Bernede A.,Allergologie et immunologie clinique |
Pralong P.,Allergologie et immunologie clinique |
Pralong P.,French Institute of Health and Medical Research |
Pralong P.,University of Lyon |
And 8 more authors.
Revue Francaise d'Allergologie | Year: 2014
We report a case of anaphylaxis in a 53-year-old patient 31. years after the last contact with amoxicillin. He had an anaphylactic reaction grade II (according to Ring and Messner) 10. minutes after ingesting an amoxicillin tablet. The allergy workup confirmed immediate allergic sensitivity to amoxicillin. This recent reaction suggests the persistence of a sufficient amount of amoxicillin-specific IgE to produce anaphylaxis and raises the question of the possibility of long-term maintenance of amoxicillin-specific sensitivity. Several hypotheses may explain this phenomenon: antibody secretion by plasma cells might last for years after antigenic stimulation, or the patient could have been exposed incidentally to penicillins. Occult exposure by intake of antigens in food has also been reported. © 2014 Elsevier Masson SAS.