Guo C.X.,National University of Singapore |
Huang S.,Alliance Technology Group |
Lu X.,National University of Singapore
Green Chemistry | Year: 2014
A green and one-step solventless thermolysis approach is developed for large-scale production of ultra-small magnetic ferrite nanocrystals with size down to 3.5 nm. By simply heating a mixed solid powder containing metal acetylacetonate and sodium citrate, a series of metal ferrite nanocrystals including Fe3O4, MnFe2O4, NiFe 2O4 and CoFe2O4 are prepared. The nanocrystals exhibit both high hydrophilicity and good biocompatibility with uniform sizes that can be controlled by varying the ratio of metal acetylacetonate to sodium citrate, a green agent that is widely used as a food additive, a buffering regulator and an anticoagulant in blood transfusions. Thanks to the high hydrophilicity, the nanocrystals are demonstrated to be efficient draw solutes for protein enrichment with retained conformational structure based on an osmotically driven process. The green and one-step solventless thermolysis approach with advantages of minimal use of organic solvents and simplicity may be extended to fabrication of other ultra-small and hydrophilic nanoparticles with biocompatibility for a variety of applications. © the Partner Organisations 2014.
Pan H.M.,National University of Singapore |
Beyer S.,Alliance Technology Group |
Beyer S.,1 CREATE Way and 04 13 14 Enterprise Wing |
Zhu Q.,National University of Singapore |
Trau D.,National University of Singapore
Advanced Functional Materials | Year: 2013
The unique inwards interweaving morphology of polyamines and polyacids within agarose hydrogels that leads to the formation of striated shells with different porosities within the spherical scaffold is reported. Microcompartments with sophisticated structures are commonly used in drug delivery, tissue engineering, and other biomedical applications. However, a method capable of producing well-defined, multiporous shells within a single compartment is still lacking. By the alternating deposition of polyallylamine (PA) and polystyrenesulfonic acid (PSS) in 1-butanol, at equal mass ratios, multiple levels of porosity are generated within an agarose microsphere. Each level of porosity is represented by a well-defined, concentric shell of interweaving PA and PSS layers. The number, thickness, and porosity of the striated shells can be easily controlled by varying the number of PA/PSS bilayers and the polymer concentration, respectively. The feasibility of utilizing this morphology for the assembly of a multi-shell porous spherical scaffold is validated by trapping different molecular weight dextrans within different regions of porosity. The unique interaction of polyacids and polyamines in hydrogels represents a facile and inexpensive approach to the development of intricate scaffold architectures. The inwards interweaving of polyamine and polyacid layers within an agarose matrix leads to the creation of well-defined, spherical multi-shells with different porosities. The higher the density of interweaving layers, the lower the porosity. The number and thickness of different levels of porosity are easily tuned by varying the number of polymer depositions and polymer concentration, respectively. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
News Article | February 15, 2017
LAS VEGAS, NV--(Marketwired - February 15, 2017) - Avaya ENGAGE - Avaya has recognized five U.S partners for outstanding support, contribution and commitment to innovation at its Avaya ENGAGE event, currently underway at the MGM Grand in Las Vegas. The Partner awards are the first accolades to be presented at the five-day event and celebrate leaders across five categories, including: Innovation, Networking, Midmarket, Cloud and Service; as well as an overall award for Partner of the Year. The following winners were announced during the ENGAGE ceremony: IPC brings together a financial community of more than 6,000, combining industry expertise and comprehensive technology to help clients anticipate change and solve problems with innovative solutions through nationwide deployments in multivendor environments. As an Avaya partner, IPC has been instrumental in the development, beta testing and positioning of Avaya's SDN Fx Solution for Healthcare. Furthermore, IPC is a leader in the development of innovative customized applications around Aura, Engagement Solutions, Breeze, Private Cloud deployment and Avaya Networking. As an Avaya partner, Alliance Technology Group built the staging facility to accelerate installation at the Air National Guard for Avaya's largest networking deal. The company is extremely proficient in unified communications and continues to sell to the strength of Avaya's networking portfolio from a technology perspective, while also delivering double-digit year over year growth in networking sales. STL Communications provides customers with complete communication system management and monitoring services. As an Avaya partner, STL uses the powered by Avaya model to provide both voice and networking as managed service offerings; it also tailors these solutions to specific customer needs as part of a long term customer relationship strategy. In FY16, STL transformed its Total Voice Offer which increased sales of the popular midmarket-solution, IP Office, via a managed services offer. Windstream Communications provides voice and data network communications and managed services to businesses across the U.S.; it's also responsible for residential broadband, phone and digital TV services for more than 8.1 million consumers across 21 states. As an Avaya Partner, Windstream has been a pioneer in the UC/CC-as-a-service market, with its first Powered-by-Avaya xCaaS (Aura) solution established in 2013. The company has been integral in migrating customers to Windstream/Avaya Cloud solutions and has a strong reputation for accelerating delivery of contact center solutions to meet customers' fast-paced and rapidly changing business needs. ConvergeOne is a single-source provider for IT needs; from phone systems and computer networks, to hardware and application development. As an Avaya partner, ConvergeOne has demonstrated best-in-class growth in services, including a maintenance services renewal rate of 80 per cent, call center growth of 30 percent and product spend growth of more than 14 percent year over year. It's also led the roll out C1 Cloud Powered by Avaya. ConvergeOne also receives the accolade for Overall Partner of the Year, recognizing its outstanding revenue growth in 2016 in Product, Maintenance and APS in all sectors. Further to its aforementioned achievements, ConvergeOne is also lauded as Avaya's top growth performance rebate partner and the leading virtual infrastructure business partner, selling more than 20 Pod Fx platforms in Avaya in 2016. "As an Avaya partner, ConvergeOne has demonstrated best-in-class growth in services with superb renewal rates, excellent customer retention and delivery metrics that demonstrate their absolute customer focus," said Gary Levy, Vice President of U.S. Channels, Avaya. "Not only have they grown their Avaya Networking business five times over since 2015, but they have also been integral in several large strategic Breeze wins for Avaya in 2016." Levy continued, "Hats off to all of our partners who join us this week to participate in Avaya ENGAGE, and special congratulations to our award winners for their commitment to customers and passion to drive results. Our partners are an important part to Avaya's success, and it's with great honor to recognize this year's winners." About Avaya Avaya enables the mission critical, real-time communication applications of the world's most important operations. As the global leader in delivering superior communications experiences, Avaya provides the most complete portfolio of software and services for contact center and unified communications with integrated, secure networking-offered on premises, in the cloud, or a hybrid. Today's digital world requires some form of communications enablement, and no other company is better positioned to do this than Avaya. For more information please visit www.avaya.com. Follow Avaya on Twitter, Facebook, YouTube, LinkedIn and the Avaya Connected Blog.
Zeiger A.S.,Massachusetts Institute of Technology |
Zeiger A.S.,Alliance Technology Group |
Hinton B.,University of Minnesota |
Van Vliet K.J.,Massachusetts Institute of Technology
Acta Biomaterialia | Year: 2013
There is wide anecdotal recognition that biological cell viability and behavior can vary significantly as a function of the source of commercial tissue culture polystyrene (TCPS) culture vessels to which those cells adhere. However, this marked material dependency is typically resolved by selecting and then consistently using the same manufacturer's product-following protocol-rather than by investigating the material properties that may be responsible for such experimental variation. Here, we quantified several physical properties of TCPS surfaces obtained from a wide range of commercial sources and processing steps, through the use of atomic force microscopy (AFM)-based imaging and analysis, goniometry and protein adsorption quantification. We identify qualitative differences in surface features, as well as quantitative differences in surface roughness and wettability that cannot be attributed solely to differences in surface chemistry. We also find significant differences in cell morphology and proliferation among cells cultured on different TCPS surfaces, and resolve a correlation between nanoscale surface roughness and cell proliferation rate for both cell types considered. Interestingly, AFM images of living adherent cells on these nanotextured surfaces demonstrate direct interactions between cellular protrusions and topographically distinct features. These results illustrate and quantify the significant differences in material surface properties among these ubiquitous materials, allowing us to better understand why the dish can make a difference in biological experiments. © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
So P.T.C.,Massachusetts Institute of Technology |
So P.T.C.,Alliance Technology Group |
Yew E.Y.S.,Alliance Technology Group |
Rowlands C.,Massachusetts Institute of Technology
Biophysical Journal | Year: 2013
High-resolution microscopy methods based on different nonlinear optical (NLO) contrast mechanisms are finding numerous applications in biology and medicine. While the basic implementations of these microscopy methods are relatively mature, an important direction of continuing technological innovation lies in improving the throughput of these systems. Throughput improvement is expected to be important for studying fast kinetic processes, for enabling clinical diagnosis and treatment, and for extending the field of image informatics. This review will provide an overview of the fundamental limitations on NLO microscopy throughput. We will further cover several important classes of high-throughput NLO microscope designs with discussions on their strengths and weaknesses and their key biomedical applications. Finally, this review will close with a perspective of potential future technological improvements in this field. © 2013 The Authors.
Zheng D.,Alliance Technology Group
American journal of respiratory cell and molecular biology | Year: 2014
Transformation-related protein 63-expressing (p63(+)) basal cells are confined to the trachea in the mouse lung. However, after influenza virus infection or bleomycin treatment, patches of p63(+) cells were observed in the damaged lung parenchyma. To address whether the newly induced p63(+) cells are derived from the p63(+) basal cells, we performed lineage tracing. In a keratin 5 promoter-driven CreER system, although preexisting p63(+) basal cells were labeled by enhanced green fluorescent protein (EGFP) after tamoxifen treatment, none or only a small fraction (∼ 15%) of the p63(+) patches was labeled by EGFP after bleomycin treatment or influenza virus infection, respectively. In contrast, > 60% of p63(+) patches contained EGFP(+) cells in Scgb1a1-CreER transgenic system where club cells are labeled. Many p63(+) cells were found in bronchiole-like lumen structures with columnar cells at the lumen side. The columnar cells were positive for club cell marker Cyp2f2 and could be traced to the newly induced p63(+) cells. These results suggest that most of the newly induced p63(+) cells in the damaged parenchyma are likely derived from club cells rather than from p63(+) basal cells and that newly induced p63(+) cells may be involved in the regeneration of bronchioles.
Derrible S.,Alliance Technology Group
PLoS ONE | Year: 2012
Whilst being hailed as the remedy to the world's ills, cities will need to adapt in the 21st century. In particular, the role of public transport is likely to increase significantly, and new methods and technics to better plan transit systems are in dire need. This paper examines one fundamental aspect of transit: network centrality. By applying the notion of betweenness centrality to 28 worldwide metro systems, the main goal of this paper is to study the emergence of global trends in the evolution of centrality with network size and examine several individual systems in more detail. Betweenness was notably found to consistently become more evenly distributed with size (i.e. no "winner takes all") unlike other complex network properties. Two distinct regimes were also observed that are representative of their structure. Moreover, the share of betweenness was found to decrease in a power law with size (with exponent 1 for the average node), but the share of most central nodes decreases much slower than least central nodes (0.87 vs. 2.48). Finally the betweenness of individual stations in several systems were examined, which can be useful to locate stations where passengers can be redistributed to relieve pressure from overcrowded stations. Overall, this study offers significant insights that can help planners in their task to design the systems of tomorrow, and similar undertakings can easily be imagined to other urban infrastructure systems (e.g., electricity grid, water/wastewater system, etc.) to develop more sustainable cities. © 2012 Sybil Derrible.
Alliance Technology Group | Date: 2017-01-27
Alliance Technology Group | Date: 2016-04-20