AlloSource

Centennial, CO, United States

AlloSource

Centennial, CO, United States
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There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose issue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.


Patent
AlloSource | Date: 2016-08-08

Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and methods. The methods involve combining tissue with a processing solution in a processing vessel and applying resonant acoustic energy thereto. In some instances, the tissue is processed in the absence of processing solution. The resonant acoustic energy rapidly agitates the tissue with the processing solution by vibration. The general method provided is broadly applicable to a variety of tissue processing methods, the processing solution and features of the resonant acoustic energy being selected based on the type of tissue to be processed and the nature of the processing to be performed. Exemplary methods include methods of bone demineralization, tissue decellularization, tissue cryopreservation, production of stromal vascular fraction, tissue homogenization, tissue cleansing, and tissue decontamination, and assessment of microbial load. By applying resonant acoustic energy to the tissue during processing, the rate or efficiency of processing, or both, may be improved.


Patent
AlloSource | Date: 2015-05-15

Embodiments of the present technology include a graft for administration at a treatment site of a patient. The graft may include a human cadaveric bone material bonded together with a polymeric binder. The human cadaveric bone material may include demineralized bone particles. The demineralized bone particles may have an average diameter less than 1.1 mm, less than 750 m, less than 500 m, or less than 250 m. The human cadaveric bone material may include non-demineralized bone, cancellous bone, and/or cortical bone in embodiments. In some embodiments, bone from animals other than humans may be used, and the patient may be an animal other than a human.


There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose tissue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.


Patent
AlloSource | Date: 2015-11-13

There is disclosed a system and method for measuring the diameter or thickness of a tendon. In an embodiment, the device includes an adjustable tube having a variably sized cross-sectional diameter in a direction perpendicular to an axis extending between the first end and the second end, the adjustable tube being positionable from an open configuration in which the variably sized cross-sectional diameter is larger than a diameter of a tendon so as to allow loading of the tendon, to a closed configuration in which the variably sized cross-sectional diameter approximates the diameter of the tendon so as to allow measurement of the tendon. The device includes a measurement gradient in operable configuration with the adjustable tube so as to allow measurement of the tendon in the closed configuration. Other embodiments are also disclosed.


Patent
AlloSource | Date: 2016-02-05

Described are permeable pouches for tissue containment and methods for their use and manufacture. Exemplary pouches include a permeable material formed to create a cavity into which tissue graft material can be placed. Tissue graft material may be enclosed within a sealed pouch or within an unsealed pouch.


Embodiments of the present invention provides bone graft compositions, and methods for their use and manufacture. A bone graft composition may include a first amount of non-demineralized cancellous bone. The composition may further include a second amount of demineralized cancellous bone. The composition may also include a third amount of demineralized cortical bone. The non-demineralized cancellous bone, the demineralized cancellous bone, and the demineralized cortical bone may be obtained from the same cadaveric donor.


There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose tissue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.


Patent
AlloSource | Date: 2015-11-13

There is disclosed a system and method for laser cutting of human allograft tissue. One embodiment includes a laser canister having a housing fabricated with a sterilizable material. The housing defines an interior portion, an exterior portion, and a selectively operable opening into the interior portion. The selectively operable opening includes a hermetic seal to maintain a sterile environment from the exterior portion when the selectively operable opening is closed. The canister includes an infrared (IR) transmissive optical window disposed in the housing and configured to allow a laser beam to penetrate therethrough to the interior portion. The canister also includes an insert within the interior portion configured to support human allograft tissue in a sterile environment, the insert being removable from the housing to move the human allograft tissue into another sterile environment after the housing has been exposed to a non-sterile environment. Other embodiments are also disclosed.


Patent
AlloSource | Date: 2015-10-05

Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.

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