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Miyazawa K.,Miyazawa Clinic | Challem J.,American Society for Nutrition
Journal of Orthomolecular Medicine | Year: 2015

Adverse reactions to food, such as allergies or intolerances, are relatively common. Current medical practice relies primarily on testing for immunoglobulin E (IgE) reactions to identify specific food allergies. However, IgE is involved in acute allergic reactions, and it has limited usefulness f or diagnosing chronic non-acute food allergies. In contrast, immunoglobulin G (IgG) reactions take longer to develop and are not usually acute. IgG levels may increase as a consequence of intestinal permeability. For example, gliadin (found in gluten) breaks down tight junctions (TJs), which are protein complexes that line the GI tract. When TJs break down, intestinal permeability (leaky gut syndrome) increases, allowing incompletely digested proteins to enter the bloodstream and trigger an IgG-based autoimmune reaction. Not surprisingly, IgG levels are often elevated in patients with celiac disease and non-celiacgluten sensitivity. Other diseases, including mood disorders and irritable bowel syndrome, also appear related to IgG-mediatedfood reactions. While IgG testing may be controversial, it remains an important tool for identifying chronic, non-acute food allergies. Source


Ohlhorst S.D.,American Society for Nutrition
Advances in nutrition (Bethesda, Md.) | Year: 2013

Proper nutrition offers one of the most effective and least costly ways to decrease the burden of many diseases and their associated risk factors, including obesity. Nutrition research holds the key to increasing our understanding of the causes of obesity and its related comorbidities and thus holds promise to markedly influence global health and economies. After outreach to 75 thought leaders, the American Society for Nutrition (ASN) convened a Working Group to identify the nutrition research needs whose advancement will have the greatest projected impact on the future health and well-being of global populations. ASN's Nutrition Research Needs focus on the following high priority areas: 1) variability in individual responses to diet and foods; 2) healthy growth, development, and reproduction; 3) health maintenance; 4) medical management; 5) nutrition-related behaviors; and 6) food supply/environment. ASN hopes the Nutrition Research Needs will prompt collaboration among scientists across all disciplines to advance this challenging research agenda given the high potential for translation and impact on public health. Furthermore, ASN hopes the findings from the Nutrition Research Needs will stimulate the development and adoption of new and innovative strategies that can be applied toward the prevention and treatment of nutrition-related diseases. The multidisciplinary nature of nutrition research requires stakeholders with differing areas of expertise to collaborate on multifaceted approaches to establish the evidence-based nutrition guidance and policies that will lead to better health for the global population. In addition to the identified research needs, ASN also identified 5 tools that are critical to the advancement of the Nutrition Research Needs: 1) omics, 2) bioinformatics, 3) databases, 4) biomarkers, and 5) cost-effectiveness analysis. Source


Lands B.,American Society for Nutrition | Lands B.,College Park
Drug Safety | Year: 2016

Cardiovascular disease (CVD) is a preventable disease, which combines two general processes: chronic vascular inflammation and acute thrombosis. Both are amplified with positive feedback signals by n-6 eicosanoids derived from food-based n-6 highly unsaturated fatty acids (n-6 HUFA). This amplification is lessened by competing actions of n-3 HUFA. Death results from fatal interactions of the vascular wall with platelets and clotting proteins. The benefits of fish oil interventions are confounded by complex details in pharmacokinetics, pharmacodynamics, adverse events, timescale factors, topology, financial incentives and people’s sense of cause and effect. Two basic aspects of n-3 HUFA that are overlooked in CVD dynamics are saturable, hyperbolic responses of the enzymes continually supplying n-6 HUFA and hard-to-control positive feedback receptor signals by excessive n-6 HUFA–based mediators. Multiple feedback loops in inflammation and thrombosis have diverse mediators, and reducing one mediator that occurs above its rate-limiting levels may not reduce the pathophysiology. Clinicians have developed some successful interventions that decrease CVD deaths in the form of secondary prevention. However, the current high CVD prevalence in the USA remains unchanged, and successful primary prevention of CVD remains uncertain. This review weighs the available evidence to help clinicians, the biomedical community and the public put the use of fish oil supplements into a balanced perspective. © 2016 The Author(s) Source


Trademark
American Society For Nutrition | Date: 2011-05-17

Printed publications, namely, journals in the field of nutrition and nutrition research. Providing online publications in the nature of journals in the field of nutrition and nutrition research.


Asn

Trademark
American Society For Nutrition | Date: 2008-08-05

Printed publications, namely, journals, newsletters and brochures in the field of nutrition, nutrition research and society affairs. Association services, namely, promoting the interests of nutrition professionals and the field of nutrition. Educational services, namely, conducting symposia, workshops and seminars in the field of nutrition and providing online publications in the nature of journals, newsletters and brochures in the field of nutrition, nutrition research and society affairs.

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