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San Carlos, CA, United States

Patent
Alvine Pharmaceuticals | Date: 2011-03-30

Gluten-degrading proteases derived from insects, including flour beetles, are isolated, and the purified, and recombinant forms can be used to make gluten-containing food safe for patients suffering from gluten intolerance.


Patent
Alvine Pharmaceuticals | Date: 2013-07-09

Gluten-degrading proteases can be used to degrade gluten and for making gluten-containing food safer for patients suffering from gluten intolerance. The present invention provides recombinant expression vectors encoding the proteases of the invention and methods for using such vectors to produce the encoded proteases. In another aspect, the present invention provides pharmaceutical formulations and unit dose forms suitable for oral administration.


Oral administration of ALV003 can protect celiac disease patients and patients otherwise suffering from gluten-intolerance from the harmful effects of ingesting food containing gluten.


Patent
Alvine Pharmaceuticals | Date: 2013-09-05

Patient reported outcome (PRO) instruments are useful for collecting information from celiac disease patients, patients with gluten intolerance or gluten sensitivity, and patients on gluten free diets.


Patent
Alvine Pharmaceuticals | Date: 2012-06-13

Gluten-degrading proteases can be used to degrade gluten and for making gluten-containing food safer for patients suffering from gluten intolerance.

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