Allergology Unit

San Bernardino, Venezuela

Allergology Unit

San Bernardino, Venezuela

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Hulett A.C.,Allergology Unit | Hulett A.C.,Centro Medico Docente La Trinidad | Hulett A.C.,Hospital San Juan Of Dios | Yibirin M.G.,LETI Laboratories | And 4 more authors.
Journal of Asthma | Year: 2013

Background. Asthma is a significant public health problem in Venezuela affecting the predominantly urban and poor majority of the population. Information regarding home and the social environment, key elements in asthma, is found to be deficient in these deprived socioeconomic sectors. This study was carried out to depict a life with asthma in this context which has been served over the years by a National Asthma Control Program. Methods. A survey of families residing in a socioeconomically deprived community of Caracas was carried out with the assumption that this community reflects the image of a life with asthma emanating from our deprived urban areas. Home physical settings were inspected for the following items: moldy walls, floors, ceilings, windows, sewage, garbage disposal, running water, plumbing, electricity, telephone, construction debris, furniture, bathrooms, food storage, and home appliances. In addition, we also gathered information regarding smoking habits, fumes exposure, pets and/or animals, and sighting of roaches and/or rodents. The presence of people with asthma was observed and their status of control was assessed through the asthma control test (ACT). Comparisons were made between families with asthmatics and those without asthmatics. Results. Randomly, 242 of 750 families (32.26%) were surveyed, with "head of family" providing information (75.6%) on most occasions. No significant association was found with respect to the previously explored items in those families with or without the presence of asthmatics. Medically diagnosed asthma was found in 14.91%, with ACT scores of <19 points in two-thirds of these adults and asthmatic children. Asthmatics reported symptoms occurring mostly during the night and an almost exclusive use of rescue medications. Families provided most treatments and children preferred to use the oral route for control medications. Significant work and school absenteeism were detected in more than 50% of these asthmatics. Conclusions. No physical home environmental/risk factors turned out to be significantly associated with families reporting the presence of asthmatics. The high impact of asthma found in this Caracas slum underscores the realities of Venezuela's impoverished urban majority. To properly address this important challenge, our National Asthma Control Program needs to be reassessed. © 2013 Informa Healthcare USA, Inc.


Guilleminault L.,Allergology unit | Guilleminault L.,French Institute of Health and Medical Research | Rigal E.,Allergology unit | Carre P.,Service de pneumologie | And 2 more authors.
Revue Francaise d'Allergologie | Year: 2012

We report a case of a woman who presented anaphylaxis to polyethylene glycol (PEG) associated with positive skin tests to a pegylated drug. To the best of our knowledge, this is the first case, which suggests a potential allergy to pegylated drugs in patients with anaphylaxis to PEG. With the increasing use of pegylated drugs, physicians and patients should be informed of this potential allergy because drug databases do not always clearly indicate that pegylated drugs contain PEG. © 2011 Elsevier Masson SAS.


Ventura M.T.,University of Bari | Napolitano S.,University of Bari | Buquicchio R.,University of Bari | Cecere R.,University of Bari | Arsieni A.,Allergology Unit
Immunopharmacology and Immunotoxicology | Year: 2012

The guidelines for the management of urticaria in adults and children have been published in outstanding position papers. By contrast, the onset of urticaria in the elderly has not yet had a clear definition. In order to approach diagnosis and treatment in a population of elderly patients, we have performed an epidemiological study on a population of elderly people observed in the Immuno Allergology Unit in Bari University Hospital. The patients underwent skin prick test for food allergy and laboratory and instrumental tests. From the data it resulted that 49% of cases have had urticaria because of adverse drug reactions (ADRs), 16% of cases were positive to food, while in 21% of cases systemic and metabolic diseases (SMDs) have been diagnosed. If we consider the young controls, urticaria for ADR was present in 48% of cases; however, in 28% it was possible to make the diagnosis of food allergy, 12% cases had a SMD. Our results show that the main cause of urticaria in the elderly is related to drug assumption because of the high number of drugs taken, followed by internal pathologies correlated to the typical immune and metabolic changes of the elderly. Furthermore, from the observation of our data it was possible to give guidelines for the treatment of urticaria in geriatric age. © 2012 Informa Healthcare USA, Inc.


Zambetti G.,University of Rome La Sapienza | Ciofalo A.,University of Rome La Sapienza | Soldo P.,University of Rome La Sapienza | Fusconi M.,University of Rome La Sapienza | And 7 more authors.
International Journal of Immunopathology and Pharmacology | Year: 2010

An eosinophilic inflammatory process is generally observed in patients suffering from nasal polyposis (NP), however its onset has not yet been defined. It has been suggested that immune activation of inflammatory cells may be the cause. The aim of this study is to verify whether autoantibodies and/or histamine-releasing factors are present in the serum of patients suffering from NP. In fact, we assume that autoantibodies and/or histamine-releasing factors, as already demonstrated in chronic idiopathic urticaria and asthma, may be involved in the pathogenesis of NP. In this case-control analytical study 40 patients with NP and 27 control subjects underwent the in vivo autologous serum skin test (ASST). The sera from 6 patients suffering from NP and 9 control group subjects, who had all been previously studied and randomly selected, underwent basophil histamine release assay from normal donor as a pilot study. The ASST showed positive results in 55% of patients suffering from NP versus 8% of the control group (p= .00006), the basophil histamine release test (BHRT) turned out positive in all patients tested and in 11% of the control group. We found a weak positive correlation between the percentage of histamine release and the wheal diameter. ASST reactivity is very frequent in patients suffering from NP, thus suggesting the presence of histamine-releasing factors in the blood stream. The BHRT was positive in the serum of all patients, thus suggesting the presence of anti-FcεRI, anti-IgE autoantibodies and/or other histamine-releasing factors, the presence of which can play a role in triggering and maintaining the eosinophilic inflammatory process in NP. Copyright © by BIOLIFE, s.a.s.

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