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Nemkov V.,AMF Life Systems LLC | Ruffini R.,AMF Life Systems LLC | Goldstein R.,AMF Life Systems LLC | Jackowski J.,AMF Life Systems LLC | And 2 more authors.
COMPEL - The International Journal for Computation and Mathematics in Electrical and Electronic Engineering

Purpose - The purpose of this paper is to continue studies previously reported with the primary focus of optimizing an inductor design. The potential benefits of hyperthermia for cancer therapy, particularly metastatic cancers of the prostate, may be realized by the use of targeted magnetic nanoparticles that are heated by alternating magnetic fields (AMFs). Design/methodology/approach - To further explore the potential of this technology, a high-throughput cell culture treatment system is needed. The AMF requirements for this research present challenges to the design and manufacture of an induction system because a high flux density field at high frequency must be created in a relatively large volume. Additional challenges are presented by the requirement that the inductor must maintain an operating temperature between 35 and 39C with continuous duty operation for 1 h or longer. Results of simulation and design of two devices for culture samples and for ITin vitro/IT tests of multiple samples in uniform field are described. Findings - The inductor design chosen provides a uniform distribution of relatively high magnetic field strength while providing an optimal reduction in the voltage and power requirement. Through development of design and selection of magnetic concentrator, the exposure of the cell cultures to the heat generated by the inductor is minimized. Originality/value - This method of generating uniform high AC magnetic fields in a large volume is beneficial for the study of hyperthermia in cells for a high throughput, necessary for cancer treatment research. © 2011 Emerald Group Publishing Limited. All rights reserved. Source

Bordelon D.E.,Johns Hopkins University | Goldstein R.C.,AMF Life Systems LLC | Nemkov V.S.,AMF Life Systems LLC | Kumar A.,Lambda Technologies | And 3 more authors.
IEEE Transactions on Magnetics

In this paper, we describe a modified solenoid coil that efficiently generates high amplitude alternating magnetic fields (AMF) having field uniformity (≤10%) within a 125-cm 3 volume of interest. Two-dimensional finite element analysis (2D-FEA) was used to design a coil generating a targeted peak AMF amplitude along the coil axis of ∼ 100 kA/m (peak-to-peak) at a frequency of 150 kHz while maintaining field uniformity to > 90% of peak for a specified volume. This field uniformity was realized by forming the turns from cylindrical sections of copper plate and by adding flux concentrating rings to both ends of the coil. Following construction, the field profile along the axes of the coil was measured. An axial peak field value of 95.8 ± 0.4 kA/m was measured with 650 V applied to the coil and was consistent with the calculated results. The region of axial field uniformity, defined as the distance over which field ≥ 90% of peak, was also consistent with the simulated results. We describe the utility of such a device for calorimetric measurement of nanoparticle heating for cancer therapy and for magnetic fluid hyperthermia in small animal models of human cancer. © 2006 IEEE. Source

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