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Mlahi M.R.,Amran University | Azhari S.J.,University of Umm Al - Qura | El-Asmy A.A.,Mansoura University | Mostafa M.M.,Mansoura University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2015

Five metal complexes derived the reactions of 4-allyl-1-(2-hydroxybenzoyl) thiosemicarbazide (L1) with MX2 (M = Co2+, Cu2+ and Zn2+ ions; X = Cl- in case of Co 2+ and Cu2+ ions and Cl- and Ac- in case of Zn2+ ion) in EtOH were synthesized and characterized. The results suggested that the binary and ternary complexes have the general formulae, [Cu(L1-2H)(EtOH)], [Co(L1-2H)(H 2O)2]H2O and [Zn(L1-2H) (H 2O)1/2]EtOH, [Cu2(dipy)(L1-2H)(OH) 2(H2O)], [Co(dipy)(L1-2H)]4H2O and [Zn(dipy)(L1-2H)]. The binary and ternary complexes were characterized by elemental analyses, molar conductivities, spectral (IR, UV-vis; 1H NMR, mass), thermal (TGA, DTG) and magnetic moments measurements. The mode of chelation is suggested using spectral data. The existence of OH group in the ternary complexes is confirmed from the results of IR, mass and 1H NMR spectra. All the geometries of the ligands and the complexes are confirmed using DFT method from DMOL3. The biological activity for the L1 and two metal complexes were tested against DNA. © 2014 Elsevier B.V. All rights reserved.

Mlahi M.R.,Amran University | Negm A.,Mansoura University | Azhari S.J.,University of Umm Al - Qura | Mostafa M.M.,Mansoura University
Applied Organometallic Chemistry | Year: 2014

A new series of Cu2+, Pt4+, Pd2+, Au 3+ and Nd3+ complexes derived from 2-(pyridin-1-ium-1-yl) acetate have been synthesized and characterized using elemental analyses, spectral (infrared (IR), UV-visible, mass, 13C NMR and 1H NMR), magnetic and thermal measurements. IR results suggest that the ligand acts in a neutral monodentate fashion in all complexes. Octahedral geometry is proposed for Cu2+ and Pt4+ complexes and square-planar for Pd2+ and Au3+ complexes. The bond lengths, bond angles, and HOMO and LUMO were calculated. Superoxide dismutase-like radical scavenger activity and cytotoxic activity of the isolated complexes on HepG2 liver cancer cells have been screened. Ligand and complexes (Pt4+ and Nd 3+) exhibit potent antioxidant activity upon coordination while Cu2+ and Au3+ complexes do not show superoxide dismutase-like radical scavenger activity. The cytotoxic activity assay against HepG2 cell line proves that the ligand and its Pt4+ complex have a high cytotoxic activity, while the other complexes showed no cytotoxic activity. Copyright © 2014 John Wiley & Sons, Ltd.

Salama T.A.,Mansoura University | Salama T.A.,Amran University | Elmorsy S.S.,Mansoura University
Chinese Chemical Letters | Year: 2011

A combination of tetrachlorosilane (TCS) and phenol in dichloromethane was found to be an efficient reagent for hydrochlorination of α,β- unsaturated ketones to afford the corresponding β-chloroketones in good yield at ambient temperature. Reactions of the titled compounds with TCS-NaN 3 as well as with nitriles utilizing TCS-ZnCl 2 to give 1,5-disubstituted tetrazole derivatives or β-amido ketones respectively are also described. © 2011 Tarek A. Salama.

El-Nagdy M.S.,Helwan University | Abdelsalam A.,Cairo University | Badawy B.M.,Egypt Atomic Energy Authority | Algaood A.,Amran University
Journal of Physical Studies | Year: 2012

This paper presents the projectile fragments emerged from non–central events of 3.7A GeV 28Si collisions in nuclear emulsion. The charges of these fragments were carefully measured and compared with those obtained from 3.7A GeV 28Si. The distributions of those charges were given and fitted by the Gaussian shapes. The topology of 28Si fragmentation is given. The dependence of fragmentation process on incident beam energy is studied. The presence of α-cluster inside silicon beam is investigated. © 2011, Iranian Epidemiological Association. All rights reserved.

Omara H.A.,Amran University | Amin A.S.,University of Umm Al - Qura
Journal of Saudi Chemical Society | Year: 2012

A simple, accurate and highly sensitive spectrophotometric methods are proposed for the rapid and accurate determination of amantadine HCl (AMD) using bromocressol green (BCG), bromophenol blue (BPB) and bromothymol blue (BTB). The developed methods involve formation of stable yellow colored chloroform extractable ion-associate complexes of the amino derivative (basic nitrogen) of the AMD with three sulphonphthalein acid dyes, namely; BCG, BPB and BTB, in acidic medium. The ion-associates exhibit absorption maxima at 415, 412 and 414nm for BCG, BPB and BTB, respectively. AMD can be determined up to 1.5-16.5, 1.4-14.0 and 1.6-17μgmL -1, respectively. The effect of optimum conditions via acidity, reagent concentration, time, and solvent was studied. The stoichiometry of the reaction was found to be 1:1 in all cases. The low relative standard deviation values indicate good precision and high recovery values. These methods have been successfully applied for the assay of AMD in pharmaceutical formulations. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision. © 2010.

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