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Rameshkumar K.B.,Tropical Botanic Garden and Research Institute | Sudheesh N.,Tropical Botanic Garden and Research Institute | George V.,Amity Institute for Herbal and Biotech Products Development | Mohanan N.,Tropical Botanic Garden and Research Institute
Journal of Essential Oil Research | Year: 2011

The essential oil from the roots of Cyperus compressas Linn. (Cyperaceae) collected from south India was analyzed by GC and GC/MS. Twenty-two compounds, representing 90.5% of the oil were identified. The oil has been characterized by the predominance of sesquiterpenoids (89.9%), with caryophyllene oxide (34.0%) and cyperene (25.6%) being the major constituents. © 2011 Allured Business Media. Source

Rameshkumar K.B.,Jawaharlal Nehru Tropical Botanic Garden and Research Institute | Sheeja D.B.A.,Indian National Institute for Interdisciplinary Science and Technology | Nair M.S.,Indian National Institute for Interdisciplinary Science and Technology | George V.,Amity Institute for Herbal and Biotech Products Development
Natural Product Research | Year: 2015

Phytochemical analysis of the rhizome extract of Curcuma ecalcarata, a hitherto uninvestigated south Western Ghats endemic species, resulted in the isolation and identification of the diaryl heptanoid trans, trans-1,7-diphenyl-5-hydroxy-4,6-heptadiene-3-one (1), steroid β-sitosterol (2), flavanone pinocembrin (4) and monoterpenoids piperitenone (3) and 8-hydroxy piperitone (5). HPTLC estimation of pinocembrin in the rhizome revealed the plant as a rich source of pinocembrin (0.37% dry wt.). The rhizome essential oil was isolated by hydrodistillation and analysed by GC-FID, GC-MS and 13C NMR. Among the 30 constituents identified in the oil, monoterpenoids predominated (94.2%) followed by sesquiterpenoids (5.8%). The major compound consisting of 65.2% of the oil was isolated and identified as piperitenone (3). The study highlights the plant as a rich source of the flavanone pinocembrin and the volatile aroma compound piperitenone. © 2015 Taylor & Francis. Source

Pushpangadan P.,Amity Institute for Herbal and Biotech Products Development | George V.,Amity Institute for Herbal and Biotech Products Development | Sreedevi P.,Amity Institute for Herbal and Biotech Products Development | Ijinu T.P.,Amity Institute for Herbal and Biotech Products Development | Ninawe A.,Government of India
Indian Journal of Traditional Knowledge | Year: 2014

Scheduled caste and scheduled tribe comprises about 16.6% and 8.6%, respectively of India’s population according to the 2011 census. The constitution lists 1108 Scheduled castes across 25 states and about 744 tribes across 22 states in the country. The tribals live in an around forests and other difficult terrains. They acquired unique knowledge about the use of many wild flora and fauna. Most of these are either lesser known or hither to unknown to the outside world. The treasure of traditional knowledge (TK) if subjected to scientific scrutiny could benefit human kind in many ways. The inroads of modernization are presently posing a threat to this TK and these are in imminent danger of losing out, this age old wisdom and expertise can be lost for all times to come. The rich diversity of traditional communities and biological resources of the country are endowed with primary advantage of evolving innumerous ethnobiological knowledge. The Tribal Co–operative Marketing Development Federation of India Limited (TRIFED) was set up with an aim to serve the interest of the tribal communities and to work for their socio-economic development by conducting its affairs in a professional, democratic and autonomous manner for undertaking marketing of tribal products. The Ethnozoological knowledge of the communities covers the edible, medicinal and therapeutic properties of animal products. However, in recent past the time-tested traditional knowledge is eroding fast, which need urgent attention. To achieve the aim of accelerating the economic development of tribal people by providing wider exposure to their art and crafts, TRIBES INDIA, the exclusive shops of tribal artifacts were set up all over India by TRIFED. They showcase and market the art and craft items produced by the tribal people and thus espouse their magical and mystical art and culture. © 2014 National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved. Source

Kartika R.,National Botanical Research Institute | Raoa C.V.,National Botanical Research Institute | Pushpangadanb P.,Amity Institute for Herbal and Biotech Products Development | Trivedic S.P.,University of Lucknow | Reddyd G.D.,Central Research Institute Ayurveda
Iranian Journal of Pharmaceutical Sciences | Year: 2010

This study was designed to explore the protective effects of Abrus precatorius L. (Leguminosae) (AP) in HepG2 cells and N-nitrosodiethylamine (NDEA) induced hepatocellular carcinoma in Swiss albino rats. The effects of aqueous/ethanolic (50%) extract of AP on hepatic markers, haematological and histopathological parameters, and antioxidant enzymes were evaluated in NDEA (200 mg/kg and CCl4, 3 ml/kg body weight) induced experimental hepatocarcinogenesis in Swiss albino rats. In addition, cytotoxicity of the extract and its effect on the expression on p53 were studied in human hepatoma cell line (HepG2). Results obtained from cytotoxicity studies showed that the AP extract has strong cytotoxic effects on HepG2 cells. The expression of p53 was markedly increased and maintained at high level from 6-12 hr with 100 μg/ml of AP extract. A decrease in the mean and relative liver weights in AP extract treated group at a dose of 100 and 200 mg/kg was observed compared to the control group. It was also demonstrated that AP extract provided significant protection against hepatic lipid peroxidation and increased antioxidant enzymes' activities such as superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and reduced glutathione levels. In a dose-dependent manner, the AP extract reduced the NDEA-induced elevated levels of various hepatic markers such as serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, total bilirubin and gamma glutamate transpeptidase. The haematological paremater viz. RBC, WBC and haemaglobin was restored upon treatment with AP extract at 100 and 200 mg/kg. Histopathology of the liver was also carried out to mark the pathological changes in groups under study. The results of these studies demonstrate the protective effect of AP extract against NDEA induced hepatocarcinogenesis in Swiss albino rats and in HepG2 cell. Source

Pushpangadan P.,Amity Institute for Herbal and Biotech Products Development | George V.,Amity Institute for Herbal and Biotech Products Development
Indian Journal of Traditional Knowledge | Year: 2010

Resurgence of public interest in the ethnomedical practices in both the developing and developed countries is increasing. As a result, the trade of herbal products in the national and international market is also growing. The rich biodiversity and associated knowledge system particularly in Asia are well known. Over 8,000 wild plant species with about 1,75,000 specific preparations are known to the tribal communities alone. Native food as a medicine particularly during the pregnancy and child raring are noteworthy. The finer aspects of native food are now incorporated in the novel designs of food and nutrition. Homestead garden and the kitchen are connected with the food and ecosystem based sustainable living. The loss of local traditions and associated knowledge system (Ethnomedicine) is resulting in poor health of mother and child especially among the rural poor. Recognition of the native healers and the time tested ethnomedical practices are therefore important in mother and childcare even in modern times. Source

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