Amicogen Inc.

Chinju, South Korea

Amicogen Inc.

Chinju, South Korea
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LONDON, June 19, 2017 /PRNewswire/ -- Global Specialty Enzymes Market: Scope This report on specialty enzymes market studies the current as well as future prospects of the market globally. The stakeholders of this report include companies and intermediaries engaged in the manufacture, commercialization, providing services of specialty enzymes products such as protease, carbohydrases, polymerases and nucleases, lipase as well as new entrants planning to enter this market. This report comprises an elaborate executive summary along with a market snapshot providing overall information of various segments and sub-segments considered in the scope of the study. This section also provides the overall information and data analysis of the global specialty enzymes market with respect to the leading market segments based on major applications segment, products segment, and geographies. Download the full report: https://www.reportbuyer.com/product/4951677/ Global Specialty Enzymes Market: Segmentation Based on the product type, the specialty enzymes market has been segmented into: protease, carbohydrases, polymerases and nucleases, lipase, and others. Each of the market segments have been extensively analyzed based on the market related factors such as increasing demand of specialty enzymes worldwide, and technological advancement. Moreover, historical year-on-year growth have been taken into consideration while estimating the market size. The market size and forecast in terms of US$ million for each segment has been provided for the period from 2015 to 2025. The report also provides the compound annual growth rate (CAGR %) for each market segment for the forecast period from 2017 to 2025, considering 2016 as the base year. Global Specialty Enzymes Market: Drivers and Restraints The market overview section of the report explores the market dynamics such as drivers, restraints, and opportunities that currently have a strong impact on the specialty enzymes market and could influence the market in the near future. Market attractiveness analysis has been provided in the market overview section in order to explain the intensity of competition in the market across different geographies. The competitive scenario among different market players is evaluated through market share analysis in the competitive landscape section of the report. All these factors would help market players to take strategic decisions in order to strengthen their positions and expand their shares in the global specialty enzymes market. Global Specialty Enzymes Market: Geographical Segmentation Geographically, specialty enzymes market has been segmented into five major regions: North America, Europe, Asia, Latin America, and Rest of World. The market size and forecast for each of these regions has been provided for the period from 2015 to 2025, along with their respective CAGRs for the forecast period from 2017 to 2025, considering 2016 as the base year. The report also provides with market size and forecast for major countries in the respective regions. A detailed qualitative analysis of factors responsible for driving and restraining the market growth and future opportunities has been provided in the market overview section. This section of the report also provides with market attractiveness analysis, Porter's five forces analysis, and market share analysis by key players, thus presenting a thorough analysis of the overall competitive scenario in the global specialty enzymes market. Key Players Mentioned in this Report are: The key findings section included in the report would assist existing market players in expanding their market shares, and new companies in establishing their presence in the global specialty enzymes market. The report also profiles key players operating in the specialty enzymes market which are Novozymes A/S, Amano Enzymes Inc., Codexis Inc., Advanced Enzymes Technologies Ltd., Affymetrix Inc., BBI Solutions, Roche CustomBiotech, Biocatalysts Ltd. and Amicogen Inc. The global specialty enzymes market is segmented as follows: Global Specialty enzymes Market, by Application Type Research & Biotechnology Diagnostics Other specialty Global Specialty enzymes Market, Product Type Protease Carbohydrases Polymerases and Nucleases Lipase Other Global Specialty enzymes Market, by Geography North America U.S. Canada Europe Germany U.K. France Italy Spain Russia Rest of the Europe Asia Pacific China Japan India Indonesia Malaysia Rest of Asia Latin America (LATAM) Brazil Mexico Rest of LATAM Middle East & Africa South Africa Rest of MEA Download the full report: https://www.reportbuyer.com/product/4951677/ About Reportbuyer Reportbuyer is a leading industry intelligence solution that provides all market research reports from top publishers http://www.reportbuyer.com For more information: Sarah Smith Research Advisor at Reportbuyer.com Email: query@reportbuyer.com Tel: +44 208 816 85 48 Website: www.reportbuyer.com To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/specialty-enzymes-market---global-industry-analysis-size-share-growth-trends--forecast-2017---2025-300476196.html


News Article | September 11, 2017
Site: www.prnewswire.com

Early buyers will receive 10% customization on this report The growth of the polymeric adsorbents market can be attributed to the increasing consumption of polymeric adsorbents in the pharmaceutical and food & beverage end-use industries for separation and purification processes. The increased use of polymeric adsorbents in end-use industries is due to their highly effective adsorption capacity, cleaner operations, high physical and chemical stability, and powdered activated carbon. Among types, the modified aromatic (brominated aromatic matrix) segment of the polymeric adsorbents market is projected to witness the highest growth during the forecast period from 2017 to 2022. Based on the type, the polymeric adsorbents market has been segmented into aromatic (cross-linked polystyrenic matrix), modified aromatic (brominated aromatic matrix), and methacrylic (methacrylic ester copolymer), among others. The modified aromatic (brominated aromatic matrix) segment is expected to witness the highest growth during the forecast period from 2017 to 2022. The increased use of aromatic (cross-linked polystyrenic matrix) polymeric adsorbents in various end-use industries can be attributed to their high hydrophobicity, high adsorption capacity, excellent pressure & flow characteristics, etc. These properties have led to an increased consumption of these adsorbents in pharmaceutical and food & beverages industries. The food & beverages end-use industry segment of the polymeric adsorbents market is projected to witness the highest growth during the forecast period between 2017 and 2022. The food & beverages end-use industry is estimated to be fastest-growing end-use industry segment during the forecast period. Polymeric adsorbents are being used an alternative to powdered activated carbon in food & beverages industry such as purification of citric juices, non-alcoholic beverages, alcoholic beverages, etc. The Asia Pacific polymeric adsorbents market is projected to witness the highest growth during the forecast period. Based on the region, the polymeric adsorbents market has been segmented into Asia Pacific, North America, Europe, South America, and the Middle East and Africa. The Asia Pacific Polymeric Adsorbents Market is projected to witness the highest growth during the forecast period. The growth of the Asia Pacific polymeric adsorbents market can be attributed to the presence of the local as well as international polymeric adsorbent manufacturers in the region. The growing demand for polymeric adsorbents from various end-use industries, such as pharmaceutical, food & beverages, and industrial segments of the countries such as China, Japan, and India also contribute to the growth of the Asia Pacific polymeric adsorbents market. The industrial segment was a major end-use industry segment of the Asia-Pacific polymeric adsorbents market. The increasing demand for polymeric adsorbents in sugar purification, chemicals purification, and gold extraction in is expected to drive the growth of the segment in the region. The Dow Chemical Company (US) Mitsubishi Chemical Corporation (Japan), Purolite Corporation (US), Shanghai Bairy Technology Co., Ltd. (China), Amicogen (China) Biopharm Co., Ltd. (China), Ajinomoto Fine-Techno Co., Inc. (Japan), Thermax Limited (India), CHEMRA GmbH (Germany), and Sunresin New Materials Co. Ltd. (China) are some of the key players operating in the polymeric adsorbents market. Activated Carbon Market by Type (Powdered, Granular, Others (Pelletized, Bead)), Application (Liquid Phase (Water Treatment, Foods & Beverages, Pharmaceutical & Medical), Gaseous Phase (Industrial, Automotive)), Region - Global Forecast to 2021 Adsorbent Market by Type (Molecular Sieves, Activated Carbon, Silica Gel, Activated Alumina, Clay, and Others), by Application (Petroleum Refining, Chemicals/Petrochemicals, Gas Refining, Water Treatment, Air Separation & Drying, Packaging, and Others), and by Region - Global Forecast to 2020 Know More About our Knowledge Store @ http://www.marketsandmarkets.com/Knowledgestore.asp MarketsandMarkets™ provides quantified B2B research on 30,000 high growth niche opportunities/threats which will impact 70% to 80% of worldwide companies' revenues. Currently servicing 5000 customers worldwide including 80% of global Fortune 1000 companies as clients. Almost 75,000 top officers across eight industries worldwide approach MarketsandMarkets™ for their painpoints around revenues decisions. Our 850 fulltime analyst and SMEs at MarketsandMarkets™ are tracking global high growth markets following the "Growth Engagement Model - GEM". The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write "Attack, avoid and defend" strategies, identify sources of incremental revenues for both the company and its competitors. MarketsandMarkets™ now coming up with 1,500 MicroQuadrants (Positioning top players across leaders, emerging companies, innovators, strategic players) annually in high growth emerging segments. MarketsandMarkets™ is determined to benefit more than 10,000 companies this year for their revenue planning and help them take their innovations/disruptions early to the market by providing them research ahead of the curve. MarketsandMarkets's flagship competitive intelligence and market research platform, "RT" connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. Visit Our Blog @ http://www.marketsandmarketsblog.com/market-reports/chemical Connect with us on LinkedIn @ http://www.linkedin.com/company/marketsandmarkets


News Article | September 11, 2017
Site: www.prnewswire.co.uk

Early buyers will receive 10% customization on this report The growth of the polymeric adsorbents market can be attributed to the increasing consumption of polymeric adsorbents in the pharmaceutical and food & beverage end-use industries for separation and purification processes. The increased use of polymeric adsorbents in end-use industries is due to their highly effective adsorption capacity, cleaner operations, high physical and chemical stability, and powdered activated carbon. Among types, the modified aromatic (brominated aromatic matrix) segment of the polymeric adsorbents market is projected to witness the highest growth during the forecast period from 2017 to 2022. Based on the type, the polymeric adsorbents market has been segmented into aromatic (cross-linked polystyrenic matrix), modified aromatic (brominated aromatic matrix), and methacrylic (methacrylic ester copolymer), among others. The modified aromatic (brominated aromatic matrix) segment is expected to witness the highest growth during the forecast period from 2017 to 2022. The increased use of aromatic (cross-linked polystyrenic matrix) polymeric adsorbents in various end-use industries can be attributed to their high hydrophobicity, high adsorption capacity, excellent pressure & flow characteristics, etc. These properties have led to an increased consumption of these adsorbents in pharmaceutical and food & beverages industries. The food & beverages end-use industry segment of the polymeric adsorbents market is projected to witness the highest growth during the forecast period between 2017 and 2022. The food & beverages end-use industry is estimated to be fastest-growing end-use industry segment during the forecast period. Polymeric adsorbents are being used an alternative to powdered activated carbon in food & beverages industry such as purification of citric juices, non-alcoholic beverages, alcoholic beverages, etc. The Asia Pacific polymeric adsorbents market is projected to witness the highest growth during the forecast period. Based on the region, the polymeric adsorbents market has been segmented into Asia Pacific, North America, Europe, South America, and the Middle East and Africa. The Asia Pacific Polymeric Adsorbents Market is projected to witness the highest growth during the forecast period. The growth of the Asia Pacific polymeric adsorbents market can be attributed to the presence of the local as well as international polymeric adsorbent manufacturers in the region. The growing demand for polymeric adsorbents from various end-use industries, such as pharmaceutical, food & beverages, and industrial segments of the countries such as China, Japan, and India also contribute to the growth of the Asia Pacific polymeric adsorbents market. The industrial segment was a major end-use industry segment of the Asia-Pacific polymeric adsorbents market. The increasing demand for polymeric adsorbents in sugar purification, chemicals purification, and gold extraction in is expected to drive the growth of the segment in the region. The Dow Chemical Company (US) Mitsubishi Chemical Corporation (Japan), Purolite Corporation (US), Shanghai Bairy Technology Co., Ltd. (China), Amicogen (China) Biopharm Co., Ltd. (China), Ajinomoto Fine-Techno Co., Inc. (Japan), Thermax Limited (India), CHEMRA GmbH (Germany), and Sunresin New Materials Co. Ltd. (China) are some of the key players operating in the polymeric adsorbents market. Activated Carbon Market by Type (Powdered, Granular, Others (Pelletized, Bead)), Application (Liquid Phase (Water Treatment, Foods & Beverages, Pharmaceutical & Medical), Gaseous Phase (Industrial, Automotive)), Region - Global Forecast to 2021 Adsorbent Market by Type (Molecular Sieves, Activated Carbon, Silica Gel, Activated Alumina, Clay, and Others), by Application (Petroleum Refining, Chemicals/Petrochemicals, Gas Refining, Water Treatment, Air Separation & Drying, Packaging, and Others), and by Region - Global Forecast to 2020 Know More About our Knowledge Store @ http://www.marketsandmarkets.com/Knowledgestore.asp MarketsandMarkets™ provides quantified B2B research on 30,000 high growth niche opportunities/threats which will impact 70% to 80% of worldwide companies' revenues. Currently servicing 5000 customers worldwide including 80% of global Fortune 1000 companies as clients. Almost 75,000 top officers across eight industries worldwide approach MarketsandMarkets™ for their painpoints around revenues decisions. Our 850 fulltime analyst and SMEs at MarketsandMarkets™ are tracking global high growth markets following the "Growth Engagement Model - GEM". The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write "Attack, avoid and defend" strategies, identify sources of incremental revenues for both the company and its competitors. MarketsandMarkets™ now coming up with 1,500 MicroQuadrants (Positioning top players across leaders, emerging companies, innovators, strategic players) annually in high growth emerging segments. MarketsandMarkets™ is determined to benefit more than 10,000 companies this year for their revenue planning and help them take their innovations/disruptions early to the market by providing them research ahead of the curve. MarketsandMarkets's flagship competitive intelligence and market research platform, "RT" connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. Visit Our Blog @ http://www.marketsandmarketsblog.com/market-reports/chemical Connect with us on LinkedIn @ http://www.linkedin.com/company/marketsandmarkets


NEW YORK, Sept. 18, 2017 /PRNewswire/ -- "The polymeric adsorbents market is projected to grow at a CAGR of 7.9% from 2017 to 2022" Read the full report: https://www.reportlinker.com/p05101832 The polymeric adsorbents market was valued at USD 86 million in 2016 and is projected to reach USD 135.20 million by 2022, at a CAGR of 7.9% from 2017 to 2022. Polymeric adsorbents, also known as synthetic adsorbents, are used in various applications in different end-use industries, such as pharmaceutical and food & beverages. These adsorbents are used as an alternative to powdered activated carbon, owing to their high adsorption capacity, excellent chemical and physical stability, and cleaner operations, which is expected to drive the market during the forecast period. However, high prices of polymeric adsorbents as compared to other adsorbents is a major challenge for the growth of the polymeric adsorbents market. Slow economic growth in South America and Europe can restrain the growth of the polymeric adsorbents market to some extent. "Among types, the aromatic (cross-linked polystyrenic matrix) segment is expected to be the largest segment of the market during the forecast period" Among types, the aromatic (cross-linked polystyrenic matrix) segment of polymeric adsorbents market is projected to be the largest segment of the market between 2017 and 2022. The high demand for aromatic (cross-linked polystyrenic matrix) polymeric adsorbents in the pharmaceutical industry in separation and purification processes of antibiotics such penicillin, ampicillin, etc., is expected to drive the growth of the segment. The modified aromatic (brominated aromatic matrix) segment of the polymeric adsorbents market is projected to witness the highest growth between 2017 and 2022. Polymeric adsorbents offer superior properties, such as high hydrophobicity, excellent adsorption capacity, and high pore size. These properties have led to the high consumption of these adsorbents in pharmaceutical and food & beverages industries. "The Asia Pacific polymeric adsorbents market is projected to witness the highest growth during the forecast period. The Asia Pacific polymeric adsorbents market is projected to witness the highest growth from 2017 to 2022. The high growth of the Asia Pacific polymeric adsorbents market can be primarily attributed to the increased use of polymeric adsorbents in pharmaceutical and food & beverages end-use industries. Moreover, the presence of the key manufacturers of polymeric adsorbents and the increased demand for polymeric adsorbents from various end-use industries is expected to drive the growth of the Asia Pacific polymeric adsorbents market during the forecast period. Breakdown of the profiles of primary interviews for the report on the polymeric adsorbents market • By Company Type – Tier 1 – 45%, Tier 2 –22%, and Tier 3 – 33% • By Designation – C Level – 50%, Director Level – 10%, and Others – 40% • By Region – Europe – 50%, Asia Pacific – 31%, North America – 13%, and RoW – 6% Some of the key companies profiled in this report are The Dow Chemical Company (US), Mitsubishi Chemical Corporation (Japan), Purolite Corporation (US), Shanghai Bairy Technology Co., Ltd. (China), Amicogen (China) Biopharm Co., Ltd. (China), Ajinomoto Fine-Techno Co., Inc. (Japan), Thermax Limited (India), CHEMRA GmbH (Germany), and Sunresin New Materials Co. Ltd. (China). Research Coverage: The report covers the polymeric adsorbents market and its use across different end-use industries and regions. It aims at estimating the market size and future growth potential of the polymeric adsorbents market across the types of polymeric adsorbents. The report also includes an in-depth competitive analysis of the key market players along with their profiles, and key growth strategies. It also includes information on the dynamic differentiators, innovators, visionary leaders, and emerging companies in the polymeric adsorbents market. Key benefits of buying the report From an insight perspective, this research report focuses on various levels of analyses, which include industry analysis (industry trends) and company profiles. These insights together comprise and discuss the basic views on the competitive landscape, emerging and high-growth segments of the polymeric adsorbents market, high-growth regions, and drivers, restraints, opportunities, and challenges for the polymeric adsorbents market. The report provides insights on the following pointers: • Market Penetration: Comprehensive information on the polymeric adsorbents offered by the top players operating in the polymeric adsorbents market • Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and new applications in the polymeric adsorbents market • Market Development: Comprehensive information about the lucrative and emerging markets. The report analyzes the markets for polymeric adsorbents across different regions • Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the polymeric adsorbents market • Competitive Assessment: In-depth assessment of strategies, products, and manufacturing capabilities of the leading players in the polymeric adsorbents market Read the full report: https://www.reportlinker.com/p05101832 About Reportlinker ReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place. https://www.reportlinker.com __________________________ Contact Clare: clare@reportlinker.com US: (339)-368-6001 Intl: +1 339-368-6001


Jung U.J.,Pukyong National University | Cho Y.-Y.,Amicogen Inc. | Choi M.-S.,Kyungpook National University
Nutrients | Year: 2016

Several in vitro and in vivo studies have reported the anti-inflammatory, anti-diabetic and anti-obesity effects of the flavonoid apigenin. However, the long-term supplementary effects of low-dose apigenin on obesity are unclear. Therefore, we investigated the protective effects of apigenin against obesity and related metabolic disturbances by exploring the metabolic and transcriptional responses in high-fat diet (HFD)-induced obese mice. C57BL/6J mice were fed an HFD or apigenin (0.005%, w/w)-supplemented HFD for 16 weeks. In HFD-fed mice, apigenin lowered plasma levels of free fatty acid, total cholesterol, apolipoprotein B and hepatic dysfunction markers and ameliorated hepatic steatosis and hepatomegaly, without altering food intake and adiposity. These effects were partly attributed to upregulated expression of genes regulating fatty acid oxidation, tricarboxylic acid cycle, oxidative phosphorylation, electron transport chain and cholesterol homeostasis, downregulated expression of lipolytic and lipogenic genes and decreased activities of enzymes responsible for triglyceride and cholesterol ester synthesis in the liver. Moreover, apigenin lowered plasma levels of pro-inflammatory mediators and fasting blood glucose. The anti-hyperglycemic effect of apigenin appeared to be related to decreased insulin resistance, hyperinsulinemia and hepatic gluconeogenic enzymes activities. Thus, apigenin can ameliorate HFD-induced comorbidities via metabolic and transcriptional modulations in the liver. © 2016 by the authors; licensee MDPI, Basel, Switzerland.


Park H.J.,Kyungpook National University | Lee M.K.,Sunchon National University | Park Y.B.,Kyungpook National University | Shin Y.C.,Amicogen Inc. | Choi M.S.,Kyungpook National University
Food and Chemical Toxicology | Year: 2011

This study was performed to evaluate the beneficial effect of Undaria pinnatifida ethanol extract (UEFx) on insulin resistance in diet-induced obese mice. A high-fat diet was supplemented with the UEFx at 0.69% (wt/wt) dose, which contains an equivalent amount of 0.02% fucoxanthin (wt/wt), or with Fx at 0.02% (wt/wt) dose in diet. After 9 weeks, both UEFx supplement significantly lowered the amount of visceral fat, the size of adipocyte, the fasting blood glucose concentration, the plasma insulin and the insulin resistance index similar to pure as shown by Fx supplement, compared to the high-fat (HF) control group. Blood glucose level was negatively correlated with hepatic glucokinase activity (r= -0.533, p< 0.05), whereas positively correlated with hepatic gluconeogenic enzyme activities (r= 0.463, p< 0.05 for glucose-6-phosphatase; r= 0.457, p< 0.05 for phosphoenolpyruvate carboxykinase). Ratio of hepatic glucokinase/glucose-6-phosphatase and glycogen content were significantly elevated by the UEFx and Fx supplements. Supplementation of the UEFx as well as Fx seemed to stimulate the β-oxidation activity and inhibit the phosphatidate phosphohydrolase activity resulting in a decrease in the hepatic lipid droplet accumulation. The results indicate that the UEFx can prevent insulin resistance and hepatic fat accumulation that is partly mediated by modulating the hepatic glucose and lipid homeostasis in the high fat-induced obese mice. © 2010 Elsevier Ltd.


Woo M.-N.,Kyungpook National University | Jeon S.-M.,Kyungpook National University | Kim H.-J.,CJ CheilJedang Corporation | Lee M.-K.,Sunchon National University | And 4 more authors.
Chemico-Biological Interactions | Year: 2010

This study investigated the effects of fucoxanthin isolated from marine plant extracts on lipid metabolism and blood glucose concentration in high-fat diet fed C57BL/6N mice. The mice were divided into high-fat control (HFC; 20% fat, w/w), low-fucoxanthin (low-Fxn; HFC+0.05% Fxn, w/w) and high-fucoxanthin (high-Fxn; HFC+0.2% Fxn, w/w) groups. Fxn supplementation significantly lowered the concentration of plasma triglyceride with a concomitant increase of fecal lipids in comparison to the HFC group. Also, the hepatic lipid contents were significantly lowered in the Fxn supplemented groups which seemed to be due to the reduced activity of the hepatic lipogenic enzymes, glucose-6-phosphate dehydrogenase, malic enzyme, fatty acid synthase and phosphatidate phosphohydrolase and the enhanced activity of β-oxidation. Plasma high-density lipoprotein cholesterol concentrations and its percentage were markedly elevated by Fxn supplementation. Activities of two key cholesterol regulating enzymes: 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A: cholesterol acyltransferase, were significantly suppressed by Fxn regardless of the dosage. Relative mRNA expressions of acyl-coA oxidase 1, palmitoyl (ACOX1) and peroxisome proliferators activated receptor α (PPARα) and γ (PPARγ) were significantly altered by Fxn supplementation in the liver. Fxn also lowered blood glucose and HbA1c levels along with plasma resistin and insulin concentrations. These results suggest that Fxn supplementation plays a beneficial role in not only regulating the plasma and hepatic lipids metabolism but also for blood glucose-lowering action in high-fat fed mice. © 2010 Elsevier Ireland Ltd.


Hwang Y.P.,Chungnam National University | Kim H.G.,Chungnam National University | Han E.H.,Chungnam National University | Choi J.H.,Chungnam National University | And 4 more authors.
Journal of Dermatological Science | Year: 2011

Background: N-Acetylglucosamine (GlcNAc) and its derivates have been utilized in dietary supplements and for therapeutic development due to their unique characteristics. GlcNAc is recognized primarily for its function as a precursor to hyaluronic acid, which plays a significant role in the structure and hydration of the extracellular matrix in skin, in both the epidermis and the dermis. Objective: We investigated the protective effects of GlcNAc on immortalized human skin fibroblasts (HS68) against UVB damage. We then explored the inhibitory effects of GlcNAc on UVB-induced collagenases and investigated the molecular mechanism underlying those effects. Methods: Those effects were assessed by semi-quantitative PCR, Western blotting and enzymatic activity assays. Results: GlcNAc increased the viability of, and inhibited ROS production in, HS68 cells exposed to UVB irradiation. Pre-treatment of HS68 cells with GlcNAc inhibited UVB-induced production of the collagenases MMP-1 and MMP-13. Western blot analysis further revealed that GlcNAc markedly suppressed the enhancement of collagen degradation in UVB-exposed HS68 cells. GlcNAc also suppressed UVB-induced activation of c-Jun, c-Fos and NF-κB and the phosphorylation of MAPKs and PI3K/Akt, upstream modulators of AP-1 and NF-κB. Moreover, GlcNAc decreased the UVB-induced influx of Ca2+ into HS68 cells and the phosphorylation of Ca2+/calmodulin-dependent kinases (CaMKs). Conclusion: The results indicate that GlcNAc inhibited UVB-induced collagenolytic MMP production by interfering with Ca2+-dependent Akt and MAPKs/AP-1 and NF-κB signaling. They may thus be potentially useful in the prevention and treatment of skin photoaging. © 2011 Japanese Society for Investigative Dermatology.


Choi G.N.,Gyeongsang National University | Kim J.H.,Gyeongsang National University | Kim J.H.,Korea forest Research Institute | Kwak J.H.,Gyeongsang National University | And 5 more authors.
Food Chemistry | Year: 2012

To investigate the anti-amnesic effect of quercetin by using in vivo Y-maze and passive avoidance tests, the learning and memory impairment in ICR mice was induced by neurotoxic trimethyltin. Quercetin pre-administration attenuated TMT-induced memory injury in both in vivo tests. Acetylcholinesterase (AChE), prepared from mice brain tissues, was inhibited by quercetin in a dose-dependent manner. Malondialdehyde generation in the brain homogenate of mice treated with quercetin decreased, indicating that peroxidation of polyunsaturated fatty acids was inhibited by the cellular membrane. In addition, potent antioxidant capacity of quercetin was confirmed through various antioxidative assays. Our findings suggest that the quercetin may improve cognitive ability against TMT-induced neuronal deficit and also have an inhibitory action against AChE. Consequently, these results demonstrate that the quercetin could possess a wide range of beneficial activities for neurodegenerative disorders, notably Alzheimer's disease (AD). © 2011 Elsevier Ltd. All rights reserved.


Patent
Amicogen Inc. | Date: 2012-06-28

A method of producing lycopene, with high productivity by means of a recombinant bacterial strain includes preparing the recombinant vector containing genes encoding proteins, which are required for lycopene biosynthesis. The genes involved in lycopene biosynthesis are crtE, crtB and crtI, and at least one of the said three genes (crtE, crtB and crtI) is selected from the group consisting of crtE with the SEQ ID NO:1, crtB with the SEQ ID NO:3 and crtI with the SEQ ID NO:5, of the Sequence List. The said recombinant vector is transformed into Escherichia coli (hereafter E. coli). The E. coli transformant is cultured to recover lycopene from the culture medium.

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