Le Blanc-Mesnil, France
Le Blanc-Mesnil, France

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Curjuric I.,University of Zürich | Curjuric I.,University of Basel | Imboden M.,University of Zürich | Schindler C.,University of Basel | And 53 more authors.
European Respiratory Journal | Year: 2010

Reduced exposure to particulate matter with a 50% cut-off aerodynamic diameter of 10 μm (PM10) attenuated age-related lung function decline in our cohort, particularly in the small airways. We hypothesised that polymorphisms in glutathione S-transferase (GST) and haem oxygenase-1 (HMOX1) genes, important for oxidative stress defence, modify these beneficial effects. A population-based sample of 4,365 adults was followed up after 11 yrs, including questionnaire, spirometry and DNA blood sampling. PM10 exposure was estimated by dispersion modelling and temporal interpolation. The main effects on annual decline in forced expiratory flow at 25-75% of forced vital capacity (FEF25-75%) and interactions with PM10 reduction were investigated for polymorphisms HMOX1 rs2071746 (T/A), rs735266 (T/A) and rs5995098 (G/C), HMOX1 (GT)n promoter repeat, GSTM1 and GSTT1 deletions, and GSTP1 p.Ile105Val, using mixed linear regression models. HMOX1 rs5995098, HMOX1 haplotype TTG and GSTP1 showed significant genetic main effects. Interactions with PM10 reduction were detected: a 10 μg·m-3 reduction significantly attenuated annual FEF25-75% decline by 15.3 mL·s-1 only in the absence of HMOX1 haplotype ATC. Similarly, carriers of long (GT)n promoter repeat alleles or the GSTP1 Val/Val genotype profited significantly more from a 10 mg?m-3 reduction (26.5 mL·s-1 and 27.3 mL·s-1 respectively) than non-carriers. Benefits of a reduction in PM10 exposure are not equally distributed across the population but are modified by the individual genetic make-up determining oxidative stress defence. Copyright©ERS Journals Ltd 2010.


Tsapis M.,Jean Verdier University Hospital | Tsapis M.,Avicenne University Hospital | Chabane H.,Delafontaine Hospital | Teychene A.M.,Jean Verdier University Hospital | And 3 more authors.
Revue Francaise d'Allergologie | Year: 2013

Allergic reactions following snail ingestion in house dust mite-sensitized patients are well known, although the allergens concerned in the cross-reactivity remain to be identified. We report the case of a fatal anaphylactic reaction following snail ingestion in a 10-year old boy, which occurred 2. months after conclusion of 3. years of house dust mite subcutaneous immunotherapy. This case highlights a possible cross-reaction between food and inhalant allergens leading to a fatal outcome. We discuss the relation between house dust mite immunotherapy and this fatal food allergic reaction. Conclusion: Physicians should be aware of the possibility of severe anaphylaxis following snail ingestion in house dust mite allergic patients undergoing subcutaneous immunotherapy as this appears to constitute a risk factor for such reactions. © 2013 Elsevier Masson SAS.


News Article | October 26, 2016
Site: www.eurekalert.org

The study team was lead by Professor Paolo Maria Matricardi, head of the Molecular Allergology Group at the Department of Pediatric Pulmonology and Immunology of the Charité and included researchers from the Medical University of Vienna, lead by Prof. Rudolf Valenta, and statisticians from Rome, Italy. The team examined the data and blood samples prospectively collected over 20 years from a cohort of 722 German children born in 1990 and monitored since their birth in the framework of the Multicenter Allergy Study (MAS). Purified or engineered molecules of the mite Dermatophagoides pteronyssinus were used with nanotechnology procedures to characterize the origins and evolution of the antibody response during the children's first decades of life. The scientists found that IgE-antibodies against three dust mite molecules (Der p 1, Der p 2 and Der p 23) appeared very early in the children's blood, often before the onset of their disease. In some (but not all) children, this first step was followed by a "cascade" of events involving other mite molecules, through a phenomenon defined as "molecular spreading". Children producing IgE to many molecules ("polymolecular sensitization") had a higher risk of developing allergic rhinitis and asthma. Earlier onset of allergic sensitization, high exposure to house dust mite allergens, and having one or both parents affected by hay fever increased the risk of polymolecular sensitization. Interestingly, healthy pre-school children showing IgE antibodies to Der p 1 or Der p 23 developed more frequently asthma at school age. These and other molecules may be used for disease prevention in early life and to precisely tailor allergen immunotherapy in pediatric and adult patients. "Mite allergy develops in childhood like an avalanche. It starts early with only one or a very few molecules and then grows to many", says Dr Daniela Posa,, first Author of the publication. "The greater the spreading of molecular sensitization, the highest the risk of developing Asthma." PD. Dr. Matricardi adds: "Our findings open new perspectives to the use of mite allergen molecules for prediction, prevention and therapy of allergic rhinitis and asthma caused or triggered by House Dust Mites."


News Article | October 28, 2016
Site: www.sciencedaily.com

Scientists at the Charité -- Universitätsmedizin Berlin found which molecules of the house dust mites are initially targeted by the immune system of children developing, even years later, allergic rhinitis and asthma. The discovery, published in the Journal of Allergy and Clinical Immunology, will open up new avenues not only to novel and more precise therapies, but also to a successful prediction and prevention of chronic rhinitis and asthma caused or aggravated by allergy to house dust mites. The study team was lead by Professor Paolo Maria Matricardi, head of the Molecular Allergology Group at the Department of Pediatric Pulmonology and Immunology of the Charité and included researchers from the Medical University of Vienna, lead by Prof. Rudolf Valenta, and statisticians from Rome, Italy. The team examined the data and blood samples prospectively collected over 20 years from a cohort of 722 German children born in 1990 and monitored since their birth in the framework of the Multicenter Allergy Study (MAS). Purified or engineered molecules of the mite Dermatophagoides Pteronyssinus were used with nanotechnology procedures to characterize the origins and evolution of the antibody response during the children's first decades of life The scientists found that IgE-antibodies against three dust mite molecules (Der p 1, Der p 2 and Der p 23) appeared very early in the children's blood, often before the onset of their disease. In some (but not all) children, this first step was followed by a "cascade" of events involving other mite molecules, through a phenomenon defined as "molecular spreading." Children producing IgE to many molecules ("polymolecular sensitization") had a higher risk of developing allergic rhinitis and asthma. Earlier onset of allergic sensitization, high exposure to house dust mite allergens, and having one or both parents affected by hay fever increased the risk of polymolecular sensitization. Interestingly, healthy pre-school children showing IgE antibodies to Der p 1 or Der p 23 developed more frequently asthma at school age. These and other molecules may be used for disease prevention in early life and to precisely tailor allergen immunotherapy in pediatric and adult patients. "Mite allergy develops in childhood like an avalanche. It starts early with only one or a very few molecules and then grows to many," says Dr Daniela Posa,, first Author of the publication. "The greater the spreading of molecular sensitization, the highest the risk of developing Asthma." PD. Dr. Matricardi adds: "Our findings open new perspectives to the use of mite allergen molecules for prediction, prevention and therapy of allergic rhinitis and asthma caused or triggered by House Dust Mites."


News Article | October 26, 2016
Site: www.cemag.us

Scientists at the Charité-Universitätsmedizin Berlin have found which molecules from house dust mites are initially targeted by the immune system of children who develop (even years later) allergic rhinitis and asthma. The discovery, published in the Journal of Allergy and Clinical Immunology, will open up new avenues not only to novel and more precise therapies, but also to a successful prediction and prevention of chronic rhinitis and asthma caused or aggravated by allergies to house dust mites. The study team was led by Professor Paolo Maria Matricardi, head of the Molecular Allergology Group at the Department of Pediatric Pulmonology and Immunology of the Charité and included researchers from the Medical University of Vienna, lead by Professor Rudolf Valenta, and statisticians from Rome. The team examined the data and blood samples collected over 20 years from a group of 722 German children born in 1990; they were monitored since their birth in the framework of the Multicenter Allergy Study (MAS). Purified or engineered molecules of the mite Dermatophagoides Pteronyssinus were used with nanotechnology procedures to characterize the origins and evolution of the antibody response during the children’s first decades of life. The scientists found that IgE-antibodies against three dust mite molecules (Der p 1, Der p 2, and Der p 23) appeared very early in the children’s blood, often before the onset of their disease. In some (but not all) children, this first step was followed by a “cascade” of events involving other mite molecules, through a phenomenon defined as “molecular spreading.” Children producing IgE to many molecules (“polymolecular sensitization”) had a higher risk of developing allergic rhinitis and asthma. Earlier onset of allergic sensitization, high exposure to house dust mite allergens, and having one or both parents affected by hay fever increased the risk of polymolecular sensitization. Interestingly, healthy pre-school children showing IgE antibodies to Der p 1 or Der p 23 developed more frequently asthma at school age. These and other molecules may be used for disease prevention in early life and to precisely tailor allergen immunotherapy in pediatric and adult patients. “Mite allergy develops in childhood like an avalanche. It starts early with only one or a very few molecules and then grows to many,” says Dr. Daniela Posa, first author of the publication. "The greater the spreading of molecular sensitization, the highest the risk of developing Asthma." Matricardi adds, “Our findings open new perspectives to the use of mite allergen molecules for prediction, prevention and therapy of allergic rhinitis and asthma caused or triggered by house dust mites.”


Spielmanns M.,St Remigius Hospital | Spielmanns M.,Witten/Herdecke University | Fuchs-Bergsma C.,St Remigius Hospital | Winkler A.,St Remigius Hospital | And 3 more authors.
Respiratory Care | Year: 2015

BACKGROUND: It is well established that physical training enhances functionality and quality of life in patients with COPD. However, little data exist concerning the effects of the usefulness of oxygen supply during exercise training for > 3 months in patients with COPD who are normoxemic at rest and during exercise. We hypothesized that oxygen supply during training sessions enables higher training intensity and thus optimizes training results in patients with COPD. METHODS: In this blinded randomized controlled study, we carried out a 24-week training program with progressively increasing loads involving large muscle groups. In addition, we compared the influences of oxygen supplementation. Thirty-six subjects with moderate-to-severe COPD who were not dependent on long-term oxygen therapy trained under supervision for 24 weeks (3 times/week at 30 min/session). Subjects were randomized into 2 groups: oxygen supply via nasal cannula at a flow of 4 L/min and compressed air at the same flow throughout the training program. Lung function tests at rest (inspiratory vital capacity, FEV1, Tiffeneau index), cycle spiroergometry (peak ventilation, peak oxygen uptake, peak respiratory exchange rate, submaximal and peak lactic acid concentrations), 6-min walk tests, and quality-of-life assessments (Medical Outcomes Study 36-Item Short Form questionnaire) were conducted before and after 12 and 24 weeks. RESULTS: Independent of oxygen supplementation, statistically significant improvements occurred in quality of life, maximal tolerated load during cycling, peak oxygen uptake, and 6-min walk test after 12 weeks of training. Notably, there were no further improvements from 12 to 24 weeks despite progressively increased training loads. CONCLUSIONS: Endurance training 3 times/week resulted in significant improvements in quality of life and exercise capacity in subjects with moderate-to-severe COPD within the initial 12 weeks, followed by a stable period over the following 12 weeks with no further benefits of supplemental oxygen. © 2015 Daedalus Enterprises.


Hoxha M.,Allergology | Deliu A.,University of Tirana | Nikolla E.,University of Tirana | Loloci G.,University of Tirana | Kalo T.,University of Tirana
Macedonian Journal of Medical Sciences | Year: 2014

Food-dependent exercise-induced anaphylaxis (FDEIA), is a severe form of allergy for which the ingestion of a specific food, usually before physical exercise induces symptoms of anaphylaxis. Patients typically have IgE antibodies to the food that triggers the reactions; however, the symptoms appear only if the co-factors act together. The most common reported cause of these reactions seems to be wheat. In some cases FDEIA is displayed even when the food is eaten immediately after exercise, showing that in FDEIA, not the sequence but rather the coincidence of triggering factors use, is of crucial importance. The risk to develop anaphylaxis in these patients depends on the presence and, in some cases, on the amount of cofactors of anaphylaxis. There are lots of evidences about the role of NSAIDs as cofactors of anaphylaxis. © 2014 Hoxha et al.


Background: Seasonal Allergic rhinitis (SAR) is characterized by runny nose, congestion, sneezing and sinus pressure. A clinical study was performed to demonstrate the efficacy of Lertal®, an innovative food supplement containing Quercetin, Perilla frutescens and Vitamin D3 formulated in a double layer “fast-slow” release tablet form, in the relief of symptoms of seasonal allergic rhinitis and in the reduction of consumption of anti-allergic drugs. Patients and methods: 23 subjects enrolled in the open clinical study had at least one year history of allergic rhinitis and positive skin prick test or RAST to Parietaria officinalis pollen. At baseline, the subjects had symptoms of nasal and/or ocular seasonal allergic rhinitis. The activity of the food supplement was evaluated using the Total Symptoms Score at first (baseline) and second (final) visit, after one month of supplementation. The consumption of anti-allergic drugs was also evaluated. Results: All subjects enrolled completed the study. The comparison of the scores obtained in the two visits (baseline and final) showed a highly significant reduction of the overall symptoms: approximately 70% for symptom scores and 73% in use of anti-allergic drugs. Sneezing, rhinorrhea, nasal obstruction, ocular itching, lacrimation and congestion of the conjunctiva, all showed a highly significant reduction. No noteworthy side effect was recorded and all patients finished the study with good compliance. Conclusions: The results showed a clear efficacy of the food supplement Lertal® in reducing nasal and/or eye symptoms. This activity was objectively confirmed by the reduction in the consumption of anti-allergic drugs used to relieve symptoms. © Mattioli 1885.

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