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Beirut, Lebanon

The American University of Beirut ; Arabic: الجامعة الأميركية في بيروت‎) is a private, secular, and independent university in Beirut, Lebanon. Degrees awarded at the American University of Beirut are officially registered with the New York Board of Regents.The university is ranked as the number one university in Lebanon and among the top 250 universities in the world by the QS World University Rankings.The American University of Beirut is governed by a private, autonomous Board of Trustees and offers programs leading to Bachelor's, Master’s, MD, and PhD degrees. It collaborates with many universities around the world, notably with Columbia University, George Washington University Medical School in Washington, DC; Johns Hopkins University School of Medicine, and the University of Paris. The current president is the American epigraphist, philologist, and cultural anthropologist, Peter Dorman.The American University of Beirut boasts an operating budget of $300 million with an endowment of approximately $500 million. The campus is composed of 64 buildings, including the American University of Beirut Medical Center , 5 libraries, 3 museums and 7 dormitories. Almost one-fifth of AUB's students attended secondary school or university outside of Lebanon before coming to AUB. AUB Graduates reside in approximately 100 countries worldwide. The language of instruction is English. Wikipedia.

Kearon C.,McMaster University | Akl E.A.,American University of Beirut
Blood | Year: 2014

It takes about 3 months to complete "active treatment" of venous thromboembolism (VTE), with further treatment serving to prevent new episodes of thrombosis ("pure secondary prevention"). Consequently, VTE should generally be treated for either 3 months or indefinitely (exceptions will be described in the text). The decision to stop anticoagulants at 3 months or to treat indefinitely is dominated by the long-term risk of recurrence, and secondarily influenced by the risk of bleeding and by patient preference. VTE provoked by a reversible risk factor, or a first unprovoked isolated distal (calf) deep vein thrombosis (DVT), has a low risk of recurrence and is usually treated for 3 months. VTE associated with active cancer, or a second unprovoked VTE, has a high risk of recurrence and is usually treated indefinitely. The decision to stop anticoagulants at 3 months or to treat indefinitely is more finely balanced after a first unprovoked proximal DVT or pulmonary embolism (PE). Indefinite anticoagulation is often chosen if there is a low risk of bleeding, whereas anticoagulation is usually stopped at 3 months if there is a high risk of bleeding. The decision to continue anticoagulation indefinitely after a first unprovoked proximal DVT or PE is strengthened if the patient is male, the index event was PE rather than DVT, and/or D-dimer testing is positive 1 month after stopping anticoagulant therapy. © 2014 by The American Society of Hematology.

Boustany R.-M.N.,American University of Beirut
Nature Reviews Neurology | Year: 2013

Since the discovery of the lysosome in 1955, advances have been made in understanding the key roles and functions of this organelle. The concept of lysosomal storage diseases (LSDs) - disorders characterized by aberrant, excessive storage of cellular material in lysosomes - developed following the discovery of α-glucosidase deficiency as the cause of Pompe disease in 1963. Great strides have since been made in understanding the pathobiology of LSDs and the neuronal ceroid lipofuscinoses (NCLs). The NCLs are neurodegenerative disorders that display symptoms of cognitive and motor decline, seizures, blindness, early death, and accumulation of lipofuscin in various cell types, and also show some similarities to 'classic' LSDs. Defective lysosomal storage can occur in many cell types, but the CNS and PNS are particularly vulnerable to LSDs and NCLs, being affected in two-thirds of these disorders. Most LSDs are inherited in an autosomal recessive manner, with the exception of X-linked Hunter disease, Fabry disease and Danon disease, and a variant type of adult NCL (Kuf disease). This Review provides a summary of known LSDs, and the pathways affected in these disorders. Existing therapies and barriers to development of novel and improved treatments for LSDs and NCLs are also discussed. © 2013 Macmillan Publishers Limited.

Kaafarani B.R.,American University of Beirut
Chemistry of Materials | Year: 2011

Discotic liquid crystals (DLCs) have been exploited in opto-electronic devices for their advantageous properties including long-range self-assembling, self-healing, ease of processing, solubility in a variety of organic solvents, and high charge-carrier mobilities along the stacking axis. An overview of DLCs and their charge-carrier mobilities, theoretical modeling, alignment, and device applications is addressed herein. The effects of alignment on charge-carrier properties of DLCs are discussed. Particular attention is devoted to processing techniques that achieve suitable alignment of DLCs for efficient electronic devices such as zone-casting, zone melting, Langmuir-Blodgett deposition, solution-casting on preoriented polytetrafluoroethylene (PTFE), surface treatment, IR irradiation, application of a magnetic field, use of sacrificial layers, use of blends, application of an electric field, and others. © 2010 American Chemical Society.

Saab R.,American University of Beirut
Seminars in Cancer Biology | Year: 2011

Cellular senescence is a tumor suppressor response that has been observed both in vitro and in vivo, and features of senescence have been documented in various human premalignant lesions, including melanoma, colon and lung adenoma, prostatic intraepithelial neoplasia, and others. The fact that a subset of these lesions eventually progress to malignant invasive tumors suggests that premalignant cells can either bypass or escape the senescent response. Much work has been done to understand the mechanisms underlying such progression, but it remains unclear whether tumors progress by evasion of senescence induction, or by disruption of senescence maintenance, or whether both mechanisms can occur in human cancer development. This review presents the current evidence for mechanisms of senescence evasion and reversion, and discusses what has been learnt about this process using in vitro and in vivo experimental systems. As we learn more about the key signaling effectors of senescence, the hope is that appropriate targets will be identified for preservation and/or re-induction of senescence in human tumors. Such knowledge may also find application in better estimation of risks of cancer progression in individual premalignant lesions, which will lead to more accurate allocation of appropriate treatment options for such patients. © 2011 Elsevier Ltd.

Jabr R.A.,American University of Beirut
IEEE Transactions on Power Systems | Year: 2013

Distribution network expansion planning (DNEP) aims at minimizing the capital and operational cost of the expansion plan; the plan entails choosing conductor types and line construction routes together with substation installation and reinforcement that allow serving the demand while satisfying the physical and technical constraints of the expanded network. Two findings are reported in this paper. First, DNEP can be exactly formulated as a disjunctive conic program, in two equivalent formulations; both formulations admit a tight polyhedral approximation and can be solved for the globally optimal solution using software for mixed-integer linear programming (MILP). Second, the DNEP solution can be computed more efficiently when the linear relaxations of the MILP formulations are strengthened using loop elimination constraints. Numerical results on practical DNEP problems reveal that combining the parallel equivalent-circuit polyhedral formulation with the spanning tree loop elimination constraints yields MILP planning solutions with a tight relative optimality gap and within reasonable computing time. In addition, the results are at least of the same quality if not better than those reported in the recent literature. © 2012 IEEE.

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