Alkharj University

Al Qurayyāt, Saudi Arabia

Alkharj University

Al Qurayyāt, Saudi Arabia
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Shahid M.,Alkharj University | Shahid M.,King Saud University | Dhillon V.S.,CSIRO | Khalil H.S.,King Saud University | And 4 more authors.
BMC Medical Genetics | Year: 2010

Background: Sex determining factor (SRY) located on the short arm of the Y chromosome, plays an important role in initiating male sex determination, resulting in development of testicular tissue. Presence of the SRY gene in females results in XY sex reversal and increased risk of gonadal germ cell tumours if the karyotype also includes the so-called GonadoBlastoma on the Y chromosome (GBY) region. The majority of mutations within the SRY gene are de novo affecting only a single individual in the family. The mutations within the high-mobility group (HMG) region have the potential to affect its DNA binding activity.Case Presentation: We performed G- and R-banding cytogenetic analysis of the patient and her family members including her father. We also performed molecular genetic analysis of SRY gene. Cytogenetic analysis in the patient (Turner Syndrome) revealed the mosaic karyotype as 45, X/46, XY (79%/21% respectively) while her father (milder features with testicular dysgenesis syndrome) has a normal male karyotype (46, XY). Using molecular approach, we screened the patient and her father for mutations in the SRY gene. Both patient and her father showed the same deletion of cytosine within HMG box resulting in frame shift mutation (L94fsX180), the father in a mosaic pattern. Histological examination of the gonads from the patient revealed the presence of gonadoblastoma formation, while the father presented with oligoasthenozoospermia and a testicular seminoma. The frameshift mutation at this codon is novel, and may result in a mutated SRY protein.Conclusion: Our results suggest that lack of a second sex chromosome in majority cells of the patient may have triggered the short stature and primary infertility, and the mutated SRY protein may be associated with the development of gonadoblastoma. It is of importance to note that mosaic patients without a SRY mutation also have a risk for malignant germ cell tumors. © 2010 Shahid et al; licensee BioMed Central Ltd.


Shahid M.,Alkharj University | Shahid M.,Jamia Millia Islamia University | Dhillon V.S.,CSIRO | Khalil H.S.,King Saud University | And 3 more authors.
European Journal of Human Genetics | Year: 2011

Microdeletions in azoospermia factor (AZF) region on distal Yq are associated with male infertility and spermatogenic failure due to intra-chromosomal homologous recombination between large nearly identical repeat amplicons and are found in 10% of azoospermic and severe oligozoospermic cases. Although AZFc is deleted in azoospermia or oligozoospermia, no definitive conclusion has been drawn for the role of partial AZFc deletions to spermatogenic failure. Therefore, this study is planned to investigate the role of gr/gr subdeletions in individuals with spermatogenic failure and to find its relationship with Y chromosome haplogroups (HGs) in infertile men from Indian population. It is a case-control study involving 236 azoospermic, 182 oligospermic and 240 healthy normozoospermic men. We found 18 gr/gr, 11 b1/b3 and 2 b2/b3 subdeletions in azoospermic patients and 12 gr/gr, 5 b1/b3 and 4 b2/b3 subdeletions in oligospermic patients. However, we also found seven gr/gr deletions in normozoospermic men. Seven patients each with spermatogenic arrest and oligospermia who carry gr/gr subdeletions have deleted DAZ3/DAZ4 genes. A total of 11 patients with sertoli cell-only syndrome (SCOS) and 5 oligospermic patients with gr/gr subdeletions also have DAZ1/DAZ2 genes deleted indicating that deletions of DAZ genes contributed differently to damage to spermatogenic process. L1 HG is found in patients showing b1/b3 subdeletions, whereas HG H1a2 and H1b were found in normozoospermic individuals with gr/gr subdeletions. Our results provide evidence of association between the occurrence of subdeletions and male infertility as well as the severity of the spermatogenic failure. © 2010 Macmillan Publishers Limited All rights reserved.


Al-Dosari M.,King Saud University | Alqasoumi S.,King Saud University | Ahmad M.,Alkharj University | Al-Yahya M.,King Saud University | And 2 more authors.
Farmacia | Year: 2011

The lyophilized aqueous extract of Beta vulgaris L. (beet root) (BVE) was investigated for its possible antihypercholesterolemic and antioxidant potential in cholesterol rich diet-induced hypercholesterolemia in Wistar albino rats. Hypercholesterolemia was induced in rats by feeding 1% cholesterol rich diet for 10 weeks. Lipid profile and glucose were estimated in serum. Malondialdehyde (MDA) and non-protein sulfhydryls (NP-SH) levels were measured in liver and heart. Hypercholesterolemic rats showed a significant increase in total cholesterol and triglycerides and a significant decrease in high-density lipoprotein-cholesterol (HDL-C) levels. BVE at the doses of 250 and 500 mg/kg body weight for 70 consecutive days showed a significant decrease in total cholesterol and triglycerides and significant increase in HDL-C. Furthermore, hypercholesterolemic rats showed free radical generation (lipid peroxidation), evident by a significant increase in MDA level and a significant reduction in NP-SH content in both liver and heart homogenates. BVE treatment significantly decreased MDA level and significantly replenished the reduced NP-SH content in both liver and heart tissue. The acute toxicity test of BVE showed no mortality or morbidity in rats. The findings indicate that BVE has a significant antihypercholesterolemic and antioxidant potential and/or free radical scavenging properties in hypercholesterolemic, rats possibly exerted by the phytoconstituents present in the beet root.


Shalaby M.,Ain Shams University | El-Labany S.K.,Mansoura University | Sabry R.,Mansoura University | Sabry R.,Alkharj University | And 2 more authors.
Physics of Plasmas | Year: 2011

Theoretical investigation is carried out for understanding the properties of three-dimensional electron-acoustic waves propagating in magnetized plasma whose constituents are cold magnetized electron fluid, hot electrons obeying nonthermal distribution, and stationary ions. For this purpose, the hydrodynamic equations for the cold magnetized electron fluid, nonthermal electron density distribution, and the Poisson equation are used to derive the corresponding nonlinear evolution equation, Zkharov-Kuznetsov (ZK) equation, in the small- but finite- amplitude regime. The ZK equation is solved analytically and it is found that it supports both solitary and blow-up solutions. It is found that rarefactive electron-acoustic solitary waves strongly depend on the density and temperature ratios of the hot-to-cold electron species as well as the nonthermal electron parameter. Furthermore, there is a critical value for the nonthermal electron parameter, which decides whether the electron-acoustic solitary wave's amplitude is decreased or increased by changing various plasma parameters. Importantly, the change of the propagation angles leads to miss the balance between the nonlinearity and dispersion; hence, the localized pulses convert to explosiveblow-up pulses. The relevance of this study to the nonlinear electron-acoustic structures in the dayside auroral zone in the light of Viking satellite observations is discussed. © 2011 American Institute of Physics.


Bougoffa L.,Al Imam University | Al-Haqbani M.,Alkharj University
Kybernetes | Year: 2012

Purpose: In this paper, Fredholm integral equations of the first kind, the Schlomilch integral equation, and a class of related integral equations of the first kind with constant limits of integration are transformed in such a manner that the Adomian decomposition method (ADM) can be applied. Some examples with closed-form solutions are studied in detail to further illustrate the proposed technique, and the results obtained indicate this approach is indeed practical and efficient. The purpose of this paper is to develop a new iterative procedure where the integral equations of the first kind are recast into a canonical form suitable for the ADM. Hence it examines how this new procedure provides the exact solution. Design/methodology/approach: The new technique, as presented in this paper in extending the applicability of the ADM, has been shown to be very efficient for solving Fredholm integral equations of the first kind, the Schlomilch integral equation and a related class of nonlinear integral equations with constant limits of integration. Findings: By using the new proposed technique, the ADM can be easily used to solve the integral equations of the first kind, the Schlomilch integral equation, and a class of related integral equations of the first kind with constant limits of integration. Originality/value: The paper shows that this new technique is easy to implement and produces accurate results. © Emerald Group Publishing Limited.


Al-Anazi A.F.,King Saud bin Abdulaziz University for Health Sciences | Qureshi V.F.,King Khalid University | Javaid K.,King Khalid University | Qureshi S.,Alkharj University
Journal of Natural Science, Biology and Medicine | Year: 2011

Estrogen deficiency is a major risk factor for osteoporosis in postmenopausal women. Although hormone replacement therapy (HRT) has been rampantly used to recompense for the bone loss, but the procedure is coupled with severe adverse effects. Hence, there is a boost in the production of newer synthetic products to ward off the effects of menopause-related osteoporosis. As of today, there are several prescription products available for the treatment of postmenopause osteoporosis; most of these are estrogenic agents and combination products. Nevertheless, in view of the lack of effect and/or toxicity of these products, majority of the postmenopausal women are now fascinated by highly publicized natural products. This is an offshoot of the generalized consensus that these products are more effective and free from any adverse effects. Recently, certain plant-derived natural products, mostly phytoestrogens (isoflavones, lignans, coumestanes, stilbenes, flavonoids) and many more novel estrogen-like compounds in plants have been immensely used to prevent menopause-related depletion in bone mineral density (BMD). Although, a number of papers are published on menopause-related general symptoms, sexual dysfunction, cardiovascular diseases, Alzheimer's disease, diabetes, colon, and breast cancers, there is paucity of literature on the accompanying osteoporosis and its treatment. In view of the controversies on synthetic hormones and drugs and drift of a major population of patients toward natural drugs, it was found worthwhile to investigate if these drugs are suitable to be used in the treatment of postmenopausal osteoporosis. Preparation of this paper is an attempt to review the (a) epidemiology of postmenopausal osteoporosis, (b) treatment modalities of postmenopausal osteoporosis by hormones and synthetic drugs and the associated drawbacks and adverse effects, and (c) prevention and treatment of postmenopausal osteoporosis by phytoestrogens, their drawbacks and toxicity. It is apparent that both the categories of treatment are useful and both have adverse effects, but the plant products are nonscientific and hence are not advised to be used till more studies are undertaken to ensure that the benefits clearly outweigh the risk, in addition to recognition by Food and Drug Administration.


El-Shewy E.K.,Mansoura University | El-Shewy E.K.,Qassim University | Abdelwahed H.G.,Mansoura University | Abdelwahed H.G.,Alkharj University | Elmessary M.A.,Mansoura University
Physics of Plasmas | Year: 2011

The reductive perturbation method has been used to derive the Korteweg-de Vries-Burger equation and modified Korteweg-de Vries-Burger for dust acoustic shock waves in a homogeneous unmagnetized plasma having electrons, singly charged ions, hot and cold dust species with Boltzmann distributions for electrons and ions in the presence of the cold (hot) dust viscosity coefficients. The behavior of the shock waves in the dusty plasma has been investigated. © 2011 American Institute of Physics.


Elwakil S.A.,Mansoura University | Zahran M.A.,Mansoura University | Zahran M.A.,Alkharj University | El-Shewy E.K.,Mansoura University | And 2 more authors.
Advances in Space Research | Year: 2011

A theoretical investigation has been made for adiabatic positive and negative dust charge fluctuations on the propagation of dust-ion acoustic waves (DIAWs) in a weakly inhomogeneous, collisionless, unmagnetized dusty plasmas consisting of cold positive ions, stationary positively and negatively charged dust particles and isothermal electrons. The reductive perturbation method is employed to reduce the basic set of fluid equations to the variable coefficients Korteweg-de Vries (KdV) equation. Either compressive or rarefactive solitons are shown to exist depending on the critical value of the ion density, which in turn, depends on the inhomogeneous distribution of the ion. The dissipative effects of non-adiabatic dust charge variation has been studied which cause generation of dust ion acoustic shock waves governed by KdV-Burger (KdVB) equation. The results of the present investigation may be applicable to some dusty plasma environments, such as dusty plasma existing in polar mesosphere region. © 2011 COSPAR. Published by Elsevier Ltd. All rights reserved.


Abd El-Salam M.M.,Alkharj University | Abd El-Salam M.M.,Alexandria University | El-Naggar H.M.,Alexandria University
Journal of Cleaner Production | Year: 2010

The paper shows implementation of in-plant control measures in two pasta plants and conducts economic analysis for revenues from these modifications. In order to reuse wastewater, 12 end-of-pipe samples for each plant were tested for physico-chemical characteristics using standard methods. The results showed that the adopted in-plant modifications such as installation of water flow meters, spring valves on water hoses, and design of a steam condensate recovery system contributed efficiently in saving water and energy consumption throughout the pasta plants. An estimated annual benefit of $228,245 can be achieved. Cost benefit analysis for the implemented environmental improvements proved to be very economic with a short payback period and resulted in great savings. © 2010 Elsevier B.V. All rights reserved.


Al-Asmari A.K.,Alkharj University | Al-Qodah M.A.,Alkharj University | Salama A.S.,Alkharj University
Proceedings - 2011 IEEE International Conference on System Engineering and Technology, ICSET 2011 | Year: 2011

This paper presents a new technique which uses pixel value differencing (PVD) method and least significant replacement method to hide data in the four first order levels decomposed by discrete wavelet transform (DWT). The simulation results show that the proposed technique gives high performance in terms of capacity, human visual quality and PSNR better than PVD+3LSB method, the Overlapping PVD method and Semi-hexagonal PVD method (SH-PVD). © 2011 IEEE.

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