Chumakova G.A.,Altai State Medical University |
Veselovskaya N.G.,Research Institute for Complex Issues of Cardiovascular Diseases
Russian Journal of Cardiology | Year: 2016
Obesity, especially visceral, is a chronic disorder with high risk of cardiometabolic complications. Precise diagnostics of visceral obesity (VO) is not easy, as most methods have benefits and restrictions for application as well. The article focuses on the opportunities and shortcomings of anthropometric, ultrasound methods, and magnet-resonance and computed tomography. We recommend to have broader application of simple and very much available method of direct VO diagnostics - echocardiography - by the measurement of epicardial fat layer. © 2016, Silicea-Poligraf. All rights reserved.
Gurjeva V.A.,Altai State Medical University |
Karacheva Y.O.,Altai State Medical University
Research Journal of Medical Sciences | Year: 2015
The study presents the ovarian reserve criteria in 93 girls with secondary amenorrhea. The ovarian reserve was evaluated by the hormone level: FSH, LH, E2, AMH, Inhibin B and ultrasonic markers ovarian volume and the number of antral follicles in the section. In 9.7% of cases the low ovarian reserve was detected. The factors that resulted in reduction in the ovarian reserve were specified and the predictive indices were estimated. © Medwell Journals, 2015.
Kuznetsova D.V.,Altai State Medical University |
Kulikov V.P.,Altai State Medical University
Blood Pressure Monitoring | Year: 2014
BACKGROUND: Arterial partial pressure alteration of CO2 (P aCO2) affects not only the cerebral blood flow velocity but also the systemic arterial blood pressure (BP). At the same time, BP can affect the cerebral blood flow. The objective of the present research is to study the impact of the PaCO2 level on cerebrovascular CO2 reactivity (CVRCO2) and BP as well as the impact of BP upon CVR CO2 alteration by hypercapnia and hypocapnia. MATERIALS AND METHODS: Cerebral blood flow velocity was recorded by means of transcranial Doppler in both middle cerebral arteries (MCAv left and right). The mean arterial pressure (MAP) was studied using the finger photoplethysmography method, arterial blood oxygen saturation was estimated by the pulse oximetry method, and end-tidal PCO2 (PETCO2) was measured with an infrared capnograph. After a recording of the reference values of all the parameters, all the volunteers underwent a rebreathing as well as a hyperventilation. RESULTS: At rest,PETCO2 was 33.6 (SD 3.1) mmHg. At rebreathing, MCAv increased at 38 mmHg PETCO2, MAP-at 43 mmHg PETCO2. By hyperventilation, MCAv decreased at 28 mmHg PETCO2, MAP-at 26 mmHg PETCO2. When PETCO2 reached 43 mmHg, CVRCO2 increased from 2.3 (SD 1.4) to 3.3 (SD 1.2)%/mmHg (P<0.01). When P ETCO2 decreased to 26 mmHg, CVRCO2 increased from-3.6 (SD 2.5) to-5.9 (SD 3.9)%/mmHg (P<0.01). CONCLUSION: Within the alteration of PETCO2 above 43 and under 26 mmHg, BP increased and decreased, respectively, leading to a change in CVRCO2. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Prognostic value of microvessel density in tumor and peritumoral area as evaluated by CD31 protein expression and argyrophilic nucleolar organizer region count in endothelial cells in uterine leiomyosarcoma
Avdalyan A.,Altai Branch of Blokhin Russian Cancer Research Center |
Bobrov I.,Altai State Medical University |
Klimachev V.,Altai State Medical University |
Lazarev A.,Altai Branch of Blokhin Russian Cancer Research Center
Sarcoma | Year: 2012
The objective of this study was to investigate the prognostic value of microvessel density (MVD) in uterine leiomyosarcoma (LMS) and peritumoral area (PA) as evaluated by CD31 expression and argyrophilic nucleolar organizer region (AgNOR) count in endothelial cells. Tissue specimens from 66 patients with uterine LMS were examined. There were no significant differences in the mean MVD between tumor itself and the PA (P = 0.9); moreover, the MVD in the PA often exceeded that in the tumor. No correlation or significant differences were also found in the MVD between different grades of malignancy of LMS (r = 0.1; P = 0.07). The number of AgNORs in tumor endothelial cells was significantly higher in tumor vessels than in the peritumoral area (P < 0.005) and increased with the tumor grade. Analysis of the prognostic value of MVD in uterine LMS and PA showed that the density of tumor vessels was not an independent criterion, while the MVD in the PA affected 10-year survival to a significantly greater extent ( ρ2 = 27.5; P = 0.0003). The number of AgNORs also had an important effect on survival of LMS patients: when the threshold of 11.6 granules was exceeded, prognosis was significantly more unfavorable than that prior to exceeding the threshold. Copyright © 2012 Ashot Avdalyan et al.
Korenovsky Y.V.,Altai State Medical University |
Remneva O.V.,Altai State Medical University
Biomedit︠s︡inskai︠a︡ khimii︠a︡ | Year: 2016
The aim of this study was to determine reference values of matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-9 and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in the amniotic fluid at the first stage of labor in physiological pregnancy. 89 women at the first stage of term labor have been examined. Samples of amniotic fluid were taken at the first period of labor by vaginal amniotomy. Concentrations ofMMP-1, MMP-2, MMP-9, and TIMP-1 were investigated in amniotic fluid by ELISA kits. We have determined normal concentration ranges for MMP-1, MMP-2, MMP-9, TIMP-1, and ratios of concentrations of MMPs and TIMP-1 (MMP-1/TIMP-1, MMP-2/TIMP-1, MMP-9/TIMP-1) in the amniotic fluid at the first period of labor in physiological pregnancy. These included: MMP-1--5.1-16.8 pg/mg of protein, MMP-2--238.3-374.1 pg/mg of protein, MMP-9--66.1-113.3 pg/mg of protein, TIMP-1--4.7-13.6 pg/mg of protein, ratio of MMP-1/TIMP-1--0.1-2.2, ratio of MMP-2/TIMP-1--19.9-55.7, ratio of MMP-9/TIMP-1--4.2-17.2.Abstract available from the publisher.