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Záhony, Hungary

Jeges G.,AMRI Hungary | Meszaros T.,AMRI Hungary | Szommer T.,AMRI Hungary | Kovacs J.,AMRI Hungary | And 6 more authors.
Synlett | Year: 2011

The synthesis of methyl 2-amino-6-methoxynicotinate, a valuable building block for the preparation of fused 2-pyridones, is reported. The optimized synthesis includes sequential microwave-induced regioselective 6-methoxylation, esterification, followed by microwave-induced reaction with p- methoxybenzylamine, and final deprotection under flow reaction hydrogenation conditions. Two key steps in the reported synthesis are a microwave-induced methoxylation and a microfluidic hydrogenation that afford improved regioselectivity and purity profile of the reaction products. © Georg Thieme Verlag Stuttgart. Source

Tymoshenko D.,AMRI | Jeges G.,AMRI Hungary | Gregg B.T.,AMRI
Progress in Heterocyclic Chemistry | Year: 2011

Synthesis of heterocycles by intramolecular C. N bond formation through a palladium-catalyzed Hartwig-Buchwald reaction is described. The review covers the results reported for the synthesis of five- and six-membered rings, as well as medium-size and macro-heterocycles over the past 15 years. The review is organized by the size of the rings formed with further partition into subsections based on number of heteroatoms on the ring or fused ring systems. A separate section deals with tandem C. C/C. N palladium-catalyzed annulation sequences and cascades. © 2011 Elsevier Ltd. Source

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