Petah Tikva, Israel
Petah Tikva, Israel

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Goldberg-Stern H.,Epilepsy Center | Goldberg-Stern H.,Tel Aviv University | Cohen R.,Epilepsy Center | Cohen R.,Tel Aviv University | And 9 more authors.
Seizure | Year: 2011

The aim of the study was to evaluate changes in electroencephalogram (EEG) recordings during the course of acute lymphoblastic leukemia (ALL) in children. The study group consisted of 48 children with ALL who underwent a total of 72 EEGs at various stages of the disease. The medical files were reviewed for pertinent clinical data, and the EEGs were evaluated for changes in brain activity. Abnormal background activity was noted in 52.2% of the EEGs done at 1-10 days of therapy, in 43.5% of those done at 10-60 days, and only 4.3% of those done at later stages (p = 0.037). These findings, together with earlier reports, suggest that early-stage ALL, even before treatment, may be associated with excessive slow EEG activity, which improves over time. The EEG changes, by themselves, are not an indication of central nervous system leukemia or a predictor of later seizures or other central nervous system involvement. © 2011 British Epilepsy Association.

Eidlitz-Markus T.,Ambulatory Day Care Center | Kivity S.,Pediatric Epilepsy Unit and EEG Laboratory | Kivity S.,Tel Aviv University | Goldberg-Stern H.,Pediatric Epilepsy Unit and EEG Laboratory | And 3 more authors.
Journal of Child Neurology | Year: 2012

This study evaluated possible long-term effects of prolonged high-dose glucocorticosteroid administration in infancy. Thirty patients (16 male, 14 female; age 4.8-33 years) who had completed treatment with adrenocorticotropic hormone (ACTH) followed by glucocorticoids for infantile spasms at a tertiary pediatric hospital at least 2 years previously were invited to undergo quantitative bone ultrasound. The mean speed of sound Z score was-1.085±1.079 for the radius and-0.22±1.19 for the tibia on the nondominant side (P =.0022). The difference from the reference mean (0) was statistically significant for the radius (P <.001). There were no significant differences in radial or tibial mean speed of sound Z scores by age (prepubertal versus pubertal/postpubertal). In conclusion, a high percentage of patients treated with glucocorticoids for infantile spasms have a low radial speed of sound Z score later in life. Long-term follow-up can help to prevent and treat impairments in bone density, especially in non- weight-bearing organs. © 2012 The Author(s).

Eidlitz-Markus T.,Ambulatory Day Care Center | Haimi-Cohen Y.,Ambulatory Day Care Center | Steier D.,Ambulatory Day Care Center | Zeharia A.,Ambulatory Day Care Center
Headache | Year: 2010

Objective.-To evaluate the effectiveness of nonpharmacologic treatment for migraine in children younger than age 6 years. Background.-The mean age of onset of migraine in children is 7.2 years for boys and 10.9 years for girls. Treatment consists of individually tailored pharmacologic and nonpharmacologic interventions. However, data on migraine management in preschoolers are very sparse. Methods.-Demographic, clinical, and outcome data were collected from the files of patients with migraine who attended a pediatric headache clinic. Only those treated by nonpharmacologic measures, namely, good sleep hygiene, diet free of food additives, and limited sun exposure, were included. Clinical factors and response to treatment were compared between children younger than 6 years and older children. Results.-Of the 92 children identified, 32 were younger than 6 years and 60 were older. There was no difference between the age groups in most of the demographic and clinical parameters. The younger group was characterized by a significantly lower frequency of migraine attacks and shorter disease duration (in months). Mean age of the patients with no response to treatment (grade 1) was 10.588 ± 3.254 years; partial response (grade 2), 9.11 ± 4.6 years; and complete response (grade 3), 8.11 ± 3.93 years (P =.02). The percentage of patients with complete to partial response as opposed to no response was significantly higher in the younger group (P =.00075). Conclusion.-As the primary option, conservative therapy for migraine appears to be more effective in children younger than 6 years than in older children, perhaps because of their shorter duration of disease until treatment and lower frequency of attacks. © 2009 American Headache Society.

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