Allegheny Singer Research Institute

Pittsburgh, PA, United States

Allegheny Singer Research Institute

Pittsburgh, PA, United States

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Methods, systems, and kits useful for determining whether a subject is likely to benefit from therapy with an antibody are provided. In particular aspects, cell-bound complement activation products (CB-CAPs) associated with B lymphocytes may serve as diagnostic biomarkers.


Patent
Allegheny Singer Research Institute | Date: 2016-09-13

Cell-bound complement activation product (CB-CAP) profiling and scoring serve as diagnostic biomarkers for patients to determine whether a patient who has not met at least four American College of Rheumatology (or similar e.g. SLICC) criteria for a definite Lupus diagnosis should be classified as exhibiting a pre-existing condition that this document refers to as pre-Lupus. This document also describes methods for determining whether a patient who has been determined to exhibit pre-Lupus has progressed to exhibiting definite Lupus.


Patent
Allegheny Singer Research Institute | Date: 2017-06-14

Provided are methods, systems, and kits for diagnosing or monitoring systemic lupus erythematosus in an individual. In particular aspects, in a blood sample containing white blood cells from the individual, autoantibodies deposited on or contacting with the surface of a T lymphocyte in the sample are quantitated.


Patent
Carnegie Mellon University, Allegheny Singer Research Institute and Carmell Therapeutics Corporation | Date: 2014-12-15

Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.


Patent
Carnegie Mellon University, Carmell Therapeutics Corporation and Allegheny Singer Research Institute | Date: 2013-03-11

Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.


Patent
Allegheny Singer Research Institute | Date: 2015-08-06

Cell-bound complement activation product (CB-CAP) profiling and scoring serve as diagnostic biomarkers for patients to determine whether a patient who has not met at least four American College of Rheumatology (or similar e.g. SLICC) criteria for a definite Lupus diagnosis should be classified as exhibiting a pre-existing condition that this document refers to as pre-Lupus.


Patent
Allegheny Singer Research Institute | Date: 2015-08-07

Provided are methods, systems, and kits for diagnosing or monitoring systemic lupus erythematosus in an individual. In particular aspects, in a blood sample containing white blood cells from the individual, autoantibodies deposited on or contacting with the surface of a T lymphocyte in the sample are quantitated.


Patent
Allegheny Singer Research Institute | Date: 2016-05-02

Methods and compositions useful for gene transfer into a salivary gland are provided. In certain aspects, methods and compositions useful in the treatment of hyposalivation and/or xerostomia are provided. In particular aspects, methods may include contacting a salivary gland of a subject with a composition containing microbubbles and a non-viral expression vector containing a nucleic acid sequence encoding a water channel, and applying ultrasound to the salivary gland.


A method and system for ordering and arranging a data set. The data set is initially accessed, the data set including includes a set of diagnostic test values and one or more outcomes for each of a plurality of patients. A first and second patient data set is retrieved from the data set. A first set of diagnostic test values are selected from the first patient data set, and a second set of diagnostic text values are selected from the second patient data set. The diagnostic test values are normalized and ordered, and equations are created describing the normalized and ordered test values. A processing device compares the created equations to determine a treatment plan for the first patient based upon determined similarities to the second patient.


Patent
University of Michigan, Allegheny Singer Research Institute and Colorado State University | Date: 2014-08-25

The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.

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