Runcorn, United Kingdom
Runcorn, United Kingdom
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Cement-based photocatalytic composition, which comprises: (a) at least one cement binder; (b) at least one photocatalyst; (c) at least one cellulose ether; (d) at least one fluidizing agent; (e) at least one first calcareous filler in the form of particles of which at least 95% by weight has a size not greater than 100 m; (f) at least one second calcareous filler in the form of particles of which at least 95% by weight has a size not greater than 30 m; (g) at least one silane supported on an inorganic support in the form of powder. Such composition can be employed as a water paint for obtaining wall coatings with very low thickness, in particular the outdoor applications, which ensure a high and stable photocatalytic effect over time even with relatively low quantities of photocatalyst, generally lower than 10% by weight, with optimal results in terms of uniformity of the coating and resistance of the same to weathering agents.


Cement-based photocatalytic composition, which comprises: (a) at least one cement binder; (b) at least one photocatalyst; (c) at least one cellulose ether; (d) at least one fluidizing agent; (e) at least one first calcareous filler in the form of particles of which at least 95% by weight has a size not greater than 100 ; (f) at least one second calcareous filler in the form of particles of which at least 95% by weight has a size not greater than 30 ; (g) at least one silane supported on an inorganic support in the form of powder. Such composition can be employed as a water paint for obtaining wall coatings with very low thickness, in particular for outdoor applications, which ensure a high and stable photocatalytic effect over time even with relatively low quantities of photocatalyst, generally lower than 10% by weight, with optimal results in terms of uniformity of the coating and resistance of the same to weathering agents.


Grant
Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.


Grant
Agency: European Commission | Branch: H2020 | Program: ECSEL-IA | Phase: ECSEL-17-2015 | Award Amount: 64.82M | Year: 2016

ENABLE-S3 will pave the way for accelerated application of highly automated and autonomous systems in the mobility domains automotive, aerospace, rail and maritime as well as in the health care domain. Virtual testing, verification and coverage-oriented test selection methods will enable validation with reasonable efforts. The resulting validation framework will ensure Europeans Industry competitiveness in the global race of automated systems with an expected market potential of 60B in 2025. Project results will be used to propose standardized validation procedures for highly automated systems (ACPS). The technical objectives addressed are: 1. Provision of a test and validation framework that proves the functionality, safety and security of ACPS with at least 50% less test effort than required in classical testing. 2. Promotion of a new technique for testing of automated systems with physical sensor signal stimuli generators, which will be demonstrated for at least 3 physical stimuli generators. 3. Raising significantly the level of dependability of automated systems due to provision of a holistic test and validation platform and systematic coverage measures, which will reduce the probability of malfunction behavior of automated systems to 10E-9/h. 4. Provision of a validation environment for rapid re-qualification, which will allow reuse of validation scenarios in at least 3 development stages. 5. Establish open standards to speed up the adoption of the new validation tools and methods for ACPS. 6. Enabling safe, secure and functional ACPS across domains. 7. Creation of an eco-system for the validation and verification of automated systems in the European industry. ENABLE-S3 is strongly industry-driven. Realistic and relevant industrial use-cases from smart mobility and smart health will define the requirements to be addressed and assess the benefits of the technological progress.


Theta-gamma network oscillations are thought to represent key reference signals for information processing in neuronal ensembles, but the underlying synaptic mechanisms remain unclear. To address this question, we performed whole-cell (WC) patch-clamp recordings from mature hippocampal granule cells (GCs) invivo in the dentate gyrus of anesthetized and awake rats. GCs invivo fired action potentials at low frequency, consistent with sparse coding in the dentate gyrus. GCs were exposed to barrages of fast AMPAR-mediated excitatory postsynaptic currents (EPSCs), primarily relayed from the entorhinal cortex, and inhibitory postsynaptic currents (IPSCs), presumably generated by local interneurons. EPSCs exhibited coherence with the field potential predominantly in the theta frequency band, whereas IPSCs showed coherence primarily in the gamma range. Action potentials in GCs were phase locked to network oscillations. Thus, theta-gamma-modulated synaptic currents may provide a framework for sparse temporal coding of information in the dentate gyrus. © 2014 The Authors.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: FoF-09-2015 | Award Amount: 8.87M | Year: 2015

HORSE aims to bring a leap forward in the manufacturing industry proposing a new flexible model of smart factory involving collaboration of humans, robots, AGVs (Autonomous Guided Vehicles) and machinery to realize industrial tasks in an efficient manner. HORSE proposes to foster technology deployment towards SMEs by developing a methodological and technical framework for easy adaptation of robotic solutions and by setting up infrastructures and environments that will act as clustering points for selected application areas in manufacturing and for product life cycle management (production and/or maintenance and/or product end of life). The main strategy builds on existing technology and research results in robotics and smart factories and integrates them in a coherent framework. The suitability of the resulting framework is not only driven by but will be validated with end-users - manufacturing companies- in two steps: In the first, the joint iterative development of the framework together with selected end-users will take place (Pilot Experiments). In the second, its suitability and transferability to further applications will be validated with new end users, which are recruited by an Open Call mechanism. The novel approaches of HORSE are the integration of concepts such as (physical) human-robot interaction, intuitive human-machine interfaces, and interaction between different robots and machines into an integrated environment with pre-existing machines and workflows. Safety of the human worker as well as reduction of health risks through physical support by the robotized equipment will contribute to better overall manufacturing processes. In these, pre-defined workflows to be customized are the basis for servitisation, for the entire value chain that allow rapid reconfiguration of the robots based collaborative production processes. HORSE aims to foster advanced manufacturing technology deployment by industries and especially SMEs.


Grant
Agency: European Commission | Branch: H2020 | Program: ECSEL-RIA | Phase: ECSEL-01-2014 | Award Amount: 8.66M | Year: 2015

Todays driver assistance systems offer comfort and safety in sound environmental conditions. However, in harsh environment conditions when needed most systems stop working due to reduced sensor information quality. Targeting to the area of highly automated driving the improvement of perception, decision and planning under adverse conditions is one of the main challenges to be addressed. RobustSENSE is a project aiming at automated and safe mobility. Its goal is making systems able to cope with real world requirements under all environmental conditions. The RobustSENSE system introduces reliable, secure and trustable sensors and software by implementing self-diagnosis, adaptation and robustness. By managing diversity, complexity and safety it increases yield, robustness and reliability. RobustSENSE develops metrics to measures sensor system reliability on every level of assistance and automation systems as well as investigate approaches to improve the system. RobustSENSE thus aims at enhancing the robustness of all sensing methods and algorithms required for advanced driver assistance systems and automated driving. RobustSENSE moves from a platform consisting of several independent subsystems to a holistic approach. RobustSENSE introduces both, reliability measures and self monitoring across all levels of the system allowing two things: 1) Taking appropriate actions and algorithms on the respective system level to react on performance reduction caused by technical failure or changing environment conditions and 2) propagating reliability measures to a higher system level for decision making and taking appropriate actions therein. Thus, the area of operation of highly automated driving functions is permanently adapted to the present available performance of the perception and decision making system in order to guarantee a safe driving status at any time.


Epithelial spreading is a common and fundamental aspect of various developmental and disease-related processes such as epithelial closure and wound healing. A key challenge for epithelial tissues undergoing spreading is to increase their surface area without disrupting epithelial integrity. Here we show that orienting cell divisions by tension constitutes an efficient mechanism by which the enveloping cell layer (EVL) releases anisotropic tension while undergoing spreading during zebrafish epiboly. The control of EVL cell-division orientation by tension involves cell elongation and requires myosin II activity to align the mitotic spindle with the main tension axis. We also found that in the absence of tension-oriented cell divisions and in the presence of increased tissue tension, EVL cells undergo ectopic fusions, suggesting that the reduction of tension anisotropy by oriented cell divisions is required to prevent EVL cells from fusing. We conclude that cell-division orientation by tension constitutes a key mechanism for limiting tension anisotropy and thus promoting tissue spreading during EVL epiboly.


Vyleta N.P.,AM Technology | Jonas P.,AM Technology
Science | Year: 2014

The distance between Ca2+ channels and release sensors determines the speed and efficacy of synaptic transmission. Tight " nanodomain" channel-sensor coupling initiates transmitter release at synapses in the mature brain, whereas loose "microdomain " coupling appears restricted to early developmental stages. To probe the coupling configuration at a plastic synapse in the mature central nervous system, we performed paired recordings between mossy fiber terminals and CA3 pyramidal neurons in rat hippocampus. Millimolar concentrations of both the fast Ca 2+ chelator BAPTA [1,2-bis(2-aminophenoxy)ethane- N,N, N′,N′-tetraacetic acid] and the slow chelator EGTA efficiently suppressed transmitter release, indicating loose coupling between Ca 2+ channels and release sensors. Loose coupling enabled the control of initial release probability by fast endogenous Ca2+ buffers and the generation of facilitation by buffer saturation. Thus, loose coupling provides the molecular framework for presynaptic plasticity.


Grant
Agency: European Commission | Branch: H2020 | Program: SME-2 | Phase: SMEInst-11-2016-2017 | Award Amount: 1.71M | Year: 2016

AM Technology Ltd is an SME founded with the objective of successfully developing and commercialising innovative functional paints based on AIRLITETM technology, an air purification technology based on the photocatalytic oxidation effect of Titanium dioxide (TiO2). The paints based on AIRLITE are capable of transforming any architectural surface into a natural air purifier, using only the energy of light, making no noise and requiring no maintenance. AIRLITETM can be used for both indoor and outdoor environments, making it a real and effective solution for effectively solving poor air quality issues at a reasonable cost. AIRLITE is a unique technology in the sense that it brings together an exceptional performance in terms of air purification (well above any other photocatalytic paint) and some other additional characteristics and advantages: AIRLITE reflects the hot component of sunlight, preventing the passage of excessive heat, which remarkably reduces the energy consumption needed to cool indoor environments. AIRLITE eliminates mould, bacteria and bad smells, and repels dirt. AIRLITE generates a high concentration of natural disinfectants which kill more than 99.99% of bacteria in the treated environment. Other advantages: Safety (is completely free of Volatile Organic Compounds (VOCs)), high durability (lifetime extended by twice that of normal paint resulting in less repainting costs), and a very low price (6 times less than existing photocatalytic paints). On their way to the market, AM Technology have developed some preliminary AIRLITE based products, and conducted an early stage commercial validation phase with them. This validation demonstrated the business viability of the project and identified the tasks and activities that need to be undertaken (from a technical and business/exploitation point of view) to successfully introduce AIRLITE into the market. Those tasks and activities are presented in this proposal.

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