Columbia, SC, United States
Columbia, SC, United States

Allen University is a private, coeducational historically Black university located in Columbia, South Carolina, United States. Allen University has over 600 students and still serves a predominantly Black constituency. It is experiencing financial troubles and has been placed on "warning status" by its regional accreditor the Southern Association of Colleges and Schools. Wikipedia.

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Solomon A.J.,Allen University | Klein E.P.,Oregon Health And Science University | Bourdette D.,Oregon Health And Science University
Neurology | Year: 2012

Objective: To describe the clinical characteristics of encounters with patients misdiagnosed with multiple sclerosis (MS). Methods: A cross-sectional Internet-based physician survey of MS specialists was performed. Results: The response rate for the survey was 50.4%. Of those who responded, the majority (95%) reported having evaluated 1 or more patients who had been diagnosed with MS, but who they strongly felt did not have MS, within the last year. The majority of respondents (≥90%) also reported the use of disease-modifying therapy in a proportion of these patients. Most respondents (94%) found clinical encounters with these patients equally or more challenging than giving a new diagnosis of MS. Fourteen percent of respondents reported that they did not always inform such patients of their opinion that they did not have MS. Conclusions: The misdiagnosis of MS is common and has significant consequences for patient care and health care system costs. Caring for a patient with a misdiagnosis of MS is challenging, and at times honest disclosure of a misdiagnosis represents an important ethical concern for neurologists. More data are needed on this patient population to improve diagnostic acumen and the care of these patients. Copyright © 2012 by AAN Enterprises, Inc.

Wilcox S.,University of South Carolina | Parrott A.,7th Episcopal District of the African Methodist Episcopal Church | Baruth M.,University of South Carolina | Laken M.,Medical University of South Carolina | And 8 more authors.
American Journal of Preventive Medicine | Year: 2013

Background: Faith-based interventions hold promise for promoting health in ethnic minority populations. To date, however, few of these interventions have used a community-based participatory research (CBPR) approach, have targeted both physical activity and healthy eating, and have focused on structural changes in the church. Purpose: To report the results of a group randomized CBPR intervention targeting physical activity and healthy eating in African-American churches. Design: Group RCT. Data were collected from 2007 to 2011. Statistical analyses were conducted in 2012. Setting/participants: Seventy-four African Methodist Episcopal (AME) churches in South Carolina and 1257 members within them participated in the study. Intervention: Churches were randomized to an immediate (intervention) or delayed (control) 15-month intervention that targeted organizational and environmental changes consistent with the structural ecologic model. A CBPR approach guided intervention development. Intervention churches attended a full-day committee training and a full-day cook training. They also received a stipend and 15 months of mailings and technical assistance calls to support intervention implementation. Main outcome measures: Primary outcomes were self-reported moderate- to vigorous-intensity physical activity (MVPA), self-reported fruit and vegetable consumption, and measured blood pressure. Secondary outcomes were self-reported fat- and fiber-related behaviors. Measurements were taken at baseline and 15 months. Intent-to-treat repeated measures ANOVA tested group X time interactions, controlling for church clustering, wave, and size, and participant age, gender, and education. Post hoc ANCOVAs were conducted with measurement completers. Results: There was a significant effect favoring the intervention group in self-reported leisure-time MVPA (d=0.18, p=0.02), but no effect for other outcomes. ANCOVA analyses showed an intervention effect for self-reported leisure-time MVPA (d=0.17, p=0.03) and self-reported fruit and vegetable consumption (d=0.17, p=0.03). Trainings were evaluated very positively (training evaluation item means of 4.2-4.8 on a 5-point scale). Conclusions: This faith-based structural intervention using a CBPR framework showed small but significant increases in self-reported leisure-time MVPA. This program has potential for broad-based dissemination and reach. Trial registration: This study is registered at NCT00379925. © 2013 American Journal of Preventive Medicine.

Kang D.G.,U.S. Army | Anderson J.C.,U.S. Army | Lehman R.A.,Allen University
Clinics in Sports Medicine | Year: 2016

Criteria for return to sports and athletic activities after cervical spine surgery are unclear. There is limited literature regarding the outcomes and optimal criteria. Determining return to play criteria remains a challenge and continues to depend on the experience and good judgment of the treating surgeon. There is strong consensus in the literature, despite lack of evidence-based data, that athletes after single-level anterior cervical discectomy and fusion (ACDF) may safely return to collision and high-velocity sports. The athlete should be counseled and managed on a case-by-case basis, taking into consideration the type of sport, player-specific variables, and type of surgery performed. © 2016

Vargas R.I.,U.S. Department of Agriculture | Pinero J.C.,Allen University | Leblanc L.,University of Hawaii at Manoa
Insects | Year: 2015

Fruit flies (Diptera: Tephritidae) are among the most economically important pest species in the world, attacking a wide range of fruits and fleshy vegetables throughout tropical and sub-tropical areas. These species are such devastating crop pests that major control and eradication programs have been developed in various parts of the world to combat them. The array of control methods includes insecticide sprays to foliage and soil, bait-sprays, male annihilation techniques, releases of sterilized flies and parasitoids, and cultural controls. During the twenty first century there has been a trend to move away from control with organophosphate insecticides (e.g., malathion, diazinon, and naled) and towards reduced risk insecticide treatments. In this article we present an overview of 73 pest species in the genus Bactrocera, examine recent developments of reduced risk technologies for their control and explore Integrated Pest Management (IPM) Programs that integrate multiple components to manage these pests in tropical and sub-tropical areas. © 2015 by the authors; licensee MDPI, Basel, Switzerland.

Jimenez-Lopez J.C.,CSIC - Experimental Station of El Zaidín | Jimenez-Lopez J.C.,Purdue University | Gachomo E.W.,Purdue University | Ariyo O.A.,Allen University | And 2 more authors.
Molecular Biology Reports | Year: 2012

Selected members of plant pathogenesis-related and seed storage proteins represent specific groups of proteins with potential characteristics of allergens. Efforts to understand the mechanism by which pathogenesis-related proteins mediate a broad cross-reactivity in pollen-plant food allergens are still limited. In this study, computational biology approach was used to reveal specific structural implications and conservation of different epitopes from members of Bet v 1 and nsLTP protein families mediating cross-reactivity between pollen and food (fruits, vegetables, legumes, and nut/seeds) allergens. A commonly shared epitope conservation was found among all pollen and food Bet v 1 and nsLTP protein families, respectively. However, other allergenic epitopes were also specifically detected in each family. The implication of these conserved epitopes in a broad cross-reactivity for allergy clinical trials is here discussed. © 2011 Springer Science+Business Media B.V.

Pinero J.C.,Allen University | Souder S.K.,U.S. Department of Agriculture | Vargas R.I.,U.S. Department of Agriculture
Florida Entomologist | Year: 2013

Key to the effectiveness of fruit fly (Diptera: Tephritidae) suppression efforts using insecticidal bait sprays is the determination of how long the bait remains attractive to adult flies after application. Using a comparative approach, field studies were conducted in commercial papaya (Carica papaya L.; Brassicales: Caricaceae) orchards in Hawaii with the goal of quantifying the response of Bactrocera dorsalis (Hendel) and Bactrocera cucurbitae (Coquillett) wild females to yellow bait stations treated with 2 dilutions (40% and 20%) of GF-120 NF Naturalyte™ Fruit Fly Bait that had been aged either outdoors (for 3 and 7 days) or indoors (for 1, 2, 3, and 7 days). Important variations in the level of female response to the baits were documented between these 2 fruit fly species, and the response levels were modulated by bait dilution, duration of aging and aging conditions. For B. dorsalis wild females, the attractiveness of 40% GF-120 and aged outdoors for either, 3 or 7 days did not differ significantly from the fresh bait, whereas for B. cucurbitae wild females a significant reduction (48 %) in bait attractiveness was recorded within 1 day of aging indoors independent of percent dilution of the bait. Environmental conditions, in particular mean temperature and relative humidity, prevailing during bait aging outdoors differed significantly from those recorded indoors, and these differences appeared to have influenced the attractiveness of GF-120. The types of variations in the level of responses to the aged baits documented in this study between fruit fly species within a genus, and potentially across genera need to be considered when developing suppression programs for fruit flies that involve the use of bait sprays.

Velez Acevedo R.N.,Virginia Commonwealth University | Velez Acevedo R.N.,Allen University | Ronpirin C.,Thammasat University | Kandler J.L.,Emory University | And 3 more authors.
Journal of Bacteriology | Year: 2014

Iron is an essential nutrient for survival and establishment of infection by Neisseria gonorrhoeae. The neisserial transferrin binding proteins (Tbps) comprise a bipartite system for iron acquisition from human transferrin. TbpA is the TonB-dependent transporter that accomplishes iron internalization. TbpB is a surface-exposed lipoprotein that makes the iron uptake process more efficient. Previous studies have shown that the genes encoding these proteins are arranged in a bicistronic operon, with the tbpB gene located upstream of tbpA and separated from it by an inverted repeat. The operon is under the control of the ferric uptake regulator (Fur); however, promoter elements necessary for regulated expression of the genes have not been experimentally defined. In this study, putative regulatory motifs were identified and confirmed by mutagenesis. Further examination of the sequence upstream of these promoter/operator motifs led to the identification of several novel repeats. We hypothesized that these repeats are involved in additional regulation of the operon. Insertional mutagenesis of regions upstream of the characterized promoter region resulted in decreased tbpB and tbpA transcript levels but increased protein levels for both TbpA and TbpB. Using RNA sequencing (RNA-Seq) technology, we determined that a long RNA was produced from the region upstream of tbpB. We localized the 5= endpoint of this transcript to between the two upstream insertions by qualitative RT-PCR. We propose that expression of this upstream RNA leads to optimized expression of the gene products from within the tbpBA operon. © 2014, American Society for Microbiology.

Hossain D.,Allen University | Pittman C.U.,Mississippi State University | Gwaltney S.R.,Mississippi State University
Journal of Inorganic and Organometallic Polymers and Materials | Year: 2014

The structures and stabilities of a series of endohedral gold clusters containing ten gold atoms M@Au10 (M = W, Mo, Ru, Co) have been determined using density functional theory. The gradient-corrected functional BP86, the Tao-Perdew-Staroverov-Scuseria TPSS meta-GGA functional, and the hybrid density functionals B3LYP and PBE1PBE were employed to calculate the structures, binding energies, adiabatic ionization potentials, and adiabatic electron affinities for these clusters. The LanL2DZ effective core potentials and the corresponding valence basis sets were employed. The M@Au10 (M = W, Mo, Ru, Co) clusters have higher binding energies than an empty Au10 cluster. In addition, the large HOMO–LUMO gaps suggest that the M@Au10 (M = W, Mo, Ru, Co) clusters are all likely to be stable chemically. The ionization potentials and electron affinities for these clusters are very high, and the W@Au10 and Mo@Au10 clusters have electron affinities similar to the super-halogen Al13. © 2013, Springer Science+Business Media New York.

Tendler A.,Allen University | Helmke S.,Allen University | Teruya S.,Allen University | Alvarez J.,Allen University | Maurer M.S.,Allen University
Amyloid | Year: 2015

Cardiac amyloidosis is a cause of diastolic heart failure in which ejection fraction (EF) remains "normal" despite progression of disease. The myocardial contraction fraction (MCF) is an index of myocardial function, defined as stroke volume (SV) over myocardial volume (MV). We hypothesized that MCF would be superior to EF, the conventional measure of left ventricular function, in predicting survival among patients with cardiac amyloidosis. Sixty-six subjects (mean age = 67 ± 12 years; 20% women) with cardiac amyloidosis (34 with light-chain amyloid and 32 with transthyretin amyloid) underwent two-dimensional echocardiography to determine left ventricular structure and function. Cox proportional hazard modeling was used to determine the association of MCF and EF with survival. Over a mean follow-up of 1.86 ± 1.78 years (range 0.03-7.36 years), 37 subjects (56.1%) died. Mean EF of the study population was 51 ± 13%. There was no significant difference in EF between patients who survived the study period and those who died (54 ± 11% versus 49 ± 14%; p = 0.1196) while there was a significant difference in MCF (35 ± 19% versus 23 ± 10%, p = 0.0065). Using Cox proportional hazards modeling, MCF was associated with death (HR = 0.953, 95% CI of 0.932-0.984, p = 0.0031) while EF was not (HR = 0.991, 95% CI of 0.968-1.014, p = 0.4320). In a multivariate model, amyloid light-chain (AL) amyloid type was an independent risk predictor of death with a HR of 2.841 (95% CI of 1.214-6.648, p = 0.0161) along with a MCF < 30 with a HR of 2.567 (95% CI of 1.197-5.508, p = 0.0155), which was driven by a higher risk in AL subjects with a MCF < 30, HR of 3.39 (95% CI of 1.20-9.55, p = 0.021) than TTR subjects with a MCF < 30, HR of 1.26 (95% CI of 0.36-3.28, p = 0.87). In conclusion, MCF, a novel measure of myocardial chamber function, is superior to EF in predicting overall survival among patients with AL cardiac amyloidosis. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.

Borovka M.,Allen University | Teruya S.,Allen University | Alvarez J.,Allen University | Helmke S.,Allen University | Maurer M.S.,Allen University
Journal of Cardiac Failure | Year: 2013

Background Hyporesponders to erythropoietin-stimulating agents (ESAs) have been associated with an increased subsequent risk of death or cardiovascular events. We hypothesized that subjects who are hyporesponsive to erythropoietin alfa would have higher plasma volumes and lower red cell deficits than subjects who are responsive to therapy. Methods As part of a prospective, single blind, randomized, placebo-controlled study comparing erythropoietin alfa with placebo in older adults (n = 56) with heart failure and a preserved ejection fraction (HFPEF), we performed blood volume analysis with the use of an indicator dilution technique with 131iodine-labeled albumin. We evaluated differences in plasma volumes and red cell volumes in hyporesponders (eg, <1 g/dL increase in hemoglobin within the first 4 weeks of treatment with erythropoetin alfa) compared with subjects who were responders and controls. Results Nine of 28 subjects (32%) assigned to ESA were hyporesponders. Hyporesponders did not differ from responders nor control subjects by any baseline demographic, clinical, or laboratory parameter, including hemoglobin. Hyporesponders had a greater total blood volume expansion (1,264.7 ± 387 vs 229 ± 206 mL; P =.02) but less of a red cell deficit (-96.2 ± 126 vs -402.5 ± 80.6 mL; P =.04) and a greater plasma volume expansion (+1,360.8 ± 264.5 vs +601.1 ± 165.5 mL; P =.01). Among responders, the increase in hemoglobin with erythropoietin alfa was associated primarily with increases in red cell volume (r = 0.91; P <.0001) as well as a decline in plasma volume (r = -0.55; P =.06). Conclusions Among older adults with HFPEF and anemia, hyporesponders to erythropoietin alfa had a hemodilutional basis of their anemia, suggesting that blood volume analysis can identify a cohort likely to respond to therapy. © 2013 Elsevier Inc. All rights reserved.

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