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Gough N.R.,American Association for the Advancement of Science
Science Signaling | Year: 2016

This Focus Issue highlights new discoveries at the level of the receptor, the a subunit, and the bg subunit and spans research in yeast on polarized growth and G protein-coupled receptor (GPCR) trafficking, in mice on an orphan GPCR with constitutive activity, and a disease-causing mutation in an a subunit that results in inappropriate GPCR-G protein coupling. Source


Ferrarelli L.K.,American Association for the Advancement of Science
Science Signaling | Year: 2013

Receptor tyrosine kinases and the signaling networks that they control contribute to cancer and resistance to therapies. Therefore, understanding these networks, how they vary within and among tumors and how they adapt to enable cancer cells to circumvent treatment, should lead to more effective therapeutic strategies in treating the diverse disease that is cancer. As Science Signaling highlights in this week's issue, systems biology and computational biology are shining light on these complex networks and enabling integration of diverse information about genetics, proteomics, and network activity to effectively predict therapeutic response and identify key components to target for intervention. Source


Gough N.R.,American Association for the Advancement of Science
Science Signaling | Year: 2012

The Wnt pathways represent key signaling networks involved in development, both in tissue specification and in cellular migration. Wnt signaling also plays key roles in tissue homeostasis in adult animals, and aberrant Wnt signaling is associated with several forms of cancer. This issue includes descriptions of a proapoptotic function for Wnt signaling in melanoma, an interplay between Wnt and bone morphogenetic proteins in tooth organogenesis, and a noncanonical role for Wnt in neuronal guidance. Source


Wong W.,American Association for the Advancement of Science
Science Signaling | Year: 2012

During the month of May, Science Signaling will publish research and commentary that use or describe the application of structural approaches to reveal the mechanisms underlying signaling molecules and events, to uncover how signaling molecules perform their biological functions or contribute to disease, and to highlight potentially fruitful avenues for drug design. Source


Wong W.,American Association for the Advancement of Science
Science Signaling | Year: 2011

Cells interpret environmental cues to extend processes in the appropriate direction, descend upon sources of inflammation or necrosis, or determine the best path to the correct position in a developing organism. This Focus Issue of Science Signaling highlights the signaling pathways and mechanisms that enable cells to sense external signals and direct their movement accordingly. © 2011 American Association for the Advancement of Science. All Rights Reserved. Source

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