Journal of Pharmacology and Pharmacotherapeutics
The rapidly increasing prevalence of diabetes on a global scale beseeches an urgent need for newer and better treatment options. Our better understanding of the pathophysiology of diabetes has enabled a continual churn out of newer antidiabetic agents with varying modes of action. Sodium-Glucose Transport Proteins-2 inhibitors, dipeptidyl peptidase IV inhibitors, glucagon-like peptide analogues, glucokinase activators, dual peroxisome proliferator-activated receptor agonists, monoclonal antibodies, and dopamine-2 receptor agonists either as monotherapy or combination therapy with the existing oral hypoglycemic agents compound our fight against diabetes. A review of the newer drugs targeting various aspects in the management of diabetes ispresented. Source
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One of the most recent semiconductor fabrication facilities added to Texas Instruments’ lineup of 12 worldwide wafer fabs is located in Richardson, Texas. Aptly named RFAB for short, the fab’s list of industry firsts and achievements in next-generation cleanroom design are much longer. RFAB is the world’s first LEED-Certified semiconductor manufacturing facility, featuring several designed-in technologies that allow for more sustainable cleanroom operation and low cost environmental control. The fab’s features include: • Well-insulated and airtight construction to maximize energy efficiency at the building envelope; • High-efficiency fan filter units (FFUs) to recirculate and remove particles from the cleanroom air stream; • Run-around coils on the make-up air systems, which allow more efficient use of heat exchange systems to minimize the reheating requirement when dehumidifying outdoor air; • Extensive use of larger and straighter pipe and ductwork to reduce inherent pressure loss/restriction, thereby enabling installation of smaller, lower cost, more efficient pumps and fans; and These eliminate the need for lift stations and reduce potential impact from airborne molecular contamination (AMC). The inception of RFAB and construction of the LEED-Certified semiconductor manufacturing facility began in 2004. Not only was focus on sustainability paramount, the design team was tasked with building a factory at 30 percent lower cost than a similar 300mm wafer fab located just six miles away. Though construction was Cooling is just one challenge posed by the tropical, oceanfront climate. Located in a hurricane zone, the college is vulnerable to both high winds and flooding. A one-button shutdown feature lets the college remotely initiate shutdown of the building’s mechanical and electrical systems in severe weather. Building systems are flexibly designed to enable future addition of a rooftop photovoltaic system. The building’s lobby features sliding glass walls that enable its transformation to an open-air space. Large, low-velocity ceiling fans maintain occupant comfort when the lobby walls are open and reduce stratification when the space is closed. Other elements contributing to the building’s anticipated Gold LEED rating are a variable-air-velocity exhaust system that reduces laboratory and fume-hood exhaust rates when labs are unoccupied, dual-pane insulated-glass windows with horizontal exterior-mounted sunshades, sensors that calibrate interior lighting to ambient daylight, and a “building dashboard” system that lets building occupants see energy consumption levels in each room. Louis, is a LEED Fellow and leader in the science and technology and sustainability practices. Punit brings extensive experience in the integration of systems, spaces and experiences for higher education and federal clients. Having designed over 24 LEED projects in the life sciences, engineering and physical sciences, he is responsible for generating innovative solutions in regenerative and net zero design for complex scientific facilities at a campus and building scale. Punit serves on the national board of the International Institute for Sustainable Laboratories and the advisory board of the Scientific Equipment and Furniture Association (SEFA). Science is always on display in and around the center. Eckerd regards its surroundings as a living, breathing classroom and a laboratory for conservation and sustainable practices.
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"I’m Swedish. Sweden is known for its melancholia." Director Johan Renck finds life in the shadows. His moody sensibility has found its way into fashion commercials, music videos, television, and film with such clients as Armani, David Bowie, and Breaking Bad. He’s now applied that tone to The Last Panthers, a trans-European crime drama inspired by the international ring of jewel thieves known as the Pink Panthers, their conspiratorial alliance with the banking industry, and the forces that try to stop them. The six-part series—created by Jack Thorne and starring Samantha Morton, John Burt, and Tahar Rahim—premieres tonight on SundanceTV. "I’m drawn to the dark but not the nihilistic aspects, the relentless parts, of darkness," says Renck. "For me, it’s about beauty. In order for something to be beautiful, it has to have a dark element, or else it’s just pretty." "It’s about finding layers below the surface, character weaknesses, and flaws," he adds. "That’s when the darkness starts to come out." The Last Panthers was shot like a movie, over 120 days, and then constructed into six parts, with the late David Bowie providing opening music. "Blackstar," the first single from Bowie’s final album of the same name, was originally written as the theme song for the series. Renck also directed the music videos for both "Blackstar" and "Lazarus." "What you love about him is his craft," says Charlie Collier, president of AMC and SundanceTV. Beyond Breaking Bad, Renck has also directed AMC shows The Walking Dead and Halt and Catch Fire. "Those shows are quite diverse and require a range of skill, understanding, and discipline. I was surprised to hear him say that he’s directed in languages he doesn’t speak. But I think that shows how intuitive he is about the human condition." Renck grew up in a family of doctors and artists, and has crafted a career blending innate technical and intuitive talents. His father, an anesthesiology professor, shuttled his family through homes around Europe, Kuwait, and Miami. Much of this background informed his directing style. "I developed a huge curiosity and cultural awareness from that experience," says Renck. "All creation requires a scientific brain. In filmmaking, the director is literally doing a dozen jobs at once—psychologist, parent, photographer, storyteller, technician—I wouldn’t be able to figure out how to do a great shot if I didn’t have the knowledge of how one would go about doing that [on a technical level]." "One of the things I love about my job is the cornucopia of different professions in one," he adds. "You have to understand the technique to understand the art. To say, 'This light is beautiful. How can I enhance it?’" Renck’s first love was photography, which he’s honed from childhood and still posts on Instagram, before turning to music as Stakka Bo, scoring a hit European dance single "Here We Go" in the mid-'90s. To save money, he leveraged his photography skills to making the band’s videos. "I started doing them for friends, and found out I loved that more than the music," he says. "Then Madonna called . . . " That was in 1998 to do the video for "Nothing Really Matters," which lead to commercial work for Nike, Armani, and Fendi. "I was immediately in the hot zone, so I decided to use advertising and music videos as film school, because I wanted to do drama." His work on the 2006 film Downloading Nancy got him to the Sundance Film Festival and attention of Breaking Bad creator Vince Gilligan, who tapped Renck for three of its seasons, opening the door to his TV directing career. His photography still informs his cinematic work. "I’m not concerned with who the DP is, because I’m so in control of the photographic aspect of the film," he says. "I construct the shots and decide on where the light is going to be." Next up, he'll direct the Hulu series Shut Eye, about storefront psychics. "My parents said, 'Make sure you find something you can do that you can be passionate about,'" he says. "Everything I’ve done has been intuitive. I went for things that interested me, not for the glory or the riches. I looked for the process [that] I could submerge myself in and thrive."
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« Fraunhofer characterizes Alphabet Energy thermoelectric PowerCard; up to 5% fuel economy improvement in automotive | Main | BESC study finds unconventional bacteria could boost efficiency of cellulosic biofuel production » Sales of new passenger cars and LCVs in Russia decreased by 457% in December 2015, with a 35.7% drop for the entire year, according to figures released by The Automobile Manufacturers Committee of the Association of European Businesses (AEB) in Russia. The Association of European Businesses is an independent non-commercial organization representing and promoting the interests of European companies conducting business in and with the Russian Federation. In December 2015, sales of new cars and light commercial vehicles in Russia decreased by 123,682 units to 146,963 cars, according to AEB AMC. For the full year, new car and LCV sales declined by 890,187 units to 1,601,126. Expectations for the new year are muted. AEB member forecast for the total market in 2016 is to reach 1.53 million units, assuming no major change in government support to the automotive sector. Under this condition, it appears possible to limit further volume erosion to a level of under 5% year-on-year. This would be some progress in view of the dramatic losses in the recent past, bearing in mind however that it remains uncertain when the market will finally stabilize and return to much needed growth.
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Technology advances have made it easier than ever to install and monitor drilling platforms hundreds of miles out into the sea or deep into isolated parts of our planet. But it’s that very connectedness that makes these facilities so vulnerable to attack. Enter SecureNOK, a Norway-born and Houston-bred energy cybersecurity startup, which says its software can detect and defuse malware before it can wreak havoc. And it’s now signed a four-year contract with Houston-based National Oilwell Varco, NOV, one of the world’s largest oil and gas equipment suppliers. Starting in April, SecureNOK will deploy its software to Varco’s land rigs with an eye toward expanding offshore at some point. “The software rests inside the equipment’s controller where it can see what happens inside the machine,” says Siv Houmb, SecureNOK’s founder. “It’s able to distinguish what’s normal and what’s potentially malicious.” Terms of the contract were not disclosed but the companies will announce the partnership Friday at a Houston reception hosted by Innovation Norway. Kirk Coburn, founder and managing director of cleantech accelerator Surge, says he’s not surprised NOV—with operations in 1,160 locations worldwide—would be keen to bring in SecureNOK’s software. “SecureNOK designed its solution from day one for oil and gas,” he says. “This is not a solution that was developed for multiple industries or a different one and then later applied.” Houmb, who teaches cyber-security at Gjøvik University College in Norway, was one of Surge’s entrepreneurs last year, and she has since then opened an office in Houston. In recent years, energy companies have been a particular target of cyberattacks. Oil and gas producers were hit by more targeted malware attacks in a six-month period in 2012 than any other industry, according to a 2013 report by the Council on Foreign Relations. Malware called “Shamoon” attacked Saudi Aramco in 2012, disabling about 30,000 computers at the state-owned oil company, which is OPEC’s biggest crude exporter. Stuxnet, which is believed to have been created by the United States and Israel to attack Iran’s nuclear program, ended up also affecting uninvolved companies such as Chevron. The number of these attacks will only grow, Houmb says. Her company has developed … Next Page » Angela Shah is the editor of Xconomy Texas. She can be reached at email@example.com or (214) 793-5763. Follow @angelashah