News Article | May 9, 2017
For additional information or to register for CPhI North America and InformEx 2017, please visit: www.cphinorthamerica.com or www.informex.com. Registration to either event offers full access to both exhibition floors. While more than 630 leading solution providers will populate the exhibition floor, the following are some of the highlights: Aavis Pharmaceuticals Inc. (booth 3210) - Has established a brand new facility and will serve as a CDMO offering end-to-end pharmaceutical development and manufacturing solutions. Capabilities as an integrated service provider and experience with a range of technologies enables ability to serve both innovator and generic companies worldwide. ACIC (booth 2431) - A full-service pharmaceutical company providing API, finished formulations and pharmaceutical machinery. The ACIC service relationship is a very flexible one structuring custom services to meet client needs. Alphora Research Inc. (booth 2138) - Provides API technology development and scale-up services for complex small molecules, including niche APIs, high potency and cytotoxic compounds. Our services cover IND enabling development, phase II & III, and commercial manufacturing of niche APIs. Amcor Flexibles (booth 3105) - Focused on improving sterile fluid delivery with barrier embedded primary containers which remove steps at critical points-of-care, maintain product integrity, and improve product stability. Anguil Environmental Systems (booth 940) - Air pollution control technologies and techniques applied to the pharmaceutical and chemical processing industries for regulatory compliance. Aptar Pharma (booth 3102) – Offering a breakthrough Ophthalmic Squeeze Dispenser, the first and only FDA-reviewed multi-dose delivery system to handle preservative-free eye treatment formulations with metal-free pathways. B&W Tek (booth 3025) - The i-Raman Pro ST is a new portable Raman system that can see through opaque packaging to identify the material inside. Bausch Advanced Technology Group (booth 3114) - Triple Container Filling & Stoppering Machine Type 535 is a flexible modular processing machine featuring three different filling systems: rotary piston pump, peristaltic pump and time pressure on one platform to offer the most flexibility for customers. Baxter BioPharma Solutions (booth 2454) - Baxter's BioPharma Solutions facility in Bloomington, Indiana, was recently recognized as the "Best Contract Manufacturing Organization" at the 2017 Annual Vaccine Industry Excellence (ViE) Awards. Benzo Chem Industries PVT. LTD. (booth 2241) - Manufacturers of pharmaceutical and agro intermediates with four ISO compliant plants. An additional GMP plant will begin operations in August 2017. Bormioli Rocco (booth 3112) - A wide range of Type I Glass, Amber and Flint, produced in a pharma approved environment, following the highest quality standards. Bosch Packaging Technology (booth 3201) - The Solidlab 2 is a multifunctional system capable of granulating, drying and coating with flexible batch sizes from 0.25 to 12 kilograms. BUCHI Corporation (booth 1252) - Introducing the first freeze dryer with unlimited capacity for continuous freeze drying. The Lyovapor L-300 offers two alternately working condensers that automatically clean while freezing down to -105°C. Capricorn Life Sciences (booth 3001) – Out-licensing food supplements, medical devices and pharmaceutical OTC's under brand names or private label. ChemicalInfo (booth 2240) - Directory of World Chemical Producers (DWCP) connects buyers and sellers of chemicals and pharmaceuticals with global producer details including contact and product information. Chemo Dynamics, Inc. (booth 938) - U.S. based CRO/CMO with cGMP facility providing pharmaceutical and biopharmaceutical contract research, custom synthesis, analytical service and small quantity manufacturing. CordenPharma (booth 2160) - Offers development & manufacturing expertise across specialized technology platforms from regulated raw materials through intermediates, APIs, drug product manufacturing & packaging. CurTec (booth 2231) - Presenting Pharma Grade Packo, screw top jars that have been tested according to European and U.S. Pharmacopoeia and are suitable as primary packaging for pharmaceuticals. DATWYLER (booth 3204) - Offering a unique range of products and services including the most advanced elastomer formulations, coatings, aluminum seals, and processing technologies. EAS Consulting Group, LLC (booth 2551) - Provider of FDA regulatory consulting services, with more than 50 years of experience. Capabilities include performing cGMP audits and mock FDA inspections, quality system implementation and remediation, product development and regulatory strategies, to submissions, filings, registrations, assistance with imports and acting as an U.S. Agent. EMBOCAPS by Suheung (booth 2733) - Introducing a premium empty capsule product line - EMBOCAPS VG ALPHA. No gelling agents, pH independent disintegration profile, and superior machinability. Erawat Pharma Limited (booth 3126) - An ultra-modern facility brings you hard capsules in easy fitting, sticky free, liquid filling, metallic , preservative and SLS free varieties driven by best standards of quality and consumer satisfaction. FabriChem, Inc. (booth 2121) - D-Galactose from plant origin, L-Tyrosine and L-Leucine from corn protein (vegetable origin) for use in bio pharmaceuticals & cell culture. 1, 2, 6 Hexane triol for moisturizing agent in creams, Guanidine hydrochloride for biopharmaceuticals, Dipicolinic Acid & Alpha Picolinic Acid. FAR Chemical, Inc. (booth 1234) - Manufacturer of fine and specialty chemicals sold to a variety of industries and applications including: pharmaceutical reagents and intermediates, advanced polymers, organometallics, silane & bromine chemistries, and structural composites. Flamma (booth 2344) - Flamma will open its cGMP workshop at Flamma Honkai (Dalian, China) in June providing customers a trusted partner to integrate projects from Italy to China. Also, project managers have been added in Italy and China in order to better serve customers, new capabilities have been added and land has been acquired for company growth and expansion. Fresenius Kabi Product Partnering (booth 2938) - The contract manufacturing platform of Fresenius Kabi offers manufacturing expertise of more than 20 facilities worldwide. A full range of services for both fill and finish of solutions are provided along with emulsions in ampoules, vials, bottles, IV-bags, and pre-filled syringes. Frontida BioPharm, Inc. (booth 2865) - Proprietary AdaptDoseTM encapsulation platform and DuraGran® coated granule technology provides speed, precision, flexibility and cost-savings in the product development through commercialization process. Large U.S., high-capacity facility, with expertise in controlled release granules, fluid bed operations, solvent processing, DEA controlled substances, HPAPI and nanoparticle milling. Fuji Chemical Industries Co., Ltd. (booth 2354) - Sales and marketing of unique specialty excipients, and the contract manufacturing and development of solid dispersion processing with closed spray driers. GBR - Global Business Reports (booth 3261) - Launching the U.S. Pharmaceuticals 2017 book which provides in-depth global analysis and up-to-date insights into all aspects of the oil and gas, pharmaceuticals, chemicals, energy, aerospace and mining industries. Grifols (booth 3037) - Premixed solutions ready-to-use in PP bag deliver a fixed dose in 50 mL to 1 L ensuring accurate delivery of the drug to the patient. Groupe PARIMA (booth 2807) - A CDMO specialized in the development and manufacturing of liquids, suspensions, semi-solids and sprays. GSK Contract Manufacturing (booth 3111) - Offering a fully integrated supply chain solution to the pharma/biopharm industry with FDA & EMA approved, multi-product facilities along with providing multiple services for Consumer and OTC markets. Haemopharm Healthcare S.r.l. (booth 3124) - Showing the first needle-free technology that not only enables the use of the syringe without the needle, but also provides a hermetic closure, minimizing contaminations and increasing safety. This patented needle-free technology has been applied to both vials (NIV®) and bags (NIP®). Halo Pharma (booth 3132) - Delivering pediatric products from clinical through commercialization (Microtablets, Stickpacks, Granules for Suspensions, Oral Solutions/Suspensions). Recognized as a Pediatric Center of Excellence. Heraeus (booth 2441) - Specializes in the production of generic pharmaceutical ingredients and is the worldwide leading supplier of Platinum hAPIs. International Process Plants (IPP) (booth 1245) - Used equipment offers the highest value rating possible by offering equipment for < 50% off new with delivery times in days instead of months. I.R.A. Istituto Ricerche Applicate (booth 2257) - Linear and cross linked hyaluronic acid for aesthetic and orthopedic fillers. Kingchem Life Science LLC (booth 1324) – Offers complex chemistry products, processes and capabilities including: Boronic acids, heterocyclic chemistry, halogenations, fluorinated compounds including trifluoromethyl and difluoroderivatives, nucleophilic fluorination, cyogenic chemistry, isocyanates, large Scale HF and KF chemistry. Laurus Labs Limited (booth 1100) - Laurus Generics has combined innovation with efficiency by developing cost effective processes to develop an in-house range of APIs and related intermediates. Laurus Synthesis strives to be recognized as the definitive example of "East Meets West" drug development by combining unparalleled front-end process chemistry expertise in both the U.S. and India with world-class back-end API manufacturing resources. LF of America Corp. (booth 3106) - Contract manufacturing, packaging manufacturing and contract filling of liquid sterile solutions in unit-dose delivery systems. LGC Standards (booth 3241) - LGC Standards is an ISO Guide 34, ISO/IEC 17025 accredited manufacturer offering more than 4,000 pharmaceutical reference standards including: impurities, APIs, excipients and primary standards LGM Pharma (booth 2501) - Provides comprehensive cGMP API sourcing solutions backed by complete technical and regulatory capabilities to a diverse array of U.S. pharmaceutical companies. Macco Organiques, s.r.o. (booth 2554) - cGMP (GMP, Q7 certified), well recognized production and supplier of inorganic and organic mineral salts for the pharmaceutical and biopharmaceutical industry, infant formulas producers, food and beverage manufacturers. ManageArtworks (booth 3235) - Packaging artwork management software that helps life science companies manage the processes, text matter, design and other components of a packaging artwork via an electronic workflow. As a CFR Part 11 compliant system, it offers transparency with effortless tracking, audit trails, alerts and dashboards. Novasep (booth 1456) - Announced that its new €11M antibody-drug conjugate bioconjugation facility is now operational to support our pharmaceutical customers in developing the latest innovative treatments against cancer. Ompi - Stevanato Group (booth 3207) - Developed a new fully passive and fully customizable, integrated needlestick protection - the Ompi EZ-fill® Integrated Safety System (ISS). It provides automatic shield retraction in an elegant and highly customizable way. PCI Synthesis (booth 2128) - Pharmaceutical development CMO based in Newburyport, MA is the largest small molecule drug substance manufacturer in the New England area. PCI is also a commercial manufacturer of new chemical entities (NCEs), generic active pharmaceutical ingredients (APIs), and other specialty chemical products for the medical device industry. Polpharma Pharmaceutical Works (booth 2250) - A cGMP-compliant and a FDA-approved European producer of API, providing a wide-range of services including FDF out-licensing and supply and contract manufacturing services. PolyCine GmbH (booth 3223) - Global leader for the packaging of IV solution bags providing: standard films and tubes, peelable films for multi-chamber bags, special films for lipids, gas barrier films, overwrap films, filling & transfer tubes, special modified granules & compounds and hot stamping foil. Polycrystalline (booth 2253) - With the mission of "Crystallization by Design," providing services for the research and development of highly potent API and controlled substances/narcotics. Polycrystalline shares protocols, methods, and raw data customizing activities to meet specifics clients' goals, timeframes and budget. PolyPeptide Group (booth 924) - A world leading GMP peptide (CDMO) with six facilities worldwide in Belgium, France, India, Sweden, San Diego and Torrance. Potasse et Produits Chimiques (booth 1034) - Extensive technical experience for bromination, hydrobromination and related technologies. Brominated compounds are widely used in specialty chemicals, in pharmaceuticals, agrochemicals, polymer additives, and cosmetics products as intermediates. PQE US, Inc. (booth 3130) - Global consulting firm specializing in the life sciences industry. Provides global support in: data integrity assurance, computer system validation, qualification and engineering, quality assurance and compliance and regulatory affairs. Pressure Chemical Co. (booth 1444) - Providing pilot, scale-up, and custom contract manufacturing services in a flexible facility with highly experienced project leaders and operations; enabling clients to: gather process information, reduce startup capital, and bridge the gap beyond current capabilities. Q Laboratories, Inc. (booth 3134) - Provides microbiology, analytical chemistry and research & development laboratory services and helps companies worldwide meet the level of excellence they demand to produce safe, high-quality products. Qosina Corporation (booth 3236) - Purchasing components from Qosina save you both time and money by eliminating tool costs and providing immediate delivery of in-stock solutions. Qualicaps (booth 2913) - Quali-V® capsules are plant-based alternative to gelatin capsules designed to meet the demanding requirements of the pharmaceutical industry. R-Pharm Germany GmbH (booth 3135) - CDMO providing manufacturing, packaging, serialization, formulation, scale-up, product-launch, analytics and stability, as well as high potency API manufacturing. REACHLaw Ltd. (booth 1052) - Offers chemical regulatory compliance helping clients gain market access for their chemical products. Services include: REACH Only Representation, REACH Registrations, REACH Authorisation, REACH Out-Tasking, Advocacy Services, Global Notifications and Consultancy Services. Regis Technologies Inc. (booth 1124) – Utilizing analytical and synthesis expertise, offers a complete structure elucidation package to support IND and NDA filings. Reliance Label Solutions (booth 1013) - GHS, BS 5609 and IMDG certified compliance labeling solutions via the www.theghsstore.com. Rohner Inc. (booth 1151) - This Swiss custom manufacturer will be unveiling their new portfolio of Multi-Customer Products that utilize their core competencies. Roquette (booth 2829) - Features new product offerings that are low endotoxin, multi-compendial grade materials for cell culture and biologic drug formulations. Sabin Metal Corporation (booth 1254) - Provides worldwide customers with logistical support, precious metal financial services, pre-reclaim kilning and safe, accurate and responsible processing, sampling and refining of PM-bearing catalysts. Senn Chemicals AG (booth 2142) - Operates cGMP and ISO certified facilities specializing in the production of peptides and amino acid derivatives. Contract manufacturer that provides the pharmaceutical and cosmetic industry with customized products and individual solutions starting from small scale for R&D, process development, scale-up to commercial production. SK Life Science Inc. (booth 2051) - A global life sciences company known for its presence in custom chemical development, advanced intermediates and active pharmaceutical ingredient (API) manufacturing including a continuous flow process for low temperature and high pressure reaction. Symbiotica Specialty Ingredients SDN. BHD. (booth 2365) - Malaysian manufacturer of steroids with ICH Q7A GMP certification. The site was successfully inspected by the U.S. FDA in 2014 and have filed 8 U.S. DMFs: hydrocortisone valerate, clobetasol propionate, mometasone furoate, betamethasone dipropionate, betamethasone valerate, dexamethasone sodium phosphate, exemestane, halobetasol propionate. Takasago International Corporation (booth 1200) - Possesses Nobel Prize winning technology including commercial experience in continuous flow manufacturing on tonne scale. Facility is FDA Inspected. TCG Lifesciences (booth 943) - Since 2001 TCG Lifesciences, a leading CDMO, offers discovery chemistry and biology services, process development, scale-up, and cGMP manufacturing with >700 highly trained scientists and 3 facilities in Kolkata and Hyderabad. Tergus Pharma (booth 2737) - A full-service topical pharmaceutical research, development, testing and manufacturing company that has been an industry leader for more than 20 years with a state-of-the-art facility in Durham, North Carolina. "Think Topical. Think Tergus." Toronto Research Chemicals (booth 2430) - Extensive product base of 90,000+ bio-chemicals manufactured and used by more than 15,000 researchers and companies in more than 100 countries worldwide. UNIPHARMA, LLC (booth 3043) - Features innovative blow-fill-seal packaging solutions: unit dose, fill seal, liquid stickpacks and conventional filling. Both contract manufacturing and private label products in a FDA compliant, GMP facility. VanDeMark Chemical Inc. (booth 1212) - Provides phosgene chemistry for many markets including pharma, agro, personal care, coatings, sealants & adhesives, plastics, polymers, etc. Ward/Kraft, Inc. (booth 941) - Kansas-based, print manufacturer specializing in the production of forms, labels and plastic products offering GHS and BS5609 section 2 & 3 certified labels. Wego Chemical Group (booth 1027) - Triflic acid and Triflic anhydride have long been used for a number of important reactions in pharmaceutical chemistry and asymmetric synthesis. Now they are more economical than ever thanks to world class production and global distribution. WeylChem (booth 1034) - Offers custom tolling and manufacturing services, as well as advanced intermediate products for the specialty and pharmaceutical markets. To see a full list of exhibitors and the floor plan, click here. Participate in the Epicenter of Pharmaceutical and Specialty Chemical Innovation CPhI North America and InformEx 2017 attendees have access to the sold-out expo floor, featuring more than 630 companies across the complete pharma supply chain, as well as show floor programming, networking events, and much more. With its unique blend of unprecedented global influence and the infrastructure to advance relationships between buyers and sellers, CPhI North America and InformEx will provide a marketplace of solutions and ideas unlike any other. Not yet registered for CPhI North America or InformEx? Free registration ends May 15 - register now! CPhI drives growth and innovation at every step of the global pharmaceutical supply chain, from drug discovery to finished dosage. Through exhibitions, conferences, and online communities, CPhI brings together more than 100,000 pharmaceutical professionals each year to network, identify business opportunities, and expand the global market. CPhI hosts events across Europe, Asia, and now North America, and co-locates with ICSE for contract services; P-MEC for machinery, equipment, and technology; InnoPack for pharmaceutical packaging; and BioPh for biopharma. CPhI provides an online buyer and supplier directory at CPhI-Online.com. UBM Americas, a part of UBM plc, delivers events and marketing services in the fashion technology, licensing, advanced manufacturing, automotive and powersports, healthcare, veterinary, and pharmaceutical industries, among others. Through a range of aligned interactive environments, both physical and digital, UBM Americas increases business effectiveness for customers and audiences through meaningful experiences, knowledge, and connections. The division also includes UBM Brazil's market-leading events in construction, cargo transportation, logistics and international trade, and agricultural production; and UBM Mexico's construction, advanced manufacturing, and hospitality services shows. For more information, visit: www.ubmamericas.com To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/leading-pharmaceutical-and-specialty-chemical-solution-providers-highlight-innovation-at-cphi-north-america-and-informex-2017-300454063.html
Rudolph A.,Alphora Research |
Alberico D.,Alphora Research |
Jordan R.,Alphora Research |
Pan M.,Alphora Research |
And 2 more authors.
Tetrahedron Letters | Year: 2013
A new synthetic strategy towards the C27-C35 subunit of Eribulin (1) has been devised to include a protected 1,2-amino alcohol at C34-C35. Early introduction of the C35 amino group in the synthesis of 1 increases the efficiency of the route. This new approach can be accomplished on a multi-gram scale and allows for the successful synthesis of Eribulin. © 2013 Elsevier Ltd. All rights reserved.
Spickler C.,Boehringer Ingelheim |
Spickler C.,Institute Of Recherche Clinique Of Montreal |
Lippens J.,Boehringer Ingelheim |
Laberge M.-K.,Boehringer Ingelheim |
And 17 more authors.
Antimicrobial Agents and Chemotherapy | Year: 2013
Human rhinovirus (HRV) is the predominant cause of the common cold, but more importantly, infection may have serious repercussions in asthmatics and chronic obstructive pulmonary disorder (COPD) patients. A cell-based antiviral screen against HRV was performed with a subset of our proprietary compound collection, and an aminothiazole series with pan-HRV species and enteroviral activity was identified. The series was found to act at the level of replication in the HRV infectious cycle. In vitro selection and sequencing of aminothiazole series-resistant HRV variants revealed a single-nucleotide mutation leading to the amino acid change I42V in the essential HRV 3A protein. This same mutation has been previously implicated in resistance to enviroxime, a former clinical-stage antipicornavirus agent. Enviroxime-like compounds have recently been shown to target the lipid kinase phosphatidylinositol 4-kinase III beta (PI4KIIIβ). A good correlation between PI4KIIIβ activity and HRV antiviral potency was found when analyzing the data over 80 compounds of the aminothiazole series, covering a 750-fold potency range. The mechanism of action through PI4KIIIβ inhibition was further demonstrated by small interfering RNA (siRNA) knockdown of PI4KB, which reduced HRV replication and also increased the potency of the PI4KIIIβ inhibitors. Inhibitors from two different structural classes with promising pharmacokinetic profiles and with very good selectivity for PI4KIIIβ were used to dissociate compound-related toxicity from target-related toxicity. Mortality was seen in all dosing groups of mice treated with either compound, therefore suggesting that short-term inhibition of PI4KIIIβ is deleterious. Copyright © 2013, American Society for Microbiology.