Alwar, India
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Khalilullah H.,Alwar Pharmacy College | Yasmin S.,Birla Institute of Technology | Jadav S.S.,Birla Institute of Technology | Govindasamy J.,Alwar Pharmacy College
BioMed Research International | Year: 2013

In search of potential therapeutics for cancer, we described herein the synthesis, characterization, and in vitro anticancer activity of a novel series of curcumin analogues. The anticancer effects were evaluated on a panel of 60 cell lines, according to the National Cancer Institute (NCI) screening protocol. There were 10 tested compounds among 14 synthesized compounds, which showed potent anticancer activity in both one-dose and 5-dose assays. The most active compound of the series was 3,5-bis(4-hydroxy-3-methylstyryl)-1H-pyrazole-1- yl(phenyl)methanone (10) which showed mean growth percent of -28.71 in one-dose assay and GI50 values between 0.0079 and 1.86 μM in 5-dose assay. © 2013 Mohamed Jawed Ahsan et al.


Nyola N.K.,Alwar Pharmacy College | Kalra N.,Alwar Pharmacy College
International Journal of Pharma and Bio Sciences | Year: 2010

It is a disease modifying anti-rheumatoid drug used in the treatment of Osteoarthritis and chronic inflammatory arthritis. Various methods of analysis are available but are time consuming and expensive. A simple, rapid and accurate colorimetric method has been developed for the estimation of diacerein in bulk and pharmaceutical dosage forms, method are based on pink colored complex formation between diacerein with sodium hydroxide which shows maximum absorbance at 514nm. The linearity was found to be 10-50μg/ml. The developed method was found to be precise and accurate form the statistical validation of the analysis data.


Khalilullah H.,Alwar Pharmacy College | Khalilullah H.,Jamia Hamdard University | Khan S.,Jamia Hamdard University | Ahsan M.J.,Alwar Pharmacy College | Ahmed B.,Jamia Hamdard University
Bioorganic and Medicinal Chemistry Letters | Year: 2011

In continuance of our search for newer antihepatotoxic agents some novel pyrazoline derivatives containing 1,4-dioxane ring system were synthesized starting from 3-(2,3-dihydro-1,4-benzodioxane-6-yl)-1-substituted-phenylprop-2- en-1-one. Some of the synthesized compounds were evaluated for antihepatotoxic activity against CCl4-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic activity comparable to standard drug silymarin. © 2011 Elsevier Ltd. All rights reserved.


Jeyabalan G.,Alwar Pharmacy College | Nyola N.,Alwar Pharmacy College | Nyola N.,Shridhar University
Journal of Applied Pharmaceutical Science | Year: 2013

In this study zero, first and second order derivative spectrophotometric method weredeveloped for the estimation of sitagliptine. In zero order spectrophotometery, absorbance value was measured at 267nm. In first derivative spectrophotometry amplitudes were measured at 213nm. In second derivative spectrophotometry amplitudes were measured at 276nm. Calibration curves were linear between the concentration range of 20-60μg/ml, 20-60μg/ml and 40-80μg/ml respectively. The % RSD value is less than 2% and the recovery were near 100% for all methods. This method has been validated for linearity, accuracy and precisionand found to be rapid, precise, accurate and economical and can be applied for routine estimation of sitagliptine in solid dosage form. The validation of method was carried out utilizing ICH-guidelines.


Khalilullah H.,Alwar Pharmacy College | Khalilullah H.,Jamia Hamdard University | Khan S.,Qassim University | Ahsan M.J.,Alwar Pharmacy College | Ahmed B.,Jamia Hamdard University
Anti-Infective Agents | Year: 2012

A series of 4-thiazolidinone derivatives containing 1,4-benzodioxane ring system was synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were characterized and evaluated for antibacterial activity against Staphylococcus aureus, Escherichia coli and Bacillus subtilis and antifungal activity against Aspergillus niger, Aspergillus flavus and Candida albicans by two fold serial dilution technique. Some of the synthesized compounds displayed comparable or even better antibacterial and antifungal activities than reference drugs norfloxacin, chloramphenicol and fluconazole, against tested strains. © 2012 Bentham Science Publishers.


Nyola N.,Shridhar University | Jeyabalan G.S.,Alwar Pharmacy College | Yadav G.,Alwar Pharmacy College | Yadav R.,Alwar Pharmacy College | And 2 more authors.
Journal of Applied Pharmaceutical Science | Year: 2012

A simple, rapid and accurate RP-HPLC method was developed for the determination of levosalbutamol in pure and tablet dosage form by RP-HPLC method using C18 BDS column (Phenomenex, 250 × 4.6 mm, 5 μm) in isocratic mode. The mobile phase consisted of Acetonitrile and buffer in the ratio of 20:80 (v/v) was used and maintain the pH 3. The flow rate was maintained at 1 mL/min and the injection volume was 20 μL . Detection wavelength with UV detector at 276 nm and run time was kept 10 min. The retention time of levosalbutamol was 5.4 min. The method was linear over the concentration range 7-12 μg/ml. The recovery was found to be 100.44± 0.27%. The validation of method was carried out utilizing ICH-guidelines. The described HPLC method was successfully employed for the analysis of pharmaceutical formulations.


Khalilullah H.,Jamia Hamdard University | Khalilullah H.,Alwar Pharmacy College | Khan S.,Qassim University | Ahsan M.J.,Alwar Pharmacy College | Ahmed B.,Jamia Hamdard University
Bulletin of the Korean Chemical Society | Year: 2012

In continuance of our search for newer antihepatotoxic agents some novel thiazolidinone derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were evaluated for antihepatotoxic activity against CCl 4-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic activity comparable to standard drug silymarin.


Kalra N.,Alwar Pharmacy College | Nyola N.,Alwar Pharmacy College | Sharma R.,Alwar Pharmacy College | Singh G.,Alwar Pharmacy College | Choudhary S.,Alwar Pharmacy College
Research Journal of Pharmacy and Technology | Year: 2011

Dendrimers are repeatedly branched, roughly spherical large molecules. The name comes from the Greek word dendron, which translates to "tree". Synonymous terms for dendrimer include arborols and cascade molecules. However, dendrimer is currently the internationally accepted term. A dendrimer is typically symmetric around the core, and often adopts a spherical three-dimensional morphology. The word dendron is also encountered frequently. A dendron usually contains a single chemically addressable group called the focal point. Dendrimers are a new class of three- dimensional, man- made molecules produced by a usual synthetic route which incorporates repetitive branching sequences to create a unique novel architecture. These are highly controlled structures with all bonds emanate from a core and like a tree. © RJPT All right reserved.


PubMed | Alwar Pharmacy College
Type: Journal Article | Journal: Bioorganic & medicinal chemistry letters | Year: 2011

In continuance of our search for newer antihepatotoxic agents some novel pyrazoline derivatives containing 1,4-dioxane ring system were synthesized starting from 3-(2,3-dihydro-1,4-benzodioxane-6-yl)-1-substituted-phenylprop-2-en-1-one. Some of the synthesized compounds were evaluated for antihepatotoxic activity against CCl(4)-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic activity comparable to standard drug silymarin.


PubMed | Alwar Pharmacy College
Type: Journal Article | Journal: Acta pharmaceutica (Zagreb, Croatia) | Year: 2011

Bearing in mind the present scenario of the increasing biological tolerance of bacteria against antibiotics, a time controlled two pulse dosage form of amoxicillin was developed. The compression coating inlay tablet approach was used to deliver the drug in two pulses to different parts of the GIT after a well defined lag time between the two releases. This was made possible by formulating a core containing one of the two drug fractions (intended to be delivered as the second pulse), which was spray coated with a suspension of ethyl cellulose and a hydrophilic but water insoluble agent as a pore former (microcrystalline cellulose). Coating of up to 5% (m/m) was applied over the core tablet, giving a corresponding lag of 3, 5, 7 and 12 h. Increasing the level of coating led to retardation of the water uptake capacity of the core, leading to prolongation of the lag time. Microcrystalline cellulose was used as a hydrophilic but water insoluble porosity modifier in the barrier layer, varying the concentration of which had a significant effect on shortening or prolongation of the lag time. This coated system was further partially compression coated with the remaining drug fraction (to be released as the first immediate release pulse) with a disintegrant, giving a final tablet. The core tablet and the final two pulse inlay tablet were further investigated for their in vitro performance.

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