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Raszkiewicz E.,American Laboratory
American Laboratory | Year: 2015

Standards and reagents are available to researchers with certain assurances as to composition, purity and performance. The American Chemical Society (ACS) produces methods for analytical testing that employ standards, reagents and solvents. The American Society for Testing and Materials (ASTM) also produces methods for the manufacture, quality control and analysis of processes and products using standards, reagents and chemicals. The National Institute of Standards and Technology (NIST) is the producer of primary standards in the United States and produces certified reference materials (CRMs), including standard reference materials. Source


Raszkiewicz E.,American Laboratory
American Laboratory | Year: 2015

Gas chromatography/mass spectrometry (GC/MS) is a highly selective analytical technique for identifying compounds using mass detection. The concept of utilizing a mass spectrometer as a detector with gas chromatography was realized in the 1950s by Gohlke and McLafferty. GC/MS coupling was first demonstrated by Holmes and Morrell in 1957, which used an oscilloscope and a mass spectrometer to observe the behavior of an effluent from a GC column. Some vendors provide the option of retrofitting an existing GC with a high-resolution or high-throughput TOF/MS. Markes International offers the BenchTOF TOF/MS adapter. Modern GC/MS testing benefits from improved instrument couplings, analytical software and column technology. Supelco offers a comprehensive line of ionic liquid GC columns. Ultra-inert GC/ MS columns, such as the Ultra Inert line from Agilent, respond to increasingly lowered detection limits by greatly reducing the surface activity that might impede detection sensitivity at the mass analyzer. Cryo-focusing GC/MS (cryo-GC/MS) is being utilized for complex observations, such as analyzing the degradation of molecules. The Thermo TSQ 8000 Evo-GC-MS/MS features cryo options to 100°C. me systems offer the option of different ionization methods, such as field desorption (FD), field ionization (FI), EI/FI/FD and liquid injection field desorption ionization (LIFDI). LECO and AB SCIEX have partnered to provide GC/TOF and LC/QTOF MS systems for metabolomics studies. Source


Raszkiewicz E.,American Laboratory
American Laboratory | Year: 2015

Debbie Bowers, VP of robotic operations at Hamilton Robotics, offers insight about laboratory automation trends, applications and offers a glimpse into what prospective attendees can expect at SLAS2015. According to her, the most prominent trends are downsizing instruments, increasing instrument flexibility. Users demand more dedicated platforms with integrated flexibility. Space on the laboratory bench is at a premium, so the smaller the system, the better. She feels that advances in laboratory automation have allowed scientists to accelerate their research at an incredible pace by increasing system flexibility and ease of use, providing higher-throughput experiments at a smaller scale, all with production of a more reliable, reproducible and accurate end result. Improvements and new innovations in automation have had a great impact on automated cell culture and cell-based assay systems. Contamination and production of aerosols by automated pipettors in a sterile environment is one of the biggest concerns for scientists when dealing with automated cell culture systems. Hamilton has been at the forefront of pipetting technology with the use of air-displacement pipetting using CO-RE tip attachment technology, which allows for delivery of sterile, noncontaminated liquids with no aerosol production. Source


Stevenson R.L.,American Laboratory
American Laboratory | Year: 2015

New instruments and accessories exhibited at Pittcon 2015 for analytical and laboratory-scale preparative chromatography are discussed. Dr. Yan Liu of Thermo Fisher Dionex introduced the Dionex EGC 500 K2CO3 cartridge and Dionex EPM 500 modifier for high-pressure effluent generation, which is rated for column pressure up to 5000 psi. This is compatible with columns packed with 4-?m-diameter ion exchangers. ASCO has revamped almost its entire product line with new systems for ultrahigh-performance liquid chromatography (UHPLC), Rapid Resolution HPLC, analytical SFC and preparative SFC. Malvern Instruments introduced the OMNISEC REVEAL system, which integrates a liquid chromatograph optimized for steric exclusion chromatography (SEC) with four detectors. The output of these detectors can be combined to provide a universal calibration curve for polymers. Dr. Ing. Herbert of Knauer GmbH introduced the Contichrom preparative LC, which is designed for developing bioprocessing purification methods including simulated moving bed (SMB), batch and continuous multicolumn purification schemes. The GlycoWorks RapiFluor-MS N-glycan kit from Waters runs on an ACQUITY UPLC H-Class equipped with a fluorescence and QDa MS detector. Glycans are usually conjugated to proteins as part of the post-translational modification, which activates the protein. The PRP-C18 stationary phase from Hamilton Co. promises useful efficiency and extended column lifetime. Source


Stevenson R.L.,American Laboratory
American Laboratory | Year: 2014

The clinical laboratory has been recognized as the leading model for applied analytical chemistry labs. The portable laboratory was the stated focus of this year?s meeting. Some of the drivers for the portable laboratory are: point of care (POC) analysis to improve turnaround time or to comply with the realities of resource-limited countries. Since half of the patient populations in the developed world use smartphones, new paradigms are in communication between physician, patient, payer, and public health. Others were attracted to POC technology, but with products that plug into the wall for electricity. Developers see the smartphone as an interesting platform that provides a common, well-engineered, and familiar human interface. The specific implementation depends upon purpose and available infrastructure. In the developed world, compliance with therapy is one of the weak points in the current healthcare paradigm. Physicians prescribe a therapy for a particular malady. Source

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