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Craigavon, United Kingdom

Hamill N.A.,Almac science | Howells M.E.,Novozymes AS
ACS Symposium Series | Year: 2014

The safe management of hazardous reagents is a key part of the transition from medicinal chemistry syntheses to pilot scale processes. The detection, investigation and circumvention of the risks associated with their use at scale are elucidated through six case studies from the contract manufacturing sector. An approach for the successful scale up using hazardous reagents is described, involving the combination of chemical hazard assessment and 'holistic process design', where the integration of hazard reduction measures and the maintenance of product quality should be viewed with equal importance. © 2014 American Chemical Society.

Maltman B.A.,Elvingston Science Center | Dunsmore C.J.,Elvingston Science Center | Couturier S.C.M.,Almac science | Tirnaveanu A.E.,Elvingston Science Center | And 5 more authors.
Chemical Communications | Year: 2010

A novel long lifetime fluorescence reporter based on 9-aminoacridine was designed, the lifetime of which can be modulated in a defined manner when in proximity to a tryptophan residue enabling fluorescence lifetime based biochemical assays to be configured. © 2010 The Royal Society of Chemistry.

Fabian L.,University College Cork | Hamill N.,Almac science | Eccles K.S.,University College Cork | Moynihan H.A.,University College Cork | And 3 more authors.
Crystal Growth and Design | Year: 2011

Cocrystal formation between nicotinamide and five fenamic acid derivative drugs (flufenamic acid, niflumic acid, tolfenamic acid, mefenamic acid and meclofenamic acid) was investigated using solution-based and solid-state preparation methods. It was anticipated that the well-known acid-aromatic nitrogen heterosynthon would provide a sufficient driving force for cocrystallization. The experiments yielded cocrystals with four of the five acids. Although the structures of these molecules are similar, they showed marked differences in both the stability and the stoichiometry of the cocrystals. A detailed analysis of the structures and properties of both the starting materials and the cocrystals allows a tentative explanation of these differences, but it also shows that even though all four cocrystals utilize one of the most predictable supramolecular synthons (COOH...N), their structures and properties remain elusive to design. © 2011 American Chemical Society.

Zlateski V.,ETH Zurich | Fuhrer R.,ETH Zurich | Koehler F.M.,ETH Zurich | Wharry S.,Almac science | And 5 more authors.
Bioconjugate Chemistry | Year: 2014

In the pursuit of robust and reusable biocatalysts for industrial synthetic chemistry, nanobiotechnology is currently taking a significant part. Recently, enzymes have been immobilized on different nanoscaffold supports. Carbon coated metallic nanoparticles were found to be a practically useful support for enzyme immobilization due to their large surface area, high magnetic saturation, and manipulatable surface chemistry. In this study carbon coated cobalt nanoparticles were chemically functionalized (diazonium chemistry), activated for bioconjugation (N,N-disuccinimidyl carbonate), and subsequently used in enzyme immobilization. Three enzymes, β-glucosidase, α-chymotrypsin, and lipase B were successfully covalently immobilized on the magnetic nonsupport. The enzyme-particle conjugates formed retained their activity and stability after immobilization and were efficiently recycled from milliliter to liter scales in short recycle times. © 2014 American Chemical Society.

Higgins C.A.,Queens University of Belfast | Bell T.,Almac science | Delbederi Z.,Almac science | Feutren-Burton S.,Almac science | And 6 more authors.
Planta Medica | Year: 2010

A study of the components of the fruits of Kigelia pinnata was undertaken to identify compounds with potential growth inhibitory activity against human melanoma cells, since extracts from the fruits of this plant have been described in traditional medicine to have application in the treatment of skin cancer and other skin ailments. A bioactivity-guided fractionation process yielded a number of crude fractions, which demonstrated cytotoxicity in vitro against human melanoma cells. Compounds isolated and identified included the isocoumarins, demethylkigelin (1) and kigelin (2), fatty acids, oleic (3) and heneicosanoic acids (4), the furonaphthoquinone, 2-(1-hydroxyethyl)-naphtho[2,3- b]furan-4,9-dione (5), and ferulic acid (6). A number of structurally related synthetic compounds were also tested using the MTT assay. The most potent series of these compounds, the furonaphthoquinones, also demonstrated a cytotoxic effect in two human breast cancer cell lines tested. © Georg Thieme Verlag KG Stuttgart · New York.

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