control) was placed in the other side of the nose, both in the middle meatus. The side of the nasal cavity receiving the topical Mitomycin C was randomized. The patients were assessed periodically (Wrst week, Wrst month, third month and sixth month) for synechiae formation and presence or absence of their symptoms. At the Wrst week follow up, there was a statistically signiWcant diVerence in the incidence of synechiae between the saline and Mitomycin C side. Furthermore, there was a statistically signiWcant improvement with regards to patient symptoms (nasal block and discharge) in the Mitomycin C side when compared to the saline side. At the third and sixth month, there was no diVerence between the two groups. The incidence of adverse tissue reaction (granulation, discharge, polypoidal mucosa and crusting) was less in the Mitomycin C side when compared to the saline side at the Wrst month follow up. Topically applied Mitomycin C reduces the incidence of synechiae in the immediate post-operative period in patients undergoing endoscopic sinus surgery. There is also an improvement in nasal obstruction and discharge with a reduction in the incidence of adverse tissue reaction in the early post-operative period. © Springer-Verlag 2011. Source


Gopakumar H.,Amrita Institute of Medical science AIMS | Sivji R.,Amrita Institute of Medical science AIMS | Rajiv P.K.,Amrita Institute of Medical science AIMS
Journal of Pediatric Neurosciences | Year: 2010

It is presently a universal practice to administer vitamin K at birth. Hence, the serious bleeding manifestations from vitamin K deficiency are nowadays very rare. We describe a case of late vitamin K deficiency bleeding presenting as intracranial hemorrhage with impending coning and the related review of literature. Such severe bleeding episodes due to vitamin K deficiency are associated with multiple cranial involvement and impending brain herniation is probably rare. Source


Hariharan G.,Amrita Institute of Medical science AIMS | Ramachandran S.,Amrita Institute of Medical science AIMS | Parapurath R.,Amrita Institute of Medical science AIMS
Italian Journal of Pediatrics | Year: 2010

Congenital afibrinogenemia is a very rare inherited coagulation disorder, characterized by virtual absence of plasma fibrinogen (factor I). There are only about 250 cases reported in the world literature [1]. We describe a case of congenital afibrinogenemia which presented as an antenatally detected intracranial bleed. © 2010 Hariharan et al. Source


Arun T.A.,Amrita Institute of Medical science AIMS | Chacko D.K.,Amrita Institute of Medical science AIMS | Madhavan A.A.,Amrita Institute of Medical science AIMS | Deepak T.G.,Amrita Institute of Medical science AIMS | And 5 more authors.
RSC Advances | Year: 2014

The present paper reports a simple route to fabricate high surface area anatase TiO2 mesoflowers from electrospun TiO2-SiO 2 composite nanostructures. Electrospun fiber- and rice-shaped TiO2-SiO2 composite nanostructures upon treatment with concentrated alkali (NaOH) under hydrothermal conditions (180°C) result in chemical transformation of the TiO2 and in situ etching of SiO 2 to give sodium titanates. The sodium titanate upon acidification followed by a low temperature sintering (180°C) results in 3D TiO 2 mesoflowers. The material is found to be superior to the commercial P-25 in photocatalysis. © 2014 The Royal Society of Chemistry. Source


Arun T.A.,Amrita Institute of Medical science AIMS | Madhavan A.A.,Amrita Institute of Medical science AIMS | Chacko D.K.,Amrita Institute of Medical science AIMS | Anjusree G.S.,Amrita Institute of Medical science AIMS | And 4 more authors.
Dalton Transactions | Year: 2014

A rice-shaped TiO2-ZnO composite was prepared by electrospinning a mixture comprising the precursors of TiO2 and ZnO in polyvinyl acetate polymer dissolved in N,N-dimethyl acetamide. The electrospun nanofibers upon heat treatment in air resulted in collapse of the continuous fiber morphology and the formation of the rice-shaped TiO2-ZnO composite. The TiO2-ZnO composite was then treated with dilute acetic acid under hydrothermal conditions to etch ZnO from the TiO2-ZnO composite to get coral-shaped anisotropic TiO2. The structural anisotropy of TiO2 produced by the selective etching of ZnO resulted in a high surface area of 148 m2 g-1 for the TiO2. The initial and final materials were characterized by scanning electron microscopy, transmission electron microscopy, Raman and XPS spectroscopies, powder X-ray diffraction and BET surface area measurements. The utility of the anisotropic TiO2 in photovoltaics and photocatalysis was explored. Dye-sensitized solar cells fabricated using the TiO2 showed a conversion efficiency of 6.54% as against 4.8% for a control experiment with the rice-shaped TiO 2. The anisotropic TiO2 also showed good photocatalysis in the degradation of methyl orange dye and phenol. © 2014 The Royal Society of Chemistry. Source

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