AlphaVax Inc.

Golden Triangle, NC, United States

AlphaVax Inc.

Golden Triangle, NC, United States
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Browse tables and figures, 05 company profiles spread across 102 pages at http://www.reportsnreports.com/reports/998417-global-botulinum-market-research-report-2017.html . Global Botulinum Market Report 2017 is a professional and in-depth survey on the current state of the Botulinum industry. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Botulinum market analysis is provided for the international market including development history, competitive landscape analysis, and major regions' development status. Market Segment by Regions, this report splits Global into several key Region, with production, consumption, revenue, market share and growth rate of Botulinum in these regions, from 2012 to 2022 (forecast), like North America, China, Europe, Japan, India, Southeast Asia split by product type, with production, revenue, price, market share and growth rate of each type Split by application, this report focuses on consumption, market share and growth rate of Botulinum in each application. This report studies Botulinum in global market, focuses on top manufacturers in global market, with sales, price, revenue and market share for each manufacturer, covering XOMA Corporation, AlphaVax Microbiotix, Molecular Targeting Technologies and Morphotek. Order a copy at http://www.reportsnreports.com/purchase.aspx?name=998417 . The 'Global and Chinese Botulinum Toxins Industry, 2012-2022 Market Research Report' is a professional and in-depth study on the current state of the global Botulinum Toxins industry with a focus on the Chinese market. The report provides key statistics on the market status of the Botulinum Toxins manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry. Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2012-2017 market shares for each company. Through the statistical analysis, the report depicts the global and Chinese total market of Botulinum Toxins industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis The Global Botulinum Toxins Industry 2017 Market Research Report is a professional and in-depth study on the current state of the Botulinum Toxins industry. Firstly, the report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Botulinum Toxins market analysis is provided for the Global market including development history, competitive landscape analysis, and major regions' development status. Secondly, development policies and plans are discussed as well as manufacturing processes and cost structures. This report also states import/export, supply and consumption figures as well as cost, price, revenue and gross margin. This report studies Botulinum Neurotoxins in Global market, focuses on price, sales, revenue of each type in Global. This report also focuses on the sales (consumption), production, import and export of Botulinum Neurotoxins in global market, forecast to 2021, from 2016. Firstly, this report focuses on price, sales, revenue and growth rate of each type, as well as the types and each type price of key manufacturers, through interviewing key manufacturers. Second on basis of segments by manufacturers, this report focuses on the sales, price of each type, average price of Botulinum Neurotoxins, revenue and market share, for key manufacturers. The Botulinum Neurotoxins industry development trends and marketing channels are also analyzed and the feasibility of new investment projects are assessed and overall research conclusions offered. With the tables and figures the report provides key statistics on the state of the industry and is a valuable source of guidance and direction for companies and individuals. ReportsnReports.com is your single source for all market research needs. Our database includes 500,000+ market research reports from over 95 leading global publishers & in-depth market research studies of over 5000 micro markets. With comprehensive information about the publishers and the industries for which they publish market research reports, we help you in your purchase decision by mapping your information needs with our huge collection of reports. We provide 24/7 online and offline support to our customers.


Browse tables and figures, 05 company profiles spread across 102 pages at http://www.reportsnreports.com/reports/998417-global-botulinum-market-research-report-2017.html . Global Botulinum Market Report 2017 is a professional and in-depth survey on the current state of the Botulinum industry. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Botulinum market analysis is provided for the international market including development history, competitive landscape analysis, and major regions' development status. Market Segment by Regions, this report splits Global into several key Region, with production, consumption, revenue, market share and growth rate of Botulinum in these regions, from 2012 to 2022 (forecast), like North America, China, Europe, Japan, India, Southeast Asia split by product type, with production, revenue, price, market share and growth rate of each type Split by application, this report focuses on consumption, market share and growth rate of Botulinum in each application. This report studies Botulinum in global market, focuses on top manufacturers in global market, with sales, price, revenue and market share for each manufacturer, covering XOMA Corporation, AlphaVax Microbiotix, Molecular Targeting Technologies and Morphotek. Order a copy at http://www.reportsnreports.com/purchase.aspx?name=998417 . The 'Global and Chinese Botulinum Toxins Industry, 2012-2022 Market Research Report' is a professional and in-depth study on the current state of the global Botulinum Toxins industry with a focus on the Chinese market. The report provides key statistics on the market status of the Botulinum Toxins manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry. Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2012-2017 market shares for each company. Through the statistical analysis, the report depicts the global and Chinese total market of Botulinum Toxins industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis The Global Botulinum Toxins Industry 2017 Market Research Report is a professional and in-depth study on the current state of the Botulinum Toxins industry. Firstly, the report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Botulinum Toxins market analysis is provided for the Global market including development history, competitive landscape analysis, and major regions' development status. Secondly, development policies and plans are discussed as well as manufacturing processes and cost structures. This report also states import/export, supply and consumption figures as well as cost, price, revenue and gross margin. This report studies Botulinum Neurotoxins in Global market, focuses on price, sales, revenue of each type in Global. This report also focuses on the sales (consumption), production, import and export of Botulinum Neurotoxins in global market, forecast to 2021, from 2016. Firstly, this report focuses on price, sales, revenue and growth rate of each type, as well as the types and each type price of key manufacturers, through interviewing key manufacturers. Second on basis of segments by manufacturers, this report focuses on the sales, price of each type, average price of Botulinum Neurotoxins, revenue and market share, for key manufacturers. The Botulinum Neurotoxins industry development trends and marketing channels are also analyzed and the feasibility of new investment projects are assessed and overall research conclusions offered. With the tables and figures the report provides key statistics on the state of the industry and is a valuable source of guidance and direction for companies and individuals. ReportsnReports.com is your single source for all market research needs. Our database includes 500,000+ market research reports from over 95 leading global publishers & in-depth market research studies of over 5000 micro markets. With comprehensive information about the publishers and the industries for which they publish market research reports, we help you in your purchase decision by mapping your information needs with our huge collection of reports. We provide 24/7 online and offline support to our customers.


Patent
AlphaVax Inc. | Date: 2014-03-28

The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.


The immune response to an antigen of interest, especially one in purified form, can be significantly enhanced by the simultaneous administration of an alphavirus replicon particle which expresses the same antigen. This allows for the use of significantly smaller quantities of the protein antigen than in conventional immunization strategies, and this new immunization strategy can also eliminate the need for boosting administration of the antigen or it can reduce the number of boosts required for an effective immune response to the antigen.


Patent
AlphaVax Inc. | Date: 2014-02-05

Provided herein are helper nucleic acids comprising at least one microRNA target sequence of an endogenous, cellular microRNA and a nucleic acid encoding a viral protein, wherein the microRNA target sequence is located in the untranslated or translated region of the nucleic acid encoding the viral protein. Also provided are vector systems, compositions and cells comprising the provided helper nucleic acids and a vector or replicon. Methods of making virus-like replicon particles and populations of virus-like replicon particles (VRP) are also provided.


Patent
AlphaVax Inc. | Date: 2016-08-11

The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.


Patent
AlphaVax Inc. | Date: 2011-03-02

Provided herein are methods for producing alphavirus replicon particles in high yield; replicon RNAs are electroporated into permissive cells, where the cells are at a relatively high density, together with at least one helper nucleic acid providing the necessary functions for packaging. After a growth period in appropriate medium, alphavirus replicon particles are harvested from the surfaces of the cells in which they were produced using a salt wash in which the salt concentration is from about 0.2 to about 5 M sodium chloride, calcium chloride, magnesium chloride, potassium chloride, ammonium acetate, ammonium bicarbonate, among others. After dilution, if necessary, the particles can be purified by a suitable chromatographic technique.


The present invention provides use of an isolated RNA molecule comprising: a) an alphavirus 5 replication recognition sequence, wherein at least one initiation codon has been removed from the 5 replication recognition sequence; b) a nucleotide sequence encoding an alphavirus structural protein; and c) an alphavirus 3 replication recognition sequence, with the proviso that the RNA molecule does not contain a promoter that directs transcription of the nucleotide sequence of (b), and wherein the alphavirus 5 and 3 replication recognition sequences of (a) and (c) direct replication of the RNA molecule in the presence of alphavirus nonstructural proteins in inducing an immune response in a subject or for use in immunizing a subject or for treating a subject.


Disclosed are methods for preparing dried (preferably lyophilized) preparations comprising a population of alphaviruses or alphavirus replicon particles, a sugar or polyol, a surfactant and a salt and preparations made by these methods, both in the dried form but also as liquids prior to drying or after reconstituting dried preparations. These preparations may further comprise a plasticizer and/or a bulking agent. These preparations are readily reconstituted, with little or no loss in infectivity of the viruses or replicon particles.


Patent
AlphaVax Inc. | Date: 2015-07-06

The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.

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