Altay State Medical University

Altay, Russia

Altay State Medical University

Altay, Russia
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Tseymakh E.A.,Altay State Medical University | Bondarenko A.V.,Altay State Medical University | Menshikov A.A.,Altay State Medical University | Bombizo V.A.,Altay State Medical University
Polytrauma | Year: 2016

Objective-to increase the efficiency of complex treatment of patients with severe associated injury and dominating chest injury with use of the low invasive curative techniques. Materials and methods. The analysis included the results of treatment of 226 patients with severe associated chest injuries. The main group (102 patients) received the modern low invasive interventions (local differentiated fibrinolytic therapy, valve bronchial blocking, videothoracoscopy, rib fixation. The comparison group (124 patients) received the conventional treatment (blind draining of pleural cavities, thoracotomy etc.). Results. The medico-diagnostic algorithm for management of patients with severe associated chest injury has been developed. The indications for the following procedures have been formulated: emergent thoracotomy, urgent videothoracoscopy, local fibrinolytic therapy for clotted hemothorax and posttraumatic pleural empyema, valve bronchial blocking for tense and longstanding non-spreading pneumothorax, osteosynthesis of fragmentary rib fractures. Conclusion. Use of the developed low invasive techniques of treatment allowed decreasing the amount of the operated patients and increasing the amount of the patients discharged with recovery.


Kulikov V.P.,Altay State Medical University
Patologicheskaia fiziologiia i èksperimental'naia terapiia | Year: 2013

We investigated the antihypoxic effect of herb mixture <> from the Altai in an experiment with rats. This mixture of herbs contains bioflavonoids. Also, it has antioxidant, anti-inflammatory, antispasmodic, angioprotective and antiplatelet properties. The animals received decoction of herbs into the stomach through a tube. Courses lasted 3, 7, 14 and 21 days. Resistance to acute hypobaric hypoxia evaluated by time of animal life in modeling rise to a height of 11,500 meters above sea level. In result, a significant antihypoxic effect was observed in rats treated with decoction of herbs for 21 days. Shorter courses of treatment were not effective.


Chumakova G.A.,Russian Academy of Medical Sciences | Veselovskaya N.G.,Altay State Medical University | Gritsenko O.V.,Russian Academy of Medical Sciences | Ott A.V.,Altay Region Cardiology Dispanser
Russian Journal of Cardiology | Year: 2014

The paper focuses on the contradictory issues related to metabolic syndrome (MS), its criteria, and real-world prognostic value. Different types of obesity, which result from a variety of combinations of general and visceral obesity, are described. The authors emphasise the need for two separate definitions of MS (a wider one and a more specific one), which are characterised by different pathogenetic mechanisms and require different therapeutic approaches. The more specific MS definition could benefit from the inclusion of such criteria as fatty liver and polycystic ovary syndrome. More detailed definitions for the multiple risk factor cluster syndrome, as an alternative to the current MS definition, are proposed for further discussion. © 2014, Russian Journal of Cardiology


Korenovskii Y.V.,Altay State Medical University | El'chaninova S.A.,Altay State Medical University
Bulletin of Experimental Biology and Medicine | Year: 2016

Synthetic antioxidant S-nitrosoglutathione suppressed the expression of MMP-1 mRNA in HT1080 cells exposed to hypoxic hypoxia; hyperexpression of superoxide dismutase 2 increased and hyperexpression of catalase inhibited the expression of MMP-1 mRNA in HT1080 cells. © 2016 Springer Science+Business Media New York


Shmelev V.V.,Altay State Medical University | Neimark M.I.,Altay State Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

It was studied 238 patients after the reconstructive surgeries of atherosclerotic stenosing lesions of carotid arteries using different types of anesthesia. Neuropsychological testing included MMSE, the Frontal Assessment battery and the Clock drawing test. Regional anesthesia in the combination with reduced general anesthesia caused the less pronounced cognitive deficits in patients with symptomatic or asymptomatic stenoses. Inhalation anesthesia with sevofluorane led to the more pronounced cognitive impairment compared to total intravenous anesthesia with propofol. Ceraxon was used for the correction of cognitive impairments. This treatment increased the recovery of brain functions and quality of life of patients.


Piven B.N.,Altay State Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Some new terms and meanings in modern psychiatry («emotional burnout syndrome», «chronic fatigue syndrome», «panic attacks», etc.) were analyzed, due to save clinic psychiatry traditions and succession of different generations of psychiatrists. Comparison of their content and well-known science concepts proves absence of any unknown phenomenon. These terms do not introduce some new items of classic determination of psychopathology catastasis, they just rename it. The reasons of this tendency were investigated.


Kulikov V.P.,Altay State Medical University
Patologicheskaia fiziologiia i èksperimental'naia terapiia | Year: 2013

In 11 healthy volunteers 21 +/- 3.7 years old was monitored cerebral blood flow (CBF) by transcranial Doppler (TCD) of middle cerebral artery and mean hemodynamic arterial blood pressure (MAP) by continuous non-invasive measurement "beat-to-beat" at normocapnia, hypercapnia and hypocapnia. Hypercapnia was creating by rebreathing, hypocapnia was creating by spontaneous hyperventilation. The partial pressure of CO2 in alveolar air (PetCO2) was monitored by capnograph, embedded in the TCD-analyzer. During hypercapnia the velocity of CBF and PetCO2 were significantly increased already at 10 s, which was considerably earlier than the increase in the MAP (30 s). During hypocapnia velocity CBF and PetCO2 were significantly decreased at 10 s, and MAP was not changed. We have installed the threshold PetCO2 42 (41; 44) mm Hg, below which amplification CBF occurs at a constant MAP and reflects the true cerebrovascular reactivity to CO2.


PubMed | RAS Pacific Institute of Bioorganic Chemistry and Altay State Medical University
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2015

We studied the role of the liver monooxygenase system in pharmacological activity of histochrome, a pharmaceutical form of echinochrome A. In experiments on rats, benzonal, an inductor of the monooxygenase system of phenobarbytal type, significantly potentiated the diuretic effect of histochrome. Benzonal withdrawal was followed by a natriuretic reaction. In view of the known inverse relation between the biological effect of the drug and the rate of its metabolism, our findings suggest that the effects of echinochrome A on some kidney excretory function parameters are produced not by native agent, but one of its metabolites.


PubMed | Altay State Medical University
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Synthetic antioxidant S-nitrosoglutathione suppressed the expression of MMP-1 mRNA in HT1080 cells exposed to hypoxic hypoxia; hyperexpression of superoxide dismutase 2 increased and hyperexpression of catalase inhibited the expression of MMP-1 mRNA in HT1080 cells.


PubMed | Institute of Molecular Pathology and Pathomorphology and Altay State Medical University
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

We examined 11 women aged 19-26 years (mean age 22.53.5 years) with secondary amenorrhea complaining frequent urination over 1.5 years and repeatedly, but unsuccessful treated for overactive bladder and chronic cystitis. The rare cause of sustained urination disorders in young female patients of reproductive age was established: development of secondary amenorrhea caused by weight loss (cosmetic amenorrhea) with subsequent estrogene deficit and urogenital atrophy. Morphological examination of the bladder mucosa, an important clue to the diagnosis, helps to identify the true cause of dysuria, urogenital atrophy of the bladder mucosa, in secondary (cosmetic) amenorrhea, and determine future course of etiopathogenic treatment of sustained dysuria in young women. The treatment is often effective in case of proper and timely diagnosis and the absence of irreversible changes.

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