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Antigua, Antigua and Barbuda

The American University of Antigua College of Medicine is a for-profit private medical institution of higher education located near the capital city of St. John's in the Caribbean nation of Antigua and Barbuda. The sole program at AUA is the College of Medicine. Wikipedia.

Shah N.N.,American University of Antigua | Wilson S.,Northside Medical Center
Consultant | Year: 2016

The risk of anesthesia is unpredictable in patients with underlying hepatitis C virus (HCV) infection. No definitive diagnostic measure is available to evaluate the severity of hepatic cell damage from chronic conditions or previous trauma, infections, or toxins. Moreover, limited data exist to guide clinical decisionmaking when quantifying the severity of cirrhosis in patients with underlying HCV infection and its relationship to the choice of anesthesia. It is imperative to consider the benefits and risks associated with the use of anesthetics during elective surgery in patients with underlying HCV infection. Awareness of these medications is important in order to prevent related intraoperative and postoperative adverse events and effects. © 2016 HMP Communications.

Alperstein A.,American University of Antigua | Bhayani R.,Wyckoff Heights Medical Center
BMJ Case Reports | Year: 2014

A 45 year-old woman who presented with non-specific neck and shoulder pain, was found to have mild hypercalcaemia, markedly elevated parathyroid hormone levels, and an irregular parathyroid gland on imaging. The patient underwent a parathyroidectomy and the pathology report came back positive for parathyroid carcinoma with muscular invasion. Parathyroid carcinoma is an exceptionally rare cause of primary hyperparathyroidism and can have a poor prognosis due to metastases and a high propensity to recur after resection. Reports of non-functioning parathyroid carcinomas tend to behave even more aggressively. Repeat imaging on this patient showed residual cancer present, so the patient underwent a second surgery with radical neck dissection and has since been doing very well postoperatively. Diagnosis and treatment is challenging and it is critical to continuously follow-up for recurrent disease. Copyright 2014 BMJ Publishing Group. All rights reserved.

Rana A.Q.,Parkinsons Clinic of Eastern Toronto and Movement Disorders Center | Ahmed U.S.,Ryerson University | Chaudry Z.M.,Saba University | Vasan S.,American University of Antigua
Expert Review of Neurotherapeutics | Year: 2015

Parkinson's disease (PD) is a neurodegenerative disorder resulting from degeneration of the substantia nigra and the dopaminergic nigrostriatal pathway. Most treatments are geared toward the management and relief of motor symptoms in Parkinson's patients; however, as the disease progresses, various complications can be observed. Non-motor symptoms (NMS) may arise simply from the disease itself and are highly destructive to quality of life. These symptoms include mood disorders, cognitive dysfunction, pain, sensory dysfunction, and dysautonomia. Though it is undisputed that many NMS may appear years or even decades prior to the clinical diagnosis of PD, the focus of this review will be the overt motor phase of the condition. As such, the focus of this paper is to review the major NMS found in PD patients status post-diagnosis, their etiology, as well as treatment options available for the individual NMS. © 2015 Informa Uk, Ltd.

Rao N.,American University of Antigua | Song F.,Indiana University | Jhamb D.,Indiana University - Purdue University Indianapolis | Wang M.,Indiana University | And 8 more authors.
BMC Developmental Biology | Year: 2014

Background: To gain insight into what differences might restrict the capacity for limb regeneration in Xenopus froglets, we used High Performance Liquid Chromatography (HPLC)/double mass spectrometry to characterize protein expression during fibroblastema formation in the amputated froglet hindlimb, and compared the results to those obtained previously for blastema formation in the axolotl limb. Results: Comparison of the Xenopus fibroblastema and axolotl blastema revealed several similarities and significant differences in proteomic profiles. The most significant similarity was the strong parallel down regulation of muscle proteins and enzymes involved in carbohydrate metabolism. Regenerating Xenopus limbs differed significantly from axolotl regenerating limbs in several ways: deficiency in the inositol phosphate/diacylglycerol signaling pathway, down regulation of Wnt signaling, up regulation of extracellular matrix (ECM) proteins and proteins involved in chondrocyte differentiation, lack of expression of a key cell cycle protein, ecotropic viral integration site 5 (EVI5), that blocks mitosis in the axolotl, and the expression of several patterning proteins not seen in the axolotl that may dorsalize the fibroblastema. Conclusions: We have characterized global protein expression during fibroblastema formation after amputation of the Xenopus froglet hindlimb and identified several differences that lead to signaling deficiency, failure to retard mitosis, premature chondrocyte differentiation, and failure of dorsoventral axial asymmetry. These differences point to possible interventions to improve blastema formation and pattern formation in the froglet limb. © 2014 Rao et al.; licensee BioMed Central Ltd.

Shetty B.S.,Melaka Manipal Medical College | Pemmineti S.,American University of Antigua
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

The plant Centella asiatica is used in traditional medicine to treat a variety of disorders. The objective of this study presented in this report was to evaluate the wound healing potential of ethanolic extract of the plant in streptozotocin-induced diabetic rats. The study was carried out by using Wistar albino rats by creating excision and dead space wounds. The measured wound area of the Centella asiatica treated group was reduced significantly when compared to diabetic control animals. Significant increase in the weight of the granulation tissue and the hydroxyproline content were observed. The histological study of the healing tissue obtained from the experimental diabetic animals showed the fast lay-down of collagen when compared to the normal and diabetic control group. The fasting blood glucose values of the diabetic experimental group animals were significantly reduced when compared to the diabetic control animals. We noticed the correlation between the wound contraction rate and the blood glucose values. The results of the present study clearly demonstrate that the ethanolic extract of Centella asiatica possesses a definite prohealing action in normal healing as well as in the diabetes induced wound healing.

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