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News Article | April 26, 2017
Site: www.chromatographytechniques.com

Suppressing production of the protein myostatin enhances muscle mass and leads to significant improvements in markers of heart and kidney health, according to a study conducted in mice. Joshua T. Butcher, PhD, a postdoctoral fellow at the Vascular Biology Center at Augusta University, will present the work at the American Physiological Society's annual meeting during the Experimental Biology 2017 meeting, to be held April 22-26 in Chicago. The researchers zeroed in on myostatin because it is known as a powerful inhibitor of skeletal muscle growth, meaning that people with more myostatin have less muscle mass and people with less myostatin have more muscle mass. Studies suggest obese people produce more myostatin, which makes it harder to exercise and harder to build muscle mass. "Given that exercise is one of the most effective interventions for obesity, this creates a cycle by which a person becomes trapped in obesity," Butcher said. Obesity is linked with a range of factors that increase the risk of heart disease and diabetes, including high blood pressure, high cholesterol, insulin resistance and kidney damage. The researchers bred four groups of mice: lean and obese mice with uninhibited myostatin production and lean and obese mice that were unable to produce myostatin. As expected, mice that were unable to produce myostatin developed markedly higher muscle mass, though the obese mice remained obese even with more muscle. The obese mice that were unable to produce myostatin showed markers of cardiovascular and metabolic health that were on par with their lean counterparts and dramatically better than obese mice with uninhibited myostatin production. "In our muscular obese mouse, despite full presentation of obesity, it appears that several of these key pathologies are prevented," Butcher said. "While much more research is needed, at this point myostatin appears to be a very promising pathway for protection against obesity-derived cardiometabolic dysfunction. "Ultimately, the goal of our research would be to create a pill that mimics the effect of exercise and protects against obesity. A pill that inhibits myostatin could also have applications for muscle wasting diseases, such as cancer, muscle dystrophy and AIDS," he added.


News Article | April 25, 2017
Site: www.sciencedaily.com

Suppressing production of the protein myostatin enhances muscle mass and leads to significant improvements in markers of heart and kidney health, according to a study conducted in mice. Joshua T. Butcher, PhD, a postdoctoral fellow at the Vascular Biology Center at Augusta University, will present the work at the American Physiological Society's annual meeting during the Experimental Biology 2017 meeting, to be held April 22-26 in Chicago. The researchers zeroed in on myostatin because it is known as a powerful inhibitor of skeletal muscle growth, meaning that people with more myostatin have less muscle mass and people with less myostatin have more muscle mass. Studies suggest obese people produce more myostatin, which makes it harder to exercise and harder to build muscle mass. "Given that exercise is one of the most effective interventions for obesity, this creates a cycle by which a person becomes trapped in obesity," Butcher said. Obesity is linked with a range of factors that increase the risk of heart disease and diabetes, including high blood pressure, high cholesterol, insulin resistance and kidney damage. The researchers bred four groups of mice: lean and obese mice with uninhibited myostatin production and lean and obese mice that were unable to produce myostatin. As expected, mice that were unable to produce myostatin developed markedly higher muscle mass, though the obese mice remained obese even with more muscle. The obese mice that were unable to produce myostatin showed markers of cardiovascular and metabolic health that were on par with their lean counterparts and dramatically better than obese mice with uninhibited myostatin production. "In our muscular obese mouse, despite full presentation of obesity, it appears that several of these key pathologies are prevented," Butcher said. "While much more research is needed, at this point myostatin appears to be a very promising pathway for protection against obesity-derived cardiometabolic dysfunction. "Ultimately, the goal of our research would be to create a pill that mimics the effect of exercise and protects against obesity. A pill that inhibits myostatin could also have applications for muscle wasting diseases, such as cancer, muscle dystrophy and AIDS," he added.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 15.00K | Year: 2013

The International Union of Physiological Sciences (IUPS) will hold the XXXVII International Congress of Physiological Sciences in Birmingham, UK, July 21-26, 2013. The American Physiological Society (APS) will administer a travel grant program offering a limited number of travel awards to qualified scientists interested in attending the IUPS Congress. The APS has conducted a travel grant program and assisted U.S. scientists engaged in physiological research and its applications to attend Congresses every four years since the IUPS Congress was held in Buenos Aires in 1959. Most recently, the APS managed a travel award program for US physiologists for the IUPS Congress in 2009 in Kyoto, Japan. Special emphasis will be given to investigators within 15 years of receiving their doctoral degree and to women and under-represented minority scientists. Travel awards resulting from this proposal will be directed to individuals working in the research areas supported by the Division of Integrative Organismal Systems. Travel awards will 1) promote widespread participation of young scientists with an emphasis on women and under-represented minorities; 2) interest new investigators and students in pursuing research designed to understand physiological processes and traits; and 3) provide opportunities for the development of collaborative interactions with scientists from the United States and those working in other countries. The scientific program for the XXXVII Congress was developed by an international program committee with representatives both from the host society, The Physiological Society, and the IUPS. The program is organized around a number of IUPS Commissions. Traditionally, the one most relevant to NSF is associated with the Commission for Comparative Physiology: Evolution, Adaptation & Environment. While the sessions associated with this Commission are most relevant, there are many others that should be of interest to comparative physiologists, providing physiological insights related to their comparative studies.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: Physiolg Mechansms&Biomechancs | Award Amount: 15.50K | Year: 2014

This award provides participant support for an American Physiological Society (APS) Intersociety Meeting on Comparative and Evolutionary physiology to be held October 5-8, 2014, in San Diego, CA. This APS Intersociety Meeting will be the sixth in a series of meetings, held every four years, on the topic of comparative and evolutionary physiology. This has been a highly successful series, attracting 400-600 attendees, with a high proportion of international, female, and junior scientists. The APS Intersociety Meeting on Comparative and Evolutionary Physiology is one of only a limited number of international meetings solely dedicated to the dissemination of recent conceptual and technological advances in this diverse and exciting area. The theme of the meeting will be Comparative Approaches to Grand Challenges in Physiology. This theme emphasizes the application of the Krogh Principle to solve major physiological questions and features the grand challenges concept articulated by the National Sciences Foundation. Examples of such challenges include evaluating the mechanistic responses of animals to changing environments, using genomes to inform physiology and vice versa, understanding the benefits (and assumptions) of animal models of human disease, and teaching integrative animal physiology to the next generation of scientists. Support from the award will: 1) fund trainee workshops on The Challenge of Teaching Physiology in a Changing Environment: Innovations and Resources and Non-Traditional Career Paths for Comparative Physiologists; and 2) promote the participation of young scientists in this Intersociety Meeting through the establishment of NSF-funded travel awards.

This meeting is anticipated to have tremendous impact on the field of comparative and evolutionary physiology and considerable influence on the development of young scientists in this area. The trainee workshops will provide valuable insights into career development and teaching methods that will ensure continued progress and vitality of this important area of physiology. Along with travel awards, this proposal will extend the reach of this meeting by (a) attracting a larger number of participants to this meeting and (b) recognizing the most meritorious research contributions by young investigators in this area. The funds will augment the APS contribution to travel and minority access awards, thereby improving support for young and minority investigators and broadening the impact of this APS Intersociety Meetings.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: TUES-Type 1 Project | Award Amount: 50.00K | Year: 2014

This incubator project is establishing the Physiology Educators Community of Practice (PECOP) which centers primarily on undergraduate education, but encompasses multiple teaching levels (K-12, grad/professional), including international and novice educators. PECOP also promotes strong participation by faculty at institutions serving underrepresented students. The American Physiological Society (APS) has developed key components to support the PECOP, including a National Science Digital Library with tools to build and support teaching and learning communities (APS Archive of Teaching Resources, www.apsarchive.org), online faculty development to promote online community involvement, and new support for a biannual conference on teaching and learning which will offer workshops and sessions for faculty from all types of institutions. The conference serves as a forum to build the PECOP structure and recruit participants, encouraging educators to interact, share resources, and collaborate on an ongoing basis. It also provides an opportunity for physiology educators to learn how to use scholarship of teaching and learning (SOTL) methodologies to improve their teaching and offers teaching professional skills training for new physiologists.

This RCN-UBE project is using Archive community tools and the teaching conference to organize and launch PECOP, a support community that provides resources, training, mentoring, and community benefits for the teaching of physiology. In the organizational stages, the project is recruiting Thought Leaders who will guide discussions at the conference and online on key topics such as curriculum development, student-centered learning, assessment, effective undergraduate research experiences, and SOTL methods. Finally, the project is providing support to promote participation in PECOP via regional and national meetings of physiology educators.

The Intellectual Merit of this initiative is the creation of an active community of practice (COP) that will increase the overall impact and effectiveness of physiology, which is among the most common undergraduate course topics worldwide. PECOP will encourage and support best teaching practices, evidence-based teaching and preparation of new educators to work with diverse students through training, resource sharing, and mentoring in live and online settings.

Broader Impacts of PECOP lie in its engagement of physiologists from diverse institutions, the support for collaborations among new and experienced educators to share educational research and best practices, and the important communication forum it provides across educational levels (undergrad-grad-professional).

This project is funded jointly by the Directorate for Biological Sciences and the Directorate of Education and Human Resources, Division of Undergraduate Education in support of efforts to address the challenges posed in Vision and Change in Undergraduate Education: A Call to Action http://visionandchange.org/finalreport/.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: CROSS-EF ACTIVITIES | Award Amount: 535.00K | Year: 2012

The American Physiological Society (APS) will address critical needs for increased diversity among physiologists conducting integrative organismal systems (IOS) biology research by building an annual cohort of underrepresented (UR) undergraduate students engaged in IOS research working with members of APS Comparative and Evolutionary Physiology Section (CEPS).

APS will build on the strengths of its existing programs to create long-term solutions to specific needs for increasing diversity in the IOS field. The APS IOSP Fellows will conduct research during the summer, present at APS conferences, gain skills through online professional development activities, and become proponents for IOS research via APS social media outlets and Physiology Understanding Week. APS expects IOSP Fellows to become active participants in the IOS professional community and will evaluate both short- and long-term impacts of the Fellowship. The project will increase the number of UR students participating in IOS-related research; develop a professional network of support among UR students and researchers; and increase understanding of, and interest in IOS careers among the target group of students.
APS will also create a resource collection on supporting students with disabilities in the research lab. The collection will be freely available via APS NSDL digital library, the Archive of Teaching Resources (www.apsarchive.org).

With diversity as a national imperative in STEM fields, this project will create and evaluate resources to improve research hosts skills in working with UR students from broad backgrounds and with diverse needs and resources for engaging UR undergraduates in research experiences, in professional socialization activities, and as advocates for science to the general public. This will provide a model for other scientific societies in identifying and addressing specific needs in their ongoing diversity efforts, which will be shared with the community at the PI meeting.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 400.00K | Year: 2012

This education project is developing, field-testing, and widely disseminating a set of teaching modules
for building graduate student skills in publication ethics to address the need to provide relevant and current knowledge of and appreciation for the facts and principles of the eight most common publication ethics issues, as well as the tools needed to integrate and apply the guidelines to actual situations using professional standards of practice. These tools are for use by higher education institutions, laboratory groups, individuals, and professional societies and incorporate proven materials and methods, as well as novel approaches. They are effective for US and international graduate students in science and engineering programs and integrate easily into Responsible Conduct of Research (RCR) training. An online Community of Practice (COP) is being designed to engage trainees and experienced scientists and engineers in ongoing discussions about scientific publishing, publication ethics, and professional standards of practice in these areas.

The American Physiological Society (APS) has extensive experience in the development and implementation of professional skills, training programs, and professional development programs in science, including for women and minorities. The collaborating societies (Society for Biological Engineers and Biomedical Engineering Society) and the Project Advisory Board include exceptionally qualified researchers, editors, and educators not only in physiology but also in engineering, research integrity, and ethics education. The outcomes are therefore expected to be broadly applicable in science and engineering across a variety of institution types including those who serve under-represented groups, especially as the materials and evaluation results are being disseminated via websites and digital libraries as well as via education journal articles and presentations and ongoing courses offered by the APS and other participating organizations.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 521.45K | Year: 2011

In this NSDL Usage Development Workshops project the American Physiological Society is transforming its existing resource repository to a dynamic platform (the Archive) supporting a community of biology educators. Participating faculty are using new Archive tools to promote discussion, sharing, and recommendations of teaching resources and strategies focusing on both how to use resources and their effectiveness in the classroom, with an eye towards forming a reflective community of practice. To organize participants, the project is creating and supporting like-minded User Groups of faculty who teach similar courses at similar institutions. Furthermore, the project is providing online faculty development workshops - Archive Scholar Online Workshops - to teach expanded skills for finding and using high quality online materials and for annotating and sharing these resources with colleagues. The strong intellectual merit of this approach is enhanced by the projects evaluation of these tools and professional development activities for their impacts on faculty skills and behaviors using a quasi-experimental design. The projects broader impacts are felt through its designation of faculty who complete these professional development activities as Archive Scholars, thus identifying a cadre of faculty leaders. In addition, the project is devoting special attention to recruiting and supporting minority faculty and faculty from historically minority institutions for both the User Groups and Archive Scholars activities.


News Article | February 16, 2017
Site: www.eurekalert.org

Join us in Chicago or register for virtual newsroom access BETHESDA, Md., Feb. 16, 2017 - World-renowned scientists will present pioneering research and discuss key issues affecting the life sciences at the 2017 Experimental Biology meeting (EB 2017), the premier annual meeting of six scientific societies in Chicago to be held April 22-26. Register for a free onsite press pass to see these speakers in person. Or, stay up to date on all the exciting research news at EB 2017 through the new EB Virtual Newsroom, your one-stop shop for press releases, meeting information and blog posts. EB 2017 will feature the latest advances in anatomy, biochemistry and molecular biology, investigative pathology, nutrition, pharmacology and physiology. This year's speaker line-up includes presentations from the following leading scientists: Want to hear these speakers and follow hundreds of other research announcements at EB 2017? Here are your next steps: Learn More about the Virtual Newsroom: Get press releases, multimedia & news tips online View the Preliminary Program: Get the latest information on planned scientific sessions & events EB sponsoring societies include the American Association of Anatomists, American Physiological Society, American Society for Biochemistry and Molecular Biology, American Society for Investigative Pathology, American Society for Nutrition and American Society for Pharmacology & Experimental Therapeutics.


News Article | March 2, 2017
Site: www.prweb.com

2017 is barely two months old, so New Year’s fitness resolutions are still mostly being honored, as people continue to watch what they eat and exercise furiously. As so often happens, however, it won’t last more than a few weeks, and that could readily lead to fat increase and weight gain. According to a study published by the American Physiological Society, researchers found that yo-yo exercising – months of regular exercise followed by a long relapse into very little, if any, exercise – is ineffective at best and seriously fat-inducing at worst. “Yo-yo exercising is as impactful on your health and weight gain as yo-yo dieting is,” Dr. Goldman said. “While intense exercise may have benefits for the heart and skin, It’s a common misconception that heavy exertion while exercising – such as cycling or running on the treadmill for 45-60 minutes – burns significantly more calories and ramps up your metabolism more than following the recommended moderate 20-25-minute routine. As a result, many people think they have a calorie deficit that allows them to maintain their weight and reduce fat even if they stop exercising for a few weeks.” Researchers found that the metabolism of participants who underwent three weeks of intense exercise adapted to the routine and began to store the participants’ extra energy in the form of fat. Accordingly, when the participants stopped exercising, their bodies quickly began the process of adipocyte hyperplasia, or they simply began growing fat cells at an alarming rate. Furthermore, research found that the type of exercise is irrelevant. “Although it shouldn’t have been, it was surprising to learn that all types of athletes doing various sports were affected the same – runners, swimmers, martial artists, cyclists, cross fitness enthusiasts, etc.,” Dr. Goldman said. “The participants all put on noticeable amounts of weight once they stopped their intense exercising. Even worse, once the participants resumed their previous routines at the same intensity levels to try and lose what they had gained, they didn’t lose as much as was expected, which leads one to wonder how much this is contributing to the rise in obesity around the country.” Dr. Goldman and others in the medical and fitness communities advocate moderate exercise on a consistent basis along with intense exercise to build muscle and improve the cardiovasculature system . Individuals enduring this type of yo-yo exercise effect do have additional options for reducing fat, including a variety of cosmetic body sculpting procedures, such as liposuction and CoolSculpting, among others. Maintaining a consistent diet and exercise routine in addition to undergoing a liposuction or body contouring procedure can help ensure long-lasting results. To learn more about body sculpting treatments that aid in reaching fat reduction goals that diet and exercise cannot, visit http://Liposuction-SanDiego.com/Stomach-Fat-Removal/. “I would caution individuals who have just started a new exercise routine for the new year to include in their exercise routine a stable form of exercise in moderation,” Dr. Goldman said. “Don’t only overdo it, as that’s a common reason for quitting – it takes too much time or it eventually gets tiresome; furthermore, don’t treat yourself to a piece of cake or an extra slice of bacon on your burger too often as a reward for hitting exercise goals. A simple, consistent regimen of walking, running, cycling, weight-training, hiking, or even doing yard work is better in the long run than on-again, off-again exercise routines.” Cosmetic Laser Dermatology is an esteemed cosmetic clinic located in beautiful San Diego, California. The team of board-certified dermatologists is committed to providing each and every patient with the highest level of care in a comfortable setting. Cosmetic Laser Dermatology’s dermatologists are all highly respected in the field for their use of innovative treatments, involvement in advanced medical research, and continued participation in clinical trials. For more information please visit http://www.CLDerm.com

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