Ahmadābād, India
Ahmadābād, India

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Talaviya P.A.,Pacific University at Udaipur | Vyas B.M.,AMC MET Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2014

Aims & Objective: The present study was aimed to evaluate anti-inflammatory activity of four fractions of ethanolic extract of Crotalaria burhia Buch.-Ham. root in Wistar albino rats.Materials and Methods: Anti-inflammatory activity of four fractions of ethanolic extract of Crotalaria burhia root (EtCB) was evaluated by Carrageenan induced paw edema and cotton pellets induced granuloma in rats. Animals were divided into eight groups (n=6), in which two control groups (25% DMSO and ddH2O), two groups treated with anti-inflammatory drugs (Indomethacin: 10 mg/kg and Diclofenac: 25 mg/kg of body weight) and four fractions treated groups [Hexane (300 mg/kg of bodyweight in 25% DMSO), chloroform (300 mg/kg body weight in 25% DMSO), ethyl acetate (300 mg/kg body weight in 25% DMSO) and aqueous (300 mg/kg of bodyweight in ddH2O)] were treated with oral intubations. Acute anti-inflammatory response was evaluated by measuring paw volume at different time intervals after treatment of test and standard drug. Chronic anti-inflammatory response was evaluated after administration of test and standard treatment for seven consecutive days. On day eighth, four sterile cotton pellets (50 mg) were implanted subcutaneously in the dorsal region of the rats. On the day 16th, the rats were sacrificed and the cotton pellets with granulomatous tissue were taken out, fresh and dry pellets were weighed. Liver tissues was also excised and stored in 0.9% saline at - 20 ◦C for biochemical analysis.Results: In acute and chronic anti-inflammatory activity hexane (HF), chloroform (CF), ethyl acetate (EAF) and aqueous (AF) of EtCB were shown significant (p<0.05 & p<0.01) anti-inflammatory activity when compared to respective control group. However, AF had shown negligible anti-inflammatory activity. Interestingly, EAF was founded more effective than HF and CF in this paradigm. Acute and chronic anti-inflammatory activity of fractions was comparable with positive standard.Conclusion: The results of present study revealed promising anti-inflammatory and antioxidant activity of EAF. Thus, results indicate that the superiority in anti-inflammatory activity of EAF was largely due to its ability to modulate In vivo antioxidant parameters. The results presented here are the first pharmacological studies of EAF of EtCB as anti-inflammatory and antioxidant.Background: Roots of medicinal plants are common ingredients in many folk and herbal medicines system to treat inflammation. The detailed study on C. burhia root was lacking to support their anti-inflammatory potential. Henceforth, present investigation was carried out to establish scientific basis for the traditional uses of Crotalaria buriha root as anti-inflammatory agent. © 2014, Mrs Deepika Charan. All rights reserved.


Shah V.,GCS Medical College | Vyas S.,AMC MET Medical College | Singh A.,Smt NHL Municipal Medical College | Shrivastava M.,Smt NHL Municipal Medical College
ecancermedicalscience | Year: 2012

Background: Carcinoma of the cervix is the second most common cancer in women worldwide, while it is the commonest cancer among Indian women. Awareness regarding cervical cancer and its prevention is quite low amongst Indian women. The Pap test is a simple and cost effective technique for early diagnosis of cervical cancer. It is necessary to make nursing staff aware of cervical cancer, so that they can impart knowledge regarding cervical cancer and its prevention to the general public. Aims and objectives: (1) To assess the knowledge level regarding symptoms, risk factors, prevention and screening of cervical carcinoma among nursing staff. (2) To find out the behaviour of respondents regarding prevention and screening of cervical carcinoma. Materials and methods: A cross-sectional interview-based survey regarding knowledge levels about cervical carcinoma was conducted among the nursing staff from one of the tertiary health institutes of Ahmedabad, India. A structured questionnaire with multiple choices was used for data collection. Provision for open-ended responses was also made in the questionnaire. Department-wise stratification was carried out, and thereafter 15% of the total nursing staff from all departments were selected randomly so as to include a total of 100 nurses in the current study. Data entry was done in Microsoft Excel. SPSS statistical software was used to generate statistical parameters like proportion, mean, standard deviation, etc. The Z test was used as a test of significance, and a P value of <0.05 was considered as the level of significance. © the authors.


Patel D.S.,AMC MET Medical College | Zariwala R.C.,AMC MET Medical College | Trivedi B.D.,Smt Nhl Municipal Medical College
Medico-Legal Update | Year: 2014

The carotid body is a small mass of tissue inside the carotid bifurcation that reacts to the body’s level of oxygen. In humans being the carotid sinus is a slight dilatation of the upper part of the common carotid and the adjacent part of the internal carotid artery. The carotid body is a small gland like structure placed on the deep surface of the carotid bifurcation; it may see twisting the arteries round and cleaning between them1. Carotid body tumors usually are painless and slow growing; they may cause a compression syndrome those results in symptoms such as dysphagia. © 2014, World Informations Syndicate, All Rights Reserved.


Patel D.S.,AMC MET Medical College | Zariwala R.C.,AMC MET Medical College | Trivedi B.D.,Smt Nhl Municipal Medical College
Medico-Legal Update | Year: 2014

Skin allografts were first used at the end of the last century by Girdner. However, routine storage of human tissue developed only in the 1930s to 1940s when reliable preservation methods became available. The first proper skin bank was the US Navy Skin Bank, set up in 1949. Several skin banks were subsequently established and in most cases they were organized as multitissue banks. Small amounts of excess auto graft are commonly harvested during burn procedures, and typically these are discarded. However, the resources of a local skin bank may be used to preserve this tissue for a later autologous use. © 2014, World Informations Syndicate, All Rights Reserved.


Prajapati T.,AMC MET Medical College | Prajapati K.,AMC MET Medical College | Tandon R.N.,Bj Medical College | Merchant S.,AMC MET Medical College
Journal of Indian Academy of Forensic Medicine | Year: 2013

The present study is a prospective study of poisoning cases (excluding animal bites) brought to the Civil Hospital Ahmadabad, from 1st October 2006 to 30th September 2007. Total 366 cases of acute poisoning were recorded over a period of one year. Of these 70.8% were males and 29.2% female. The majority (45.08%) cases were from age group of 21-30 years.71.6% cases were from rural area. Commonest type of poison was pesticide in 33.9% cases, followed by household chemicals 26.8%, in 74.6% cases cause of poisoning was intentional. Fatality in pesticide poisoning was 25.8%. Our data supports the other study from India regarding Age and Sex distribution. However, compared to data reported from poison information centre, NIOH, Ahmedabad, Household chemicals were encountered as the 2nd most common cause of poisoning. Of these Acid Ingestion accounted for 55.10% cases of household chemical cases. The prevention and treatment of poisoning due to pesticide and household poisoning should merit high priority and need for identifying unknown substance in the health care of Gujarat population.


Zariwala R.C.,AMC MET Medical College | Patel D.S.,AMC MET Medical College
Medico-Legal Update | Year: 2011

Human Anatomy is the branch of science which studies the structure of human body by dissecting so as to understand the structural parts. Cadaver dissection forms the basic Of understanding human body in the field of medicine, dentistry and all paramedical sciences.


Vyas F.I.,AMC MET Medical College | Prakash S.,AMC MET Medical College | Singh A.J.,AMC MET Medical College
Indian Journal of Pharmacology | Year: 2010

Aim: The study was designed to establish relationship between the plasma concentration and QTc interval prolonging effect of fexofenadine and demonstrate the phenomenon of anticlockwise hysteresis. Materials and Methods: Six subjects were given fexofenadine 60 mg tablet orally under stable conditions, and their drug concentrations were measured at regular intervals. At predetermined time, their ECGs were recorded. Data were analyzed and plotted graphically. Design and Setting: Randomized parallel design, single group study conducted at clinical research organization of Ahmadabad. Results: In all subjects time taken for maximum plasma concentration of fexofenadine (T max ) was around 3 h and the value of average maximum plasma concentration was 460.63 ng/mL, the effect of fexofenadine on the heart (measured as QTc interval prolongation) was maximum (E max ) after 6 h and average QTc interval was 469.75 ms. Thus, the time to maximum concentration of fexofenadine did not match with the maximum effect on the heart as measured by QTc interval. Conclusion: The relationship between the drug concentration and drug effect on the heart are at two different time scales. It can be understood by two-compartment model of pharmacokinetics, and this retardation or lagging of an effect behind the concentration is known as hysteresis. The increase of QTc was not beyond 500 ms and not sustained, demonstrating overall cardiac safety of fexofenadine.


Upasani V.V.,University of California at San Diego | Bomar J.D.,Rady Childrens Hospital | Parikh G.,AMC MET Medical College | Hosalkar H.,Rady Childrens Hospital
Journal of Children's Orthopaedics | Year: 2012

Introduction: Few studies have evaluated the reliability and reproducibility of the femoral neck-shaft angle (NSA), center-edge angle (CEA), and acetabular index (AI) in young children with developmental dysplasia of the hip (DDH). We wanted to determine whether these parameters could be used reliably by practitioners. Methods: Fifty radiographs from 21 children with DDH were reviewed. Analysis was performed by three observers, at two time periods. The intra- and inter-observer reliability for each measure was assessed. Results: At time period one, we noted a "high" level of agreement between observers when measuring the NSA, a "low" level when measuring the CEA, and a "moderate" level when measuring the AI. At time period two, we noted a "very high" level of agreement between observers when measuring the NSA and a "high" level when measuring the CEA and AI. When comparing the measurements of observer 1 at the two different time periods, we noted nearly "very high" agreement when measuring the NSA, a "moderate" agreement when measuring the CEA, and a "high" agreement for the AI. In comparing the measurements of observer 2, we noted "very high" agreement for the NSA and "high" agreement for the CEA and AI. In comparing the measurements for observer 3, we noted nearly "very high" agreement for the NSA, nearly "high" agreement for the CEA, and "high" agreement for the AI. Conclusion: It is difficult to reliably measure three-dimensional pelvic morphology on a frontal plane radiograph, especially when important pelvic landmarks have yet to ossify. © 2012 EPOS.


Bhatt G.,AMC MET Medical College | Vyas S.,AMC MET Medical College | Trivedi K.,Gautam Adani Institute of Medical science
Indian Journal of Tuberculosis | Year: 2012

The emergence of resistance to anti-tuberculosis drugs in general and Multi Drug Resistan Tuberculosis (MDR-TB) in particular, has become a significant public health problem and an obstacle to effective TB control. Baseline and adequate information on epidemiological factors and their interaction are prerequisites for its effective control. Objectives'. To study socio-demographic profile, housing environment, health-seeking behaviour, present and past history regarding treatment of tuberculosis, drug resistance pattern and the preventive practice adopted by the patients. Methodology: A cross-sectional study was carried out on 81 MDR-TB patients registered under RNTCP of Ahmedabad city during July 2007-June 2008. To accomplish the objectives, information was collected by personal interviews using pre-designed, pre-tested proforma. Data, so collected, was analyzed and tabulated using appropriate statistical software. Results: More than 2/3 rd1 were males and majority were in age group 16-45 years, educated up to primary level, living in overcrowded and ill-ventilated houses. Initially almost all had pulmonary TB. At the start of category II, maximum number of patients were defaulters, the prime cause being financial crunch. The mean number of Anti Tubercular Treatment (ATT) taken before start of category IV was 2.85. More than 90% experienced side-effects of drugs. Although indiscriminate spitting was less, other methods of sputum disposal were also unsafe. Resistance to all four drugs (H, R, S & E) was found in more than 2/3 rd1 of cases. Smear and culture conversion rate at three month follow up was 62.0% and 58.7% respectively. Only one patient (1.2%) was reactive for HIV in the study. Most of the patients perceived some degree of improvement in their condition following treatment. Conclusion: Most of the MDR cases were living in poor envirmental conditions, had previous history of TB and defaulter of treatment regimen prescribed. Motivation of private practitioners for increasing referrals, use of incentives and enablers, enhancing contact tracing and increasing awareness regarding sputum disposal practices and measures to prevent the spread are necessary for effective control of tuberculosis.


PubMed | AMC MET Medical College
Type: Journal Article | Journal: Malaysian orthopaedic journal | Year: 2014

The aim of the study was to evaluate results of closed intramedullary nailing using Talwarkar square nails in adult forearm fractures. We prospectively evaluated 34 patients with both bone forearm fractures. The average time to union was 12.8 (SD +3.2) weeks with cast support for a mean of 8.2 weeks. Union was achieved in 31 out of 34 patients. Using the Grace and Eversmann rating system, 17 patients were excellent, 10 were good, and 4 had an acceptable result. Three patients had non-unions, 2 for the radius and one for the ulna. There were two cases of superficial infection, one subject had olecranon bursitis, and one case of radio-ulnar synostosis. Complication rates associated with the use of square nails were lower compared to plate osteosynthesis and locked intramedullary nails. To control rotation postoperatively, there is a need for application of an above-elbow cast after nailing.Adult radius-ulna fractures, square nail, closed intramedullary nailing, radius-ulna nailing.

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