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Bhubaneshwar, India

Senapati S.,All India Institute of Medical Sciences | Samal S.C.,AMRI Hospital | Kumar R.,All India Institute of Medical Sciences | Patra S.,All India Institute of Medical Sciences
Indian Journal of Pathology and Microbiology | Year: 2016

Necrotizing sialometaplasia is a rare benign and self-limiting disease, which commonly affects the minor salivary glands. Typically, it involves the seromucinous glands located at palate, buccal mucosa, tongue, tonsil, nasal cavity, trachea, larynx, maxillary sinus, and retromolar trigone. We report two such cases of necrotizing sialometaplasia to create awareness among the pathologists and surgeons because of its close morphological and clinical resemblance to squamous cell carcinoma. We have also documented that, the ischemic necrosis of salivary gland is the result of a vasculitic process. © 2016 Indian Journal of Pathology and Microbiology | Published by Wolters Kluwer - Medknow. Source

Sinha B.,AMRI Hospital | Gangopadhyay K.K.,Fortis and Peerless Hospital | Ghosal S.,Nightingale
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy | Year: 2014

Insulin therapy is not without side effects. In patients with complications on complex regimens, failure to attain adequate glycemic control exposes the patient to high risks and the considerable mental distress associated with failed injectable therapy. As clinicians, we felt it necessary to undertake a trial of newer therapies like insulin degludec, which according to published literature, appears to be superior to earlier basal analogs by fewer hypoglycemic episodes, better glycemic predictability, and genuine 24-hour coverage. Here we report on three cases seen in our own clinical practice where insulin degludec was used in patients experiencing inadequacies with their current basal insulin therapy (insulin glargine). Switching to insulin degludec resulted in clinically meaningful reductions in hypoglycemia, along with reduced fasting plasma glucose and glycosylated hemoglobin and improved satisfaction with treatment. We also explored the use of long-acting insulin in renal failure and the possibility of dose reduction when switching from existing basal insulin therapy. © 2014 Sinha et al. This work is published by Dove Medical Press Limited. Source

Ghosal S.,Nightingale | Sinha B.,AMRI Hospital | Gangopadhyay K.K.,Fortis and Peerless Hospital
Diabetes and Metabolic Syndrome: Clinical Research and Reviews | Year: 2016

Objective To compare the changes in various glycemic parameters in insulin-naïve type 2 diabetes mellitus (DM) patients who were initiated on insulin glargine or insulin degludec in a real world setting. Methods Retrospective data were analyzed in consecutive type 2 DM patients in a real world setting, who failed oral therapy (at least 2 oral anti-diabetic drugs) and were initiated with either insulin glargine or insulin degludec. The parameters assessed were the changes in HbA1c, fasting plasma glucose, body weight, dose of Insulin and the total number of patient reported hypoglycemic episodes up to 6 months after initiation. Result At baseline, insulin glargine and insulin degludec groups were similar in terms of gender, age, weight, HbA1c and duration of diabetes. After 6 months follow up the change in HbA1c (−1.09 versus −1.45 P = 0.124), change in FPG (−72.81 mg/dl [−4mmol/L] versus −75.88 mg/dl [−4.2 mmol/L] P = 0.755), and the change in body weight (+1.65 versus +0.85 P = 0.082) were similar in glargine and degludec groups, respectively. Patients in insulin degludec group experienced significantly lesser patient reported hypoglycemic episodes (12 versus 40) and required significantly lesser dose (25.68 Units versus 18.61 Units per day; P = 0.002) compared to insulin glargine. 41% of the patients reached HbA1C target of ≤7% with insulin glargine compared to 69% with insulin degludec within the specified time period. Conclusion Results from this real world analysis suggest that among type 2 DM patients who were initiated on insulin degludec as compared to insulin glargine may be associated with significantly lesser patient reported hypoglycemic episodes and lesser dose of insulin while achieving similar glycemic control. This study is however limited by the retrospective nature of the data collection. © 2016 Diabetes India Source

Sinha R.,AMRI Hospital | Dionne J.,British Columbia Children Hospital
Indian Pediatrics | Year: 2011

Recently there have been great advances in the use of ambulatory blood pressure monitoring (ABPM) in children. A major boost has been the publication of normative data for blood pressure in children. ABPM has been able to detect significant differences in blood pressure in many disease states including chronic renal failure, polycystic kidney disease and post renal transplantation and has helped in identifying both white coat hypertension and masked hypertension. Current evidence does suggest that sole reliance on clinic blood pressure might not be always appropriate and ABPM has a definite role in pediatric hypertension. © 2011 Indian Academy of Pediatrics. Source

Pan A.,AMRI Hospital | Chatterjee D.,BC Roy Polio Clinic and Hospital for Crippled Children | Garg A.K.,NRS Medical College and Hospital | Mukhopadhyay K.K.,NRS Medical College and Hospital | And 2 more authors.
Journal of the Indian Medical Association | Year: 2011

Operative treatment modalities for calcaneal fracture are still controversial. The outcome of intra - articular calcaneal fracture is mainly influenced by the soft tissue and the subtalar joint. Percutaneous method of internal fixation has been attempted to avoid the problems. Patients with displaced intra- articular calcaneal fracture types IIA, IIB and IIC were treated by initial distraction of subtalar joint, restoration the of subtalar joint, reduction of lateral expansion and finally fixation with screws percutaneously. Twenty-two patients with 26 calcaneal fractures were included. After a mean follow-up of 2 1/2 years and with American Orthopaedic Foot and Ankle Society hind foot score 82 points out of 100. Percutaneous fixation of calcaneum fracture is good alternative method in types IIA, IIB and IIC and selective type III fractures. Source

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